SG11202103478RA - Trispecific anti-cd38, anti-cd28, and anti-cd3 binding proteins and methods of use for treating viral infection - Google Patents
Trispecific anti-cd38, anti-cd28, and anti-cd3 binding proteins and methods of use for treating viral infectionInfo
- Publication number
- SG11202103478RA SG11202103478RA SG11202103478RA SG11202103478RA SG11202103478RA SG 11202103478R A SG11202103478R A SG 11202103478RA SG 11202103478R A SG11202103478R A SG 11202103478RA SG 11202103478R A SG11202103478R A SG 11202103478RA SG 11202103478R A SG11202103478R A SG 11202103478RA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- trispecific
- binding proteins
- viral infection
- treating viral
- Prior art date
Links
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 208000036142 Viral infection Diseases 0.000 title 1
- 108091008324 binding proteins Proteins 0.000 title 1
- 230000009385 viral infection Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2018/055084 WO2019074973A2 (en) | 2017-10-10 | 2018-10-09 | Anti-cd38 antibodies and methods of use |
US201962831608P | 2019-04-09 | 2019-04-09 | |
US201962831572P | 2019-04-09 | 2019-04-09 | |
EP19306097 | 2019-09-11 | ||
PCT/US2019/055232 WO2020076853A1 (en) | 2018-10-09 | 2019-10-08 | Trispecific anti-cd38, anti-cd28, and anti-cd3 binding proteins and methods of use for treating viral infection |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202103478RA true SG11202103478RA (en) | 2021-05-28 |
Family
ID=70165121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202103478RA SG11202103478RA (en) | 2018-10-09 | 2019-10-08 | Trispecific anti-cd38, anti-cd28, and anti-cd3 binding proteins and methods of use for treating viral infection |
Country Status (14)
Country | Link |
---|---|
US (2) | US11530268B2 (en) |
EP (1) | EP3864043A1 (en) |
JP (1) | JP7462621B2 (en) |
KR (1) | KR20210075129A (en) |
CN (1) | CN113166254A (en) |
AU (1) | AU2019357467A1 (en) |
BR (1) | BR112021006558A2 (en) |
CA (1) | CA3115679A1 (en) |
CO (1) | CO2021004534A2 (en) |
IL (1) | IL282126A (en) |
MX (1) | MX2021004147A (en) |
SG (1) | SG11202103478RA (en) |
TW (1) | TW202035458A (en) |
WO (1) | WO2020076853A1 (en) |
Families Citing this family (21)
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TWI671315B (en) * | 2011-03-28 | 2019-09-11 | 法商賽諾菲公司 | Dual variable region antibody-like binding proteins having cross-over binding region orientation |
CA3002664A1 (en) | 2015-10-25 | 2017-05-04 | Sanofi | Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection |
HRP20231188T1 (en) | 2016-04-13 | 2024-02-02 | Sanofi | Trispecific and/or trivalent binding proteins |
PT3443006T (en) | 2017-03-17 | 2023-10-26 | Sanofi Sa | Trispecific and/or trivalent binding proteins |
AU2018348093A1 (en) | 2017-10-10 | 2020-05-28 | Sanofi | Anti-CD38 antibodies and combinations with anti-CD3 and anti-CD28 antibodies |
KR20210005169A (en) | 2018-04-25 | 2021-01-13 | 프로메테우스 바이오사이언시즈, 인크. | Optimized anti-TL1A antibody |
MX2021004147A (en) | 2018-10-09 | 2021-09-08 | Sanofi Sa | Trispecific anti-cd38, anti-cd28, and anti-cd3 binding proteins and methods of use for treating viral infection. |
US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
CA3136821A1 (en) * | 2019-04-09 | 2020-10-15 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
KR20220103721A (en) | 2019-10-24 | 2022-07-22 | 프로메테우스 바이오사이언시즈, 인크. | Humanized Antibodies to TNF-Like Ligand 1A (TL1A) and Uses Thereof |
CA3192204A1 (en) | 2020-08-19 | 2022-02-24 | Xencor, Inc. | Anti-cd28 and/or anti-b7h3 compositions |
AU2022206324A1 (en) | 2021-01-11 | 2023-07-20 | Sana Biotechnology, Inc. | Use of cd8-targeted viral vectors |
CA3202891A1 (en) | 2021-01-28 | 2022-08-04 | Kara Olson | Compositions and methods for treating cytokine release syndrome |
TW202321457A (en) | 2021-08-04 | 2023-06-01 | 美商薩那生物科技公司 | Use of cd4-targeted viral vectors |
WO2023150518A1 (en) | 2022-02-01 | 2023-08-10 | Sana Biotechnology, Inc. | Cd3-targeted lentiviral vectors and uses thereof |
WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
US20230357446A1 (en) | 2022-04-11 | 2023-11-09 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for universal tumor cell killing |
WO2023215560A1 (en) | 2022-05-05 | 2023-11-09 | Atoosa Corporation | Tumor cell/immune cell multivalent receptor engager – bio-nanoparticle (timre-bnp) |
WO2023246911A1 (en) * | 2022-06-24 | 2023-12-28 | 北京可瑞生物科技有限公司 | T cell receptor-based bispecific polypeptide molecule and use thereof |
WO2024026377A1 (en) | 2022-07-27 | 2024-02-01 | Sana Biotechnology, Inc. | Methods of transduction using a viral vector and inhibitors of antiviral restriction factors |
WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
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JP2755395B2 (en) | 1987-09-23 | 1998-05-20 | ブリストル―マイアーズ スクイブ コムパニー | Antibody heteroconjugate that kills HIV-infected cells |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
PT1068241E (en) | 1998-04-02 | 2007-11-19 | Genentech Inc | Antibody variants and fragments thereof |
CN1294148C (en) | 2001-04-11 | 2007-01-10 | 中国科学院遗传与发育生物学研究所 | Single-stranded cyctic trispecific antibody |
JP5068072B2 (en) | 2003-06-27 | 2012-11-07 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Modified binding molecule comprising a linking peptide |
US9200061B2 (en) | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i |
CN100376599C (en) | 2004-04-01 | 2008-03-26 | 北京安波特基因工程技术有限公司 | Recombining single chained three specific antibodies of anti CCA, anti CD 3, anti CD 28 through genetic engineering |
EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
AR072001A1 (en) | 2008-06-03 | 2010-07-28 | Abbott Lab | IMMUNOGLOBULIN WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME |
CN103403026B (en) | 2009-09-25 | 2016-05-11 | 美国政府(由卫生和人类服务部的部长所代表) | HIV-1 neutralizing antibody and uses thereof |
WO2011154453A1 (en) | 2010-06-09 | 2011-12-15 | Genmab A/S | Antibodies against human cd38 |
JOP20210044A1 (en) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | Anti-cd38 antibodies |
TWI671315B (en) | 2011-03-28 | 2019-09-11 | 法商賽諾菲公司 | Dual variable region antibody-like binding proteins having cross-over binding region orientation |
WO2012154312A1 (en) | 2011-05-09 | 2012-11-15 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Neutralizing antibodies to hiv-1 and their use |
JP6323718B2 (en) | 2011-05-17 | 2018-05-16 | ザ ロックフェラー ユニバーシティー | Antibodies that detoxify human immunodeficiency virus and methods of use thereof. |
EP2776463B1 (en) | 2011-11-07 | 2017-09-20 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Neutralizing gp41 antibodies and their use |
EP2788376B1 (en) | 2011-12-08 | 2018-10-03 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Neutralizing antibodies to hiv-1 and their use |
WO2013163427A1 (en) | 2012-04-25 | 2013-10-31 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Antibodies to treat hiv-1 infection |
EP2928924A4 (en) | 2012-12-04 | 2016-07-13 | Univ Maryland | Hiv-1 env-binding antibodies, fusion proteins, and methods of use |
US20140213772A1 (en) | 2012-12-28 | 2014-07-31 | Abbvie, Inc. | Cross-over dual variable domain immunoglobulin constructs |
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TW201446800A (en) | 2013-03-15 | 2014-12-16 | Abbvie Inc | Dual specific binding proteins directed against TNF α |
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RS59907B1 (en) | 2014-03-28 | 2020-03-31 | Xencor Inc | Bispecific antibodies that bind to cd38 and cd3 |
CA2996848C (en) | 2014-09-04 | 2021-01-05 | Stemcell Technologies Inc. | Soluble antibody complexes for t cell or nk cell activation and expansion |
US10428155B2 (en) | 2014-12-22 | 2019-10-01 | Xencor, Inc. | Trispecific antibodies |
PL3247725T3 (en) | 2015-01-23 | 2021-01-11 | Sanofi | Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123 |
US10654943B2 (en) | 2015-06-02 | 2020-05-19 | The Rockefeller University | Tri-specific antibodies for HIV therapy |
CA3002664A1 (en) | 2015-10-25 | 2017-05-04 | Sanofi | Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection |
CN105837688B (en) | 2015-11-20 | 2019-02-26 | 北京大学深圳研究生院 | Single domain antibody and its encoding gene, immunotoxin and its encoding gene, preparation method, expression vector, application and host cell |
EP3575319A4 (en) * | 2016-12-30 | 2021-03-10 | Shanghai Sinobio Biotech Co., Ltd. | Bifunctional molecule and use thereof |
US10626169B2 (en) | 2017-02-17 | 2020-04-21 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
PT3443006T (en) | 2017-03-17 | 2023-10-26 | Sanofi Sa | Trispecific and/or trivalent binding proteins |
AU2018348093A1 (en) | 2017-10-10 | 2020-05-28 | Sanofi | Anti-CD38 antibodies and combinations with anti-CD3 and anti-CD28 antibodies |
MX2021004147A (en) | 2018-10-09 | 2021-09-08 | Sanofi Sa | Trispecific anti-cd38, anti-cd28, and anti-cd3 binding proteins and methods of use for treating viral infection. |
US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
-
2019
- 2019-10-08 MX MX2021004147A patent/MX2021004147A/en unknown
- 2019-10-08 EP EP19791158.9A patent/EP3864043A1/en active Pending
- 2019-10-08 CN CN201980079373.3A patent/CN113166254A/en active Pending
- 2019-10-08 WO PCT/US2019/055232 patent/WO2020076853A1/en unknown
- 2019-10-08 AU AU2019357467A patent/AU2019357467A1/en active Pending
- 2019-10-08 BR BR112021006558-0A patent/BR112021006558A2/en unknown
- 2019-10-08 CA CA3115679A patent/CA3115679A1/en active Pending
- 2019-10-08 TW TW108136331A patent/TW202035458A/en unknown
- 2019-10-08 SG SG11202103478RA patent/SG11202103478RA/en unknown
- 2019-10-08 JP JP2021519642A patent/JP7462621B2/en active Active
- 2019-10-08 US US16/596,474 patent/US11530268B2/en active Active
- 2019-10-08 KR KR1020217013675A patent/KR20210075129A/en unknown
-
2021
- 2021-04-07 IL IL282126A patent/IL282126A/en unknown
- 2021-04-12 CO CONC2021/0004534A patent/CO2021004534A2/en unknown
-
2022
- 2022-11-11 US US18/054,734 patent/US20230357401A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CO2021004534A2 (en) | 2021-04-30 |
AU2019357467A1 (en) | 2021-05-27 |
MX2021004147A (en) | 2021-09-08 |
JP2022512649A (en) | 2022-02-07 |
IL282126A (en) | 2021-05-31 |
KR20210075129A (en) | 2021-06-22 |
JP7462621B2 (en) | 2024-04-05 |
TW202035458A (en) | 2020-10-01 |
CA3115679A1 (en) | 2020-04-16 |
EP3864043A1 (en) | 2021-08-18 |
US20230357401A1 (en) | 2023-11-09 |
US11530268B2 (en) | 2022-12-20 |
BR112021006558A2 (en) | 2021-07-13 |
WO2020076853A1 (en) | 2020-04-16 |
CN113166254A (en) | 2021-07-23 |
US20200140552A1 (en) | 2020-05-07 |
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