US20150118300A1 - Immediate Release Abuse-Deterrent Granulated Dosage Forms - Google Patents

Immediate Release Abuse-Deterrent Granulated Dosage Forms Download PDF

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Publication number
US20150118300A1
US20150118300A1 US14/333,986 US201414333986A US2015118300A1 US 20150118300 A1 US20150118300 A1 US 20150118300A1 US 201414333986 A US201414333986 A US 201414333986A US 2015118300 A1 US2015118300 A1 US 2015118300A1
Authority
US
United States
Prior art keywords
dosage form
immediate release
core
abuse deterrent
form according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US14/333,986
Other languages
English (en)
Inventor
Dinesh K. Haswani
Derek V. Moe
Victoria A. O'Neill
Manuel A. Vega Zepeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cima Labs Inc
Original Assignee
Cima Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51263565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20150118300(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cima Labs Inc filed Critical Cima Labs Inc
Priority to US14/333,986 priority Critical patent/US20150118300A1/en
Priority to PCT/US2014/054061 priority patent/WO2015065586A1/en
Priority to US14/477,354 priority patent/US20150118301A1/en
Priority to US14/484,793 priority patent/US20150118295A1/en
Assigned to CIMA LABS INC. reassignment CIMA LABS INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HASWANI, DINESH K., VEGA ZEPEDA, MANUEL A., MOE, DEREK V., O'NEILL, VICTORIA A.
Priority to EA201690874A priority patent/EA032013B1/ru
Priority to CN201480059281.6A priority patent/CN105682647A/zh
Priority to PE2016000556A priority patent/PE20160606A1/es
Priority to KR1020167013870A priority patent/KR102363573B1/ko
Priority to EP14858628.2A priority patent/EP3062778A4/en
Priority to PCT/US2014/062887 priority patent/WO2015066172A1/en
Priority to US15/032,658 priority patent/US20160250203A1/en
Priority to CA2900858A priority patent/CA2900858C/en
Priority to MX2016005482A priority patent/MX2016005482A/es
Priority to JP2016552219A priority patent/JP6659925B2/ja
Priority to US14/527,215 priority patent/US9707224B2/en
Priority to AU2014342412A priority patent/AU2014342412B2/en
Priority to US14/539,231 priority patent/US9757371B2/en
Publication of US20150118300A1 publication Critical patent/US20150118300A1/en
Priority to IL245125A priority patent/IL245125B/en
Priority to ZA2016/04451A priority patent/ZA201604451B/en
Priority to CL2016001031A priority patent/CL2016001031A1/es
Priority to HK16112327.1A priority patent/HK1223856A1/zh
Priority to US15/908,013 priority patent/US10568881B2/en
Priority to US16/751,043 priority patent/US11207318B2/en
Priority to US17/527,528 priority patent/US11844796B2/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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US14/333,986 2013-10-31 2014-07-17 Immediate Release Abuse-Deterrent Granulated Dosage Forms Abandoned US20150118300A1 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
US14/333,986 US20150118300A1 (en) 2013-10-31 2014-07-17 Immediate Release Abuse-Deterrent Granulated Dosage Forms
PCT/US2014/054061 WO2015065586A1 (en) 2013-10-31 2014-09-04 Immediate release abuse-deterrent granulated dosage forms
US14/477,354 US20150118301A1 (en) 2013-10-31 2014-09-04 Immediate Release Abuse-Deterrent Granulated Dosage Forms
US14/484,793 US20150118295A1 (en) 2013-10-31 2014-09-12 Immediate Release Abuse-Deterrent Granulated Dosage Forms
US14/527,215 US9707224B2 (en) 2013-10-31 2014-10-29 Immediate release abuse-deterrent granulated dosage forms
CA2900858A CA2900858C (en) 2013-10-31 2014-10-29 Immediate release abuse-deterrent granulated dosage forms
CN201480059281.6A CN105682647A (zh) 2013-10-31 2014-10-29 立即释放型滥用制止粒状剂型
AU2014342412A AU2014342412B2 (en) 2013-10-31 2014-10-29 Immediate release abuse-deterrent granulated dosage forms
PE2016000556A PE20160606A1 (es) 2013-10-31 2014-10-29 Formas de dosificacion granuladas disuasivas del abuso de liberacion inmediata
KR1020167013870A KR102363573B1 (ko) 2013-10-31 2014-10-29 즉시 방출 남용 저지 입상 투여 형태
EP14858628.2A EP3062778A4 (en) 2013-10-31 2014-10-29 Immediate release abuse-deterrent granulated dosage forms
PCT/US2014/062887 WO2015066172A1 (en) 2013-10-31 2014-10-29 Immediate release abuse-deterrent granulated dosage forms
US15/032,658 US20160250203A1 (en) 2013-10-31 2014-10-29 Immediate release abuse-deterrent granulated dosage forms
EA201690874A EA032013B1 (ru) 2013-10-31 2014-10-29 Препятствующие злоупотреблению гранулированные лекарственные формы с немедленным высвобождением
MX2016005482A MX2016005482A (es) 2013-10-31 2014-10-29 Formas de dosificacion granuladas disuasivas del abuso de liberacion inmediata.
JP2016552219A JP6659925B2 (ja) 2013-10-31 2014-10-29 即放性乱用抑止性剤形
US14/539,231 US9757371B2 (en) 2013-10-31 2014-11-12 Immediate release abuse-deterrent granulated dosage forms
IL245125A IL245125B (en) 2013-10-31 2016-04-14 Immediate-release granulated dosage forms prevent abuse
ZA2016/04451A ZA201604451B (en) 2013-10-31 2016-04-22 Immediate release abuse-deterrent granulated dosage forms
CL2016001031A CL2016001031A1 (es) 2013-10-31 2016-04-29 Forma de dosificación de liberación inmediata que evita el abuso, que comprende partículas de núcleo recubiertas y una matriz; su uso para preparar un medicamento útil para prevenir, aliviar o aminorar un nivel de dolor y para prevenir el abuso de un fármaco analgésico narcótico, entre otros.
HK16112327.1A HK1223856A1 (zh) 2013-10-31 2016-10-26 立即釋放型濫用制止粒狀劑型
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US20220071990A1 (en) 2022-03-10
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US9707224B2 (en) 2017-07-18
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US20200155544A1 (en) 2020-05-21
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US20150118302A1 (en) 2015-04-30
US11207318B2 (en) 2021-12-28
PE20160606A1 (es) 2016-07-06
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US11844796B2 (en) 2023-12-19
US20180185354A1 (en) 2018-07-05
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US20160250203A1 (en) 2016-09-01
WO2015065547A1 (en) 2015-05-07

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