US20140045813A1 - Heteroaromatic compounds as btk inhibitors - Google Patents

Heteroaromatic compounds as btk inhibitors Download PDF

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Publication number
US20140045813A1
US20140045813A1 US13/962,260 US201313962260A US2014045813A1 US 20140045813 A1 US20140045813 A1 US 20140045813A1 US 201313962260 A US201313962260 A US 201313962260A US 2014045813 A1 US2014045813 A1 US 2014045813A1
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Prior art keywords
chosen
mmol
alkoxy
pharmaceutically acceptable
heterocycle
Prior art date
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Abandoned
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US13/962,260
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English (en)
Inventor
Joerg Martin Bentzien
Angela Kay BERRY
Todd Bosanac
Michael Jason Burke
Darren Todd DISALVO
Joshua Courtney Horan
Shuang LIANG
Can Mao
Wang Mao
Yue Shen
Fariba Soleymanzadeh
Renee M. Zindell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Rosemount Aerospace Inc
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Boehringer Ingelheim International GmbH
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49029216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20140045813(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Assigned to OXFORD RF SENSORS LIMITED reassignment OXFORD RF SENSORS LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HARRISON, MARTIN
Assigned to OXFORD RF SENSORS LIMITED reassignment OXFORD RF SENSORS LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WHERRITT, PETER
Assigned to ROSEMOUNT AEROSPACE INC. reassignment ROSEMOUNT AEROSPACE INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: OXFORD RF SENSORS LIMITED
Assigned to OXFORD RF SENSORS LIMITED reassignment OXFORD RF SENSORS LIMITED ONE-HALF UNDIVIDED INTEREST Assignors: ROSEMOUNT AEROSPACE INC.
Assigned to OXFORD RF SENSORS LIMITED reassignment OXFORD RF SENSORS LIMITED CORRECTIVE ASSIGNMENT TO CORRECT THE STREET NAME OF ASSIGNEE'S ADDRESS PREVIOUSLY RECORDED ON REEL 026897 FRAME 0808. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT OF ASSIGNOR'S INTEREST. Assignors: HARRISON, MARTIN
Assigned to OXFORD RF SENSORS LIMITED reassignment OXFORD RF SENSORS LIMITED CORRECTIVE ASSIGNMENT TO CORRECT THE THE STREET NAME OF ASSIGNEE'S ADDRESS PREVIOUSLY RECORDED ON REEL 026897 FRAME 0336. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT OF ASSIGNOR'S INTEREST. Assignors: WHERRITT, PETER
Assigned to ROSEMOUNT AEROSPACE INC. reassignment ROSEMOUNT AEROSPACE INC. CORRECTIVE ASSIGNMENT TO CORRECT THE STREET NAME OF ASSIGNEE'S ADDRESS PREVIOUSLY RECORDED ON REEL 026901 FRAME 0446. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT OF ASSIGNOR'S INTEREST. Assignors: OXFORD RF SENSORS LIMITED
Assigned to OXFORD RF SENSORS LIMITED reassignment OXFORD RF SENSORS LIMITED CORRECTIVE ASSIGNMENT TO CORRECT THE STREET NAME OF ASSIGNEE'S ADDRESS PREVIOUSLY RECORDED ON REEL 026915 FRAME 0665. ASSIGNOR(S) HEREBY CONFIRMS THE ONE-HALF UNDIVIDED INTEREST. Assignors: ROSEMOUNT AEROSPACE INC.
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Priority to US13/962,260 priority Critical patent/US20140045813A1/en
Assigned to BOEHRINGER INGELHEIM INTERNATIONAL GMBH reassignment BOEHRINGER INGELHEIM INTERNATIONAL GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BERRY, Angela Kay, BENTZIEN, JOERG MARTIN, DISALVO, DARREN TODD, HORAN, JOSHUA COURTNEY, LIANG, SHUANG, MAO, CAN, MAO, WANG, SHEN, YUE, SOLEYMANZADEH, FARIBA, BOSANAC, TODD, BURKE, MICHAEL JASON, ZINDELL, RENEE
Publication of US20140045813A1 publication Critical patent/US20140045813A1/en
Priority to US14/884,826 priority patent/US20160031872A1/en
Priority to US15/661,644 priority patent/US20170320867A1/en
Priority to US15/814,927 priority patent/US10138229B2/en
Priority to US16/160,048 priority patent/US10875852B2/en
Abandoned legal-status Critical Current

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C—CHEMISTRY; METALLURGY
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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    • C07—ORGANIC CHEMISTRY
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
US13/962,260 2012-08-10 2013-08-08 Heteroaromatic compounds as btk inhibitors Abandoned US20140045813A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US13/962,260 US20140045813A1 (en) 2012-08-10 2013-08-08 Heteroaromatic compounds as btk inhibitors
US14/884,826 US20160031872A1 (en) 2012-08-10 2015-10-16 Heteroaromatic compounds as btk inhibitors
US15/661,644 US20170320867A1 (en) 2012-08-10 2017-07-27 Heteroaromatic compounds as btk inhibitors
US15/814,927 US10138229B2 (en) 2012-08-10 2017-11-16 Heteroaromatic compounds as BTK inhibitors
US16/160,048 US10875852B2 (en) 2012-08-10 2018-10-15 Heteroaromatic compounds as BTK inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261681684P 2012-08-10 2012-08-10
US13/962,260 US20140045813A1 (en) 2012-08-10 2013-08-08 Heteroaromatic compounds as btk inhibitors

Related Child Applications (1)

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US14/884,826 Continuation US20160031872A1 (en) 2012-08-10 2015-10-16 Heteroaromatic compounds as btk inhibitors

Publications (1)

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US20140045813A1 true US20140045813A1 (en) 2014-02-13

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Application Number Title Priority Date Filing Date
US13/962,260 Abandoned US20140045813A1 (en) 2012-08-10 2013-08-08 Heteroaromatic compounds as btk inhibitors
US14/884,826 Abandoned US20160031872A1 (en) 2012-08-10 2015-10-16 Heteroaromatic compounds as btk inhibitors
US15/661,644 Abandoned US20170320867A1 (en) 2012-08-10 2017-07-27 Heteroaromatic compounds as btk inhibitors
US15/814,927 Active US10138229B2 (en) 2012-08-10 2017-11-16 Heteroaromatic compounds as BTK inhibitors
US16/160,048 Active US10875852B2 (en) 2012-08-10 2018-10-15 Heteroaromatic compounds as BTK inhibitors

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Application Number Title Priority Date Filing Date
US14/884,826 Abandoned US20160031872A1 (en) 2012-08-10 2015-10-16 Heteroaromatic compounds as btk inhibitors
US15/661,644 Abandoned US20170320867A1 (en) 2012-08-10 2017-07-27 Heteroaromatic compounds as btk inhibitors
US15/814,927 Active US10138229B2 (en) 2012-08-10 2017-11-16 Heteroaromatic compounds as BTK inhibitors
US16/160,048 Active US10875852B2 (en) 2012-08-10 2018-10-15 Heteroaromatic compounds as BTK inhibitors

Country Status (25)

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US (5) US20140045813A1 (pt)
EP (1) EP2882741B1 (pt)
JP (1) JP6348492B2 (pt)
KR (1) KR20150040292A (pt)
CN (1) CN104603124B (pt)
AP (1) AP2015008203A0 (pt)
AU (1) AU2013299557B2 (pt)
BR (1) BR112015002590A2 (pt)
CA (1) CA2881519A1 (pt)
CL (1) CL2015000256A1 (pt)
EA (1) EA029210B1 (pt)
EC (1) ECSP15008851A (pt)
GE (1) GEP201706748B (pt)
HK (1) HK1210161A1 (pt)
IL (1) IL236495A0 (pt)
IN (1) IN2015DN00524A (pt)
MA (1) MA37830B1 (pt)
MX (1) MX2015001802A (pt)
NZ (1) NZ703607A (pt)
PE (1) PE20150756A1 (pt)
PH (1) PH12015500294B1 (pt)
SA (1) SA515360007B1 (pt)
SG (1) SG11201500499TA (pt)
TN (1) TN2015000029A1 (pt)
WO (1) WO2014025976A1 (pt)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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