US20140039064A1 - Use of gingerone or derivatives thereof for reducing or delaying the signs of skin ageing - Google Patents
Use of gingerone or derivatives thereof for reducing or delaying the signs of skin ageing Download PDFInfo
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- US20140039064A1 US20140039064A1 US14/009,218 US201214009218A US2014039064A1 US 20140039064 A1 US20140039064 A1 US 20140039064A1 US 201214009218 A US201214009218 A US 201214009218A US 2014039064 A1 US2014039064 A1 US 2014039064A1
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- United States
- Prior art keywords
- skin
- signs
- compound
- gingerone
- ageing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 [2*]C(CC1=CC=C(O)C([1*]O)=C1)C([3*])C Chemical compound [2*]C(CC1=CC=C(O)C([1*]O)=C1)C([3*])C 0.000 description 5
- CLNNPXNIUKIPIP-UHFFFAOYSA-N CCCCCCC(=O)CCC1=CC(OC)=C(O)C=C1 Chemical compound CCCCCCC(=O)CCC1=CC(OC)=C(O)C=C1 CLNNPXNIUKIPIP-UHFFFAOYSA-N 0.000 description 2
- MDOAFJBLZREPFB-UHFFFAOYSA-N CCC(=O)CCC1=CC(OC)=C(O)C=C1 Chemical compound CCC(=O)CCC1=CC(OC)=C(O)C=C1 MDOAFJBLZREPFB-UHFFFAOYSA-N 0.000 description 1
- SCXGTFGNENUXKL-UHFFFAOYSA-N CCC(=O)CCC1=CC(OC)=C(O)C=C1.CCCCC(=O)CCC1=CC(OC)=C(O)C=C1.CCCCCCC(=O)CCC1=CC(OC)=C(O)C=C1.CCOC1=C(O)C=CC(CCC(C)=O)=C1.CCOC1=C(O)C=CC(CCC(C)O)=C1.COC1=C(O)C=CC(CC(C)C(C)=O)=C1.COC1=C(O)C=CC(CCC(C)=O)=C1 Chemical compound CCC(=O)CCC1=CC(OC)=C(O)C=C1.CCCCC(=O)CCC1=CC(OC)=C(O)C=C1.CCCCCCC(=O)CCC1=CC(OC)=C(O)C=C1.CCOC1=C(O)C=CC(CCC(C)=O)=C1.CCOC1=C(O)C=CC(CCC(C)O)=C1.COC1=C(O)C=CC(CC(C)C(C)=O)=C1.COC1=C(O)C=CC(CCC(C)=O)=C1 SCXGTFGNENUXKL-UHFFFAOYSA-N 0.000 description 1
- WKCSWVXARWGWMM-UHFFFAOYSA-N CCCCC(=O)CCC1=CC(OC)=C(O)C=C1 Chemical compound CCCCC(=O)CCC1=CC(OC)=C(O)C=C1 WKCSWVXARWGWMM-UHFFFAOYSA-N 0.000 description 1
- MXLOKFOWFPJWCW-UHFFFAOYSA-N CCOC1=C(O)C=CC(CCC(C)=O)=C1 Chemical compound CCOC1=C(O)C=CC(CCC(C)=O)=C1 MXLOKFOWFPJWCW-UHFFFAOYSA-N 0.000 description 1
- IQWMODAOIUINKR-UHFFFAOYSA-N COC1=C(O)C=CC(CC(C)C(C)=O)=C1 Chemical compound COC1=C(O)C=CC(CC(C)C(C)=O)=C1 IQWMODAOIUINKR-UHFFFAOYSA-N 0.000 description 1
- OJYLAHXKWMRDGS-UHFFFAOYSA-N COC1=C(O)C=CC(CCC(C)=O)=C1 Chemical compound COC1=C(O)C=CC(CCC(C)=O)=C1 OJYLAHXKWMRDGS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
Definitions
- the present invention relates to the field of ageing and of the signs that are associated therewith, on the skin. It relates in particular to the adjustment of the equilibrium between the proliferation and the differentiation of the epidermal cells.
- the skin constitutes a physical barrier between the body and its surroundings. It is constituted of two tissues: the epidermis and the dermis.
- the dermis provides the epidermis with a solid support. It is also its nourishing element. It is formed mainly from fibroblasts and an extracellular matrix, which is itself composed mainly of collagen, elastin and a substance known as ground substance, these components being synthesized by the fibroblast. Leukocytes, mast cells or else tissue macrophages are also found therein. It also contains blood vessels and nerve fibres.
- the epidermis is a desquamating pluristratified epithelium that is 100 ⁇ m thick on average and is conventionally divided into a basal layer of keratinocytes that constitutes the germinal layer of the epidermis, a spinous layer constituted of several layers of polyhedral cells positioned on the germinal cells, a granular layer constituted of flattened cells containing distinct cytoplasmic inclusions, keratohyalin granules, and finally an upper layer known as the cornified layer (or stratum corneum), constituted of keratinocytes at the terminal stage of their differentiation, known as corneocytes. These are mummified anucleated cells which derive from keratinocytes.
- the stack of these corneocytes constitutes the cornified layer that is responsible, inter alia, for the barrier function of the epidermis, i.e. it constitutes a barrier against external attacks, especially chemical, mechanical or infectious attacks and it also makes it possible to protect the body from water loss.
- Epidermal differentiation follows a process of continuous and oriented maturation in which the basal keratinocytes transform while migrating so as to result in the formation of corneocytes, dead cells that are completely keratinized.
- This differentiation is the result of perfectly coordinated phenomena which will result in the thickness of the epidermis being kept constant and thus ensure the homeostasis of the epidermis.
- This goes through a regulation of the number of cells that enter into the differentiation process and of the number of cells that desquamate. In the course of the normal desquamation process, only the most superficial corneocytes detach from the surface of the epidermis.
- Keratins are insoluble proteins produced by the epithelial cells in the form of structurally well organized filaments. These proteins are the main marker of differentiation since throughout epidermal differentiation, various types of keratin will be more or less expressed by the keratinocytes.
- Filaggrin or filagrin
- a protein present in keratohyalin granules is produced during the final stages of the differentiation of the epidermis. It is especially involved in the maturation process of the cornified layer by enabling type I and type II keratins to be arranged into coils. This protein thus enables the formation of the cytoplasmic matrix of the surface corneocytes which in particular gives the skin its normal thickness, its smooth appearance and its light-reflecting properties.
- filaggrin via its degradation within corneocytes, filaggrin provides water-soluble substances having a high osmotic power (natural moisturizing factors or NMFs) that enable a good hydration of the cornified layer of the skin to be maintained and thus avoid the feelings of “dry skin”. Filaggrin therefore enables the barrier function of the epidermis to be maintained and makes it possible to avoid drying out the skin.
- gingerone and some of the derivatives thereof increased the expression of filaggrin in the keratinocytes.
- filaggrin is a marker of the differentiation of keratinocytes
- gingerone and some of the derivatives thereof therefore have an effect of stimulating the differentiation of these cells and thus the maturation of the cornified layer. They thus enable the skin to retain or regain a normal thickness, to also have a smooth appearance, i.e without, or with fewer, wrinkles and fine lines than before their use and a more radiant, less dull complexion.
- filaggrin is involved in the skin hydration process, by increasing the expression of this protein in keratinocytes, these compounds enable the skin to fully carry out its barrier function while avoiding, in particular, the drying out thereof. They therefore make it possible to reestablish or maintain good hydration of the skin.
- Gingerone (INCI name: Zingerone), is a phenolic compound from the vanilloid family. Its formula and those of several of its derivatives are given below. Ginger ( Zingiber officinale ), mango, cranberry or raspberry may be natural sources of gingerone. Ginger, and in particular ginger oleoresin, is however the main source thereof. This molecule is to a large extent responsible for the hot flavour of ginger.
- Gingerone has already been cited among the ingredients of topical anti-ageing care compositions but it was used as a blood circulation “accelerator” (JP 2004323401, JP 2005066831) or as a hyperemizing agent (EP 1 938 789) or as an antioxidant (EP 1 932 514) or as a caustic, bitter or acid substance (JP 2004210656).
- gingerone and some of the derivatives thereof have never been described as being pro-differentiating for keratinocytes and as being able to be used specifically for treating or delaying the appearance of the signs of skin ageing.
- these compounds are of general formula (I) in which:
- the compound of general formula (I) mentioned above will preferably be chosen, alone or as a mixture, from the following compounds:
- the preferred compound will be chosen from gingerone (or zingerone) or ethyl gingerone.
- the gingerone may be, for example, supplied by the company Aldrich. Most preferred is ethyl gingerone.
- Compounds 2 and 7 may be, for example, supplied by the company SinoChemExper.
- the compounds of general formula (I), as targeted above, could be used in the form of a more or less purified molecule of natural or synthetic origin. They will preferably be of natural origin. In particular, some of these compounds could be provided in the form of plant extracts containing them, and especially in the form of an extract of ginger, of mango, of cranberry and/or of raspberry.
- Such compounds may be synthesized via synthesis pathways known in the prior art. They may in particular be prepared from commercial vanillin or ethyl vanillin. Gingerone, for example, could be obtained via the condensation of vanillin by acetone, followed by a hydrogenation.
- the expression “cutaneous signs of ageing” is understood to mean any modification in the external appearance of the skin due to ageing, whether chronobiological and/or photoinduced, such as, for example, wrinkles and fine lines, withered skin, flaccid skin, slack skin, thinned skin, dry skin, dull skin that lacks radiance, heterogeneity of the complexion and of the surface of the skin.
- the signs of chronobiological or chronological ageing correspond to internal degradations of the skin due to the intrinsic ageing of the individuals.
- the signs of photoinduced ageing (or photoageing) correspond to internal degradations of the skin following exposure to ultraviolet radiation.
- skin is understood to mean, for the purposes of the invention, the whole of the body covering, and in particular the skin, mucous membranes and scalp.
- the reduction of the signs of skin ageing and/or the delaying of their appearance, via the use of the compounds according to the present invention, takes place in particular owing to the increase or improvement in the differentiation of the epidermal cells and/or the increase or stimulation in particular of the expression of filaggrin in the epidermal keratinocytes.
- compositions used according to the invention are cosmetic compositions, i.e. they are intended to improve the aesthetic appearance of the individual.
- the use according to the present invention is especially effective for combating the signs, in particular aesthetic signs, of chronobiological and/or photoinduced ageing of the epidermis.
- combating the signs of chronobiological ageing of the skin will preferably be targeted.
- the present invention is thus effective in any person regardless of their age.
- the individuals preferably targeted will be individuals of more than 30 years old, preferably more than 40 years old.
- the signs of skin ageing are preferably chosen from the appearance of wrinkles and fine lines and/or the weakening and/or the slackening and/or the withering and/or the thinning and/or the dryness and/or the dull and/or non-radiant appearance and/or the complexion and/or the heterogeneous surface of the skin.
- the compound of general formula (I) as targeted above is present, in a composition comprising a physiologically acceptable medium, in a content between 0.1% and 10% by weight relative to the total weight of said composition.
- a “physiologically acceptable medium” is, according to the invention, a cosmetically acceptable medium that is compatible with the skin, the mucous membranes, the nails and/or the hair.
- cosmetically acceptable medium is understood to mean a medium that has no unpleasant appearance, and that does not cause the user any unacceptable stinging, tautness or redness.
- physiologically acceptable medium will be adapted to the nature of the support onto which the composition is to be applied, and also to the form in which the composition is intended to be packaged, in particular solid or fluid at room temperature and atmospheric pressure.
- composition is preferably suitable for topical application.
- the composition according to the invention of course comprises a cosmetically acceptable support, i.e. a support that is compatible with the skin, the mucous membranes, the nails, the hair, and may be in any galenic form normally used for a topical application, in particular in the form of an aqueous, aqueous-alcoholic or oily solution, an oil-in-water or water-in-oil or multiple emulsion, an aqueous or oily gel, a liquid, pasty or solid anhydrous product, a suspension or a dispersion; for example a dispersion of oil in an aqueous phase using spherules, it being possible for these spherules to be polymeric nanoparticles, such as nanospheres and nanocapsules, or better still lipid vesicles of ionic and/or nonionic type.
- a cosmetically acceptable support i.e. a support that is compatible with the skin, the mucous membranes, the nails, the hair, and
- This composition may be more or less fluid and may have the appearance of a white or coloured cream, an ointment, a milk, a lotion, a serum, a paste or a foam. It can optionally be applied to the skin in aerosol form. It can also be in solid form, for example in the form of a stick. It can be used as a care product or as a cleansing product or as a makeup product.
- the composition of the invention may contain adjuvants that are common in the cosmetic and dermatological fields, such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preserving agents, antioxidants, solvents, fragrances, fillers, screening agents, pigments, chelating agents, odour absorbers and colorants.
- adjuvants that are common in the cosmetic and dermatological fields, such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preserving agents, antioxidants, solvents, fragrances, fillers, screening agents, pigments, chelating agents, odour absorbers and colorants.
- the amounts of these various adjuvants are those conventionally used in the fields under consideration, for example from 0.01% to 20% of the total weight of the composition.
- these adjuvants may be introduced into the fatty phase, into the aqueous phase, into the lipid vesicles and/or into the nanoparticles.
- the proportion of the fatty phase may range from 5% to 80% by weight and preferably from 5% to 50% of the total weight of the composition.
- the oils, emulsifiers and coemulsifiers used in the composition in emulsion form are chosen from those conventionally used in the field under consideration.
- the emulsifier and the coemulsifier are present in the composition in a proportion ranging from 0.3% to 30% by weight and preferably from 0.5% to 20% of the total weight of the composition.
- oils that can be used in the invention mention may be made of mineral oils, oils of plant origin (apricot oil, sunflower oil), oils of animal origin, synthetic oils, silicone-based oils and fluorinated oils (perfluoropolyethers).
- oils of plant origin apricot oil, sunflower oil
- synthetic oils silicone-based oils and fluorinated oils (perfluoropolyethers).
- fatty substances use may also be made of fatty alcohols (cetyl alcohol), fatty acids and waxes (beeswax).
- emulsifiers and coemulsifiers that can be used in the invention, mention may for example be made of polyethylene glycol fatty acid esters such as PEG-40 stearate and PEG-100 stearate, and polyol fatty acid esters such as glyceryl stearate and sorbitan tristearate.
- hydrophilic gelling agents mention may particularly be made of carboxyvinyl polymers (carbomer), acrylic copolymers such as acrylate/alkyl acrylate copolymers, polyacrylamides, polysaccharides, natural gums and clays, and, as lipophilic gelling agents, mention may be made of modified clays such as bentones, metal salts of fatty acids, hydrophobic silica and polyethylenes.
- compositions according to the invention will contain at least one other active agent chosen from anti-UV screening agents, moisturizers, depigmenting agents, anti-glycation agents, NO-synthase inhibitors, agents for stimulating the synthesis of dermal or epidermal macromolecules and/or for preventing their degradation, agents for stimulating fibroblast or keratinocyte proliferation, myorelaxants or dermo-decontracting agents, tensioning agents, agents for combating pollution or free-radical scavengers, calmatives and active agents that act on the energy metabolism of cells.
- active agent chosen from anti-UV screening agents, moisturizers, depigmenting agents, anti-glycation agents, NO-synthase inhibitors, agents for stimulating the synthesis of dermal or epidermal macromolecules and/or for preventing their degradation, agents for stimulating fibroblast or keratinocyte proliferation, myorelaxants or dermo-decontracting agents, tensioning agents, agents for combating pollution or free-radical
- the amount of these additional active agents could vary to a large extent and will be for example from 10 -6 % to 20% by weight, especially from 0.001% to 10% by weight relative to the total weight of the composition.
- the agents for stimulating fibroblast proliferation may be chosen, for example, from plant proteins or polypeptides, extracted especially from soybean (for example a soybean extract sold by the company LSN under the name Eleseryl SH-VEG 8® or sold by the company Silab under the trade name Raffermine®); and plant hormones such as gibberellins and cytokinins.
- soybean for example a soybean extract sold by the company LSN under the name Eleseryl SH-VEG 8® or sold by the company Silab under the trade name Raffermine®
- plant hormones such as gibberellins and cytokinins.
- the agents for stimulating keratinocyte proliferation that can be used in the composition according to the invention especially comprise retinoids such as retinol and esters thereof, including retinyl palmitate; adenosine, cinnamic acid and derivatives thereof, lycopene and derivatives thereof; phloroglucinol; the walnut meal extracts sold by the company Gattefossé; and the extracts of Solanum tuberosum sold by the company Sederma.
- retinoids such as retinol and esters thereof, including retinyl palmitate; adenosine, cinnamic acid and derivatives thereof, lycopene and derivatives thereof; phloroglucinol; the walnut meal extracts sold by the company Gattefossé; and the extracts of Solanum tuberosum sold by the company Sederma.
- the compound of general formula (I) as described above, and/or the composition containing it will be applied to the part of the skin to be treated, in particular to the face, the neck or the hands, daily or several times daily; the application will be repeated every day for a variable period depending on the effects desired, generally from 3 to 6 weeks, but which could be extended or carried out continuously.
- the compound of general formula (I) as described above or the composition containing it will preferably be applied to the areas of skin affected by the signs of ageing that it is desired to combat.
- the composition of the invention may be in any suitable form, particularly in the form of a solution to be taken orally, a tablet, a gel capsule, a capsule or alternatively a nutritional food or a nutritional supplement.
- composition additionally comprises at least one appropriate excipient suitable for oral administration.
- the oral administration may be daily or several times daily, for example morning and evening. It could be continued for several weeks and/or several months, depending on the effects desired.
- the method of preparing compound 3 comprises a supplementary reduction step:
- the compounds according to the invention are prepared here either from commercial vanillin (CAS: 121-33-5), or from commercial ethyl vanillin (CAS: 121-32-4).
- gingerone compound 1, the chemical formula of which is given above
- the expression and the location of the marker of filaggrin differentiation are especially studied in keratinocytes in culture which thus makes it possible to evaluate the capacity of this compound to increase the differentiation of these cells.
- NHEKs Normal human keratinocytes
- a complete SFM medium is an SFM culture medium supplemented with pituitary extract (25 ⁇ g/ml), EGF (0.25 ng/ml) and gentamicin (25 ⁇ g/ml).
- the medium was withdrawn and replaced with culture medium that did or did not contain various concentrations of the test product or reference molecules.
- Calcium chloride and retinoic acid which are known respectively as a stimulator and as an inhibitor of the keratinocyte differentiation, were used as reference molecules for this test.
- the culture medium was removed and the cells were rinced, fixed, permeabilized then labelled with the primary antibody targeted against the filaggrin protein of interest (in situ immunolabelling). This antibody was then revealed by a secondary antibody coupled to a fluorochrome (GAM-Alexa 488). At the same time, the nuclei of the cells were stained with Hoechst 33258 (bisbenzimide).
- Image acquisition was carried out using an INCell AnalyzerTM 1000 machine.
- the labels were quantified by measuring the fluorescence intensity of the proteins relative to the number of nuclei identified by the Hoechst product.
- Gingerone significantly and dose-dependently increases the expression of the filaggrin protein in normal human epidermal keratinocytes.
- Gingerone therefore has a pro-differentiating effect on normal human keratinocytes and therefore can thus reduce and/or delay the signs of skin ageing.
- a lotion is prepared, comprising (% by weight):
- Example 1 compound tested in Example 1 (gingerone) 0.75% glycerol 2% ethyl alcohol 20% demineralized water qs 100%
- composition according to the invention applied daily to the face makes it possible to combat the signs of skin ageing.
- a facial gel comprising (% by weight):
- composition according to the invention applied daily to the face makes it possible to combat the signs of skin ageing.
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/009,218 US20140039064A1 (en) | 2011-04-01 | 2012-03-30 | Use of gingerone or derivatives thereof for reducing or delaying the signs of skin ageing |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1152803 | 2011-04-01 | ||
FR1152803A FR2973230B1 (fr) | 2011-04-01 | 2011-04-01 | Utilisation de gingerone ou de ses derives pour diminuer ou retarder les signes du vieillissement de la peau |
US201161472659P | 2011-04-07 | 2011-04-07 | |
US14/009,218 US20140039064A1 (en) | 2011-04-01 | 2012-03-30 | Use of gingerone or derivatives thereof for reducing or delaying the signs of skin ageing |
PCT/EP2012/055886 WO2012131072A1 (en) | 2011-04-01 | 2012-03-30 | Use of gingerone or derivatives thereof for reducing or delaying the signs of skin ageing |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2012/055886 A-371-Of-International WO2012131072A1 (en) | 2011-04-01 | 2012-03-30 | Use of gingerone or derivatives thereof for reducing or delaying the signs of skin ageing |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US15/894,530 Continuation US11602496B2 (en) | 2011-04-01 | 2018-02-12 | Use of gingerone or derivatives thereof for reducing or delaying the signs of skin ageing |
Publications (1)
Publication Number | Publication Date |
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US20140039064A1 true US20140039064A1 (en) | 2014-02-06 |
Family
ID=44548809
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/009,218 Abandoned US20140039064A1 (en) | 2011-04-01 | 2012-03-30 | Use of gingerone or derivatives thereof for reducing or delaying the signs of skin ageing |
US15/894,530 Active US11602496B2 (en) | 2011-04-01 | 2018-02-12 | Use of gingerone or derivatives thereof for reducing or delaying the signs of skin ageing |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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US15/894,530 Active US11602496B2 (en) | 2011-04-01 | 2018-02-12 | Use of gingerone or derivatives thereof for reducing or delaying the signs of skin ageing |
Country Status (8)
Country | Link |
---|---|
US (2) | US20140039064A1 (es) |
EP (2) | EP3372220B1 (es) |
JP (1) | JP6282582B2 (es) |
CN (1) | CN103957876A (es) |
BR (1) | BR112013025122B1 (es) |
ES (2) | ES2673120T3 (es) |
FR (1) | FR2973230B1 (es) |
WO (1) | WO2012131072A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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BR112014031168B1 (pt) * | 2012-06-15 | 2018-05-02 | Symrise Ag | Método não terapêutico para a estimulação da biossíntese de hialuronana, composição farmacêutica ou dermatológica, e uso da mesma |
FR3029911B1 (fr) | 2014-12-12 | 2018-03-09 | L'oreal | Nouveaux composes 1,2-diphenylethylene glycol pour lutter contre le vieillissement cutane et utilisation en cosmetique |
FR3029910B1 (fr) * | 2014-12-12 | 2019-12-27 | L'oreal | Nouveaux composes 1-phenyl mono ou polyhydroxypropane, compositions et utilisation en cosmetique |
US10568819B2 (en) | 2016-10-31 | 2020-02-25 | Sytheon Limited | Skin enhancing compositions and methods |
FR3059231B1 (fr) * | 2016-11-29 | 2019-09-20 | L'oreal | Composition comprenant un extrait de truffe et une dihydrochalcone |
US11077035B2 (en) | 2017-08-11 | 2021-08-03 | Sytheon Limited | Hair treatment compositions and methods |
US10828241B2 (en) * | 2018-06-15 | 2020-11-10 | Sytheon Limited | Skin lightening compositions and methods |
JP7505680B2 (ja) | 2020-07-08 | 2024-06-25 | ハウスウェルネスフーズ株式会社 | フィラグリン及び/又はインボルクリン遺伝子発現増強用組成物、並びに、線維芽細胞賦活用組成物 |
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JPS61263909A (ja) * | 1985-05-20 | 1986-11-21 | Shiseido Co Ltd | 皮膚外用剤 |
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2012
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- 2012-03-30 JP JP2014501663A patent/JP6282582B2/ja active Active
- 2012-03-30 WO PCT/EP2012/055886 patent/WO2012131072A1/en active Application Filing
- 2012-03-30 EP EP18165491.4A patent/EP3372220B1/en active Active
- 2012-03-30 BR BR112013025122-0A patent/BR112013025122B1/pt active IP Right Grant
- 2012-03-30 CN CN201280016198.1A patent/CN103957876A/zh active Pending
- 2012-03-30 EP EP12711196.1A patent/EP2694025B1/en active Active
- 2012-03-30 ES ES18165491T patent/ES2767923T3/es active Active
- 2012-03-30 US US14/009,218 patent/US20140039064A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
---|---|
BR112013025122A8 (pt) | 2017-12-19 |
JP2014509631A (ja) | 2014-04-21 |
EP3372220B1 (en) | 2019-11-06 |
US11602496B2 (en) | 2023-03-14 |
ES2767923T3 (es) | 2020-06-19 |
US20180161257A1 (en) | 2018-06-14 |
FR2973230B1 (fr) | 2013-11-01 |
WO2012131072A1 (en) | 2012-10-04 |
EP3372220A1 (en) | 2018-09-12 |
EP2694025A1 (en) | 2014-02-12 |
JP6282582B2 (ja) | 2018-02-21 |
ES2673120T3 (es) | 2018-06-19 |
BR112013025122A2 (pt) | 2016-08-16 |
CN103957876A (zh) | 2014-07-30 |
BR112013025122B1 (pt) | 2018-05-29 |
FR2973230A1 (fr) | 2012-10-05 |
EP2694025B1 (en) | 2018-04-25 |
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