US20130035660A1 - Multidirectional microfluidic drug delivery devices with conformable balloons - Google Patents

Multidirectional microfluidic drug delivery devices with conformable balloons Download PDF

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Publication number
US20130035660A1
US20130035660A1 US13/563,787 US201213563787A US2013035660A1 US 20130035660 A1 US20130035660 A1 US 20130035660A1 US 201213563787 A US201213563787 A US 201213563787A US 2013035660 A1 US2013035660 A1 US 2013035660A1
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US
United States
Prior art keywords
fluid
fluid delivery
delivery conduit
scaffold
outlet port
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US13/563,787
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English (en)
Inventor
PJ Anand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcyone Therapeutics Inc
Original Assignee
Alcyone Lifesciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcyone Lifesciences Inc filed Critical Alcyone Lifesciences Inc
Priority to US13/563,787 priority Critical patent/US20130035660A1/en
Assigned to ALCYONE LIFESCIENCES, INC. reassignment ALCYONE LIFESCIENCES, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ANAND, Pj
Publication of US20130035660A1 publication Critical patent/US20130035660A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/03—Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure ; Measuring pressure in body tissues or organs
    • A61B5/036—Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure ; Measuring pressure in body tissues or organs by means introduced into body tracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M2025/0042—Microcatheters, cannula or the like having outside diameters around 1 mm or less
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic

Definitions

  • FIG. 1 is a perspective schematic view of one exemplary embodiment of a microfabricated CED device
  • FIG. 4 is a schematic diagram of a fluid delivery system operatively coupled to a microfabricated CED device
  • FIG. 23A is a schematic view of a wafer layout that includes a plurality of microfabricated CED devices
  • injected media e.g., a drug-containing fluid
  • injected media can be supplied under positive pressure to the CED device 10 through one or more fluid inlet ports of one or more fluid delivery conduits 16 of the device 10 .
  • the injected media is expelled under pressure from the fluid outlet ports of the fluid delivery conduits of the device 10 in the target region of tissue.
  • the delivery profile 54 can be adjusted by varying parameters such as outlet port size, outlet port shape, delivery conduit size, delivery conduit shape, fluid supply pressure, fluid velocity, etc.
  • step S 818 aluminum hard mask evaporation can be performed to apply an aluminum layer 912 over the parylene layer 910 , as shown in FIG. 20G .
  • the following process can be used for the aluminum hard mask evaporation:
  • OXFORD 80 150 wattsRF, 50 sccms O2, 60 mTorr, 30 sec
  • each device is held in place only by the device “tabs” or “bridges” in the 1 ⁇ m silicon layer.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Materials For Medical Uses (AREA)
US13/563,787 2011-08-01 2012-08-01 Multidirectional microfluidic drug delivery devices with conformable balloons Abandoned US20130035660A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/563,787 US20130035660A1 (en) 2011-08-01 2012-08-01 Multidirectional microfluidic drug delivery devices with conformable balloons

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161513952P 2011-08-01 2011-08-01
US201161513948P 2011-08-01 2011-08-01
US201161513954P 2011-08-01 2011-08-01
US201161513935P 2011-08-01 2011-08-01
US201161513939P 2011-08-01 2011-08-01
US201161513961P 2011-08-01 2011-08-01
US201161513943P 2011-08-01 2011-08-01
US201261615939P 2012-03-27 2012-03-27
US13/563,787 US20130035660A1 (en) 2011-08-01 2012-08-01 Multidirectional microfluidic drug delivery devices with conformable balloons

Publications (1)

Publication Number Publication Date
US20130035660A1 true US20130035660A1 (en) 2013-02-07

Family

ID=47627379

Family Applications (4)

Application Number Title Priority Date Filing Date
US13/563,787 Abandoned US20130035660A1 (en) 2011-08-01 2012-08-01 Multidirectional microfluidic drug delivery devices with conformable balloons
US13/563,786 Active 2033-02-13 US10137244B2 (en) 2011-08-01 2012-08-01 Microfluidic drug delivery devices with venturi effect
US13/563,785 Active 2033-04-15 US10434251B2 (en) 2011-08-01 2012-08-01 Multi-directional microfluidic drug delivery device
US16/188,402 Abandoned US20190117886A1 (en) 2011-08-01 2018-11-13 Microfluidic drug delivery devices with venturi effect

Family Applications After (3)

Application Number Title Priority Date Filing Date
US13/563,786 Active 2033-02-13 US10137244B2 (en) 2011-08-01 2012-08-01 Microfluidic drug delivery devices with venturi effect
US13/563,785 Active 2033-04-15 US10434251B2 (en) 2011-08-01 2012-08-01 Multi-directional microfluidic drug delivery device
US16/188,402 Abandoned US20190117886A1 (en) 2011-08-01 2018-11-13 Microfluidic drug delivery devices with venturi effect

Country Status (9)

Country Link
US (4) US20130035660A1 (https=)
EP (2) EP2739341B1 (https=)
JP (1) JP6230996B2 (https=)
KR (1) KR102059383B1 (https=)
CN (1) CN103826690B (https=)
AU (4) AU2012290129B2 (https=)
CA (3) CA3050475C (https=)
ES (1) ES2854832T3 (https=)
WO (1) WO2013019830A2 (https=)

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US20170348493A1 (en) * 2015-03-17 2017-12-07 John F. Wells Fluid management of adipose tissue
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US20130035560A1 (en) 2013-02-07
AU2017200202B2 (en) 2018-12-13
EP3881876A1 (en) 2021-09-22
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AU2012290129B2 (en) 2016-10-13
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US20190117886A1 (en) 2019-04-25
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US10137244B2 (en) 2018-11-27
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US10434251B2 (en) 2019-10-08
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CA2843587A1 (en) 2013-02-07
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