US20110276078A1 - Filling structure for a graft system and methods of use - Google Patents

Filling structure for a graft system and methods of use Download PDF

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US20110276078A1
US20110276078A1 US12/966,852 US96685210A US2011276078A1 US 20110276078 A1 US20110276078 A1 US 20110276078A1 US 96685210 A US96685210 A US 96685210A US 2011276078 A1 US2011276078 A1 US 2011276078A1
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wall
aneurysm
filling structure
lumen
filling
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US12/966,852
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English (en)
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K.T. Venkateswara Rao
Raj P. Ganpath
Amy Lee
Anupama Karwa
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Sanofi SA
Endologix LLC
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Nellix Inc
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Assigned to NELLIX, INC. reassignment NELLIX, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: RAO, K.T. VENKATESWARA, GANPATH, RAJ P., KARWA, ANUPAMA, LEE, AMY
Publication of US20110276078A1 publication Critical patent/US20110276078A1/en
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Assigned to TRIVASCULAR, INC., NELLIX, INC., ENDOLOGIX, INC. reassignment TRIVASCULAR, INC. RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: DEERFIELD ELGX REVOLVER, LLC, AS AGENT
Assigned to DEERFIELD ELGX REVOLVER, LLC, AS AGENT reassignment DEERFIELD ELGX REVOLVER, LLC, AS AGENT SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ENDOLOGIX, INC., NELLIX, INC., TRIVASCULAR, INC.
Priority to US16/382,118 priority patent/US11638638B2/en
Assigned to WILMINGTON TRUST, NATIONAL ASSOCIATION reassignment WILMINGTON TRUST, NATIONAL ASSOCIATION SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ENDOLOGIX, INC.
Assigned to ENDOLOGIX LLC reassignment ENDOLOGIX LLC CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: ENDOLOGIX, INC.
Assigned to DEERFIELD PRIVATE DESIGN FUND IV, L.P. reassignment DEERFIELD PRIVATE DESIGN FUND IV, L.P. SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ENDOLOGIX LLC (F/K/A ENDOLOGIX, INC.), NELLIX, INC., TRIVASCULAR CANADA, LLC, TRIVASCULAR TECHNOLOGIES, INC., TRIVASCULAR, INC.
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/077—Stent-grafts having means to fill the space between stent-graft and aneurysm wall, e.g. a sleeve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004—Rounded shapes, e.g. with rounded corners
    • A61F2230/0008—Rounded shapes, e.g. with rounded corners elliptical or oval
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0067—Three-dimensional shapes conical

Definitions

  • the present invention relates generally to medical systems and methods for treatment. More particularly, the present invention relates to apparatus and methods for treating aneurysms.
  • Previous patent applications have described an approach to repairing an aneurysm by introducing a filling structure into the aneurysm, supporting the structure with a support structure, and filling the filling structure with a hardenable material that fills the aneurysm sac. Removing the support structure leaves a lumen for blood flow, and the hardenable material fills the sac and prevents blood pressure from enlarging it further.
  • the filling structure experiences pulsatile pressure, and by design shields the aneurysm from most of this pressure.
  • the aneurysm itself may change shape by reabsorption of thrombus between the filling structure and the artery wall, and shrinkage or remodeling of the artery wall itself. This may result in reduced pressure on the exterior of the filling structure. In some designs this may cause the inner lumen of the filling structure to grow through time-dependent elastic deformation or creep. It is desirable to prevent this change in the inner lumen as the aneurysm changes shape.
  • Aneurysms can occur in a range of shapes and sizes depending on the individual anatomy of the affected artery, the length of time it took to detect the aneurysm, blood pressure, and other factors.
  • structures designed to repair aneurysms by filling the aneurism sac must either be designed to be effective across a range of sac shapes and sizes, or they must be supplied in multiple stock sizes, or they must be custom-made for a specific anatomy.
  • the structures may have a combination of the aforementioned properties.
  • a promising class of intraluminal aneurysm repair devices employs a double walled filling structure to fill the aneurysm sac while maintaining a lumen for continued blood flow in the artery.
  • the double walled filling structure may be chosen such that it is capable of expanding to at least the size of the sac in all parts of the aneurysm. This obviates the need to make a custom version of the device for each aneurysm, and instead allows the surgeon to choose among a limited number of stock sized devices.
  • the filling structure is selected to be at least as large as the sac to be filled.
  • Some embodiments may have an elastic outer wall that expands and conforms to the inner aneurysm wall, while other filling structures use a substantially inelastic outer wall that is thin and flexible so that as the filling structure is filled, the outer wall expands partially to completely fill the sac, and any remaining capacity takes the form of wrinkles or pleats in the outer wall of the filling structure.
  • An advantage of the elastic outer wall is the potential absence of wrinkles, but a drawback is that an elastic outer wall will not conform exactly to abrupt changes in curvature of the sac.
  • the filling structure and filling medium needs to be stiff enough that its internal lumen does not change shape as this happens. Discontinuities in the filling medium caused by wrinkles and pleats on the walls of the filling structure reduce the strength of the filled structure. It would be advantageous to have a filling structure that can be filled in such a way that no internal wrinkles remain in some of its parts. It would also be advantageous to have a filling structure that is strong enough to resist creep even in the absence of an uninterrupted fill, yet still be thin enough to be percutaneously deliverable through the vasculature, which typically requires a 14 Fr or less device.
  • a filling medium with a chemistry that also adheres to walls of the filling structure during or after curing, so that the in-situ formed device can withstand the biomechanical loads and accommodate long-term remodeling of the aneurysm.
  • This can be accomplished through additives thereby modifying the chemistry of the filling medium or modifying the chemistry or coating the inner layers of the filling structure so that filling medium adheres to the filling structure as the device forms in-situ.
  • the device when filled with hardened filling material, conform as closely as possible to the shape of the aneurysm at its proximal and distal ends. It is also desirable to provide means by which the filling structure may be made to conform closely to the necks of the aneurysm, while being made of a thin, inelastic material. It is also desirable to resist creep deformation and remodeling caused by the pulsatile pressure of blood against the device.
  • U.S. Patent Publication No. 2006/0025853 describes a double-walled filling structure for treating aortic and other aneurysms.
  • Copending, commonly owned U.S. Patent Publication No. 2006/0212112 describes the use of liners and extenders to anchor and seal such double-walled filling structures within the aorta. The full disclosures of both these publications are incorporated herein by reference.
  • PCT Publication No. WO 01/21108 describes expandable implants attached to a central graft for filling aortic aneurysms. See also U.S. Pat. Nos.
  • a double-walled filling structure comprises a thin, flexible, non-porous and biocompatible outer material that prevents movement of fluids across its boundary and that is flexible enough to fill and conform to the irregular contours of the aneurysm wall.
  • An inner lumen of the filling structure may be made of the same or a different material selected and oriented so as to have high resistance to circumferential creep and elastic deflection.
  • the inner lumen may be reinforced by including a reinforcing member including fibers, wires, strips, or a sleeve oriented circumferentially so as to improve resistance to hoop stresses.
  • the inner lumen may also be reinforced by the use of multiple layers of material.
  • the inner lumen may be inserted into a tubular mesh or membrane of metal, polymer, or fibers in order to provide resistance against creep. If the inner lumen is tapered or contoured to provide a gradual change in diameter from one end to the other, the reinforcing lumen may also be tapered to match the lumen taper.
  • the inner lumen of the filling structure is constructed of a material with thickness and/or composition chosen to be capable of withstanding the maximum pulsatile pressure exerted by blood flow, without undergoing creep or significant elastic deformation. It is generally desirable to minimize thickness of the filling structure, so a variation on this aspect is to employ materials with anisotropic stress properties oriented and processed so as to have greatest strength in the circumferential direction.
  • a material with anisotropic stress properties oriented and processed so as to have greatest strength in the circumferential direction.
  • An example of such a material is expanded polytetrafluoroethylene, or ePTFE, which is typically stretched in one direction and may also be calendared to reduce its thickness and decrease its porosity.
  • the ePTFE sheet exhibits anisotropic modulus with greatest value in the pre-stress axis, and also exhibits a strain hardening property in which the modulus increases with deformation along the axis of pre-stress.
  • a third aspect of the present invention involves attaching a support structure to the inside of the inner lumen of the filling structure.
  • the internal support frame (endoframe) may be made of a biocompatible superelastic material such as Nickel-Titanium alloy (for example Nitinol), and may be used to support the inner lumen of the filling structure while it is being filled with hardenable material.
  • the inner lumen of the filling structure may be contoured so that it matches the diameter of the endoframe at every position along its length to avoid wrinkles
  • the frame provides additional creep resistance to the lumen. This may be involve suturing, heat staking, solvent welding, or other methods well known in the art for attaching dissimilar materials to each other.
  • the internal reinforcing elements may be made from balloon-expandable materials like stainless steel, cobalt-chromium alloys, etc.
  • Ring shaped stiffeners may be sintered to either the outside or the inside of the inner lumen of the filling structure to provide support.
  • the frame may comprise a set of such rings.
  • the rings may be made of a biocompatible metal or polymer.
  • the rings may be shaped such that they are compressible and readily expandable in situ, for example by forming each ring from an undulating or zigzag pattern.
  • a reinforcing tube surrounds an inner lumen of a filling structure to provide additional reinforcement.
  • This tube may be made of the same material as the inner lumen, or it may differ. Because the reinforcing tube does not contact blood or tissue, its biocompatibility requirements are lessened.
  • the reinforcing tube may be of a continuous material, or it may be a mesh attached to the inner lumen by one of several methods well known in the art, including for example suturing, heat staking, solvent welding, ultrasonic welding, or adhesives.
  • the tube material is chosen to have strength in the circumferential direction that, in combination with the strength provided by the inner lumen, resists creep caused by the peaks in blood pressure. Using Laplace's law:
  • hoop stress pressure*vessel radius/wall thickness.
  • the filling medium may be modified through additives/covalent bonding so that it adheres to the walls of the filling structure and keeps the device intact and accommodates remodeling.
  • the inner walls of the filling structure may be modified through additives, coatings and covalent bonding so that the filling medium adheres to the filling structure and maintains the shape of the device.
  • the filling structure includes two or more coaxial compartments, the inner of which is a hollow cylinder surrounding the inner lumen, and the outer of which is shaped to fill the aneurysm and conform to the irregular contours of the aneurysm wall.
  • the inner compartment may be in fluid communication with the outer compartment.
  • the inner and outer compartments may have separate fill ports, or a valve or flap may be provided to direct a flow of filling material first to one region, and then to the other region.
  • the filling material is introduced to the inner region, and may flow to the outer region when the inner region fills, thereby providing a continuous layer of hardening medium surrounding the blood lumens of the filling structure.
  • the inner compartment is sized such that it may be fully expanded without wrinkles while the outer compartment is sized to fill a wide range of aneurysm geometries that may be encountered and therefore may be of an elastic material, or of a flexible, substantially inelastic material such as PTFE or ePTFE that is large enough to fill a range of aneurysm cavities.
  • PTFE substantially inelastic material
  • ePTFE substantially inelastic material
  • the filling medium delivered to the inner region may be selected to have material properties that enhance its resistance to pulsatile pressure or creep.
  • the inner region material may be a Polyethylene Glycol (PEG)-based Hydrogel with a higher bulk modulus than the material delivered to the outer region.
  • PEG Polyethylene Glycol
  • a harder material in the inner compartment dampens pulsatile forces and a softer material in the outer compartment allows ease of shaping and remodeling.
  • the material targeted to the outer region may for example be selected to have lower viscosity before hardening so it fills the sac more evenly, a different hardening time, or the ability to bond with the wall of the filling structure.
  • This may be achieved for example through chemical/covalent bonding by adding reactive functional groups to either the hydrogel or the inner wall of the filling structure or both.
  • Hydrogen bonding may be preferentially used to create attachment of hydrogel to the inner surface of the filling structure. This may entail imparting donor hydrogen atoms and acceptor entity atoms in either the hydrogel or the wall of the filling structure or both.
  • Physical adhesive/cohesive forces may be used to attach hydrogel to the inner surface at various pre-determined locations on the interface.
  • the inner surface of the filling structure's outer wall may be modified by surface derivitization or by lamination to allow the filling material to bonds to it to improve overall strength.
  • the filling structure's outer surface is coated with substances that promote the growth of epithelium on the outer surface, thus creating an enclosure around the filling structure that serves to maintain containment pressure over time.
  • This approach may be combined with other approaches described herein to add strength.
  • a method for treating an aneurysm comprises providing a double-walled filling structure having an outer wall and an inner wall, and positioning the double-walled filling structure adjacent the aneurysm.
  • the filling structure is filled with a hardenable fluid filling medium so that the outer wall conforms to an inside surface of the aneurysm and the inner wall forms a generally tubular lumen to permit blood flow therethrough.
  • the lumen is constrained from creeping or elastically expanding due to the blood flow through the lumen.
  • the constraining step may comprise providing a reinforcing layer disposed at least partially around the tubular lumen, or filling a compartment disposed at least partially around the tubular lumen with the hardenable fluid filling medium.
  • FIG. 1 illustrates the anatomy of an infrarenal abdominal aortic aneurysm.
  • FIG. 2 illustrates a filling structure comprising a multi-layer reinforced inner lumen.
  • FIG. 3 illustrates a filling structure comprising an inner lumen with tapered ends.
  • FIG. 4 illustrates a filling structure comprising multiple compartments.
  • FIGS. 5A-5D illustrate an exemplary method of deploying a filling structure in an aneurysm.
  • the anatomy of an infrarenal abdominal aortic aneurysm comprises the thoracic aorta (TA) having renal arteries (RA) at its distal end above the iliac arteries (IA).
  • the abdominal aortic aneurysm (AAA) typically forms between the renal arteries (RA) and the iliac arteries (IA) and may have regions of mural thrombus (T) over portions of its inner surface (S).
  • FIG. 2 illustrates a filling structure 201 embodying aspects of the invention.
  • Filling structure 201 comprises central lumen 204 defined by luminal wall 202 , outer wall 209 , and reinforcing sleeve 203 .
  • Fill tube 208 is attached to a cannula during placement of the device, and allows hardenable filling material to enter the interior volume of the filling structure, then seals itself to prevent backflow of filling material when the cannula is removed.
  • Fill tube 208 may comprise a tear line 210 created by a partial perforation or notched edges. The tear line allows part or the entire exterior portion of the fill tube to be removed when the fill cannula is removed so that none of the fill tube protrudes beyond the filling structure once the filling structure is placed. This prevents contact between the fill tube and the artery wall, reducing the risk of thrombosis.
  • reinforcing sleeve 203 may be laminated, welded, sewn, or adhesively attached to central lumen 204 , or may be a separate sleeve that is placed over central lumen 204 during the assembly process. Both reinforcing sleeve 203 and central lumen 204 may vary in diameter in order to conform more closely to the natural diameter of the target artery, particularly at the ends. This may afford superior sealing by matching the diameter of the filling structure more closely to the diameter of the neck of the aneurysm.
  • a filling structure 301 may be constructed such that inner lumen 303 varies in diameter over the length of the filling structure in order to increase filled volume 305 and improve sealing against one or more necks of the aneurysm.
  • the filling structure 301 has an exterior wall 302 and a lumen 303 .
  • the lumen 303 has a larger diameter 304 at each end than at a point therebetween, and may comprise a cylindrical middle portion 303 a with one or more conical end portions 303 b.
  • the slope of the shoulder of conical end portions 303 b may be chosen to control the shape of filling structure 301 after it is filled.
  • Choosing a maximum diameter of conical section 303 b that is close to the outside diameter of the filling structure results in a more circular cross-section, while a smaller maximum diameter relative to the outside diameter of filling structure 301 results in an oval or eye-shaped cross-section.
  • Other taper profiles for the inner lumen may be selected; for example it is possible to use a parabolic or hyperbolic profile to provide a continuous transition from one inner diameter to another, which may reduce turbulent flow in the lumen. Note that the foregoing description is for exemplary purposes and is not meant to exclude other diameter profiles.
  • FIG. 4 illustrates a filling structure 401 comprising at least two filling compartments.
  • Endoframe 402 may be used to support the filling structure while it is being filled, maintaining a diameter of interior lumen 403
  • Inner compartment 404 may be connected directly to a fill valve 407 such that filling material enters compartment 404 forming an inner polymer jacket 405 before flowing to outer compartment 406 .
  • the two compartments may be in fluid communication with each other, optionally with a restriction between the two compartments such that the viscosity of the filling medium inflates the inner compartment fully before filling the outer compartment.
  • U.S. patent application Ser. No. 12/429,474 (Attorney Docket No. 025925-002610US) discloses various delivery system configurations and methods for delivering and deploying a filling structure that may be used for any of the filling structures disclosed herein, the entire contents of which are incorporated herein by reference.
  • inner compartment 404 may be separated from outer compartment 406 and each compartment may have a separate fill valve similar to fill valve 407 .
  • valve 407 communicates with the inner compartment and another fill valve (not shown) communicates with the outer compartment.
  • the inner compartment-filling medium may be selected for a fast cure time to allow rapid removal of the endoframe 402 , or for a larger bulk modulus to provide enhanced resistance to pulsatile pressure.
  • the outer compartment-filling medium may for example be selected for enhanced adhesion to an inner wall of filling structure 401 .
  • Separate fill valves also allow the compartments to be filled in a controlled order.
  • the inner compartment is filled before the outer compartment to allow the inner compartment to be fully filled, providing a solid structure for resisting pulsatile pressure.
  • the outer compartment is then filled sufficiently to fill the aneurysm sac without overloading the artery wall.
  • Furled filling structure 501 is introduced to the aneurysm on guidewire 503 and cannula 502 .
  • Sheath 504 is withdrawn to release filling structure 501 .
  • Cannula 502 contains guidewire 503 as well as one or more optional lumens (not illustrated) for filling the filling structure compartments, and possibly for introducing an endoframe and expansion balloon, as well as lines permitting detachment of the filling structure and other components from the cannula for deployment.
  • the unfurled filling structure may be unfurled completely by filling with a solution containing contrast agent, saline, combinations thereof, as well as other fluids. This is advantageous since the walls of the filling structure may stick against adjacent walls, especially after terminal sterilization and storage.
  • the volume of solution required to unfurl may be used as an estimate of the volume of hydrogel mix to introduce in order to fill the aneurysm sac completely without overpressure on the wall.
  • endoframe 505 may be introduced into the inner lumen of filling structure 501 to support the inner lumen during the hydrogel filling step.
  • Endoframe 505 may be self-expanding, or may be expanded by an expandable member such as a balloon (not illustrated) introduced via cannula 502 .
  • Endoframe 505 may be withdrawn after the filling step, or may be left in place indefinitely.
  • uncured liquid hydrogel is introduced through cannula 502 into inner partition 506 of filling structure 501 .
  • inner partition 506 may be in restricted fluid communication with outer partition 507 of filling structure 501 .
  • hydrogel flows to outer partition 507 via a passageway.
  • the hydrogel's viscosity in combination with the cross-section area of the passageway causes inner partition 506 to stay inflated while outer partition 507 fills with the remaining volume of hydrogel until filling structure 501 completely fills the aneurysm sac.
  • inner partition 506 and outer partition 507 may be filled by independent filling tubes (not illustrated) in cannula 502 .
  • inner partition 506 is filled until a measured pressure of the hydrogel reaches a threshold pressure, or until a dispensed volume of hydrogel reaches a threshold volume indicating complete filling of inner partition 506 .
  • outer partition 507 is filled with the remaining volume of hydrogel as estimated in the pre-fill step described previously.
  • the filling structure may comprise more than two compartments, in which case the filling process continues until all compartments are properly and completely filled.
  • this process may be conducted on two filling structures simultaneously, with one filling structure inserted through each iliac artery.
  • Filling of the filling structure may be performed with the endoframe expanded fully or partially, or the endoframe may be unexpanded. Additionally, the expandable member may be partially or fully expanded, or unexpanded during the filling procedure. Filling may also be visualized using fluoroscopy, ultrasound, or other methods in order to ensure that the filling structure properly expands and fills the aneurismal space.

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  • Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
US12/966,852 2009-12-30 2010-12-13 Filling structure for a graft system and methods of use Abandoned US20110276078A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/966,852 US20110276078A1 (en) 2009-12-30 2010-12-13 Filling structure for a graft system and methods of use
US16/382,118 US11638638B2 (en) 2009-12-30 2019-04-11 Filling structure for a graft system and methods of use

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US29127909P 2009-12-30 2009-12-30
US12/966,852 US20110276078A1 (en) 2009-12-30 2010-12-13 Filling structure for a graft system and methods of use

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