US20210369438A1 - Sealing apparatus and methods of use - Google Patents
Sealing apparatus and methods of use Download PDFInfo
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- US20210369438A1 US20210369438A1 US17/403,515 US202117403515A US2021369438A1 US 20210369438 A1 US20210369438 A1 US 20210369438A1 US 202117403515 A US202117403515 A US 202117403515A US 2021369438 A1 US2021369438 A1 US 2021369438A1
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- filling
- filling structure
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- aneurysm
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Definitions
- the sealing feature may comprise a pair of fillable legs that are coupled with the first filling structure.
- the sealing feature may comprise a first region of the first filling structure having a first compliance and a second region of the first filling structure having a second compliance different than the first compliance. One of these regions may be embossed and another region may remain unembossed.
- FIGS. 4H-1 and 4H-2 are cross-sectional views taken along line 4 H 1 - 4 H 1 or 4 H 2 - 4 H 2 in FIG. 4H .
- FIGS. 19A-20 illustrate filling structures with regions of different compliance.
- the first scaffold 250 may be placed in the tubular lumen of the first filling structure 112 while a second scaffold 252 may be placed in the tubular lumen of the second filling structure 212 .
- the scaffolds are stent-like structures which extend into the iliac arteries IA at the lower end of the filling structures.
- the scaffolds 250 , 252 may also be deployed simultaneously with the filling structures 112 , 212 .
- the upper regions of the scaffolds 254 and 256 may be cut or otherwise modified to form open C-shaped cross-sections.
- the expanded scaffolds can be arranged so that the C-shaped regions engage each other to form a continuous ring structure about the inner wall of the aorta.
- the open C-shaped regions will transition into a tubular region as the scaffolds enter the tubular lumens of the filling structures 112 and 212 .
- the scaffolds 254 and 256 may be partially or fully covered with a membrane or graft material and such coverings may extend partially or fully over the portion of the scaffold that extends into the adjacent blood vessel.
- the lower handle section is then invaginated and pulled through the flat pan section as indicated by arrow 514 .
- the unsealed portions are then sealed. Sealing may be accomplished using a hot wire, impulse sealing. RF heat sealing or laser welding.
- a filling tube 506 may be used to allow filling of the filling structure as seen in FIG. 5A or a filling port 516 may be used as illustrated in FIG. 5F .
- the filling port 516 may be an elastomeric plug such as latex or polymer that allows a needle or other tube to penetrate the filling port and that self seals when the needle or tube is withdrawn.
- FIGS. 10A-10B illustrate the use of additional seals in the filling structure to define additional filling regions.
- the two layers of material are sealed together along a line 644 forming a pocket 646 which is fillable with the hardenable filling material.
- the seal 644 is seen running across both the left and right halves of the filling structure and in a direction generally transverse to the longitudinal axis of the filling structure. The length of the scal, number of seals and angle of the seal relative to the filling structure longitudinal axis may be varied.
- the pocket 646 is still in fluid communication with the main fillable region of the filling structure.
- FIG. 10B illustrates an end view of the filling structure seen in FIG. 10A .
- a first filling structure has an outer wall with a taper 652 and a generally tubular lumen L.
- a second filling structure has an outer wall W with a taper 654 that is complementary to the first taper 652 , therefore the two filling structures will engage one another where the two tapers meet. Because the two tapers are complementary with one another, they will be flush against one another.
- the use of two filling structures may be used when two endograft systems are deployed in an aneurysm, such as in FIGS. 4A-4G above.
- FIG. 21 a first docking scaffold 790 is deployed in the neck of the aneurysm AAA and an optional filling structure 792 may be used to seal the neck region off from blood flow.
- Two leg extension scaffolds 796 and 798 are then advanced an expanded at least partially within the docking scaffold 790 .
- FIG. 22 shows an embodiment of a filling structure having two legs 802 , 804 .
- the main body 806 of the filing structure may be coupled with the docking scaffold to help seal at the neck of the aneurysm.
- Two leg regions 802 , 804 help to seal around the leg extension scaffolds that are received by the docking scaffold.
- FIG. 23 shows another embodiment of a filling structure which may be used in conjunction with a docking scaffold.
- the filling structure has a main body region 812 with an enlarged head region 810 and a tapered lower region 814 .
- the enlarged head region 810 and the tapered lower region help seal the docking scaffold around the neck of the aneurysm.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Prostheses (AREA)
- Surgical Instruments (AREA)
Abstract
Description
- The present application is a divisional of U.S. application Ser. No. 12/478,225 filed Jun. 4, 2009 (now U.S. Pat. No. 8,945,199), which is a non-provisional of, and claims the benefit of priority under 35 U.S.C. § 119(e) of U.S. Provisional Application No. 61/058,810 filed Jun. 4, 2008; each of which the entire contents are incorporated herein by reference.
- The present invention relates generally to medical systems and methods for treatment. More particularly, the present invention relates to apparatus and methods for treating aneurysms.
- Aneurysms are enlargements or “bulges” in blood vessels which are often prone to rupture and which therefore present a serious risk to the patient. Aneurysms may occur in any blood vessel but are of particular concern when they occur in the cerebral vasculature or the patient's aorta.
- The present invention is particularly concerned with aneurysms occurring in the aorta, particularly those referred to as aortic aneurysms. Abdominal aortic aneurysms (AAA's) are classified based on their location within the aorta as well as their shape and complexity. Aneurysms which are found below the renal arteries are referred to as infrarenal abdominal aortic aneurysms. Suprarenal abdominal aortic aneurysms occur above the renal arteries, while thoracic aortic aneurysms (TAA's) occur in the ascending, transverse, or descending part of the upper aorta.
- Infrarenal aneurysms are the most common, representing about eighty percent (80%) of all aortic aneurysms. Suprarenal aneurysms are less common, representing about 20% of the aortic aneurysms. Thoracic aortic aneurysms are the least common and often the most difficult to treat.
- The most common form of aneurysm is “fusiform,” where the enlargement extends about the entire aortic circumference. Less commonly, the aneurysms may be characterized by a bulge on one side of the blood vessel attached at a narrow neck. Thoracic aortic aneurysms are often dissecting aneurysms caused by hemorrhagic separation in the aortic wall, usually within the medial layer. The most common treatment for each of these types and forms of aneurysm is open surgical repair. Open surgical repair is quite successful in patients who are otherwise reasonably healthy and free from significant co-morbidities. Such open surgical procedures may be problematic, however, since access to the abdominal and thoracic aortas is difficult to obtain and because the aorta must be clamped off, placing significant strain on the patient's heart.
- Over the past decade, endoluminal grafts have come into widespread use for the treatment of aortic aneurysm in patients who cannot undergo open surgical procedures. In general, endoluminal repairs access the aneurysm “endoluminally” through either or both iliac arteries in the groin. The grafts, which typically have been fabric or membrane tubes supported and attached by various stent structures, are then implanted, typically requiring several pieces or modules to be assembled in situ. Successful endoluminal procedures have a much shorter recovery period than open surgical procedures.
- Present endoluminal aortic aneurysm repairs, however, suffer from a number of limitations. For example, a significant number of endoluminal repair patients experience leakage at the proximal juncture (attachment point closest to the heart) within two years of the initial repair procedure. While such leaks can often be fixed by further endoluminal procedures, the need to have such follow-up treatments significantly increases cost and is certainly undesirable for the patient. A less common but more serious problem has been graft migration. In instances where the graft migrates or slips from its intended position, open surgical repair is required. This is a particular problem since the patients receiving the endoluminal grafts are often those who are not considered to be good surgical candidates.
- Further shortcomings of the present endoluminal graft systems relate to both deployment and configuration. For example, many of the commercially available endovascular systems are too large (above 12F) for percutaneous introduction. Moreover, current devices often have an annular support frame that is stiff and difficult to deliver as well as unsuitable for treating many geometrically complex aneurysms, particularly infrarenal aneurysms with little space between the renal arteries and the upper end of the aneurysm, referred to as short-neck or no-neck aneurysms. Aneurysms having torturous geometries, are also difficult to treat.
- In order to overcome some of the aforementioned challenges, the use of endograft systems having a scaffold structure and a filling structure has been proposed, such as in U.S. patent application Ser. No. 11/413,460 (Attorney Docket No. 025925-001610US) filed Apr. 28, 2006, the entire contents of which are incorporated herein by reference. These systems utilize a filling structure to help seal off and fill the aneurismal sac while creating a lumen for blood to traverse the aneurysm. Several references disclosing filling structures and which are the subject of the commonly owned, copending applications are described below. These systems may also include a stent-like scaffold which helps support the filling structure thereby further defining the lumen for blood flow. The filling structure may require a pre-filling step to help unfurl the filling structure prior to filling it with the hardenable filling material and an expandable balloon often is used to help support the endograft during filling and during hardening in order to ensure proper formation of a lumen for blood flow. Because the filling material may take some time to harden, the expanded balloon can occlude flow for an undesirable time. Additionally, even after filling and hardening of filling material in the filling structure, the aneurismal sac may not be completely sealed off and blood can still flow into the sac. For these reasons it would be desirable to provide alternative apparatus and methods that create a better seal between the aneurismal sac and the endograft. It would also be desirable to provide apparatus and methods that help filling structures expand and conform to the aneurysm anatomy. Moreover, it would also be desirable for sealing apparatus and methods to minimize or eliminate the need for a separate unfurling step as well as minimizing the need to use an inflated balloon for support during filling and hardening that can obstruct blood flow. It would also be desirable that the alternative apparatus have a low profile for ease of delivery and percutaneous introduction as well as flexibility to allow advancement of the device through torturous vessels such as the iliac arteries. It would further be desirable that such devices can accommodate a variety of different vessel and aneurysm anatomies. At least some of these objectives will be met by the inventions described hereinbelow.
- U.S. Patent Publication No. 2006/0025853 describes a double-walled filling structure for treating aortic and other aneurysms. Copending, commonly owned U.S. Patent Publication No. 2006/0212112, describes the use of liners and extenders to anchor and seal such double-walled filling structures within the aorta. The full disclosures of both these publications are incorporated herein by reference. PCT Publication No. WO 01/21108 describes expandable implants attached to a central graft for filling aortic aneurysms. See also U.S. Pat. Nos. 5,330,528; 5,534,024; 5,843,160; 6,168,592; 6,190,402; 6,312,462; 6,312,463; U.S. Patent Publications 2002/0045848; 2003/0014075; 2004/0204755; 2005/0004660; and PCT Publication No. WO 02/102282.
- The present invention provides apparatus and methods for the treatment of aneurysms, particularly aortic aneurysms including both abdominal aortic aneurysms (AAA) and thoracic aortic aneurysms (TAA).
- In a first aspect of the present invention, a system for treating an aneurysm comprises at least a first double-walled filling structure having an outer wall and an inner wall and the filling structure is adapted to be filled with a hardenable fluid filling medium so that the outer wall conforms to the inside surface of the aneurysm and the inner surface forms a generally tubular lumen to provide blood flow. The first filling structure comprises a sealing feature which forms a fluid seal between the filling structure and the aneurysm or an adjacent endograft when the filling structure is filled with the hardenable fluid filling medium. This minimizes or prevents blood flow downstream of the seal.
- The walls of the filling structure may comprise ePTFE and the seal may be disposed upstream of the aneurysm, for example in the aneurysm neck. Sometimes the walls of the filling structure may be coated with another polymer such as polyurethane. The tubular lumen may have a substantially circular cross-section and the first filling structure may comprise an elliptical cross-section when the filling structure is filled with the hardenable filling medium. The edges of the first filling structure may be sealed together so that the filling structure can withstand a filling pressure of up to 300 mm Hg above a patient's normal systolic blood pressure without bursting. Some systems may also comprise a thrombogenic material such as polyurethane, polycarbonate, polyester, ePTFE, polyolefin, parylene, gelatin and silicone. The thrombogenic material may be coupled with an outer surface of the first filling structure and it may be formed into one of sutures, felts, velours, weaves, knits, hydrogels, foams, coils, sheets and combinations thereof. The thrombogenic material may also comprise a thrombogenic drug.
- In some embodiments the first filling structure may include a main body having a main body width and the sealing feature may comprise a narrow neck region that is coupled with the main body. The narrow neck region may have a width that is less than the main body width. The width of the narrow neck region may be approximately 2% to approximately 20% of the main body width. Sometimes the sealing feature may include a flat shoulder on an upper portion of the filling structure. Other embodiments may have a sealing feature which includes a tapered shoulder region on an upper portion of the filling structure.
- Still, in other embodiments the first filling structure may comprise an upper layer of material having an upper layer width and a lower layer of material having a lower layer width that is wider than the upper layer width. The upper and lower layers are fixedly coupled together so as to form the sealing feature which comprises a substantially flat upper outer surface and an arcuate lower outer surface when the first filling structure is filled with hardenable filling medium. The first filling structure may comprise a D-shaped cross-section when filled with hardenable filling medium.
- The sealing feature may comprise a tapered region in the tubular lumen with the taper disposed near an upper portion of the first filling structure. The tapered region may flare inwardly from the upper portion of the first filling structure to a lower portion of the first filling structure. In other embodiments, the first filling structure may comprise an upper layer of material and a lower layer of material, wherein at least a portion of the upper layer is fixedly coupled with at least a portion of the lower layer of material which forms the sealing feature. In this case, the sealing feature comprises an upper filling region and a lower filling region formed by the seal with the two filling regions in fluid communication with one another. The upper filling region may hold a smaller volume of filling medium than the lower filling region and the seal may be formed along a line. The line may extend from an outer edge of the first filling structure inward towards the tubular lumen.
- In other embodiments, the system may further comprise a second double-walled filling structure having an outer wall and an inner wall, wherein the second filling structure is adapted to be filled with a hardenable fluid filling medium so that the outer wall conforms to the inside surface of the aneurysm and the inner surface forms a generally tubular lumen to provide blood flow. The second filling structure may comprise a sealing feature which forms a fluid seal between the filling structure and the aneurysm or an adjacent endograft when the second filling structure is filled with the hardenable fluid filling medium. This minimizes or prevents blood flow downstream of the seal. The sealing feature of the first double-walled filling structure may comprise an outer surface having a first shape and the sealing feature of the second double-walled filling structure may comprise an outer surface having a second shape. The first and second shapes may be complementary to one another. In some embodiments, the first and second shapes comprise complementary tapers.
- In still other embodiments, the sealing feature may comprise a foam filled region of the first filling structure and the foam filled region may be discrete from the remainder of the first filling structure. The discrete foam filled region may be fluidly isolated from the region filled with the hardenable filling medium. In other embodiments, the sealing feature may comprise an arm in fluid communication with the region filled with the hardenable filling medium. Alternatively, the sealing feature may comprise a slot that is substantially transverse to a longitudinal axis of the first double-walled filling structure. The slot may at least partially bisect the first double-walled filling structure into two fillable sections. The foam may be substituted for any other material that provides the desired compliance to the foam filled region, such as gels, suture material, etc.
- Some embodiments may have a sealing feature which comprises a winged region that flares radially outward from the first double-walled filling structure. The winged region may comprise a tapered shoulder on an outer surface of the first double-walled filling structure. The sealing feature may further comprise a tapered lower region in the tubular lumen which flares radially outward from an upper part to a lower part of the first filling structure. Sometimes the sealing feature may also comprise a restraining element that is disposed at least partially around the tubular lumen. The restraining element may be adapted to restrict radial expansion of the tubular lumen to a predetermined size or shape. Sometimes the restraining element comprises a band extending circumferentially around the tubular lumen.
- The sealing feature may comprise an enlarged head region and a tapered lower region on the first filling structure. The tapered region flares radially outward as the distance from the head region increases. The sealing feature may comprise a lower tubular cuff region coupled with the first filling structure and a winged portion on the first filling structure. The sealing feature may also include an upper tubular cuff region coupled with the first filling structure. Sometimes the sealing feature includes a skeletal frame disposed in between the inner and outer walls of the first filling structure and the inner wall radially expands inward as the first filling structure is filled with hardenable filling material. Alternatively, the first filling structure may be disposed on the inside surface of a radially expandable scaffold and the sealing feature may comprise a portion of the inner wall that is adapted to radially expand inward to engage and seal against an adjacent endograft.
- The sealing feature may comprise an angled bottom edge on the first filling structure. In some embodiments, the filling structure may comprise a straight top edge and the angled bottom edge forms an acute angle relative to the top edge. In other embodiments, the sealing feature comprises a discrete filling compartment separate from the filling space of the first double-walled filling structure and fluidly uncoupled thereto. The discrete filling compartment may have a rectangular shaped region and the hardenable filling medium may surround the discrete filling compartment. An elongate flexible filling tube may be slidably engaged with the discrete filling compartment and the filling space.
- In other embodiments, the sealing feature may comprise a shoulder that is disposed on a lower portion of the first filling structure. The first filling structure may have a main body width and the shoulder may have a shoulder width that is less than the main body width. The sealing feature may comprise an undercut region in the first filling structure that is adapted to expand outwardly when the first filling structure is filled with hardenable filling material.
- The sealing feature may include a plurality of filaments coupled with the first filling structure and extending axially therefrom. These filaments may include a thrombogenic material. The thrombogenic material may also be a cape that is disposed at least partially over the first filling structure and coupled thereto. The sealing feature could also be a thrombogenic annular ring that is disposed at least partially around the first filling structure. Other sealing features may include a plurality of flanges that are coupled with the first filling structure. The flanges may have a width that progressively decreases relative to an adjacent flange. Also, the flanges may have a thickness that progressively decreases relative to an adjacent flange.
- In still other embodiments the sealing feature may comprise a skeletal frame that is coupled with the first filling structure. The skeletal frame may comprise a plurality of self-expanding struts that are adapted to radially expand outward along with the outer wall of the first filling structure. The skeletal frame may comprise a wire-like helically shaped filament made from a material such as nitinol.
- The scaling feature may also comprise an upper and a lower tubular shaped cuff that is coupled with the first filling structure. At least one of the upper or lower cuffs may comprise a reinforced region. The reinforced region may comprise a wire-like frame and sometimes the upper and lower reinforced cuffs may be coupled together with a plurality of struts.
- In still other embodiments, the sealing feature may comprise a pair of fillable legs that are coupled with the first filling structure. The sealing feature may comprise a first region of the first filling structure having a first compliance and a second region of the first filling structure having a second compliance different than the first compliance. One of these regions may be embossed and another region may remain unembossed.
- The system may further comprise a delivery catheter that has an expandable tubular support such as a balloon, which can be positioned within the tubular lumen to carry the double-walled filling structure. The system may also comprise a scaffold that is radially expandable from a collapsed configuration to an expanded configuration. A filling port that is fluidly coupled with the filling structure may also be included in the system. The filling port may be an elastomeric plug, and may be adapted to receive the hardenable filling medium and also provides a seal to prevent leakage thereof. The filling port may be substantially contained within the inner lumen of the filling structure when the filling structure is filled with the hardenable filling medium.
- In another embodiment of the invention, a system for treating an aneurysm comprises at least a first double-walled filling structure having an outer wall and an inner wall. The filling structure is adapted to be filled with a hardenable fluid filling medium so that the outer wall conforms to the inside surface of the aneurysm and the inner surface forms a generally tubular lumen to provide blood flow. The system also includes a filling port that is substantially contained within the generally tubular lumen of the filling structure when the filling structure is filled with the hardenable fluid filling medium. A first end of the generally tubular lumen may comprise an invaginated tapered portion that flares radially outward. A second end of the tubular lumen may comprise an invaginated tapered portion that flares radially outward. The second end may be opposite of the first end. The first filling structure may comprise a sealing feature that forms a fluid seal between the filling structure and the aneurysm or an adjacent endograft when the filling structure is filled with the hardenable fluid filling medium. This reduces or prevents blood flow downstream of the seal. The sealing feature may comprise a tapered shoulder region on at least one end of the filling structure. The outer wall of the filling structure may be invaginated into the filling structure thereby forming a convex exterior surface on one end of the filling structure when the filling structure is filled with the hardenable fluid filling medium. A convex exterior surface may also be similarly formed on a second end of the filling structure opposite the first end. Either convex exterior surface may taper radially inwardly to merge with the tubular lumen.
- These and other embodiments are described in further detail in the following description related to the appended drawing figures.
-
FIG. 1 illustrates the anatomy of an infrarenal abdominal aortic aneurysm. -
FIG. 2 illustrates a single prosthesis system comprising a filling structure mounted over a delivery catheter. -
FIG. 3 illustrates a pair of prostheses for delivery to an aneurysm, where each prosthesis comprises a filling structure mounted on a delivery catheter. -
FIGS. 4A-4F illustrate use of the filling structures of the prosthesis system inFIG. 3 for treating an aortic aneurysm. -
FIGS. 4G-4H illustrate the placement of scaffolds into the adjacent tubular lumens of the two filling structures of the prostheses ofFIGS. 4A-4F . -
FIGS. 4H-1 and 4H-2 are cross-sectional views taken along line 4H1-4H1 or 4H2-4H2 inFIG. 4H . -
FIGS. 5A-5B illustrate one embodiment of a double-walled filling structure. -
FIGS. 5C-5E illustrate an exemplary method of fabricating the filling structure inFIGS. 5A-5B . -
FIG. 5F illustrates a filling port. -
FIGS. 6A-18 illustrate alternative embodiments of a double-walled filling structure. -
FIGS. 19A-20 illustrate filling structures with regions of different compliance. -
FIG. 21 illustrates a system for treating an aneurysm having three endografts. -
FIGS. 22-26B illustrate various embodiments of filling structures that may be used in the endograft system ofFIG. 21 . -
FIGS. 27-29 illustrate various thrombogenic features used to help create a seal. -
FIGS. 30A-30C illustrate several embodiments of resilient frames coupled with the filling structure. -
FIGS. 31A-32D illustrate various reinforced regions and patterns that may be used on a filling structure. -
FIGS. 33A-33B illustrate another embodiment of a filling structure. -
FIGS. 34A-34D illustrate the use of multiple filling structures stacked together. -
FIGS. 35A-35B illustrate an alternative embodiment of a double-walled filling structure. - Referring now to
FIG. 1 , the anatomy of an infrarenal abdominal aortic aneurysm comprises the thoracic aorta (TA) having renal arteries (RA) at its distal end above the iliac arteries (IA). The abdominal aortic aneurysm (AAA) typically forms between the renal arteries (RA) and the iliac arteries (IA) and may have regions of mural thrombus (T) over portions of its inner surface (S). -
FIG. 2 illustrates a single endograft system comprising a filling structure mounted over a delivery catheter. Asystem 10 constructed in accordance with the principles of the present invention for delivering a double-walled filling structure 12 to an aneurysm includes the filling structure and a delivery catheter 14 having anexpandable element 16, typically an inflatable balloon, at its distal end. The catheter 14 will comprise aguidewire lumen 18, a balloon inflation lumen (not illustrated) or other structure for expanding other expandable components, and a fillingtube 20 for delivering a filling medium or material to aninternal space 22 of the double-walled filling structure 12. Theinternal space 22 is defined between anouter wall 24 andinner wall 26 of the filling structure. Upon inflation with the filling material or medium, the outer wall will expand radially outwardly, as shown in broken line, as will theinner wall 26, also shown in broken line. Expansion of theinner wall 26 defines aninternal lumen 28. The expandable balloon orother structure 16 will be expandable to support an inner surface of thelumen 28, as also in broken line inFIG. 1 . A single endograft system such as that seen inFIG. 1 may be used to treat an aneurysm as disclosed in U.S. patent application Ser. No. 11/413,460 (Attorney Docket No. 025925-001610US), the entire contents of which are incorporate herein by reference. - In preferred embodiments, a system comprising two endografts may be used to treat an aneurysm, such as the system seen in
FIG. 3 . A system comprising such a pair of filling structures includes afirst filling structure 112 and asecond filling structure 212. Each of the fillingstructures delivery catheters structures delivery catheters filling structure system 10 ofFIG. 2 . Corresponding parts of each of thefillings systems structures structure 12 ofFIG. 2 is that the pair of filling structures will generally have asymmetric configurations which are meant to be positioned adjacent to each other within the aneurismal space and to jointly fill that space, as will be described in greater detail below. - In treating an infrarenal abdominal aortic aneurysm using the pair of filling
structures FIG. 3 , a pair of guidewires (GW) will first be introduced, one from each of the iliac arteries (IA), as seen inFIG. 4A . Thefirst delivery catheter 114 will then be positioned over one of the guidewires to position the double-walled filling structure 112 across the aortic aneurysm (AAA), as illustrated inFIG. 4B . Thesecond delivery catheter 214 is then delivered over the other guidewire (GW) to position thesecond filling structure 212 adjacent to thefirst structure 112 within the aneurysm (AAA), as illustrated inFIG. 4C . Typically, one of the filling structures and associated balloons will be expanded first, followed by the other of the filling structures and balloon, as illustrated inFIG. 4D where the fillingstructure 112 andballoon 116 are inflated to fill generally half of the aneurismal volume, as illustrated inFIG. 4D . Filling can generally be carried out as described for one filling structure in U.S. patent application Ser. No. 11/413,460 (Attorney Docket No. 025925-001610US) which has been previously incorporated herein by reference, except of course that the fillingstructure 112 will be expanded to occupy only about one-half of the aneurismal volume. After thefirst filling structure 112 has been filled, thesecond filling structure 212 may be filled, as illustrated inFIG. 4E . In other protocols the two filling structures may be filled simultaneously. The upper ends of theballoons balloons - After filling the filling
structures FIG. 4E , the filling materials or medium will be cured or otherwise hardened, and thedelivery catheters 114 and removed, respectively. The hardened filling structures will then provide a pair of tubular lumens opening from the aorta beneath the renal arteries to the right and left iliac arteries, as shown in broken line inFIG. 4F . The ability of the fillingstructures FIG. 4F , helps the structures to remain immobilized within the aneurysm with little or no migration. Immobilization of the fillingstructures - As with the single filling structure embodiments, the double filling structure embodiments will include at least one separate scaffold deployed within each of the tubular blood flow lumens. The scaffolds will generally be stent-like or graft-like vascular structures and will be deployed within the tubular lumens using balloon or other expansion catheters (in the case of malleable or balloon-expandable scaffolds) or using constraining sheaths (in the case of self-expanding scaffolds).
- Referring in particular to
FIG. 4G , thefirst scaffold 250 may be placed in the tubular lumen of thefirst filling structure 112 while asecond scaffold 252 may be placed in the tubular lumen of thesecond filling structure 212. As illustrated, the scaffolds are stent-like structures which extend into the iliac arteries IA at the lower end of the filling structures. Thescaffolds structures - Referring now to
FIG. 4H , first andsecond scaffolds structures FIG. 4H-1 , the upper ends of thescaffolds flat faces FIG. 4H-2 , the upper regions of thescaffolds structures scaffolds - Various modifications of the protocols described above will be within the scope of the present invention. For example, while the scaffolds have been shown as being delivered after deployment of the filling structure(s), it will also be possible to deliver the scaffolds simultaneously with or prior to deployment of the filling structures. Moreover, the scaffolds could be delivered on the same delivery catheter(s) used to deliver and/or shape the filling structures. The scaffolds could then be expanded at the same time as filling the filling structure or even prior to filling the filling structure. Additional details on these embodiments are disclosed in U.S. patent application Ser. No. 11/413,460 (Attorney Docket No. 025925-001610US), previously incorporated herein by reference.
- The filling structure used in
FIGS. 4A-4H are more fully described inFIGS. 5A-5E .FIG. 5A illustrates the double-walled filling structure separated from the delivery catheter and scaffold. InFIG. 5A , theouter wall 502 is the portion of the filling structure which expands into engagement with the aneurysm wall when filled with filling material and inner wall forms lumen 504 in which blood traverses the aneurysm. A filling tab FT is coupled with the filling structure and acts as a valve to allow filling of the filling structure.FIG. 5B shows an end view of the filling structure with an oval or elliptical-shapedouter wall 502 and a roundinner lumen 504. The walls of the filling structure are preferably made from ePTFE with a polyurethane inner lining which prevents extravasation of the filling material through the pores of the ePTFE. Other polymers or fabrics may also be used such as Dacron polyester. Any of the filling structure embodiments in this disclosure may use these materials. - The filling structure of
FIGS. 5A-5B may be fabricated from two sheets of polymer as seen inFIGS. 5C and 5D . InFIG. 5C , an upper sheet is die cut from ePTFE and has an upperflat pan section 508 a and alower handle section 510 a. InFIG. 5D , a second sheet is also die cut from ePTFE and also has anupper pan section 508 b and alower handle section 510 b. The upper and lower sheets are substantially the same size. The two sheets are then placed on top of one another and the edges are then sealed together around most of the perimeter, as seen byseam 512 inFIG. 5E . The lower handle section is then invaginated and pulled through the flat pan section as indicated byarrow 514. The unsealed portions are then sealed. Sealing may be accomplished using a hot wire, impulse sealing. RF heat sealing or laser welding. This forms the inner lumen of the filling structure, as indicated by dotted lines inFIG. 5A . A filling tube 506 may be used to allow filling of the filling structure as seen inFIG. 5A or a fillingport 516 may be used as illustrated inFIG. 5F . The fillingport 516 may be an elastomeric plug such as latex or polymer that allows a needle or other tube to penetrate the filling port and that self seals when the needle or tube is withdrawn. This method of fabrication generally applies to any of the embodiments disclosed herein. Other fabrication methods include inverting a tubular extrusion and sealing the ends which is advantageous since it minimizes seams. Also, in some embodiments, the filling structure may be composed of separate components that are joined together. For example, the tubular lumen section may be formed separately and then coupled with the main body of the filling portion. - As previously discussed, these filling structures show promise in the treatment of aneurysms as they help seal the aneurysm and also they help fix an endograft system in place thereby minimizing the possibility of migration. However, the filling structures can still leak. Therefore, other filling structure configurations and features are disclosed herein which may provide better sealing.
- In
FIG. 6A , the filling structure has an outer wall W and an inner wall forms the lumen L. This embodiment also includes aflat shoulder 608 and anarrow neck region 610 which may accommodate aneurysm anatomies better and therefore provide better sealing.FIG. 6B shows and end view of the filling structure inFIG. 6A . The neck region may have a width any size, but in preferred embodiments, the width of theneck region 610 is approximately 2% to approximately 20% of the filling structure width measured at it's widest point.FIGS. 7A-7B show another embodiment of a filling structure. InFIG. 7A , a double-walled filling structure includes a taperedupper portion 620 which provides a flat surface against which a seal may be made.FIG. 7B shows an end view of the filling structure seen inFIG. 7A which has a generally oval shape when filled with filling material and the lumen L is generally round. -
FIGS. 8A-8B show another embodiment of a filling structure. InFIG. 8A , a first layer of material is welded to a second layer of material that is wider than the first. This results in one side of the filling structure having more material than the opposite side. Therefore, one side of the outer wall W will have a substantiallyflat section 626 and the opposite side will be arcuate 630 with astraight section 628 joining the two sections together. The end view of the filling structure will be D-shaped as seen inFIG. 8B . - Still another filling structure embodiment is seen in
FIGS. 9A-9B . InFIG. 9A the inner wall of the filling structure forms lumen L. Lumen L includes a straight tubular section and atapered portion 640 near an upper portion of the filling structure. The taperedportion 640 flares radially outward.FIG. 9B shows an end view of the filling structure seen inFIG. 9A . InFIG. 9B , outer wall W forms a round or oval shape and lumen L is generally round. -
FIGS. 10A-10B illustrate the use of additional seals in the filling structure to define additional filling regions. InFIG. 10A , the two layers of material are sealed together along aline 644 forming apocket 646 which is fillable with the hardenable filling material. In this embodiment, theseal 644 is seen running across both the left and right halves of the filling structure and in a direction generally transverse to the longitudinal axis of the filling structure. The length of the scal, number of seals and angle of the seal relative to the filling structure longitudinal axis may be varied. Also, in this embodiment, thepocket 646 is still in fluid communication with the main fillable region of the filling structure.FIG. 10B illustrates an end view of the filling structure seen inFIG. 10A . - In
FIG. 11 , two filling structures are used to complement one another and help for a seal. InFIG. 11 , a first filling structure has an outer wall with ataper 652 and a generally tubular lumen L. A second filling structure has an outer wall W with ataper 654 that is complementary to thefirst taper 652, therefore the two filling structures will engage one another where the two tapers meet. Because the two tapers are complementary with one another, they will be flush against one another. The use of two filling structures may be used when two endograft systems are deployed in an aneurysm, such as inFIGS. 4A-4G above. -
FIG. 12 shows a foam filledregion 660 near an upper portion of the filling structure. The foam filledregion 660 is separated from the remainder of the fillable space by aseal 662 which may be made by heat sealing, bonding or other attachment methods known in the art. The foam filled region provides a compliant end that allows the filling structure to conform to the aneurysm anatomy thereby helping create a seal. -
FIG. 13 shows an alternative embodiment of a filling structure having a flexible arm coupled with the filling structure. Aslot 668 separates thearm 666 from the main body of the filling structure, although achannel 670 fluidly couples thearm 666 with the main body of the filling structure. Therefore, as the filling structure is filled with hardenable medium, thearm 666 will also fill up. The arm is flexible and therefore will flex and fit into various aneurysms spaces thereby creating the seal. -
FIG. 14 illustrates an angled filling structure. InFIG. 14 , abottom edge 680 of the filling structure is angled relative to thetop edge 682. In this embodiment, the bottom edge forms an acute angle relative to thetop edge 682 although the angle may be adjusted to accommodate different aneurysm anatomies. -
FIG. 15 illustrates the use of two filling regions in the filling structure. InFIG. 15 , the filling structure has amain filling region 688 and a separate, discrete filling region near a top of the filling structure. A filling tab FT is fluidly coupled with bothfillable regions upper filling region 686. After this region is filled, the filling tube is retracted out of the upper filling tab and into the lower filling tab so that the main filling region can then be filled. The upper filling region may be created by scaling a region off from the main body of the filling structure. This two stage filling process may allow the filling structure to create a better seal with the aneurysm. -
FIG. 16 illustrates still another embodiment of a double-walled filling structure. InFIG. 16 , the filling structure comprises a widemain body section 704 and anarrow neck region 702 on an upper end of the filling structure. A lower end of the filling structure has anannular flange 706 that has a width less than themain body section 704. This helps prevent or minimize pinching in the lower end of the filling structure and may help the filling structure accommodate various aneurysm anatomies. -
FIG. 17 illustrates another embodiment of a double-walled filling structure. InFIG. 17 , the filling structure has a widemain body section 728, ashoulder region 722 and anarrow neck region 720. Additionally, a concavebottom region 724 of the filling structure may expand outward when filled as indicated bydotted line 726. -
FIG. 18 shows another filling structure embodiment having multiple annular flanges. InFIG. 18 , the filling structure comprises a widemain body section 742 and a taperedlower region 744. The main body section has a taperedshoulder region 752 which transitions into a region of multiple annular flanges. A first annular flange 746 is followed by two additionalannular flanges flange 750 is the thinnest. The multiple flanges help create a seal at one end of the filling structure by minimizing pinch points. -
FIGS. 19A-19B illustrate how the compliance of the filling structure may be modified to affect how it expands. InFIG. 19A , the wall forming the inner lumen L may be made from a material having one compliance and the wall forming the outer wall W may be made from a material having greater compliance. Thus, when the filling structure is filled with the hardenable filling material, the outer wall will preferentially radially expand outward before the inner lumen wall. Thus, the lumen will remain relatively unchanged during filling and the outer wall will conform to the aneurysm. InFIG. 19B , the upper half of the outer wall of the filling structure is fabricated from a material more compliant relative to the lower half of the filling structure. Thus, the upperouter half 762 will radially expand more than the lower half during filling. One will appreciate that compliance of the filling structure walls may be varied to obtain desired expansion characteristics. Instead of using different materials to control filling structure compliance, surface modification may be used to alter a material's compliance. For example, inFIG. 20 , anupper portion 770 of a filling structure has been embossed while alower portion 772 remains unembossed. Embossing the material alters material characteristics such as compliance. In the case of expanded polytetrafluorinated ethylene (ePTFE), embossing increases material compliance soregion 770 will have a greater compliance and expand more than theunembossed region 772. - While most of the filling structure embodiments disclosed above are described as being used when two endograft systems are deployed (e.g.
FIG. 3 ) to treat an aneurysm, the embodiments described above may also be used in other endograft systems as well. For example, in some cases, it may be desirable to use a three piece endograft system to treat an aneurysm, such as inFIG. 21 . InFIG. 21 , afirst docking scaffold 790 is deployed in the neck of the aneurysm AAA and anoptional filling structure 792 may be used to seal the neck region off from blood flow. Twoleg extension scaffolds docking scaffold 790. Theleg scaffolds optional filling structures -
FIG. 22 shows an embodiment of a filling structure having twolegs FIG. 22 , themain body 806 of the filing structure may be coupled with the docking scaffold to help seal at the neck of the aneurysm. Twoleg regions FIG. 23 shows another embodiment of a filling structure which may be used in conjunction with a docking scaffold. InFIG. 23 , the filling structure has amain body region 812 with anenlarged head region 810 and a taperedlower region 814. Theenlarged head region 810 and the tapered lower region help seal the docking scaffold around the neck of the aneurysm.FIGS. 24A-24C illustrate other embodiments which may be used with the docking scaffold. For example, inFIG. 24A a filling structure has amain body portion 824 with atapered shoulder 822 and anarrow neck region 820. The inner lumen L in the embodiment ofFIG. 24A is substantially tubular and has a constant diameter. InFIG. 24B , the filling structure has generally the same shape as inFIG. 24A except in this embodiment, the lumen L is tapered outwardly 826 near a lower end of the filling structure. The embodiment ofFIG. 24C is also similar to that ofFIG. 24A but also has a modified lumen L. InFIG. 24C , the filling structure lumen L has a lower portion that is constrained 828 in order to limit its expansion. Theconstraint 828 may be a band or corset coupled with the inner wall, or a low compliance material may be used in that region to limit expansion of the lumen L. -
FIGS. 25A-25C illustrate still other embodiments of filling structures which may be used with the docking scaffold. InFIG. 25A , the filling structure comprises amain body section 840 with atapered shoulder 842 that transitions to anarrow neck region 844.FIG. 25B is similar to the embodiment ofFIG. 25A except that both ends of the filling structure have anarrow neck region tapered shoulder region 846 may couple thenarrow neck region FIG. 25C shows another variation of the embodiment inFIG. 25A . InFIG. 25C , the filling structure hasnarrow neck regions tapered shoulder region 842 couples the uppernarrow neck region 844 with the filling structure main body and a flatlower shoulder 849 couples the lowernarrow neck region 848 with the main body of the filling structure. - The previous embodiments generally are disposed over a scaffold structure and radially expand outward to seal against the aneurysm wall. In
FIGS. 26A-26B , a filling structure is used to fill the internal space of the docking scaffold.FIG. 26A illustrates a top view of a docking scaffold. InFIG. 26A , a double-walled filling structure 862 is coupled to the internal surface of thedocking scaffold 860. Twoleg extension scaffolds 864 are slidably received by thedocking scaffold 860. InFIG. 26B , the fillingstructure 862 is filled with a hardenable filling medium. The external wall of the fillingstructure 862 radially expands outward to engage and seal against the inner surface of thedocking scaffold 860. The inner wall of the fillingstructure 862 radially expands inward to seal around theleg extension scaffolds 864. - The embodiments described above generally rely on radial expansion of a filling structure to form a seal. The use of thrombogenic materials in combination with a filling structure enhances the resulting seal. In
FIG. 27 , the filling structure has a plurality of filament-like hairs 880 coupled to an upper portion of the filling structure. Thesehairs 880 may be made of any thrombogenic material such as those disclosed herein or other materials known in the art. Additionally, thehairs 880 may be coupled with a thrombogenic agent to further cause clotting. Thehairs 880 cause blood to clot thereby further sealing the aneurysm. Thehairs 880 may be glued, bonded, welded, heat sealed, sintered, sutured, electrospun, sprayed, vapor deposited, drape coated, press fit or otherwise attached to the filling structure. Exemplary materials forhairs 880 include but are not limited to polyurethanes, polycarbonates, polyesters such as Dacron, ePTFE, polyolefins, parylenes, gelatins, silicones, etc. The hair-like structures 880 may be formed into sutures, felts, velours, weaves, knits, hyodrogels, foams, embolization coils or sheets that are attached to the filling structure.FIG. 28 shows an alternative embodiment of a filling structure having a thrombogenic material attached thereto. InFIG. 28 , acape 882 is attached to the filling structure. The cape may drape over all or a portion of the filling structure and is fabricated from any of the materials disclosed herein. Because the cape is thin and flexible it will fit into the space between the filling structure and the aneurysm wall and will help form a blood clot which further creates a seal. Thecape 882 may take any shape and may be attached to the filling structure using any of the previously described methods.FIG. 29 illustrates yet another embodiment of a filling structure with a thrombogenic material attached thereto. InFIG. 29 , anannular cuff 884 is coupled with a neck region of the filling structure. The cuff may be a Dacron cuff or it may be any material that is known to be thrombogenic and it is attached to the filling structure using techniques known to those of skill in the art. The cuff helps form a seal by causing thrombosis in the neck region of the filling structure. A cape structure havingmultiple lobes 1002 may also be used to heal seal the aneurysm as shown inFIG. 33A . Thelobes 1002 may be fillable or not. If fillable, as seen inFIG. 33B , the lobes have a low profile prior to filling and a larger profile after filling as seen inFIG. 33A . - Still another embodiment of a filling structure is one that is seen in
FIGS. 34A-34D . InFIG. 34A , multiple fillingcylinders FIG. 34C .FIG. 34C shows an alternative embodiment of a stacked filling structure having threecylinders FIG. 34D shows the cylinders ofFIG. 34B after they have been stacked together. - Another filling structure embodiment is seen in
FIGS. 35A-35B . InFIG. 35A the inner wall of the filling structure forms lumen 3500.Lumen 3500 includes astraight tubular section 3501 and taperedportions tapered portions port 3504 is recessed into the tapered part oflumen 3503. This substantially prevents the fill port from contacting the aneurysm wall once the filling structure is filled.FIG. 35B shows an end view of the filling structure seen inFIG. 35A . InFIG. 35B ,outer wall 3505 forms a round or oval shape andlumen 3500 is generally round. Additionally,outer wall 3505 is invaginated inwardly to form a convex end rim. The opposite end may also be similarly formed. Fillport 3504 is situated within the tapered part oflumen 3500. In further alternative embodiments, the fill port may be located at either end of the fill structure, or may be exposed to contact the aneurysm wall. The cross-sectional shape at each end depends on the rate of taper of the correspondingtapered portions FIG. 7A . - In addition to filling structures and thrombogenic materials, a resilient spring-like frame or skeleton may be used to help radially expand the filling structure into engagement with the aneurysm walls, thereby further enhancing the seal. For example, in
FIG. 30A , the filling structure comprises a plurality ofelongate struts 902 or ribs that are coupled with the filling structure. Thestruts 902 are biased to flex radially outward, therefore after a constraint is released, the struts will bow radially outward, forcing the filling structure to also expand outward.FIG. 30B illustrates another embodiment where the resilient frame comprises ahelical coil 904 andFIG. 30C illustrates how the resilient frame may comprise struts which are transverse to the longitudinal axis of the filling structure. The spring-like frame may be made from any number of resilient metals such as stainless steel, nitinol or resilient polymers. The frame may be coupled to the inside or outside surface of the filling structure, or it may be embedded in between the inner and outer filling structure walls. - Reinforcing the ends of the filling structures may also provide a better seal since the reinforced region and/or lumen L will be rigid and cannot collapse.
FIGS. 31A-31C illustrate exemplary embodiments of reinforced filling structures. InFIG. 31A , the filling structure comprisesnarrow neck regions narrow neck regions 912 is reinforced with a frame to provide additional stiffness in that region. The oppositenarrow neck region 914 is shown unreinforced although it may also be reinforced.FIG. 31B illustratesreinforcement 916 along the entire filling structure longitudinal axis.FIG. 31C illustrates reinforcement onopposite ends patterns 932 as seen inFIG. 32A , diamond shapes 934 as inFIG. 32B , weaves 936 as inFIG. 32C orhelical coils 938 as inFIG. 32D . Many other geometries may also be used. - A number of embodiments of filling structure have been disclosed. Any combination of these embodiments may also be made or substituted with one another. While use of the filling structures may have been described with respect to a two piece or a three piece endograft system, one of skill in the art will appreciate that any filling structure may be used in any endograft system. Additional features such as thrombogenic materials, thrombogenic agents, radially expanding frames and reinforced regions have also been discussed. Any of these features may also be used in combination with any of the filling structures.
- A number of thrombogenic materials have also been disclosed such as polyurethanes, polycarbonates, polyesters, ePTFE, polyolefins, parylene, gelatin, silicone, etc. Any of these materials may be used as the thrombogenic material and these materials may be formed into any number of configurations such as sutures, felts, velours, weaves, knits, hydrogels, foams, embolization coils or sheets. Attachment methods include but are not limited to gluing, heat sealing, welding, sintering, suturing/sowing, electrospinning, spraying, vapor deposition or drape coating. The thrombogenic materials may be fabricated as a part of the filling structure or they may be introduced during deployment of the filling structure.
- In addition to using thrombogenic materials, the surfaces of the filling structure may be modified in order to provide various material properties. For example, the surface may be textured, dimpled, etc. in order to provide a surface that helps provide the desired amount of thrombogenicity. Furthermore, the preferred embodiments have been disclosed as being composed of ePTFE with an inner layer of polyurethane. Other materials may be used as the filling structure base material and a second or third or even more layers of other materials may be coupled to the base layer in order to provide the desired material characteristics of the filling structure. Specific regions of the filling structure may also be modified with a material or drug to provide a desired effect, for example, a portion of the filling structure may be modified to be thrombogenic to help create a seal while other regions remain unmodified or modified to have a different effect. Other materials or therapeutic agents like heparin may also be applied to the surface of the tubular lumen to minimize thrombogenicity, or to promote healing and endothelialization as blood flows therethrough.
- Filling materials may be any one or combination of materials that may fill the filling structure and be hardened in situ. Examples of filling materials include polyethylene glycol (PEG), silicones, etc. One of skill in the art will appreciate that any of the features disclosed herein may be substituted or combined with any of the embodiments described herein. Moreover, in this disclosure the filling structure is referred to as having an inner wall and an outer wall that may be filled and that can withstand pressures of approximately from about 30 mm Hg to about 300 mm Hg above normal systolic blood pressure. One will appreciate the filling structure may also have multiple layers. For example, as disclosed, often the filling structure comprises an ePTFE layer with a coating of polyurethane thereover. Additional layers with other materials may similarly be used in order to control the material properties such as porosity and compliance. Therapeutic agents may also be coupled to the filling structure such as a thrombogenic agent on the outside of the filling structure.
- While the above is a complete description of the preferred embodiments of the invention, various alternatives, modifications, and equivalents may be used. Therefore, the above description should not be taken as limiting in scope of the invention which is defined by the appended claims.
Claims (20)
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Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1542616B1 (en) | 2002-09-20 | 2015-04-22 | Endologix, Inc. | Stent-graft with positioning anchor |
ES2407684T3 (en) | 2004-05-05 | 2013-06-13 | Direct Flow Medical, Inc. | Heart valve without stent with support structure formed on site |
US8048145B2 (en) | 2004-07-22 | 2011-11-01 | Endologix, Inc. | Graft systems having filling structures supported by scaffolds and methods for their use |
ATE540640T1 (en) * | 2004-07-22 | 2012-01-15 | Nellix Inc | SYSTEMS FOR THE TREATMENT OF ENDOVASCULAR ANEURYSMS |
JP5119148B2 (en) | 2005-06-07 | 2013-01-16 | ダイレクト フロウ メディカル、 インク. | Stentless aortic valve replacement with high radial strength |
EP1903985A4 (en) | 2005-07-07 | 2010-04-28 | Nellix Inc | Systems and methods for endovascular aneurysm treatment |
US7790273B2 (en) * | 2006-05-24 | 2010-09-07 | Nellix, Inc. | Material for creating multi-layered films and methods for making the same |
US7935144B2 (en) | 2006-10-19 | 2011-05-03 | Direct Flow Medical, Inc. | Profile reduction of valve implant |
US8133213B2 (en) | 2006-10-19 | 2012-03-13 | Direct Flow Medical, Inc. | Catheter guidance through a calcified aortic valve |
AU2008288796B2 (en) | 2007-08-23 | 2014-03-20 | Dfm, Llc | Cardiovascular prosthetic valve |
WO2009103011A1 (en) * | 2008-02-13 | 2009-08-20 | Nellix, Inc. | Graft endoframe having axially variable characteristics |
WO2009132309A1 (en) | 2008-04-25 | 2009-10-29 | Nellix, Inc. | Stent graft delivery system |
US10716573B2 (en) | 2008-05-01 | 2020-07-21 | Aneuclose | Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm |
US10028747B2 (en) | 2008-05-01 | 2018-07-24 | Aneuclose Llc | Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm |
JP2011522615A (en) | 2008-06-04 | 2011-08-04 | ネリックス・インコーポレーテッド | Sealing device and method of use |
US10772717B2 (en) | 2009-05-01 | 2020-09-15 | Endologix, Inc. | Percutaneous method and device to treat dissections |
US9579103B2 (en) | 2009-05-01 | 2017-02-28 | Endologix, Inc. | Percutaneous method and device to treat dissections |
US8118856B2 (en) | 2009-07-27 | 2012-02-21 | Endologix, Inc. | Stent graft |
US9358140B1 (en) | 2009-11-18 | 2016-06-07 | Aneuclose Llc | Stent with outer member to embolize an aneurysm |
US20110130826A1 (en) * | 2009-12-01 | 2011-06-02 | Altura Medical, Inc. | Modular endograft devices and associated systems and methods |
US20110276078A1 (en) * | 2009-12-30 | 2011-11-10 | Nellix, Inc. | Filling structure for a graft system and methods of use |
US9433501B2 (en) | 2010-05-19 | 2016-09-06 | Direct Flow Medical, Inc. | Inflation media for implants |
US8425548B2 (en) * | 2010-07-01 | 2013-04-23 | Aneaclose LLC | Occluding member expansion and then stent expansion for aneurysm treatment |
WO2012068298A1 (en) | 2010-11-17 | 2012-05-24 | Endologix, Inc. | Devices and methods to treat vascular dissections |
US8801768B2 (en) | 2011-01-21 | 2014-08-12 | Endologix, Inc. | Graft systems having semi-permeable filling structures and methods for their use |
EP2693980B1 (en) | 2011-04-06 | 2022-07-13 | Endologix LLC | System for endovascular aneurysm treatment |
US20130204351A1 (en) * | 2012-02-02 | 2013-08-08 | Inceptus Medical LLC | Aneurysm Graft Devices And Methods |
JP6669495B2 (en) * | 2012-06-05 | 2020-03-18 | カルディオジスKardiozis | Stents and delivery devices |
FR2991162B1 (en) * | 2012-06-05 | 2015-07-17 | Ass Marie Lannelongue | ENDOPROTHESIS, IN PARTICULAR VASCULAR OR CARDIAC, WITH THROMBOGENIC ELEMENTS |
WO2014026173A1 (en) | 2012-08-10 | 2014-02-13 | Cragg Andrew H | Stent delivery systems and associated methods |
WO2014110231A2 (en) | 2013-01-10 | 2014-07-17 | Trivascular, Inc. | Sac liner for aneurysm repair |
EP2961349A1 (en) | 2013-02-28 | 2016-01-06 | Boston Scientific Scimed, Inc. | Stent with balloon for repair of anastomosis surgery leaks |
BR112015022688B1 (en) | 2013-03-14 | 2020-10-06 | Endologix, Inc. | METHOD FOR FORMING A MATERIAL IN SITU THROUGH INCREASING THE VOLUME OF AN EXPANDABLE MEMBER OF A MEDICAL DEVICE |
US9737426B2 (en) | 2013-03-15 | 2017-08-22 | Altura Medical, Inc. | Endograft device delivery systems and associated methods |
US9907684B2 (en) | 2013-05-08 | 2018-03-06 | Aneuclose Llc | Method of radially-asymmetric stent expansion |
WO2015183489A1 (en) * | 2014-05-30 | 2015-12-03 | Endologix, Inc. | Modular stent graft systems and methods with inflatable fill structures |
CN106999272B (en) | 2014-09-18 | 2018-12-11 | 波士顿科学国际有限公司 | The device for Weight reduction bracket for allowing pyloric sphincter normally to play a role |
WO2016172629A1 (en) | 2015-04-22 | 2016-10-27 | Aneumed, Inc. | Personalized prosthesis and methods of deployment |
WO2017117068A1 (en) * | 2015-12-31 | 2017-07-06 | Endologix, Inc. | Systems and methods with fenestrated graft and filling structure |
US10188500B2 (en) * | 2016-02-12 | 2019-01-29 | Medtronic Vascular, Inc. | Stent graft with external scaffolding and method |
US10441407B2 (en) * | 2016-04-12 | 2019-10-15 | Medtronic Vascular, Inc. | Gutter filling stent-graft and method |
WO2018005969A1 (en) | 2016-06-30 | 2018-01-04 | Washington University | Device and method of inhibiting endoleaks |
CN109862850B (en) * | 2016-08-31 | 2022-04-08 | 恩朵罗杰克斯有限责任公司 | System and method with stent and filling structure |
US11911532B2 (en) | 2017-03-29 | 2024-02-27 | The Regents Of The University Of Colorado, A Body Corporate | Reverse thermal gels and their use as vascular embolic repair agents |
CN117323060A (en) | 2017-12-21 | 2024-01-02 | 得克萨斯农业及机械体系综合大学 | Vascular prosthesis for leak protection in endovascular aneurysm repair |
US11717392B2 (en) | 2018-04-23 | 2023-08-08 | Endologix Llc | Modulation of inflammatory response following endovascular treatment |
EP3801381A1 (en) * | 2018-05-31 | 2021-04-14 | Endologix LLC | Systems and methods with anchor device for fixation of filling structures in blood vessels |
CN109498211B (en) * | 2018-11-27 | 2021-10-19 | 深圳市先健畅通医疗有限公司 | Lumen stent |
CA3121617A1 (en) * | 2019-01-30 | 2020-08-06 | Toray Industries, Inc. | Medical base material for indwelling cardiovascular device |
JP2022525788A (en) | 2019-03-20 | 2022-05-19 | インキュベート メディカル テクノロジーズ、 エルエルシー | Aortic dissection implant |
EP3795096A1 (en) * | 2019-09-19 | 2021-03-24 | Kardiozis SAS | Endoprosthesis and a method of producing an endoprosthesis |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5330528A (en) * | 1989-12-01 | 1994-07-19 | British Technology Group Limited | Vascular surgical devices |
US5665117A (en) * | 1995-11-27 | 1997-09-09 | Rhodes; Valentine J. | Endovascular prosthesis with improved sealing means for aneurysmal arterial disease and method of use |
US5693088A (en) * | 1993-11-08 | 1997-12-02 | Lazarus; Harrison M. | Intraluminal vascular graft |
US5769882A (en) * | 1995-09-08 | 1998-06-23 | Medtronic, Inc. | Methods and apparatus for conformably sealing prostheses within body lumens |
US20040073288A1 (en) * | 2001-07-06 | 2004-04-15 | Andrew Kerr | Stent/graft assembly |
US20050015140A1 (en) * | 2003-07-14 | 2005-01-20 | Debeer Nicholas | Encapsulation device and methods of use |
US20050090804A1 (en) * | 2003-10-22 | 2005-04-28 | Trivascular, Inc. | Endoluminal prosthesis endoleak management |
US6918926B2 (en) * | 2002-04-25 | 2005-07-19 | Medtronic Vascular, Inc. | System for transrenal/intraostial fixation of endovascular prosthesis |
US20060206197A1 (en) * | 2002-12-30 | 2006-09-14 | Hesham Morsi | Endovascular balloon graft |
US20060212112A1 (en) * | 2004-07-22 | 2006-09-21 | Nellix, Inc. | Graft systems having filling structures supported by scaffolds and methods for their use |
US20080039923A1 (en) * | 2002-09-20 | 2008-02-14 | Nellix, Inc. | Stent-graft with positioning anchor |
US20100094409A1 (en) * | 2006-08-23 | 2010-04-15 | Stephen George Edward Barker | Improvements in and relating to medical devices |
Family Cites Families (332)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1980000007A1 (en) | 1978-06-02 | 1980-01-10 | A Rockey | Medical sleeve |
US4604762A (en) * | 1981-02-13 | 1986-08-12 | Thoratec Laboratories Corporation | Arterial graft prosthesis |
US4638803A (en) * | 1982-09-30 | 1987-01-27 | Rand Robert W | Medical apparatus for inducing scar tissue formation in a body |
GB8315001D0 (en) * | 1983-06-01 | 1983-07-06 | Ici Plc | Multiple-layer polyolefin films |
US5669936A (en) | 1983-12-09 | 1997-09-23 | Endovascular Technologies, Inc. | Endovascular grafting system and method for use therewith |
JPS60227763A (en) | 1984-04-27 | 1985-11-13 | 筏 義人 | Anti-thrombotic medical material |
US4728328A (en) | 1984-10-19 | 1988-03-01 | Research Corporation | Cuffed tubular organic prostheses |
US4704126A (en) | 1985-04-15 | 1987-11-03 | Richards Medical Company | Chemical polishing process for titanium and titanium alloy surgical implants |
US4936057A (en) | 1985-06-21 | 1990-06-26 | Extrude Hone Corporation | Method of finish machining the surface of irregularly shaped fluid passages |
US4733665C2 (en) * | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
US4710192A (en) | 1985-12-30 | 1987-12-01 | Liotta Domingo S | Diaphragm and method for occlusion of the descending thoracic aorta |
US5330520A (en) | 1986-05-15 | 1994-07-19 | Telectronics Pacing Systems, Inc. | Implantable electrode and sensor lead apparatus |
US4858264A (en) | 1986-09-02 | 1989-08-22 | The United States Of America As Represented By The Secretary Of The Air Force | Ultrasonic assisted protective coating removal |
US4763654A (en) * | 1986-09-10 | 1988-08-16 | Jang G David | Tandem independently inflatable/deflatable multiple diameter balloon angioplasty catheter systems and method of use |
US5002532A (en) * | 1987-01-06 | 1991-03-26 | Advanced Cardiovascular Systems, Inc. | Tandem balloon dilatation catheter |
US4800882A (en) | 1987-03-13 | 1989-01-31 | Cook Incorporated | Endovascular stent and delivery system |
US5133732A (en) | 1987-10-19 | 1992-07-28 | Medtronic, Inc. | Intravascular stent |
US4892544A (en) * | 1988-03-07 | 1990-01-09 | Dow Corning Wright Corporation | Methods for forming hollow, porous-surfaced elastomeric bodies |
CA1322628C (en) * | 1988-10-04 | 1993-10-05 | Richard A. Schatz | Expandable intraluminal graft |
US4856516A (en) | 1989-01-09 | 1989-08-15 | Cordis Corporation | Endovascular stent apparatus and method |
US5425739A (en) | 1989-03-09 | 1995-06-20 | Avatar Design And Development, Inc. | Anastomosis stent and stent selection system |
US5074845A (en) | 1989-07-18 | 1991-12-24 | Baxter International Inc. | Catheter with heat-fused balloon with waist |
US5292331A (en) * | 1989-08-24 | 1994-03-08 | Applied Vascular Engineering, Inc. | Endovascular support device |
CA2026604A1 (en) * | 1989-10-02 | 1991-04-03 | Rodney G. Wolff | Articulated stent |
US5199226A (en) * | 1990-01-26 | 1993-04-06 | E. B. Thomas | Method and apparatus for removing outer coatings from pipe |
DE4010975A1 (en) | 1990-03-28 | 1991-10-02 | Guenter Dr Siebert | Nasal membrane pressure instrument - has controller between pressure source and inflatable balloon |
US5221261A (en) * | 1990-04-12 | 1993-06-22 | Schneider (Usa) Inc. | Radially expandable fixation member |
US5242399A (en) | 1990-04-25 | 1993-09-07 | Advanced Cardiovascular Systems, Inc. | Method and system for stent delivery |
SE9001957L (en) | 1990-05-31 | 1991-12-01 | Chemrec Ab | Purification of process gas from partial combustion of black liquor |
US5122154A (en) | 1990-08-15 | 1992-06-16 | Rhodes Valentine J | Endovascular bypass graft |
US5139480A (en) | 1990-08-22 | 1992-08-18 | Biotech Laboratories, Inc. | Necking stents |
US4976692A (en) | 1990-09-13 | 1990-12-11 | Travenol Laboratories (Israel) Ltd. | Catheter particularly useful for inducing labor and/or for the application of a pharmaceutical substance to the cervix of the uterus |
US5108417A (en) * | 1990-09-14 | 1992-04-28 | Interface Biomedical Laboratories Corp. | Anti-turbulent, anti-thrombogenic intravascular stent |
US5156620A (en) * | 1991-02-04 | 1992-10-20 | Pigott John P | Intraluminal graft/stent and balloon catheter for insertion thereof |
JPH066125B2 (en) | 1991-02-05 | 1994-01-26 | 寛治 井上 | Device for introducing a medium into the human body |
US5217484A (en) | 1991-06-07 | 1993-06-08 | Marks Michael P | Retractable-wire catheter device and method |
US5766151A (en) | 1991-07-16 | 1998-06-16 | Heartport, Inc. | Endovascular system for arresting the heart |
US5222970A (en) | 1991-09-06 | 1993-06-29 | William A. Cook Australia Pty. Ltd. | Method of and system for mounting a vascular occlusion balloon on a delivery catheter |
CA2079417C (en) * | 1991-10-28 | 2003-01-07 | Lilip Lau | Expandable stents and method of making same |
CA2082090C (en) | 1991-11-05 | 2004-04-27 | Jack Fagan | Improved occluder for repair of cardiac and vascular defects |
FR2683449A1 (en) * | 1991-11-08 | 1993-05-14 | Cardon Alain | ENDOPROTHESIS FOR TRANSLUMINAL IMPLANTATION. |
US5234437A (en) | 1991-12-12 | 1993-08-10 | Target Therapeutics, Inc. | Detachable pusher-vasoocclusion coil assembly with threaded coupling |
US5261916A (en) | 1991-12-12 | 1993-11-16 | Target Therapeutics | Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling |
US5316023A (en) | 1992-01-08 | 1994-05-31 | Expandable Grafts Partnership | Method for bilateral intra-aortic bypass |
US5507767A (en) * | 1992-01-15 | 1996-04-16 | Cook Incorporated | Spiral stent |
DE69324239T2 (en) | 1992-01-21 | 1999-11-04 | Univ Minnesota | SEPTUAL DAMAGE CLOSURE DEVICE |
FR2688401B1 (en) | 1992-03-12 | 1998-02-27 | Thierry Richard | EXPANDABLE STENT FOR HUMAN OR ANIMAL TUBULAR MEMBER, AND IMPLEMENTATION TOOL. |
US5282823A (en) | 1992-03-19 | 1994-02-01 | Medtronic, Inc. | Intravascular radially expandable stent |
FR2689388B1 (en) | 1992-04-07 | 1999-07-16 | Celsa Lg | PERFECTIONALLY RESORBABLE BLOOD FILTER. |
US5263964A (en) | 1992-05-06 | 1993-11-23 | Coil Partners Ltd. | Coaxial traction detachment apparatus and method |
EP0639958A1 (en) | 1992-05-08 | 1995-03-01 | Schneider (Usa) Inc. | Esophageal stent and delivery tool |
US5507771A (en) * | 1992-06-15 | 1996-04-16 | Cook Incorporated | Stent assembly |
US5342387A (en) * | 1992-06-18 | 1994-08-30 | American Biomed, Inc. | Artificial support for a blood vessel |
USD380831S (en) | 1992-08-06 | 1997-07-08 | William Cook Europe A/S | Implantable self-expanding stent |
US5366473A (en) | 1992-08-18 | 1994-11-22 | Ultrasonic Sensing And Monitoring Systems, Inc. | Method and apparatus for applying vascular grafts |
US5527338A (en) | 1992-09-02 | 1996-06-18 | Board Of Regents, The University Of Texas System | Intravascular device |
US5250071A (en) | 1992-09-22 | 1993-10-05 | Target Therapeutics, Inc. | Detachable embolic coil assembly using interlocking clasps and method of use |
US5350397A (en) | 1992-11-13 | 1994-09-27 | Target Therapeutics, Inc. | Axially detachable embolic coil assembly |
US5530528A (en) | 1992-09-28 | 1996-06-25 | Fujitsu Limited | Image forming apparatus having contact type, one-component developing unit |
US5494029A (en) | 1992-09-29 | 1996-02-27 | Hood Laboratories | Laryngeal stents |
US5383926A (en) * | 1992-11-23 | 1995-01-24 | Children's Medical Center Corporation | Re-expandable endoprosthesis |
US5423849A (en) | 1993-01-15 | 1995-06-13 | Target Therapeutics, Inc. | Vasoocclusion device containing radiopaque fibers |
US5630840A (en) | 1993-01-19 | 1997-05-20 | Schneider (Usa) Inc | Clad composite stent |
US5441515A (en) * | 1993-04-23 | 1995-08-15 | Advanced Cardiovascular Systems, Inc. | Ratcheting stent |
US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5352199A (en) | 1993-05-28 | 1994-10-04 | Numed, Inc. | Balloon catheter |
IL105828A (en) | 1993-05-28 | 1999-06-20 | Medinol Ltd | Medical stent |
US5514115A (en) | 1993-07-07 | 1996-05-07 | Device For Vascular Intervention, Inc. | Flexible housing for intracorporeal use |
AU693779B2 (en) | 1993-07-23 | 1998-07-09 | Cook Medical Technologies Llc | A flexible stent having a pattern formed from a sheet of material |
US5735892A (en) * | 1993-08-18 | 1998-04-07 | W. L. Gore & Associates, Inc. | Intraluminal stent graft |
US5441510A (en) | 1993-09-01 | 1995-08-15 | Technology Development Center | Bi-axial cutter apparatus for catheter |
WO1995008289A2 (en) | 1993-09-16 | 1995-03-30 | Scimed Life Systems, Inc. | Percutaneous repair of cardiovascular anomalies and repair compositions |
JP3365658B2 (en) | 1993-09-30 | 2003-01-14 | 株式会社日本吸収体技術研究所 | Absorbent products |
US5639278A (en) | 1993-10-21 | 1997-06-17 | Corvita Corporation | Expandable supportive bifurcated endoluminal grafts |
US5723004A (en) * | 1993-10-21 | 1998-03-03 | Corvita Corporation | Expandable supportive endoluminal grafts |
JP2703510B2 (en) | 1993-12-28 | 1998-01-26 | アドヴァンスド カーディオヴァスキュラー システムズ インコーポレーテッド | Expandable stent and method of manufacturing the same |
US5507769A (en) * | 1994-10-18 | 1996-04-16 | Stentco, Inc. | Method and apparatus for forming an endoluminal bifurcated graft |
US5443477A (en) | 1994-02-10 | 1995-08-22 | Stentco, Inc. | Apparatus and method for deployment of radially expandable stents by a mechanical linkage |
US5485667A (en) * | 1994-03-03 | 1996-01-23 | Kleshinski; Stephen J. | Method for attaching a marker to a medical instrument |
US5549663A (en) | 1994-03-09 | 1996-08-27 | Cordis Corporation | Endoprosthesis having graft member and exposed welded end junctions, method and procedure |
US5417708A (en) | 1994-03-09 | 1995-05-23 | Cook Incorporated | Intravascular treatment system and percutaneous release mechanism therefor |
US5733303A (en) * | 1994-03-17 | 1998-03-31 | Medinol Ltd. | Flexible expandable stent |
US5449373A (en) | 1994-03-17 | 1995-09-12 | Medinol Ltd. | Articulated stent |
JPH09510637A (en) | 1994-03-18 | 1997-10-28 | クック インコーポレイティッド | Spiral embolization coil |
DE69510986T2 (en) * | 1994-04-25 | 1999-12-02 | Advanced Cardiovascular System | Radiation-opaque stent markings |
US5554181A (en) | 1994-05-04 | 1996-09-10 | Regents Of The University Of Minnesota | Stent |
US5824044A (en) | 1994-05-12 | 1998-10-20 | Endovascular Technologies, Inc. | Bifurcated multicapsule intraluminal grafting system |
US5765418A (en) | 1994-05-16 | 1998-06-16 | Medtronic, Inc. | Method for making an implantable medical device from a refractory metal |
US5867762A (en) * | 1994-05-26 | 1999-02-02 | Rafferty; Kevin | Masking tape |
US5728068A (en) * | 1994-06-14 | 1998-03-17 | Cordis Corporation | Multi-purpose balloon catheter |
US5846261A (en) | 1994-07-08 | 1998-12-08 | Aga Medical Corp. | Percutaneous catheter directed occlusion devices |
US6123715A (en) | 1994-07-08 | 2000-09-26 | Amplatz; Curtis | Method of forming medical devices; intravascular occlusion devices |
US5636641A (en) | 1994-07-25 | 1997-06-10 | Advanced Cardiovascular Systems, Inc. | High strength member for intracorporeal use |
US5531741A (en) | 1994-08-18 | 1996-07-02 | Barbacci; Josephine A. | Illuminated stents |
US5609605A (en) * | 1994-08-25 | 1997-03-11 | Ethicon, Inc. | Combination arterial stent |
US5591230A (en) * | 1994-09-07 | 1997-01-07 | Global Therapeutics, Inc. | Radially expandable stent |
US5578149A (en) | 1995-05-31 | 1996-11-26 | Global Therapeutics, Inc. | Radially expandable stent |
US5545210A (en) | 1994-09-22 | 1996-08-13 | Advanced Coronary Technology, Inc. | Method of implanting a permanent shape memory alloy stent |
US5733299A (en) | 1994-10-20 | 1998-03-31 | Cordis Corporation | Two balloon catheter |
US5522882A (en) | 1994-10-21 | 1996-06-04 | Impra, Inc. | Method and apparatus for balloon expandable stent-graft delivery |
NL9500283A (en) | 1994-10-21 | 1996-06-03 | Cordis Europ | Catheter with guide wire channel. |
US5534024A (en) | 1994-11-04 | 1996-07-09 | Aeroquip Corporation | Intraluminal stenting graft |
JP3182301B2 (en) | 1994-11-07 | 2001-07-03 | キヤノン株式会社 | Microstructure and method for forming the same |
US5549662A (en) | 1994-11-07 | 1996-08-27 | Scimed Life Systems, Inc. | Expandable stent using sliding members |
US5578074A (en) | 1994-12-22 | 1996-11-26 | Target Therapeutics, Inc. | Implant delivery method and assembly |
USD380266S (en) | 1994-12-30 | 1997-06-24 | Cook Incorporated | Implantable, actively expandable stent |
NL9500094A (en) | 1995-01-19 | 1996-09-02 | Industrial Res Bv | Y-shaped stent and method of deployment. |
US5591226A (en) * | 1995-01-23 | 1997-01-07 | Schneider (Usa) Inc. | Percutaneous stent-graft and method for delivery thereof |
US5755770A (en) | 1995-01-31 | 1998-05-26 | Boston Scientific Corporatiion | Endovascular aortic graft |
EP0810845A2 (en) | 1995-02-22 | 1997-12-10 | Menlo Care Inc. | Covered expanding mesh stent |
US5683449A (en) | 1995-02-24 | 1997-11-04 | Marcade; Jean Paul | Modular bifurcated intraluminal grafts and methods for delivering and assembling same |
US6451047B2 (en) | 1995-03-10 | 2002-09-17 | Impra, Inc. | Encapsulated intraluminal stent-graft and methods of making same |
US6124523A (en) | 1995-03-10 | 2000-09-26 | Impra, Inc. | Encapsulated stent |
US5605530A (en) * | 1995-03-23 | 1997-02-25 | Fischell; Robert E. | System for safe implantation of radioisotope stents |
BE1009278A3 (en) * | 1995-04-12 | 1997-01-07 | Corvita Europ | Guardian self-expandable medical device introduced in cavite body, and medical device with a stake as. |
BE1009277A3 (en) | 1995-04-12 | 1997-01-07 | Corvita Europ | Guardian self-expandable medical device introduced in cavite body, and method of preparation. |
US5591228A (en) * | 1995-05-09 | 1997-01-07 | Edoga; John K. | Methods for treating abdominal aortic aneurysms |
US5662614A (en) | 1995-05-09 | 1997-09-02 | Edoga; John K. | Balloon expandable universal access sheath |
AU716005B2 (en) | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
CA2223479A1 (en) * | 1995-06-08 | 1996-12-27 | Bard Galway Limited | Endovascular stent |
US5728131A (en) * | 1995-06-12 | 1998-03-17 | Endotex Interventional Systems, Inc. | Coupling device and method of use |
US5725568A (en) | 1995-06-27 | 1998-03-10 | Scimed Life Systems, Inc. | Method and device for recanalizing and grafting arteries |
US5782907A (en) | 1995-07-13 | 1998-07-21 | Devices For Vascular Intervention, Inc. | Involuted spring stent and graft assembly and method of use |
US5785679A (en) * | 1995-07-19 | 1998-07-28 | Endotex Interventional Systems, Inc. | Methods and apparatus for treating aneurysms and arterio-venous fistulas |
US5601600A (en) * | 1995-09-08 | 1997-02-11 | Conceptus, Inc. | Endoluminal coil delivery system having a mechanical release mechanism |
US5824036A (en) | 1995-09-29 | 1998-10-20 | Datascope Corp | Stent for intraluminal grafts and device and methods for delivering and assembling same |
US6193745B1 (en) | 1995-10-03 | 2001-02-27 | Medtronic, Inc. | Modular intraluminal prosteheses construction and methods |
US5824037A (en) | 1995-10-03 | 1998-10-20 | Medtronic, Inc. | Modular intraluminal prostheses construction and methods |
US5776161A (en) | 1995-10-16 | 1998-07-07 | Instent, Inc. | Medical stents, apparatus and method for making same |
US5591195A (en) * | 1995-10-30 | 1997-01-07 | Taheri; Syde | Apparatus and method for engrafting a blood vessel |
DE69612507T2 (en) * | 1995-10-30 | 2001-08-09 | Childrens Medical Center | SELF-CENTERING, SHIELD-LIKE DEVICE FOR CLOSING A SEPTAL DEFECT |
US6287315B1 (en) | 1995-10-30 | 2001-09-11 | World Medical Manufacturing Corporation | Apparatus for delivering an endoluminal prosthesis |
US5632762A (en) | 1995-11-09 | 1997-05-27 | Hemodynamics, Inc. | Ostial stent balloon |
US5607442A (en) * | 1995-11-13 | 1997-03-04 | Isostent, Inc. | Stent with improved radiopacity and appearance characteristics |
US5868685A (en) * | 1995-11-14 | 1999-02-09 | Devices For Vascular Intervention | Articulated guidewire |
IT1276141B1 (en) * | 1995-11-16 | 1997-10-27 | Soten Srl | MULTI-LAYER COEXTRUDED POLYOLEFIN SHRINK FILM WITH IMPROVED WELDING RESISTANCE |
US5788626A (en) | 1995-11-21 | 1998-08-04 | Schneider (Usa) Inc | Method of making a stent-graft covered with expanded polytetrafluoroethylene |
US5593417A (en) * | 1995-11-27 | 1997-01-14 | Rhodes; Valentine J. | Intravascular stent with secure mounting means |
US5824040A (en) | 1995-12-01 | 1998-10-20 | Medtronic, Inc. | Endoluminal prostheses and therapies for highly variable body lumens |
US6576009B2 (en) | 1995-12-01 | 2003-06-10 | Medtronic Ave, Inc. | Bifurcated intraluminal prostheses construction and methods |
US6878161B2 (en) * | 1996-01-05 | 2005-04-12 | Medtronic Vascular, Inc. | Stent graft loading and deployment device and method |
DE69732794T2 (en) | 1996-01-05 | 2006-04-06 | Medtronic, Inc., Minneapolis | EXPANDABLE ENDOLUMINARY PROSTHESIS |
US5800512A (en) | 1996-01-22 | 1998-09-01 | Meadox Medicals, Inc. | PTFE vascular graft |
US6168622B1 (en) | 1996-01-24 | 2001-01-02 | Microvena Corporation | Method and apparatus for occluding aneurysms |
US5871537A (en) * | 1996-02-13 | 1999-02-16 | Scimed Life Systems, Inc. | Endovascular apparatus |
US5690643A (en) | 1996-02-20 | 1997-11-25 | Leocor, Incorporated | Stent delivery system |
US5925054A (en) * | 1996-02-20 | 1999-07-20 | Cardiothoracic Systems, Inc. | Perfusion device for maintaining blood flow in a vessel while isolating an anastomosis |
EP0795304B1 (en) * | 1996-03-10 | 2004-05-19 | Terumo Kabushiki Kaisha | Implanting stent |
US5843160A (en) | 1996-04-01 | 1998-12-01 | Rhodes; Valentine J. | Prostheses for aneurysmal and/or occlusive disease at a bifurcation in a vessel, duct, or lumen |
US6458096B1 (en) | 1996-04-01 | 2002-10-01 | Medtronic, Inc. | Catheter with autoinflating, autoregulating balloon |
BE1010183A3 (en) * | 1996-04-25 | 1998-02-03 | Dereume Jean Pierre Georges Em | Luminal endoprosthesis FOR BRANCHING CHANNELS OF A HUMAN OR ANIMAL BODY AND MANUFACTURING METHOD THEREOF. |
US6544276B1 (en) | 1996-05-20 | 2003-04-08 | Medtronic Ave. Inc. | Exchange method for emboli containment |
US5800514A (en) | 1996-05-24 | 1998-09-01 | Meadox Medicals, Inc. | Shaped woven tubular soft-tissue prostheses and methods of manufacturing |
US5617878A (en) * | 1996-05-31 | 1997-04-08 | Taheri; Syde A. | Stent and method for treatment of aortic occlusive disease |
US5755773A (en) | 1996-06-04 | 1998-05-26 | Medtronic, Inc. | Endoluminal prosthetic bifurcation shunt |
US5697971A (en) | 1996-06-11 | 1997-12-16 | Fischell; Robert E. | Multi-cell stent with cells having differing characteristics |
US6190402B1 (en) | 1996-06-21 | 2001-02-20 | Musc Foundation For Research Development | Insitu formable and self-forming intravascular flow modifier (IFM) and IFM assembly for deployment of same |
US5928279A (en) | 1996-07-03 | 1999-07-27 | Baxter International Inc. | Stented, radially expandable, tubular PTFE grafts |
US5980514A (en) | 1996-07-26 | 1999-11-09 | Target Therapeutics, Inc. | Aneurysm closure device assembly |
US5676697A (en) | 1996-07-29 | 1997-10-14 | Cardiovascular Dynamics, Inc. | Two-piece, bifurcated intraluminal graft for repair of aneurysm |
US6325819B1 (en) | 1996-08-19 | 2001-12-04 | Cook Incorporated | Endovascular prosthetic device, an endovascular graft prothesis with such a device, and a method for repairing an abdominal aortic aneurysm |
US6306165B1 (en) | 1996-09-13 | 2001-10-23 | Meadox Medicals | ePTFE small caliber vascular grafts with significant patency enhancement via a surface coating which contains covalently bonded heparin |
US6007573A (en) | 1996-09-18 | 1999-12-28 | Microtherapeutics, Inc. | Intracranial stent and method of use |
US5807404A (en) | 1996-09-19 | 1998-09-15 | Medinol Ltd. | Stent with variable features to optimize support and method of making such stent |
EP0934035B8 (en) * | 1996-09-26 | 2006-01-18 | Boston Scientific Scimed, Inc. | Support structure/membrane composite medical device |
US5755778A (en) | 1996-10-16 | 1998-05-26 | Nitinol Medical Technologies, Inc. | Anastomosis device |
US5976178A (en) | 1996-11-07 | 1999-11-02 | Vascular Science Inc. | Medical grafting methods |
AU7178698A (en) | 1996-11-15 | 1998-06-03 | Advanced Bio Surfaces, Inc. | Biomaterial system for in situ tissue repair |
US5860998A (en) * | 1996-11-25 | 1999-01-19 | C. R. Bard, Inc. | Deployment device for tubular expandable prosthesis |
US6015431A (en) * | 1996-12-23 | 2000-01-18 | Prograft Medical, Inc. | Endolumenal stent-graft with leak-resistant seal |
US5868782A (en) * | 1996-12-24 | 1999-02-09 | Global Therapeutics, Inc. | Radially expandable axially non-contracting surgical stent |
EP0850607A1 (en) | 1996-12-31 | 1998-07-01 | Cordis Corporation | Valve prosthesis for implantation in body channels |
US5947991A (en) | 1997-01-07 | 1999-09-07 | Cowan; Robert K. | Single balloon device for cervix |
US5827321A (en) | 1997-02-07 | 1998-10-27 | Cornerstone Devices, Inc. | Non-Foreshortening intraluminal prosthesis |
US6254633B1 (en) | 1997-02-12 | 2001-07-03 | Corvita Corporation | Delivery device for a medical device having a constricted region |
US5919224A (en) | 1997-02-12 | 1999-07-06 | Schneider (Usa) Inc | Medical device having a constricted region for occluding fluid flow in a body lumen |
US5800393A (en) | 1997-03-07 | 1998-09-01 | Sahota; Harvinder | Wire perfusion catheter |
US5810872A (en) | 1997-03-14 | 1998-09-22 | Kanesaka; Nozomu | Flexible stent |
US5824054A (en) | 1997-03-18 | 1998-10-20 | Endotex Interventional Systems, Inc. | Coiled sheet graft stent and methods of making and use |
US5718713A (en) * | 1997-04-10 | 1998-02-17 | Global Therapeutics, Inc. | Surgical stent having a streamlined contour |
US5741327A (en) * | 1997-05-06 | 1998-04-21 | Global Therapeutics, Inc. | Surgical stent featuring radiopaque markers |
US5868708A (en) * | 1997-05-07 | 1999-02-09 | Applied Medical Resources Corporation | Balloon catheter apparatus and method |
US5836966A (en) | 1997-05-22 | 1998-11-17 | Scimed Life Systems, Inc. | Variable expansion force stent |
AUPO700897A0 (en) | 1997-05-26 | 1997-06-19 | William A Cook Australia Pty Ltd | A method and means of deploying a graft |
US5800525A (en) | 1997-06-04 | 1998-09-01 | Vascular Science, Inc. | Blood filter |
US5746691A (en) | 1997-06-06 | 1998-05-05 | Global Therapeutics, Inc. | Method for polishing surgical stents |
US5843175A (en) | 1997-06-13 | 1998-12-01 | Global Therapeutics, Inc. | Enhanced flexibility surgical stent |
GB9713624D0 (en) | 1997-06-28 | 1997-09-03 | Anson Medical Ltd | Expandable device |
US5944750A (en) | 1997-06-30 | 1999-08-31 | Eva Corporation | Method and apparatus for the surgical repair of aneurysms |
US5863627A (en) * | 1997-08-26 | 1999-01-26 | Cardiotech International, Inc. | Hydrolytically-and proteolytically-stable polycarbonate polyurethane silicone copolymers |
US6187033B1 (en) * | 1997-09-04 | 2001-02-13 | Meadox Medicals, Inc. | Aortic arch prosthetic graft |
US6306164B1 (en) * | 1997-09-05 | 2001-10-23 | C. R. Bard, Inc. | Short body endoprosthesis |
US5984955A (en) | 1997-09-11 | 1999-11-16 | Wisselink; Willem | System and method for endoluminal grafting of bifurcated or branched vessels |
US6042606A (en) * | 1997-09-29 | 2000-03-28 | Cook Incorporated | Radially expandable non-axially contracting surgical stent |
US6132457A (en) | 1997-10-22 | 2000-10-17 | Triad Vascular Systems, Inc. | Endovascular graft having longitudinally displaceable sections |
US6331191B1 (en) | 1997-11-25 | 2001-12-18 | Trivascular Inc. | Layered endovascular graft |
US6190406B1 (en) * | 1998-01-09 | 2001-02-20 | Nitinal Development Corporation | Intravascular stent having tapered struts |
US5873907A (en) * | 1998-01-27 | 1999-02-23 | Endotex Interventional Systems, Inc. | Electrolytic stent delivery system and methods of use |
US6395019B2 (en) | 1998-02-09 | 2002-05-28 | Trivascular, Inc. | Endovascular graft |
DE69929036T2 (en) | 1998-02-12 | 2006-08-31 | Thomas R. North Vancouver Marotta | ENDOVASCULAR PROSTHESIS |
US5931866A (en) | 1998-02-24 | 1999-08-03 | Frantzen; John J. | Radially expandable stent featuring accordion stops |
US5938697A (en) * | 1998-03-04 | 1999-08-17 | Scimed Life Systems, Inc. | Stent having variable properties |
US6099497A (en) | 1998-03-05 | 2000-08-08 | Scimed Life Systems, Inc. | Dilatation and stent delivery system for bifurcation lesions |
US6129756A (en) | 1998-03-16 | 2000-10-10 | Teramed, Inc. | Biluminal endovascular graft system |
US6290731B1 (en) * | 1998-03-30 | 2001-09-18 | Cordis Corporation | Aortic graft having a precursor gasket for repairing an abdominal aortic aneurysm |
US6887268B2 (en) | 1998-03-30 | 2005-05-03 | Cordis Corporation | Extension prosthesis for an arterial repair |
US6463317B1 (en) | 1998-05-19 | 2002-10-08 | Regents Of The University Of Minnesota | Device and method for the endovascular treatment of aneurysms |
US6293960B1 (en) | 1998-05-22 | 2001-09-25 | Micrus Corporation | Catheter with shape memory polymer distal tip for deployment of therapeutic devices |
US6296603B1 (en) | 1998-05-26 | 2001-10-02 | Isostent, Inc. | Radioactive intraluminal endovascular prosthesis and method for the treatment of aneurysms |
US6203732B1 (en) * | 1998-07-02 | 2001-03-20 | Intra Therapeutics, Inc. | Method for manufacturing intraluminal device |
US6099548A (en) | 1998-07-28 | 2000-08-08 | Taheri; Syde A. | Apparatus and method for deploying an aortic arch graft |
US6093199A (en) | 1998-08-05 | 2000-07-25 | Endovascular Technologies, Inc. | Intra-luminal device for treatment of body cavities and lumens and method of use |
US6152943A (en) | 1998-08-14 | 2000-11-28 | Incept Llc | Methods and apparatus for intraluminal deposition of hydrogels |
US6179860B1 (en) | 1998-08-19 | 2001-01-30 | Artemis Medical, Inc. | Target tissue localization device and method |
US6299604B1 (en) | 1998-08-20 | 2001-10-09 | Cook Incorporated | Coated implantable medical device |
US6196230B1 (en) | 1998-09-10 | 2001-03-06 | Percardia, Inc. | Stent delivery system and method of use |
US6547814B2 (en) | 1998-09-30 | 2003-04-15 | Impra, Inc. | Selective adherence of stent-graft coverings |
US6368345B1 (en) | 1998-09-30 | 2002-04-09 | Edwards Lifesciences Corporation | Methods and apparatus for intraluminal placement of a bifurcated intraluminal garafat |
US6293967B1 (en) * | 1998-10-29 | 2001-09-25 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
US6152144A (en) | 1998-11-06 | 2000-11-28 | Appriva Medical, Inc. | Method and device for left atrial appendage occlusion |
US6083259A (en) | 1998-11-16 | 2000-07-04 | Frantzen; John J. | Axially non-contracting flexible radially expandable stent |
AU1525800A (en) | 1998-11-19 | 2000-06-05 | Percusurge, Inc. | Low volume syringe and method for inflating surgical balloons |
US6187034B1 (en) | 1999-01-13 | 2001-02-13 | John J. Frantzen | Segmented stent for flexible stent delivery system |
US6022359A (en) | 1999-01-13 | 2000-02-08 | Frantzen; John J. | Stent delivery system featuring a flexible balloon |
US7524289B2 (en) | 1999-01-25 | 2009-04-28 | Lenker Jay A | Resolution optical and ultrasound devices for imaging and treatment of body lumens |
GB9904722D0 (en) | 1999-03-03 | 1999-04-21 | Murch Clifford R | A tubular intraluminal graft |
US6663607B2 (en) | 1999-07-12 | 2003-12-16 | Scimed Life Systems, Inc. | Bioactive aneurysm closure device assembly and kit |
IT1307263B1 (en) * | 1999-08-05 | 2001-10-30 | Sorin Biomedica Cardio Spa | ANGIOPLASTIC STENT WITH RESTENOSIS ANTAGONIST ACTION, RELATED KIT AND COMPONENTS. |
US7022100B1 (en) * | 1999-09-03 | 2006-04-04 | A-Med Systems, Inc. | Guidable intravascular blood pump and related methods |
US6409757B1 (en) | 1999-09-15 | 2002-06-25 | Eva Corporation | Method and apparatus for supporting a graft assembly |
US6312462B1 (en) | 1999-09-22 | 2001-11-06 | Impra, Inc. | Prosthesis for abdominal aortic aneurysm repair |
AUPQ302899A0 (en) | 1999-09-23 | 1999-10-21 | Endogad Research Pty Limited | Implants for the use in the treatment of aneurysmal disease |
US6344056B1 (en) * | 1999-12-29 | 2002-02-05 | Edwards Lifesciences Corp. | Vascular grafts for bridging a vessel side branch |
US6280466B1 (en) | 1999-12-03 | 2001-08-28 | Teramed Inc. | Endovascular graft system |
US6331184B1 (en) | 1999-12-10 | 2001-12-18 | Scimed Life Systems, Inc. | Detachable covering for an implantable medical device |
US6663667B2 (en) | 1999-12-29 | 2003-12-16 | Edwards Lifesciences Corporation | Towel graft means for enhancing tissue ingrowth in vascular grafts |
US6241761B1 (en) | 2000-01-26 | 2001-06-05 | Cabg Medical, Inc. | Stented grafts for coupling vascular members |
US6312463B1 (en) | 2000-02-01 | 2001-11-06 | Endotex Interventional Systems, Inc. | Micro-porous mesh stent with hybrid structure |
US6432129B2 (en) | 2000-02-22 | 2002-08-13 | Scimed Life Systems, Inc. | Stent delivery system |
ATE255860T1 (en) | 2000-03-03 | 2003-12-15 | Cook Inc | ENDOVASCULAR DEVICE WITH STENT |
WO2001066167A2 (en) | 2000-03-03 | 2001-09-13 | Chuter Timothy A M | Large vessel stents and occluders |
US6290722B1 (en) | 2000-03-13 | 2001-09-18 | Endovascular Technologies, Inc. | Tacky attachment method of covered materials on stents |
US20020026217A1 (en) | 2000-04-26 | 2002-02-28 | Steven Baker | Apparatus and method for repair of perigraft flow |
US6729356B1 (en) | 2000-04-27 | 2004-05-04 | Endovascular Technologies, Inc. | Endovascular graft for providing a seal with vasculature |
US6692486B2 (en) | 2000-05-10 | 2004-02-17 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of cerebral aneurysms, arterial-vascular malformations and arterial fistulas |
US6773454B2 (en) | 2000-08-02 | 2004-08-10 | Michael H. Wholey | Tapered endovascular stent graft and method of treating abdominal aortic aneurysms and distal iliac aneurysms |
US6776771B2 (en) | 2000-09-14 | 2004-08-17 | Tuborg Engineering | Adaptive balloon with improved flexibility |
US6945989B1 (en) | 2000-09-18 | 2005-09-20 | Endotex Interventional Systems, Inc. | Apparatus for delivering endoluminal prostheses and methods of making and using them |
US6695833B1 (en) | 2000-09-27 | 2004-02-24 | Nellix, Inc. | Vascular stent-graft apparatus and forming method |
US6730119B1 (en) | 2000-10-06 | 2004-05-04 | Board Of Regents Of The University Of Texas System | Percutaneous implantation of partially covered stents in aneurysmally dilated arterial segments with subsequent embolization and obliteration of the aneurysm cavity |
US7229472B2 (en) | 2000-11-16 | 2007-06-12 | Cordis Corporation | Thoracic aneurysm repair prosthesis and system |
US7314483B2 (en) * | 2000-11-16 | 2008-01-01 | Cordis Corp. | Stent graft with branch leg |
US6579301B1 (en) | 2000-11-17 | 2003-06-17 | Syntheon, Llc | Intragastric balloon device adapted to be repeatedly varied in volume without external assistance |
US6645242B1 (en) | 2000-12-11 | 2003-11-11 | Stephen F. Quinn | Bifurcated side-access intravascular stent graft |
US6623452B2 (en) | 2000-12-19 | 2003-09-23 | Scimed Life Systems, Inc. | Drug delivery catheter having a highly compliant balloon with infusion holes |
US6547804B2 (en) * | 2000-12-27 | 2003-04-15 | Scimed Life Systems, Inc. | Selectively permeable highly distensible occlusion balloon |
US20020169497A1 (en) | 2001-01-02 | 2002-11-14 | Petra Wholey | Endovascular stent system and method of providing aneurysm embolization |
WO2002076346A1 (en) | 2001-03-23 | 2002-10-03 | Hassan Tehrani | Branched aortic arch stent graft |
EP1372534B1 (en) | 2001-03-28 | 2006-11-29 | Cook Incorporated | Set of sections for a modular stent graft assembly |
US6761733B2 (en) | 2001-04-11 | 2004-07-13 | Trivascular, Inc. | Delivery system and method for bifurcated endovascular graft |
US6733521B2 (en) | 2001-04-11 | 2004-05-11 | Trivascular, Inc. | Delivery system and method for endovascular graft |
US7175651B2 (en) * | 2001-07-06 | 2007-02-13 | Andrew Kerr | Stent/graft assembly |
US6969373B2 (en) * | 2001-04-13 | 2005-11-29 | Tricardia, Llc | Syringe system |
US6796960B2 (en) | 2001-05-04 | 2004-09-28 | Wit Ip Corporation | Low thermal resistance elastic sleeves for medical device balloons |
US6890303B2 (en) | 2001-05-31 | 2005-05-10 | Matthew Joseph Fitz | Implantable device for monitoring aneurysm sac parameters |
GB0114918D0 (en) | 2001-06-19 | 2001-08-08 | Vortex Innovation Ltd | Devices for repairing aneurysms |
AU2002315223A1 (en) * | 2001-06-19 | 2003-01-02 | Eva Corporation | Positioning apparatus for use in repairing a vessel |
US20030014075A1 (en) | 2001-07-16 | 2003-01-16 | Microvention, Inc. | Methods, materials and apparatus for deterring or preventing endoleaks following endovascular graft implanation |
JP4180509B2 (en) | 2001-07-26 | 2008-11-12 | ウイルソンークック メディカル インク. | Vessel occlusion member and distribution device thereof |
US20030028209A1 (en) * | 2001-07-31 | 2003-02-06 | Clifford Teoh | Expandable body cavity liner device |
US7192441B2 (en) | 2001-10-16 | 2007-03-20 | Scimed Life Systems, Inc. | Aortic artery aneurysm endovascular prosthesis |
AU2002336650B2 (en) | 2001-10-25 | 2008-06-05 | Emory University | Catheter for modified perfusion |
AUPR847201A0 (en) | 2001-10-26 | 2001-11-15 | Cook Incorporated | Endoluminal graft |
US6958051B2 (en) | 2001-10-29 | 2005-10-25 | Scimed Life Systems, Inc. | Dual balloon valve control with pressure indicator |
US20060292206A1 (en) | 2001-11-26 | 2006-12-28 | Kim Steven W | Devices and methods for treatment of vascular aneurysms |
US7823267B2 (en) | 2001-11-28 | 2010-11-02 | Aptus Endosystems, Inc. | Devices, systems, and methods for prosthesis delivery and implantation, including the use of a fastener tool |
US6746465B2 (en) | 2001-12-14 | 2004-06-08 | The Regents Of The University Of California | Catheter based balloon for therapy modification and positioning of tissue |
CA2468951A1 (en) | 2001-12-20 | 2003-07-03 | Trivascular, Inc. | Advanced endovascular graft |
US7147661B2 (en) | 2001-12-20 | 2006-12-12 | Boston Scientific Santa Rosa Corp. | Radially expandable stent |
FR2834199B1 (en) | 2001-12-27 | 2004-10-15 | Doron Carmi | ENDOPROSTHESIS ADAPTED TO THE ENDOLUMINAL ENVIRONMENT |
US7326237B2 (en) * | 2002-01-08 | 2008-02-05 | Cordis Corporation | Supra-renal anchoring prosthesis |
US20030130720A1 (en) | 2002-01-08 | 2003-07-10 | Depalma Donald F. | Modular aneurysm repair system |
US20030130725A1 (en) | 2002-01-08 | 2003-07-10 | Depalma Donald F. | Sealing prosthesis |
US6679300B1 (en) * | 2002-01-14 | 2004-01-20 | Thermogenesis Corp. | Biological adhesive loading station and method |
US20030135269A1 (en) | 2002-01-16 | 2003-07-17 | Swanstrom Lee L. | Laparoscopic-assisted endovascular/endoluminal graft placement |
US7131991B2 (en) | 2002-04-24 | 2006-11-07 | Medtronic Vascular, Inc. | Endoluminal prosthetic assembly and extension method |
US20030204249A1 (en) | 2002-04-25 | 2003-10-30 | Michel Letort | Endovascular stent graft and fixation cuff |
US6780170B2 (en) * | 2002-05-15 | 2004-08-24 | Liebel-Flarsheim Company | Hydraulic remote for a medical fluid injector |
US20030225446A1 (en) | 2002-05-29 | 2003-12-04 | William A. Cook Australia Pty Ltd. | Multi-piece prosthesis deployment apparatus |
US6656220B1 (en) | 2002-06-17 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Intravascular stent |
US6833003B2 (en) | 2002-06-24 | 2004-12-21 | Cordis Neurovascular | Expandable stent and delivery system |
US7314484B2 (en) | 2002-07-02 | 2008-01-01 | The Foundry, Inc. | Methods and devices for treating aneurysms |
US20050096731A1 (en) | 2002-07-11 | 2005-05-05 | Kareen Looi | Cell seeded expandable body |
JP2004063081A (en) | 2002-07-24 | 2004-02-26 | Renesas Technology Corp | Socket for semiconductor package |
AU2003272226A1 (en) | 2002-08-20 | 2004-03-11 | Cook Incorporated | Stent graft with improved proximal end |
US20060265043A1 (en) | 2002-09-30 | 2006-11-23 | Evgenia Mandrusov | Method and apparatus for treating vulnerable plaque |
US20040098096A1 (en) | 2002-10-22 | 2004-05-20 | The University Of Miami | Endograft device to inhibit endoleak and migration |
US7588825B2 (en) * | 2002-10-23 | 2009-09-15 | Boston Scientific Scimed, Inc. | Embolic compositions |
US20040153025A1 (en) | 2003-02-03 | 2004-08-05 | Seifert Paul S. | Systems and methods of de-endothelialization |
DE10305553B4 (en) | 2003-02-10 | 2005-11-03 | Lothar Dr.med. Göbel | Device for tamponade of body cavities |
WO2004093746A1 (en) | 2003-03-26 | 2004-11-04 | The Foundry Inc. | Devices and methods for treatment of abdominal aortic aneurysm |
US7396540B2 (en) | 2003-04-25 | 2008-07-08 | Medtronic Vascular, Inc. | In situ blood vessel and aneurysm treatment |
US7625401B2 (en) * | 2003-05-06 | 2009-12-01 | Abbott Laboratories | Endoprosthesis having foot extensions |
US20050028484A1 (en) | 2003-06-20 | 2005-02-10 | Littlewood Richard W. | Method and apparatus for sleeving compressed bale materials |
US20050065592A1 (en) | 2003-09-23 | 2005-03-24 | Asher Holzer | System and method of aneurism monitoring and treatment |
WO2005032340A2 (en) | 2003-09-29 | 2005-04-14 | Secant Medical, Llc | Integral support stent graft assembly |
US7727228B2 (en) | 2004-03-23 | 2010-06-01 | Medtronic Cryocath Lp | Method and apparatus for inflating and deflating balloon catheters |
US20050245891A1 (en) | 2004-04-13 | 2005-11-03 | Mccormick Paul | Method and apparatus for decompressing aneurysms |
ATE540640T1 (en) | 2004-07-22 | 2012-01-15 | Nellix Inc | SYSTEMS FOR THE TREATMENT OF ENDOVASCULAR ANEURYSMS |
JP2008514370A (en) | 2004-09-28 | 2008-05-08 | ウィリアム・エイ・クック・オーストラリア・プロプライエタリー・リミテッド | Aortic dissection treatment device |
US20060074481A1 (en) * | 2004-10-04 | 2006-04-06 | Gil Vardi | Graft including expandable cuff |
US20060095121A1 (en) | 2004-10-28 | 2006-05-04 | Medtronic Vascular, Inc. | Autologous platelet gel on a stent graft |
JP2008518710A (en) * | 2004-11-03 | 2008-06-05 | セガン,ジャック | Vascular graft and deployment system |
US20070032850A1 (en) * | 2004-12-16 | 2007-02-08 | Carlos Ruiz | Separable sheath and method for insertion of a medical device into a bodily vessel using a separable sheath |
JP2008532573A (en) | 2005-01-21 | 2008-08-21 | ジェン 4,リミティド ライアビリティー カンパニー | Modular stent graft with bifurcated graft and leg-attached stent elements |
CN102302390B (en) | 2005-04-04 | 2016-05-25 | 灵活支架解决方案股份有限公司 | Flexible stent |
WO2006116725A2 (en) * | 2005-04-28 | 2006-11-02 | Nellix, Inc. | Graft systems having filling structures supported by scaffolds and methods for their use |
EP1903985A4 (en) | 2005-07-07 | 2010-04-28 | Nellix Inc | Systems and methods for endovascular aneurysm treatment |
US20070043420A1 (en) * | 2005-08-17 | 2007-02-22 | Medtronic Vascular, Inc. | Apparatus and method for stent-graft release using a cap |
US20070150041A1 (en) | 2005-12-22 | 2007-06-28 | Nellix, Inc. | Methods and systems for aneurysm treatment using filling structures |
US20070162109A1 (en) | 2006-01-11 | 2007-07-12 | Luis Davila | Intraluminal stent graft |
US7790273B2 (en) | 2006-05-24 | 2010-09-07 | Nellix, Inc. | Material for creating multi-layered films and methods for making the same |
US7872068B2 (en) | 2006-05-30 | 2011-01-18 | Incept Llc | Materials formable in situ within a medical device |
US7771476B2 (en) | 2006-12-21 | 2010-08-10 | Warsaw Orthopedic Inc. | Curable orthopedic implant devices configured to harden after placement in vivo by application of a cure-initiating energy before insertion |
US20080228259A1 (en) | 2007-03-16 | 2008-09-18 | Jack Fa-De Chu | Endovascular devices and methods to protect aneurysmal wall |
US20080294237A1 (en) | 2007-04-04 | 2008-11-27 | Jack Fa-De Chu | Inflatable devices and methods to protect aneurysmal wall |
BRPI0817488A2 (en) | 2007-10-04 | 2017-05-16 | Trivascular Inc | low percutaneous profile modular vascular graft |
WO2009103011A1 (en) | 2008-02-13 | 2009-08-20 | Nellix, Inc. | Graft endoframe having axially variable characteristics |
US9259225B2 (en) | 2008-02-19 | 2016-02-16 | St. Jude Medical, Cardiology Division, Inc. | Medical devices for treating a target site and associated method |
WO2009132309A1 (en) * | 2008-04-25 | 2009-10-29 | Nellix, Inc. | Stent graft delivery system |
JP2011522615A (en) | 2008-06-04 | 2011-08-04 | ネリックス・インコーポレーテッド | Sealing device and method of use |
CA2726452A1 (en) | 2008-06-04 | 2009-12-30 | Nellix, Inc. | Docking apparatus and methods of use |
-
2009
- 2009-06-04 JP JP2011512667A patent/JP2011522615A/en active Pending
- 2009-06-04 EP EP09759453.5A patent/EP2299931B1/en active Active
- 2009-06-04 CA CA2726596A patent/CA2726596A1/en not_active Abandoned
- 2009-06-04 US US12/478,225 patent/US8945199B2/en not_active Expired - Fee Related
- 2009-06-04 WO PCT/US2009/046310 patent/WO2009149294A1/en active Application Filing
- 2009-06-04 AU AU2009256084A patent/AU2009256084A1/en not_active Abandoned
-
2015
- 2015-02-02 US US14/612,048 patent/US20150148892A1/en not_active Abandoned
-
2021
- 2021-08-16 US US17/403,515 patent/US20210369438A1/en active Pending
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5330528A (en) * | 1989-12-01 | 1994-07-19 | British Technology Group Limited | Vascular surgical devices |
US5693088A (en) * | 1993-11-08 | 1997-12-02 | Lazarus; Harrison M. | Intraluminal vascular graft |
US5769882A (en) * | 1995-09-08 | 1998-06-23 | Medtronic, Inc. | Methods and apparatus for conformably sealing prostheses within body lumens |
US5665117A (en) * | 1995-11-27 | 1997-09-09 | Rhodes; Valentine J. | Endovascular prosthesis with improved sealing means for aneurysmal arterial disease and method of use |
US20040073288A1 (en) * | 2001-07-06 | 2004-04-15 | Andrew Kerr | Stent/graft assembly |
US6918926B2 (en) * | 2002-04-25 | 2005-07-19 | Medtronic Vascular, Inc. | System for transrenal/intraostial fixation of endovascular prosthesis |
US20080039923A1 (en) * | 2002-09-20 | 2008-02-14 | Nellix, Inc. | Stent-graft with positioning anchor |
US20060206197A1 (en) * | 2002-12-30 | 2006-09-14 | Hesham Morsi | Endovascular balloon graft |
US20050015140A1 (en) * | 2003-07-14 | 2005-01-20 | Debeer Nicholas | Encapsulation device and methods of use |
US20050090804A1 (en) * | 2003-10-22 | 2005-04-28 | Trivascular, Inc. | Endoluminal prosthesis endoleak management |
US20060212112A1 (en) * | 2004-07-22 | 2006-09-21 | Nellix, Inc. | Graft systems having filling structures supported by scaffolds and methods for their use |
US20100094409A1 (en) * | 2006-08-23 | 2010-04-15 | Stephen George Edward Barker | Improvements in and relating to medical devices |
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AU2009256084A1 (en) | 2009-12-10 |
US20150148892A1 (en) | 2015-05-28 |
US20090318949A1 (en) | 2009-12-24 |
EP2299931B1 (en) | 2020-01-08 |
WO2009149294A1 (en) | 2009-12-10 |
JP2011522615A (en) | 2011-08-04 |
EP2299931A4 (en) | 2015-07-01 |
US8945199B2 (en) | 2015-02-03 |
CA2726596A1 (en) | 2009-12-10 |
EP2299931A1 (en) | 2011-03-30 |
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