US20110262989A1 - Isolating a target analyte from a body fluid - Google Patents

Isolating a target analyte from a body fluid Download PDF

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Publication number
US20110262989A1
US20110262989A1 US12/850,203 US85020310A US2011262989A1 US 20110262989 A1 US20110262989 A1 US 20110262989A1 US 85020310 A US85020310 A US 85020310A US 2011262989 A1 US2011262989 A1 US 2011262989A1
Authority
US
United States
Prior art keywords
target
magnetic
bacteria
particles
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/850,203
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English (en)
Inventor
Lisa-Jo Ann CLARIZIA
Eddie W. Adams
Sergey A. Dryga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DNAE Group Holdings Ltd
Original Assignee
NanoMR Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US12/850,203 priority Critical patent/US20110262989A1/en
Application filed by NanoMR Inc filed Critical NanoMR Inc
Assigned to NANOMR, INC. reassignment NANOMR, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ADAMS, EDDIE W., CLARIZIA, LISA-JO ANN, DRYGA, SERGEY A.
Priority to JP2013506262A priority patent/JP5814344B2/ja
Priority to PCT/US2011/033184 priority patent/WO2011133630A1/en
Priority to ES11772606.7T priority patent/ES2656965T3/es
Priority to CA2796767A priority patent/CA2796767C/en
Priority to EP11772606.7A priority patent/EP2561360B9/en
Publication of US20110262989A1 publication Critical patent/US20110262989A1/en
Priority to US13/720,771 priority patent/US20130109590A1/en
Priority to US14/102,861 priority patent/US20140100136A1/en
Assigned to DNA ELECTRONICS, INC. reassignment DNA ELECTRONICS, INC. MERGER (SEE DOCUMENT FOR DETAILS). Assignors: NANOMR, INC.
Assigned to DNA ELECTRONICS, INC. reassignment DNA ELECTRONICS, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: NANOMR, INC.
Assigned to DNAE GROUP HOLDINGS LIMITED reassignment DNAE GROUP HOLDINGS LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DNA ELECTRONICS, INC.
Priority to US15/869,146 priority patent/US11448646B2/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
US12/850,203 2010-04-21 2010-08-04 Isolating a target analyte from a body fluid Abandoned US20110262989A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US12/850,203 US20110262989A1 (en) 2010-04-21 2010-08-04 Isolating a target analyte from a body fluid
JP2013506262A JP5814344B2 (ja) 2010-04-21 2011-04-20 体液からの標的分析物の単離
PCT/US2011/033184 WO2011133630A1 (en) 2010-04-21 2011-04-20 Isolating a target analyte from a body fluid
ES11772606.7T ES2656965T3 (es) 2010-04-21 2011-04-20 Aislamiento de un analito diana a partir de un fluido corporal
CA2796767A CA2796767C (en) 2010-04-21 2011-04-20 Isolating a target analyte from a body fluid
EP11772606.7A EP2561360B9 (en) 2010-04-21 2011-04-20 Isolating a target analyte from a body fluid
US13/720,771 US20130109590A1 (en) 2010-04-21 2012-12-19 Isolating a target analyte from a body fluid
US14/102,861 US20140100136A1 (en) 2010-04-21 2013-12-11 Isolation and characterization of pathogens
US15/869,146 US11448646B2 (en) 2010-04-21 2018-01-12 Isolating a target analyte from a body fluid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32658810P 2010-04-21 2010-04-21
US12/850,203 US20110262989A1 (en) 2010-04-21 2010-08-04 Isolating a target analyte from a body fluid

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US13/720,771 Continuation-In-Part US20130109590A1 (en) 2010-04-21 2012-12-19 Isolating a target analyte from a body fluid
US14/102,861 Continuation-In-Part US20140100136A1 (en) 2010-04-21 2013-12-11 Isolation and characterization of pathogens
US15/869,146 Continuation US11448646B2 (en) 2010-04-21 2018-01-12 Isolating a target analyte from a body fluid

Publications (1)

Publication Number Publication Date
US20110262989A1 true US20110262989A1 (en) 2011-10-27

Family

ID=44816109

Family Applications (11)

Application Number Title Priority Date Filing Date
US12/850,203 Abandoned US20110262989A1 (en) 2010-04-21 2010-08-04 Isolating a target analyte from a body fluid
US12/855,147 Active 2032-08-07 US9389225B2 (en) 2010-04-21 2010-08-12 Separating target analytes using alternating magnetic fields
US13/091,548 Active 2031-11-03 US9671395B2 (en) 2010-04-21 2011-04-21 Analyzing bacteria without culturing
US13/091,518 Abandoned US20110262932A1 (en) 2010-04-21 2011-04-21 Compositions
US13/091,527 Abandoned US20110262933A1 (en) 2010-04-21 2011-04-21 Compositions and method for isolating mid-log phase bacteria
US13/091,534 Active 2032-05-11 US9562896B2 (en) 2010-04-21 2011-04-21 Extracting low concentrations of bacteria from a sample
US15/206,751 Active 2032-01-06 US11073513B2 (en) 2010-04-21 2016-07-11 Separating target analytes using alternating magnetic fields
US15/425,539 Abandoned US20170145406A1 (en) 2010-04-21 2017-02-06 Extracting low concentrations of bacteria from a sample
US15/496,790 Active US9869671B2 (en) 2010-04-21 2017-04-25 Analyzing bacteria without culturing
US15/866,628 Active 2031-04-28 US10677789B2 (en) 2010-04-21 2018-01-10 Analyzing bacteria without culturing
US15/869,146 Active 2031-08-17 US11448646B2 (en) 2010-04-21 2018-01-12 Isolating a target analyte from a body fluid

Family Applications After (10)

Application Number Title Priority Date Filing Date
US12/855,147 Active 2032-08-07 US9389225B2 (en) 2010-04-21 2010-08-12 Separating target analytes using alternating magnetic fields
US13/091,548 Active 2031-11-03 US9671395B2 (en) 2010-04-21 2011-04-21 Analyzing bacteria without culturing
US13/091,518 Abandoned US20110262932A1 (en) 2010-04-21 2011-04-21 Compositions
US13/091,527 Abandoned US20110262933A1 (en) 2010-04-21 2011-04-21 Compositions and method for isolating mid-log phase bacteria
US13/091,534 Active 2032-05-11 US9562896B2 (en) 2010-04-21 2011-04-21 Extracting low concentrations of bacteria from a sample
US15/206,751 Active 2032-01-06 US11073513B2 (en) 2010-04-21 2016-07-11 Separating target analytes using alternating magnetic fields
US15/425,539 Abandoned US20170145406A1 (en) 2010-04-21 2017-02-06 Extracting low concentrations of bacteria from a sample
US15/496,790 Active US9869671B2 (en) 2010-04-21 2017-04-25 Analyzing bacteria without culturing
US15/866,628 Active 2031-04-28 US10677789B2 (en) 2010-04-21 2018-01-10 Analyzing bacteria without culturing
US15/869,146 Active 2031-08-17 US11448646B2 (en) 2010-04-21 2018-01-12 Isolating a target analyte from a body fluid

Country Status (6)

Country Link
US (11) US20110262989A1 (ja)
EP (5) EP2561099B1 (ja)
JP (3) JP5814344B2 (ja)
CA (4) CA2796897C (ja)
ES (3) ES2656965T3 (ja)
WO (4) WO2011133630A1 (ja)

Cited By (13)

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US20110262893A1 (en) * 2010-04-21 2011-10-27 Nanomr, Inc. Separating target analytes using alternating magnetic fields
US20130109590A1 (en) * 2010-04-21 2013-05-02 Lisa-Jo Ann CLARIZIA Isolating a target analyte from a body fluid
US9476812B2 (en) 2010-04-21 2016-10-25 Dna Electronics, Inc. Methods for isolating a target analyte from a heterogeneous sample
US9551704B2 (en) 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
US9599610B2 (en) 2012-12-19 2017-03-21 Dnae Group Holdings Limited Target capture system
US9696302B2 (en) 2010-04-21 2017-07-04 Dnae Group Holdings Limited Methods for isolating a target analyte from a heterogeneous sample
US9804069B2 (en) 2012-12-19 2017-10-31 Dnae Group Holdings Limited Methods for degrading nucleic acid
US9902949B2 (en) 2012-12-19 2018-02-27 Dnae Group Holdings Limited Methods for universal target capture
US9995742B2 (en) 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US10151749B2 (en) * 2015-08-05 2018-12-11 Alfaisal University Method and kit for the detection of microorganisms
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US10386373B2 (en) 2015-11-11 2019-08-20 Serimmune Inc. Methods and compositions for assessing antibody specificities

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US9428547B2 (en) 2010-04-21 2016-08-30 Dna Electronics, Inc. Compositions for isolating a target analyte from a heterogeneous sample
US20140100136A1 (en) * 2010-04-21 2014-04-10 Nanomr, Inc. Isolation and characterization of pathogens
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US20160296944A1 (en) * 2013-03-15 2016-10-13 Ancera, Inc. Systems and methods for three-dimensional extraction of target particles ferrofluids
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JP6252933B2 (ja) * 2013-09-17 2017-12-27 学校法人上智学院 構造体ならびにこれを用いた細菌の捕集および検出方法
US20150119285A1 (en) * 2013-10-28 2015-04-30 Chin-Yih Hong Magnetic-assisted rapid aptamer selection method for generating high affinity dna aptamer
CN104655838A (zh) * 2013-11-19 2015-05-27 北京市理化分析测试中心 一种检测样品中金黄色葡萄球菌活菌体的方法
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CN108289990B (zh) 2015-09-14 2021-10-01 医疗过滤有限公司 磁性过滤设备及方法
JP2018534588A (ja) * 2015-09-22 2018-11-22 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 稀少細胞の遠心分離なしの単離および検出
CA3031721A1 (en) 2016-07-28 2018-02-01 Medisieve Ltd. Magnetic mixer and method
EP3529595B1 (en) 2016-10-20 2023-05-31 Quantum Diamond Technologies Inc. Methods and apparatus for magnetic particle analysis using wide-field diamond magnetic imaging
CN110023758B (zh) * 2016-11-24 2022-08-30 西门子医疗系统荷兰有限公司 用于从体液样本中分离分析物的设备、系统、方法和套件
JP7249281B2 (ja) * 2016-12-23 2023-03-30 クアンタム ダイヤモンド テクノロジーズ インク． 磁気式多ビーズアッセイのための方法および装置
JP7204733B2 (ja) 2017-07-31 2023-01-16 クアンタム ダイヤモンド テクノロジーズ インク． 試料測定のための方法および装置
WO2019031815A1 (ko) * 2017-08-07 2019-02-14 울산과학기술원 자성 입자를 이용한 유체 분리 시스템 및 방법
US11154828B2 (en) * 2018-09-14 2021-10-26 Uchicago Argonne, Llc Turbulent mixing by microscopic self-assembled spinners
JP2022543209A (ja) * 2019-07-26 2022-10-11 ベクトン・ディキンソン・アンド・カンパニー 凝集を低減するための緩衝剤組成物

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