US20110065728A1 - Lipoprotein lipase-activating compositions comprising benzene derivatives - Google Patents

Lipoprotein lipase-activating compositions comprising benzene derivatives Download PDF

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US20110065728A1
US20110065728A1 US12/992,394 US99239408A US2011065728A1 US 20110065728 A1 US20110065728 A1 US 20110065728A1 US 99239408 A US99239408 A US 99239408A US 2011065728 A1 US2011065728 A1 US 2011065728A1
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lower alkyl
phenyl
group
compound
lower alkoxy
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Irina Neagu
Michael Ohlmeyer
Vidyadhar M. Paradkar
Kurt W. Saionz
Koushi Iwata
Takashi Okamura
Tadao Shibutani
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Areva NP SAS
Otsuka Pharmaceutical Factory Inc
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Otsuka Pharmaceutical Factory Inc
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Assigned to OTSUKA PHARMACEUTICAL FACTORY, INC reassignment OTSUKA PHARMACEUTICAL FACTORY, INC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: IWATA, KOUSHI, NEAGU, IRINA, OHLMEYER, MICHAEL, OKAMURA, TAKASHI, PARADKAR, VIDYADHAR M., SAIONZ, KURT W., SHIBUTANI, TADAO
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/4164—1,3-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61P3/06—Antihyperlipidemics
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Definitions

  • the present invention relates to compositions for activating lipoprotein lipase (hereinafter referred to as “LPL”) and benzene compounds.
  • LPL lipoprotein lipase
  • the invention is further directed to the use of compounds activating LPL for preparing LPL-activating compositions, and a method for activating LPL using such compounds.
  • Contemporary society is called a society of gluttony, and the number of people diagnosed with hyperlipidemia, obesity, etc., has been sharply rising.
  • Hyperlipidemia, obesity and the like are extremely dangerous causing diabetes and arteriosclerosis that may result in cardiac infarction, cerebral infarction, and the like.
  • LPL activation is considered to be effective for preventing or treating hyperlipidemia, obesity, arteriosclerosis, cataract, cachexia, nephrosis, etc.
  • Various publications describes the relationship between LPL activation and these diseases. For example, the relationship between LPL activation and arteriosclerosis is described in J. Clin. Invest., 92, 411 (1993). The relationship between LPL activation and cataract is described in Biol. Phar. Bull., 19, 1570 (1996).
  • LPL activation and cachexia The relationship between LPL activation and cachexia is described in Anticancer Research, 19, 4099 (1999).
  • the relationship between LPL activation and nephrosis is described in Metabolism, 49, 588 (2000).
  • the relationship between LPL activation and hyperlipidemia is described in Diabetes, 44, 414 (1995).
  • the relationship between LPL activation and obesity is described in Diabetologia, 43, 875 (2000).
  • the inventors researched compounds having an LPL-activating action to obtain pharmaceuticals (chemotherapeutic agents) effective for preventing and treating hyperlipidemia, obesity, and the like, and subsequently found that specific compounds represented by General Formula (1) below strongly activate LPL. Although such compounds may include some known compounds, it has not been known that they activate LPL. The present invention has been accomplished by further research based on the above findings.
  • Item 1 A method for activating LPL in a patient in need of LPL activation treatment, comprising administering an effective amount of a benzene compound into the patient, the benzene compound being represented by General Formula (1):
  • R 1 is hydrogen, hydroxy, lower alkyl, lower alkoxy, lower alkoxycarbonyl, carboxy, or phenyl lower alkyl
  • R 2 is hydrogen; lower alkyl; 1,2,3,4-tetrahydronaphthyl; cycloalkyl lower alkyl; phenyl; phenyl having one or two substituents selected from the group consisting of halogen, lower alkoxy, cyano, halogenated lower alkyl, and halogenated lower alkoxy; phenyl lower alkyl; phenyl lower alkyl having on the benzene ring one or two substituents selected from the group consisting of halogen, lower alkyl, halogenated lower alkyl, cyano, nitro, lower alkoxycarbonyl, carboxy, lower alkoxy, and halogenated lower alkoxy; or lower alkyl having one cycloalkyl and one phenyl or halogenated phenyl; or
  • R 4 is hydrogen, lower alkyl, or halogen
  • R 5 is hydrogen, lower alkyl, halogen, hydroxy, lower alkoxy, phenyl lower alkoxy
  • R 6 is hydrogen, lower alkyl, carboxy, or halogenated lower alkyl
  • R 7 is hydrogen, lower alkyl, halogen, halogenated lower alkyl, lower alkoxycarbonyl, carboxy, cyano, carbamoyl, or phenyl
  • R 8 is hydrogen or lower alkyl, provided, however, that when Z is a group (e), R 1 is lower alkoxy, R 2 is phenyl lower alkyl, and R 3 is hydrogen.
  • a method according to item 1 wherein the benzene compound is a compound of General Formula (1) wherein Z is a group (a).
  • Item 3. A method according to item 1 wherein the benzene compound is a compound of General Formula (1) wherein Z is a group (b).
  • Item 4. A method according to item 1 wherein the benzene compound is a compound of General Formula (1) wherein Z is a group (d).
  • Item 5. A method according to item 1 wherein the benzene compound is a compound of General Formula (1) wherein Z is a group (e).
  • a method according to item 1 wherein the benzene compound is a compound of General Formula (1) wherein Z is a group (f), (g) or (h).
  • a method according to item 1 wherein the benzene compound is a compound shown in any one of (1-1) to (1-4): (1-1) a compound of formula (1) wherein R 1 is lower alkoxy, and R 2 is phenyl, phenyl having one or two halogen atoms as substituents on the benzene ring, phenyl lower alkyl group, phenyl lower alkyl group having on the benzene ring one or two substituents selected from the group consisting of halogen, and cyano, or R 1 and R 2 are jointed to form —CH ⁇ C(Ph)- (wherein Ph is phenyl), and Z is a group (h); (1-2) a compound of formula (1) wherein R 1 is lower alkoxy, R 2 is phenyl lower alkyl having one or two halogen atoms as substituents on the benzene ring, and Z is a group (a); (1-3) a compound of formula (1) wherein R 1 is lower al
  • R 2 is phenyl lower alkyl, or phenyl lower alkyl having one or two halogen atoms as substituents on the benzene ring, and Z is a group (f);
  • a method according to item 1, wherein the benzene compound is one member selected from the group consisting of 2-(4-benzyloxy-3-methoxyphenyl)imidazo[1,2-a]pyridine, 2-[4-(4-cyanobenzyloxy)-3-methoxyphenyl]imidazo[1,2-a]pyridine, 2-[4-(4-bromo-2-fluorobenzyloxy)-3-methoxyphenyl]imidazo[1,2-a]pyridine, and 2-[4-(4-chlorobenzyloxy)-3-methoxyphenyl]imidazo[1,2-a]pyridine.
  • the benzene compound is one member selected from the group consisting of 2-(4-benzyloxy-3-methoxyphenyl)imidazo[1,2-a]pyridine, 2-[4-(4-cyanobenzyloxy)-3-methoxyphenyl]imidazo[1,2-a]pyridine, 2-[4-(4-bromo-2-
  • a method according to item 1, wherein the benzene compound is 6-[4-(4-chlorobenzyloxy)-3-methoxyphenyl]imidazo[2,1-b]thiazole.
  • Item 12 A method according to item 1, wherein the benzene compound is 4-(4-benzyloxy-3-methoxyphenyl)-2-(4-trifluoromethylphenyl)imidazole.
  • An LPL-activating composition comprising a pharmaceutically acceptable carrier and a benzene compound represented by General Formula (1):
  • R 1 is hydrogen, hydroxy, lower alkyl, lower alkoxy, lower alkoxycarbonyl, carboxy, or phenyl lower alkyl
  • R 2 is hydrogen; lower alkyl; 1,2,3,4-tetrahydronaphthyl; cycloalkyl lower alkyl; phenyl; phenyl having one or two substituents selected from the group consisting of halogen, lower alkoxy, cyano, halogenated lower alkyl, and halogenated lower alkoxy; phenyl lower alkyl; phenyl lower alkyl having on the benzene ring one or two substituents selected from the group consisting of halogen, lower alkyl, halogenated lower alkyl, cyano, nitro, lower alkoxycarbonyl, carboxy, lower alkoxy, and halogenated lower alkoxy; or lower alkyl having one cycloalkyl, and one phenyl or halogenated phenyl;
  • R 4 is hydrogen, lower alkyl, or halogen
  • R 5 is hydrogen, lower alkyl, halogen, hydroxy, lower alkoxy, phenyl lower alkoxy
  • R 6 is hydrogen, lower alkyl, carboxy, or halogenated lower alkyl
  • R 7 is hydrogen, lower alkyl, halogen, halogenated lower alkyl, lower alkoxycarbonyl, carboxy, cyano, carbamoyl, or phenyl
  • R 8 is hydrogen or lower alkyl, provided, however, that when Z is a group (e), R 1 is lower alkoxy, R 2 is phenyl lower alkyl, and R 3 is hydrogen.
  • An LPL-activating composition according to item 13 wherein the benzene compound is a compound of General Formula (1) wherein Z is a group (a).
  • An LPL-activating composition according to item 13 wherein the benzene compound is a compound of General Formula (1) wherein Z is a group (b).
  • An LPL-activating composition according to item 13 wherein the benzene compound is a compound of General Formula (1) wherein Z is a group (d).
  • An LPL-activating composition according to item 13 wherein the benzene compound is a compound of General Formula (1) wherein Z is a group (e).
  • An LPL-activating composition according to item 13 wherein the benzene compound is a compound of General Formula (1) wherein Z is a group (f), (g) or (h).
  • Item 19 An LPL-activating composition according to item 13 wherein the benzene compound is a compound shown in any one of (1-1) to (1-4): (1-1) a compound of formula (1) wherein R 1 is lower alkoxy, R 2 is phenyl, phenyl having one or two halogen atoms as substituents on the benzene ring, phenyl lower alkyl group, phenyl lower alkyl group having on the benzene ring one or two substituents selected from the group consisting of halogen, and cyano, or R 1 and R 2 join to form —CH ⁇ C(Ph)- (wherein Ph is phenyl), and Z is a group (h); (1-2) a compound of formula (1) wherein R 1 is lower alkoxy, R 2 is phenyl lower
  • Item 20 A pharmaceutical composition according to item 13, wherein the benzene compound is one member selected from the group consisting of 2-(4-benzyloxy-3-methoxyphenyl)imidazo[1,2-a]pyridine, 2-[4-(4-cyanobenzyloxy)-3-methoxyphenyl]imidazo[1,2-a]pyridine, 2-[4-(4-bromo-2-fluorobenzyloxy)-3-methoxyphenyl]imidazo[1,2-a]pyridine, and 2-[4-(4-chlorobenzyloxy)-3-methoxyphenyl]imidazo[1,2-a]pyridine.
  • the benzene compound is one member selected from the group consisting of 2-(4-benzyloxy-3-methoxyphenyl)imidazo[1,2-a]pyridine, 2-[4-(4-cyanobenzyloxy)-3-methoxyphenyl]imidazo[1,2-a]pyridine, 2-[4-(4-bro
  • a pharmaceutical composition according to item 13, wherein the benzene compound is 6-[4-(4-chlorobenzyloxy)-3-methoxyphenyl]imidazo[2,1-b]thiazole.
  • Item 22. A pharmaceutical composition according to item 13, wherein the benzene compound is 4-(4-benzyloxy-3-methoxyphenyl)-2-(4-trifluoromethylphenyl)imidazole.
  • Item 23. A pharmaceutical composition according to item 13 used for hyperlipidemia prevention or treatment.
  • Item 24. A pharmaceutical composition according to item 13 used for anti-obesity.
  • Item 25 A benzene compound represented by General Formula (1a)
  • R 1a is lower alkoxy
  • R 2a is phenyl lower alkyl having on the benzene ring one or two substituents selected from the group consisting of halogen, cyano, and nitro
  • Z a is a group (a);
  • R 1a is lower alkoxy
  • R 2a is hydrogen, phenyl; phenyl having one or two lower alkoxy groups as substituents; phenyl lower alkyl; or phenyl lower alkyl having on the benzene ring one or two substituents selected from the group consisting of halogen, lower alkyl, halogenated lower alkyl, cyano, nitro, lower alkoxy, and halogenated lower alkoxy
  • Z a is a group (d), (f), or (g);
  • R 1a is lower alkoxy
  • R 2a is phenyl lower alkyl
  • Z a is a group (e); or
  • R 1a is hydroxy or lower alkoxy
  • R 2a is 1,2,3,4-tetrahydronaphthyl, cycloalkyl lower alkyl, phenyl; phenyl having one or two substituents selected from the group consisting of halogen, lower alkoxy, cyano, halogenated lower alkyl, and halogenated lower alkoxy; phenyl lower alkyl having on the benzene ring one or two substituents selected from the group consisting of halogen, lower alkyl, halogenated lower alkyl, cyano, nitro, lower alkoxycarbonyl, carboxy, lower alkoxy, and halogenated lower alkoxy; or lower alkyl having one cycloalkyl and one phenyl or halogenated phenyl; or R 1a and R 2a are joined to form —CH ⁇ C(Ph)- (wherein Ph is phenyl), and Z a is a group (h)
  • (3-1) a compound wherein R 1a is lower alkoxy, and R a is phenyl, pheny having one or two halogen atoms as substituents, or phenyl lower alkyl having on the benzene ring one or two substituents selected from the group consisting of halogen and cyano, or R 1 and R 2 are joined to form —CH ⁇ C(Ph)- (wherein Ph is phenyl), and Z a is a group (h),
  • R 1a is lower alkoxy
  • R 2a is phenyl lower alkyl, or phenyl lower alkyl having one or two halogen atoms as substituents on the benzene ring
  • Z a is a group (f).
  • Item 27 A benzene compound according to item 25, wherein Z a in General Formula (1a) is a group (d), (f), or (g).
  • Item 28 A benzene compound according to item 25, wherein R 2a in General Formula (1a) is phenyl lower alkyl having on the benzene ring one or two substituents selected from the group consisting of halogen, cyano, and nitro; and Z a is a group (a).
  • Item 29 A benzene compound according to item 25, wherein Z a in General Formula (1a) is a group (e).
  • Item 30 A benzene compound according to item 25, wherein Z a in General Formula (1a) is a group (h). Item 31.
  • a benzene compound according to item 25 selected from the group consisting of 2-[4-(4-cyanobenzyloxy)-3-methoxyphenyl]imidazo[1,2-a]pyridine, 2-[4-(4-bromo-2-fluorobenzyloxy)-3-methoxyphenyl]imidazo[1,2-a]pyridine, 2-[4-(4-chlorobenzyloxy)-3-methoxyphenyl]imidazo[1,2-a]pyridine, 6-[4-(4-chlorobenzyloxy)-3-methoxyphenyl]imidazo[2,1-b]thiazole, and 4-(4-benzyloxy-3-methoxyphenyl)-2-(4-trifluoromethylphenyl)imidazole.
  • Item 32 Use of the benzene compound of item 13 for preparing an LPL activating composition.
  • Item 33 Use of the benzene compound of item 13 for preparing a hyperlipidemia preventive or therapeutic composition.
  • Item 34 Use of the benzene compound of item 13 for preparing an anti-obesity composition.
  • Item 35 A pharmaceutical composition comprising the benzene compound of item 25, and a pharmaceutically acceptable carrier.
  • Item 36. A pharmaceutical composition according to item 25 used as an LPL activating composition.
  • Item 37 A pharmaceutical composition according to item 25 used as a hyperlipidemia preventive or therapeutic composition.
  • Item 38 A pharmaceutical composition according to item 25 used as an anti-obesity composition.
  • a method for preventing hyperlipidemia in a patient in need of hyperlipidemia prevention comprising administering an effective amount of at least one benzene compound of item 25 into the patient.
  • Item 40. A method for treating obesity in a patient in need of obesity treatment, comprising administering an effective amount of at least one benzene compound of item 25 into the patient.
  • Item 41. Use of the benzene compound of item 13 for preventing or treating hyperlipidemia.
  • lower alkyl groups include C 1-6 linear or branched alkyl groups such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, hexyl, etc.
  • lower alkoxy groups include C 1-6 linear or branched alkoxy groups such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, pentyloxy, hexyloxy, etc.
  • lower alkoxy carbonyl groups include C 1-6 linear or branched alkoxycarbonyl groups such as methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, 1-methylethoxycarbonyl, butoxycarbonyl, 2-methylpropoxycarbonyl, 1,1-dimethylethoxycarbonyl, pentyloxycarbonyl, hexyloxycarbonyl, etc.
  • phenyl lower alkoxy groups include C 1-6 linear or branched alkoxy groups having one phenyl substituent, such as 1-phenylethoxy, 2-phenylethoxy, 3-phenylpropoxy, 2-phenylpropoxy, 4-phenylbutyloxy, 5-phenylpentyloxy, 6-phenylhexyloxy, etc.
  • 1,2,3,4-tetrahydronaphthyl groups include 1,2,3,4-tetrahydronaphthalen-1-yl and 1,2,3,4-tetrahydronaphthalen-2-yl.
  • cycloalkyl lower alkyl groups include C 1-6 alkyl groups having one C 3-8 cycloalkyl substituent, such as cyclopropylmethyl, 2-cyclopropylethyl, 3-cyclopropylpropyl, 4-cyclopropylbutyl, 5-cyclopropylpentyl, 6-cyclopropylhexyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, cycloheptylmethyl, cyclooctylmethyl, etc.
  • cycloalkyl groups include C 3-8 cycloalkyl groups such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, etc.
  • phenyl groups having one or two substituents selected from the group consisting of halogen, lower alkoxy, cyano, halogenated lower alkyl, and halogenated lower alkoxy include 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 4-fluorophenyl, 4-bromophenyl, 4-iodophenyl, 3,4-dichlorophenyl, 2,4-dichlorophenyl, 2,6-dichlorophenyl, 2-cyanophenyl, 3-cyanophenyl, 4-cyanophenyl, 2-trifluoromethoxyphenyl, 3-trifluoromethoxyphenyl, 4-trifluoromethoxyphenyl, 4-tetrafluoroethoxyphenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 2,4-dimethoxyphenyl, 3,4-dimethoxyphenyl, 3,5-dimethoxy
  • halogen atoms include fluorine, chlorine, bromine, iodine, etc.
  • lower alkoxy groups include C 1-6 linear or branched alkoxy groups, such as methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 2-methylpropoxy, pentyloxy, hexyloxy, and the like.
  • halogenated lower alkyl groups include C 1-6 perhalogeno-alkyl groups, especially C 1-6 perfluoro-alkyl groups.
  • the halogen substituents are of the same type, selected from the group consisting of fluorine, chlorine, bromine, and iodine. Specific examples are trifluoromethyl, pentafluoroethyl, heptafluoropropyl, nonafluorobutyl, undecafluoropentyl, tridecafluorohexyl, etc.
  • halogenated lower alkoxy groups include C 1-6 perhalogeno-alkoxy groups, especially C 1-6 perfluoro-alkoxy groups.
  • the halogen substituents are of the same type, selected from the group consisting of fluorine, chlorine, bromine, and iodine. Specific examples are trifluoromethoxy, pentafluoroethoxy, heptafluoropropoxy, nonafluorobutyloxy, undecafluoropentyloxy, tridecafluorohexyloxy, etc.
  • phenyl lower alkyl groups include C 1-6 alkyl groups having as a substituent one phenyl group, such as benzyl, 1-phenylethyl, 2-phenylethyl, 3-phenylpropyl, 2-phenylpropyl, 4-phenylbutyl, 5-phenylpentyl, 6-phenylhexyl, etc.
  • phenyl lower alkyl groups having on the benzene ring one or two substituents selected from the group consisting of halogen, lower alkyl, halogenated alkyl, cyano, nitro, lower alkoxycarbonyl, carboxy, lower alkoxy, and halogenated lower alkoxy include:
  • Phenyl lower alkyl groups having one halogen atom as a substituent (1) Phenyl lower alkyl groups having one halogen atom as a substituent:
  • halogenated lower phenyl groups include 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl, 4-iodophenyl, 3-chlorophenyl, 2-chlorophenyl, etc.
  • lower alkyl groups having one cycloalkyl and one phenyl or halogenated phenyl include ⁇ -cyclopropylbenzyl, ⁇ -cyclopropyl-4-chlorobenzyl, ⁇ -cyclopropyl-4-fluorobenzyl, ⁇ -cyclopropyl-4-bromobenzyl, ⁇ -cyclopropyl-4-iodobenzyl, ⁇ -cyclopropyl-3-chlorobenzyl, ⁇ -cyclopropyl-2-chlorobenzyl, ⁇ -cyclobutylbenzyl, ⁇ -cyclopentylbenzyl, ⁇ -cyclohexylbenzyl, ⁇ -cycloheptylbenzyl, ⁇ -cyclooctylbenzyl, etc.
  • Examples categorized as (a), i.e., imidazo[2,1-b]thiazol-6-yl or imidazo[2,1-b]thiazol-6-yl having one lower alkyl substituent include imidazo[2,1-b]thiazol-6-yl, 2-methylimidazo[2,1-b]thiazol-6-yl, 3-methylimidazo[2,1-b]thiazol-6-yl, 5-methylimidazo[2,1-b]thiazol-6-yl, 2-ethylimidazo[2,1-b]thiazol-6-yl, 2-propylimidazo[2,1-b]thiazol-6-yl, 2-butylimidazo[2,1-b]thiazol-6-yl, 2-pentylimidazo[2,1-b]thiazol-6-yl, 2-hexyl[2,1-b]thiazol-6-yl, etc.
  • Examples categorized as (e), i.e., imidazole-4-yl having one phenyl substituent or one halogenated lower alkyl-substituted lower alkyl phenyl substituent include 2-phenylimidazol-4-yl, 5-phenylimidazol-4-yl, 2-(4-trifluoromethylphenyl)imidazol-4-yl, 5-(4-trifluoromethylphenyl)imidazol-4-yl, 2-(3-trifluorophenyl)imidazol-4-yl, 2-(2-trifluoromethylphenyl)imidazol-4-yl, 2-(4-pentafluoroethylphenyl)imidazol-4-yl, 2-(4-heptafluoropropylphenyl)imidazol-4-yl, 2-(4-nonafluorobutylphenyl)imidazol-4-yl, 2-(4-undeca
  • those belonging to (I), (IV) and (V) are preferable.
  • Compounds (1) active compounds for the LPL-activating compositions of the invention
  • novel benzene compounds herein include their sodium salts, potassium salts, and like alkaline metal salts; calcium salts, magnesium salts, and like alkaline-earth metal salts; and copper salts and other salts.
  • These salts can be prepared according to known methods. These salts thus obtained have pharmacological activity identical to that of the compounds in the free form, and are also of use in LPL-activating compositions and the like.
  • Compounds (1) and Compounds (1a) include their pharmaceutically acceptable acid addition salts, for example, hydrochlorides, nitrates, sulfates, hydrobromides, phosphates, carbonates, acetates, lactates, citrates, and the like.
  • acid addition salts can be prepared according to known methods. These acid addition salts have pharmacological activity identical to that of the compounds in the free form. Therefore, the present invention further provides acid addition salts and pharmaceutical compositions such as LPL-activating compositions and the like containing such acid addition salts as active ingredients.
  • Compounds (1) and Compounds (1a) may include optical isomers having a carbon atom as an asymmetric center.
  • the present invention further provides racemates that are mixtures of such optical isomers, optically active forms of such optical isomers, and LPL-activating compositions containing as active ingredients either such racemates or optical isomers.
  • the aforementioned optical isomers can be separated according to known separation methods.
  • Compounds (1) of the invention may be known compounds or may be prepared according to known methods.
  • compounds wherein Z is imidazo[2,1-b]thiazole-6-yl or imidazo[2,1-b]thiazole-6-yl having one lower alkyl substituent and categorized as (a) can be either compounds described in Japanese Unexamined Patent Application Publication No. 291976/1995, or have a skeletal structure similar to that of the compounds described in the publication.
  • These compounds can be prepared according to Method 1 or 3 described in the above publication, or can be prepared with reference to its methods. More specifically, these compounds can be prepared by subjecting, as starting materials, Compounds (2) described in Method 1 of the above publication or corresponding compounds having a suitable substituent and Compounds (3) or corresponding compounds having a suitable substituent to cyclization reaction. Alternatively, they can be prepared by hydrolyzing Compounds (1c) described in Method 3 of the publication or corresponding compounds having a suitable substituent, and adding suitable halides to the compounds thus obtained. Conditions for these reactions can be selected according to the publication.
  • Compounds wherein Z is benzimidazol-2-yl and categorized as (b) can be prepared according to a method described in European Patent Application Publication No. 694535 or can be prepared in reference to this method. More specifically, these compounds can be prepared according to page 6, lines 24 to 58, of the publication by subjecting, as starting materials, o-phenylenediamines having a suitable substituent to cyclization reaction.
  • the desired compounds wherein Z is benzothiazol-2-yl and categorized as (c) can be prepared, for example, by reacting suitable o-aminothiophenols and aromatic acids in the presence of a phosphorous trichloride, conducting this reaction in the presence of a boric acid catalyst, or subjecting suitable o-aminothiophenols and aromatic aldehydes to condensation reaction.
  • Compounds wherein Z is imidazo[1,2-a]pyrimidin-2-yl and categorized as (d) can be the compounds represented by General Formula Ia in European Patent Application Publication No. 113236 or be compounds similar to them. These compounds can be prepared according to a method described in the above publication or prepared in reference to the method. More specifically, these compounds can be prepared according to page 7, line 15 to page 8, line 28, or Example 1 of the above publication using suitable starting materials corresponding to amines of General Formula II and ⁇ -haloketones of General Formula III of the publication.
  • Compounds wherein Z is imidazol-4-yl or imidazol-4-yl having a phenyl substituent and categorized as (e) can be prepared according to methods described in Japanese Unexamined Patent Application Publication No. 163861/2001, or can be prepared with reference to these methods. More specifically, these compounds can be prepared according to Preparation Methods 1 and 2, Example 8, etc., by reacting compounds corresponding to the ⁇ -diketones of General Formula (II) and compounds corresponding to the benzaldehyde compounds of General Formula (III).
  • compounds wherein Z is categorized as (e) can be prepared by reacting suitable compounds corresponding to 2-acetophenones wherein a halogen atom is substituted at the 2 position of General Formula (IV) and those corresponding to the benzamidine compounds represented by General Formula (V) of the publication.
  • ⁇ -Diketones of General Formula (II) can be prepared according to known methods. Examples of such methods are, for example, (1) reacting suitable amino acids with suitable alkyl, aryl, or allyl metal reagents (see Tetrahedron. Lett. 24 (23) (1983): 2375); (2) reacting suitable halogenated aryls with aryl acetylenes (see Tetrahedron. Lett . (1971): 2941; (3) reacting suitable ⁇ -aryl ketones ( J. Org. Chem. 53 (1988): 129 ; J. Org. Chem. 24 (1995): 516 ; Tetrahedron Lett . (1972): 1175 ; Org. Syn.
  • Compounds wherein Z is a specific heterocyclic group categorized as (h) can be the compounds described in, for example, Japanese Unexamined Patent Application Publication No. 291972/1995. These compounds can be prepared according to methods described in the above publication, or can be prepared with reference to these methods. More specifically, these compounds can be prepared according to Methods 1 to 3, Examples 1 to 20, etc.
  • compounds wherein Z is a specific heterocyclic group categorized as (h) can be prepared by (Method 1) subjecting suitable compounds corresponding to Compounds (2) and those corresponding to Compounds (3) of the publication to cyclization reaction; (Method 2) hydrolyzing compounds corresponding to Compounds (1b); or (Method 3) reacting cycloalkylhalides (4) with compounds corresponding to Compounds (1c).
  • R 1 , R 2 and R 3 are as defined above;
  • X represents halogen;
  • B represents boron;
  • R and R b may be the same or different and independently represent hydrogen or lower alkyl, or R and R b are joined to form lower alkylene that may have a lower alkyl substituent; and
  • Z b is a group (f) or (g).
  • Compound (4) shown in Reaction Scheme 1 is obtained by reacting Compound (2) with a slight excess of Compound (3).
  • This reaction can be conducted in a suitable inert solvent such as N,N-dimethylformamide (DMF), N,N-dimethylacetamide (DMA), or the like, in the presence of an aqueous solution containing an excess, relative to Compound (2), of potassium phosphate, and in the presence of a catalytic amount of tetrakis(triphenylphosphinato)palladium.
  • the reaction temperature is selected from 50° C. to the reflux temperature of the solvent. The reaction completes in about 5 to about 50 hours.
  • Compound (2) can be prepared according to the method described in J. Org. Chem., 60. 7508 (1995).
  • Compound (3) can be prepared according to the method described in J. Org. Chem., 30 (12), 4085 (1965), and Japanese Unexamined Patent Publication No. 324688/1998.
  • R 1A is hydrogen, hydroxy, lower alkyl, lower alkoxy, lower alkoxycarbonyl, carboxyl, or phenyl lower alkoxy.
  • R 2A is lower alkyl; 1,2,3,4-tetrahydronaphthyl; cycloalkyl lower alkyl; phenyl; phenyl having 1 or 2 substituents selected from the group consisting of halogen, lower alkoxy, cyano, halogenated lower alkyl, and halogenated lower alkoxy; phenyl lower alkyl; phenyl lower alkyl having on the benzene ring one or two substituents selected from the group consisting of halogen, lower alkyl, halogenated lower alkyl, cyano, nitro, lower alkoxycarbonyl, carboxyl, phenyl lower alkyl having one or two substituents selected from the group consisting of lower alkoxy and halogenated lower alkoxy, or lower alkyl having one
  • the compound of General Formula (1a) wherein Z is a group (f) or (g) can be produced by a method according to the above Reaction Scheme-1.
  • the compound of General Formula (1a) wherein Z is a group (a) can be produced by the method described in Example 23 or a method similar thereto.
  • the compound of General Formula (1a) wherein Z is a group (d) can be produced by the method described in Example 28 or a method similar thereto.
  • the compound of General Formula (1a) wherein Z is a group (e) can be produced by the method described in Example 95 or a method similar thereto.
  • the compound of General Formula (1a) wherein Z is a group (h) can be produced by the method described in Example 1 or a method similar thereto.
  • the desired compounds (Compounds 1) shown in the aforementioned Reaction Formulae and salts thereof can be readily separated and purified according to conventional separation methods. Examples of such methods include adsorption chromatography, preparative thin layer chromatography, recrystallization, solvent extraction, etc.
  • Compounds 1 activate lipoprotein lipase (LPL) and are of use for preventing or treating hyperlipidemia, arteriosclerosis, obesity, etc. Therefore, the present invention further provides hyperlipidemia preventive and therapeutic agents, hyperlipidemia preventive and therapeutic compositions, anti-obesity agents, and anti-obesity compositions.
  • LPL lipoprotein lipase
  • the LPL-activating compositions (including hyperlipidemia preventive and therapeutic agents, anti-obesity agents, etc.) of the present invention are prepared as pharmaceutical compositions (in the form of pharmaceutical preparations) containing Compound 1 and pharmaceutically acceptable carriers.
  • pharmaceutically acceptable carriers for use in the pharmaceutical compositions of the invention include fillers, extenders, binders, humectants, disintegrants, surfactants, lubricants, and like diluents and excipients that are usually used depending on the application of the pharmaceutical preparations. These carriers are suitably selected according to the unit dosage form of the pharmaceutical preparations to be created.
  • a variety of unit dosage forms can be suitably selected for the pharmaceutical compositions according to their therapeutic purposes. Typical examples are tablets, pills, powders, solutions, suspensions, emulsions, granules, capsules, suppositories, injections (solutions, suspensions, etc.), ointments, etc.
  • pharmaceutically acceptable carriers include lactose, saccharose, sodium chloride, glucose, urea, starch, calcium carbonate, kaolin, crystalline cellulose, silicic acid, potassium phosphate, and like excipients; water, ethanol, propanol, simple syrup, glucose solution, starch solution, gelatin solution, carboxylmethylcellulose, hydroxypropylcellulose, methylcellulose, polyvinylpyrrolidone, and like binders; sodium carboxymethylcellulose, calcium carboxymethylcellulose, low-substituted hydroxypropylcellulose, dried starch, sodium alginate, powdered agar, powdered laminaran, sodium hydrogencarbonate, calcium carbonate, and like disintegrants; polyoxyethylene sorbitan fatty acid esters, sodium lauryl sulfate, stearic acid monoglyceride, and like surfactants; saccharose, stearin, cacao butter, hydrogenated oils, and like disintegration inhibitors; quaternary ammonium bases
  • pharmaceutically acceptable carriers include, for example, glucose, lactose, starch, cacao butter, hydrogenated vegetable oil, kaolin, talc, and like excipients; powdered gum arabic, powdered tragacanth, gelatin, ethanol, and like binders; laminaran, agar, and like disintegrants; etc.
  • pharmaceutically acceptable carriers include, for example, polyethylene glycol, cacao butter, higher alcohols and their esters, gelatin, semisynthetic glycerides, etc.
  • Capsules can be prepared in a conventional manner usually by encapsulating Compound 1 in combination with the aforementioned pharmaceutically acceptable carriers into hard gelatin capsules, soft gelatin capsules, and the like.
  • compositions of the invention are formulated into injectable forms such as solutions, emulsions, suspensions, and the like, they are preferably sterilized and isotonic with blood.
  • examples of diluents usable are water, ethanol, macrogol, propylene glycol, ethoxylated isostearyl alcohol, polyoxylated isostearyl alcohol, polyoxyethylene sorbitan fatty acid esters, etc.
  • common salt, glucose, or glycerin can be used in the pharmaceutical preparations in an amount sufficient to produce isotonic solutions.
  • conventional auxiliary cosolvents, buffers, soothing agents can be added.
  • compositions of the invention are formulated into ointments, such as paste, cream, gel, and the like
  • examples of diluents usable are white petrolatum, paraffin, glycerin, cellulose compounds, polyethylene glycol, silicone, bentonite, etc.
  • the amount of active compound contained in the pharmaceutical composition of the invention is not limited and can be suitably selected from a wide range. It is generally preferable that the active compound accounts for about 0.5 to about 90 wt. %, preferably about 1 to about 85 wt. %, of the pharmaceutical composition.
  • Administrative routes for the pharmaceutical preparations of the invention are not limited, and can be selected according to the form of each preparation, age of the patient, gender, degree of the disease, and other conditions.
  • tablets, pills, solutions, suspensions, emulsions, granules, and capsules are administered orally.
  • Injections are intravenously, intramuscularly, intracutaneously, subcutaneously, or intraperitoneally administered alone or in combination with glucose, amino acid, or like conventional replenisher fluids.
  • Suppositories are administered intrarectally.
  • Dosage of the pharmaceutical preparation of the invention can be suitably selected according to the application, age of the patient, gender, degree of the disease, and other conditions.
  • the pharmaceutical preparation is administered such that the active ingredient, i.e., Compound (1), can be given to an adult in a dose of about 0.5 to about 20 mg, and preferably about 1 to about 10 mg, per kg body weight.
  • the pharmaceutical preparation can be given in a single dose or divided (2 to 4) doses per day.
  • the present invention provides a method for activating LPL in a patient in need of LPL activation including administering to the patient at least one member of Compounds 1 in an amount effective for LPL activation.
  • the invention is directed to a method for preventing hyperlipidemia for a patient requiring hyperlipidemia prevention including administering to the patient at least one member of Compounds 1 in an amount effective for hyperlipidemia prevention.
  • the invention further relates to a method for treating hyperlipidemia for a patient requiring hyperlipidemia treatment including administering to the patient at least one member of Compounds 1 in an amount effective for hyperlipidemia treatment.
  • the invention provides a method for preventing obesity for a patient requiring obesity prevention including administering to the patient at least one member of Compounds 1 in an amount effective for obesity prevention.
  • the invention also pertains to a method for treating obesity for a patient requiring obesity treatment including administering to the patient at least one member of Compounds 1 in an amount effective for obesity treatment.
  • the present invention provides a use of Compounds 1 for preparing LPL-activating compositions, use of Compounds 1 for preparing hyperlipidemia preventive compositions, use of Compounds 1 for preparing hyperlipidemia therapeutic compositions, and use of Compounds 1 for preparing anti-obesity compositions.
  • the crystalline phenyltrimethylammonium tribromide present in the suspension was removed by suction filtration and rinsed with 50 ml of ethyl acetate/hexane (1:1 v/v). The filtered solution was concentrated under reduced pressure, thereby giving 30 g of crude product.
  • Example Compound 145 At room temperature, 14.95 g (158.9 mmol) of 2-aminopyridine was added to 150 ml of an acetonitrile solution of the crude product (30 g) obtained above. The mixture was stirred for 45 minutes at 50° C. and 30 minutes at 80° C. The reaction mixture was left to stand at room temperature overnight, and the precipitated crystals were collected by suction filtration and rinsed with about 50 ml of acetonitrile. The crystals thus obtained were dried at 80° C. under reduced pressure, thereby yielding 19.0 g 2-(4-hydroxy-3-methoxyphenyl)imidazo[1,2-a]pyridine hydrobromide. This compound hereinafter is referred to as “Example Compound 145”.
  • Example Compound 131 The crystals thus obtained were recrystallized using methanol-hexane, thereby producing 2.82 g of 3-(4-hydroxy-3-methoxyphenyl)imidazo[1,2-a]pyridine (yield: 70%). This compound will be referred to as “Example Compound 131”.
  • Examples 105-113, 116-118, 120, 122, 124, 132, 133, 135 and 137 were prepared by repeating the procedures described in Step 1, or Steps 1 and 2 of Example 12 using the appropriate starting materials.
  • the precipitated crystals were suction filtered, and recrystallized from 50 ml of 50% methanol, thereby giving 2.4 g of 2-(4-hydroxy-3-methoxyphenyl)imidazo[1,2-a]pyrimidine in an yield of 62%.
  • Example Compound 29 was prepared by repeating the procedures described in Example 28 using the appropriate starting materials.
  • the crystals (1.5 g) obtained above were suspended in 100 ml of ethanol. This suspension was mixed with 4.5 g of tin chloride 2-hydrate and stirred at 80° C. for 2 hours. The reaction mixture was added to ice-cooled saturated sodium hydrogencarbonate solution (50 ml), and subjected to celite filtration to remove insoluble matter. The filtered solution was diluted with 200 ml of ethyl acetate. The mixture (ethyl acetate phase) was sequentially washed with water and brine. The organic phase (ethyl acetate phase) thus obtained was dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was crystallized by diethyl ether, thereby yielding the desired compound in an amount of 1.2 g.
  • Example Compound 77 was prepared by repeating the procedures described in Example 76 using the appropriate starting materials.
  • Example 79 The compound of Example 79 was prepared by repeating the procedures described in Example 95 using the appropriate starting materials.
  • Table 1 shows the structures and properties (melting points, 1 H-NMR spectroscopic data, and mass spectrometric data) of the compounds obtained in the Examples above. Abbreviations in the tables are
  • Me methyl MeO: methoxy Et: ethyl EtO (OEt): ethoxy n-Pr: n-propyl n-PrO (O-n-Pr): n-propoxy t-Bu: tert-butyl
  • a luciferase assay was employed to simply and quickly detect an increase in human LPL mRNA.
  • the principle of the assay is as follows:
  • Luciferase emits light when reacted with luciferine (substrate).
  • the expression of LPL mRNA is controlled by 5′-UTR and 3′-UTR (promoter regions) of the LPL gene.
  • a plasmid reporter plasmid
  • a plasmid expresses luciferase only under conditions in which LPL mRNA can increase. Therefore, when the substrate is introduced to the expression system and the amount of luciferase expression (luciferase activity) is quantified as the extent of chemiluminescence, the amount of LPL mRNA expression can be estimated.
  • test herein was performed as follows: Using a plasmid for the luciferase assay manufactured by Clontech, wherein human LPL 5′-UTR (Enerback, S., et al., Mol. Cell. Biol. 12 (10) (1992): 4622-4633) and 3′-UTR (Wion, K. L., et al., Science 235 (1987): 4796, 1638-1641) had been inserted, human-derived liposarcoma cell line SW872 (ATCC Accession No. HTB-92) was transformed to prepare an HTB-92/p387/p383 cell line, which stably expresses luciferase.
  • human LPL 5′-UTR Enerback, S., et al., Mol. Cell. Biol. 12 (10) (1992): 4622-4633
  • 3′-UTR Wion, K. L., et al., Science 235 (1987): 4796, 1638-1641
  • This HTB-92/p387/p383 cell line was introduced into a 225 cm 2 culture flask furnished with a culture medium and cultured at 37° C. in the absence of CO 2 until reaching confluence.
  • Leibovitz's L-15 culture medium containing 10% FBS, 1% GlutaMaxII, 10 ⁇ g/ml streptomycin, 1 ⁇ g/ml puromycin, 250 ⁇ g/ml hygromycin B
  • the cells were collected, plated on 384-well plates to have 20000 cells/well, and cultured with 50 ⁇ l/well of the culture medium under the same conditions as above (37° C., absence of CO 2 ).
  • the culture medium was replaced by 50 ⁇ l/well phenol-red-free DMEM (containing 10% FBS, 1% GlutaMax, 10 U/ml penicillin, 10 ⁇ g/ml streptomycin, 1 ⁇ g/ml puromycin, 250 ⁇ g/ml hygromycin, 1 ⁇ M dexamethasone, 0.5 ⁇ M IBMX; differentiation medium), and the cells were cultured for 5 more days at 37° C. in the presence of CO 2 to differentiate.
  • DMEM containing 10% FBS, 1% GlutaMax, 10 U/ml penicillin, 10 ⁇ g/ml streptomycin, 1 ⁇ g/ml puromycin, 250 ⁇ g/ml hygromycin, 1 ⁇ M dexamethasone, 0.5 ⁇ M IBMX; differentiation medium
  • the culture medium was replaced by a 50 ⁇ l/well medium containing a compound of the invention (compound prepared in an Example) as a test substance wherein the compound had been conditioned with DMSO to a specific concentration selected from 10 ⁇ 4 M to 3 ⁇ 10 ⁇ 10 M.
  • the cells were cultured for 5 days at 37° C. in the presence of CO 2 .
  • luciferase substrate solution manufactured by Promega Corporation
  • a luciferase substrate solution manufactured by Promega Corporation
  • the cells were left to stand 10 minutes at room temperature, and luciferase activities were measured by a luminometer (a microplate scintilltion counter; The Wallac MicroBeta Trilux, manufactured by Perkin Elmer, Inc.).
  • DMEM medium differentiated medium not containing phenol red
  • the luciferase activity of these control cells were measured as above.
  • the EC 50 value (the concentration of test substance that can increase the amount of LPL mRNA expression over the control by 50%, unit: M) was calculated based on the straight line obtained by plotting the results of the tests performed using the test substances at varying concentrations.
  • the maximum induction (Max. Ind. values) was calculated according to the following equation:
  • Lt represents the maximum luciferase activity occurred in response to test substance stimulation
  • Lc represents the value indicating the luciferase activity of the control.
  • the table 2 below shows the results (EC 50 values and Max. Ind. values) of using the compounds of the present invention as test substances, with the Example numbers representing by what Example methods the respective compounds were prepared.
  • the compounds of the present invention remarkably increase LPL mRNA expression.
  • the results show that the compounds of the invention have excellent LPL increasing effects, even when compared with ethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzyl phosphonate, which is known to have LPL increasing effects and whose Max. Ind. Value is about 1.2.
  • test rats According to the body weight of the test rats when they were 5 weeks old, the test rats were divided into test groups and a control group with 6 rats per group.
  • test samples were prepared by further adding 5% aqueous gum arabic solution gradually. Subsequently, these test samples were subjected to ultrasonic washing for 10 minutes to homogenize. Test samples were prepared as and when necessary.
  • the rats of the test groups were orally administered with the compounds of the invention such that rats received the compounds in an amount of 10, 30, or 100 mg/kg.
  • the compounds of the invention were formulated as 5% gum arabic suspensions as described above.
  • the rats of the control group were orally administered with 5% aqueous gum arabic solution (not containing the compounds of the invention) in an amount of 5 ml/kg body weight. Administration was conducted once a day continuously for one week at a specific time of day after the rats reached 6 weeks of age. This test was performed under non-fasting conditions (rats had free access to feed and water), and the rats were fasted after the final administration of the compounds or 5% aqueous gum arabic solution.
  • E represents the average plasma triglyceride level in each test group; and C represents the average plasma triglyceride level in the control group.
  • the compounds of the present invention decrease plasma triglyceride levels remarkably.
  • Zucker fatty rats are obese rats discovered by Zucker et al., in 1961 as mutants among 13 M rats, which are a hybrid between 13C and M rats. These rats (fa/fa) start to appear distinctly obese from normal broods around the age of 3 weeks. As they age, the weight difference between the fatty rats and normal rats increases. Zucker fatty rats are currently kept by a variety of organizations as simple obesity models, and are readily obtainable.
  • test samples were prepared in the same manner as in Test Example 2.
  • test samples were orally administered using an oral gavage so that the compounds of the invention contained in the test samples were given in an amount of 100 mg/kg body weight (test sample dosage: 5 ml/kg body weight). The test samples were administered once a day over 4 weeks at a specific time of day.
  • a group of rats were administered with the same amount of 5% aqueous gum arabic solution (5 ml/kg body weight) instead of the test samples.
  • the rats of all groups were weighed on the last day of administration.
  • the average body weight of the rats of each test group was compared with the average body weight (standard weight) of the rats of the control group to obtain the weight variations (differences).
  • the weight differences were expressed as percentages in relation to the standard weight. The values thus calculated are referred to as “weight change %”. When a weight difference is negative relative to the standard weight, weight change % is shown with “ ⁇ ” (minus).
  • the rats of the respective groups had free access to rat feed (“CRF-1”, manufactured by Oriental Yeast, Co., Ltd.) and water (tap water).
  • the table 4 below shows the results of the above-described test performed using as test samples compounds of the present invention prepared in the Examples.
  • the purpose of this test is to investigate whether the compounds of the invention inhibit the weight increase of food-induced-obesity model AKR/J mice, which are considered to be closer to humans.
  • the model mice used in this test exhibit a correlation between body weight increase and blood leptin level increase, and therefore anti-obesity action can be determined in terms of both body weight decrease and leptin level decrease (see J. Clin. Invest. 99 (3), 1 Feb. 1997: 385-90).
  • this test enables the evaluation of therapeutic effects on diabetes. That is, it is reported that insulinemia can be observed in AKR/J mice when they are fed with a high-fat diet (see Am. J. Physiol. 266 (5 Pt 2), May 1994: R1423-8). It is thus known that insulinemia is strongly associated with diabetes (see, for example, J. Cardiovasc. Nurs. 16 (2), January 2002: 17-23). Therefore, this test can verify the therapeutic effects of the compounds of the present invention, used as test compounds, on diabetes.
  • CRF-1 (Charles River Formula I, manufactured by Oriental Yeast, Co., Ltd.) was used as normal feed.
  • high-fat feed that prepared by blending CRF-1 with 18% safflower oil (Oriental Yeast, Co., Ltd.) was used.
  • Test substances were blended with the high-fat feed in an amount of 1 mg per gram of CRF-1.
  • AKR/J mice (from CLEA Japan, Inc.) were purchased at the age of 4 weeks. They were roughly divided into 2 groups according to body weight when the mice reached 5 weeks old. During this period, all mice were given the normal feed.
  • mice of one group (8 mice) continued to be fed with the normal feed (normal feed group).
  • the mice of the other group (8 ⁇ (the number of the test substances+1) mice) were given the high-fat feed (high-fat feed group).
  • mice of each group were measured daily.
  • the mice of the high-fat feed group were further divided into groups (8 mice per group), and the feed (high-fat feed) that had been given to these mice was replaced by high-fat feeds containing the test substances.
  • test substances+high-fat feed groups were further reared for 7 weeks.
  • n 8 per type of test substance.
  • the administration of the test substances was continued for 7 weeks.
  • mice of the “test substances+high fat feed groups” were measured. Blood was collected from the abdominal aorta of the mice using a heparinized syringe, and the leptin and insulin levels in the plasma were measured using an Elisa kit (produced by Morinaga). The mice of the other groups (normal feed group and high-fat feed control group) were reared till the last day of the test as above, and 4 hours after the last feeding on the last day of the test the measurements were performed according to the same procedures.
  • Example Compound 10-mixed high-fat feed group and “Example Compound 58-mixed high-fat feed group”
  • Example Compound 58-mixed high-fat feed group were compared with the respective average values (standard values) of the results obtained from the mice of the high-fat control group to obtain the variations (differences).
  • the differences were expressed as percentages in relation to the standard values.
  • the values thus calculated were referred to as “weight change (%)”, “leptin level change (%)”, and “insulin level change (%)”.
  • the symbols “ ⁇ ” (minus) indicate that the differences are negative relative to the standard values.
  • the table 5 shows the weight change (%), leptin level change (%), and insulin level change (%) of the mice of the Example Compound 10-mixed high-fat feed group, Example Compound 58-mixed high-fat feed group, normal feed group, and high-fat feed control group.
  • the compounds of the present invention prepared in Examples 10 and 58 both have excellent anti-obesity action and an outstanding therapeutic effect on diabetes.
  • 6-week-old SD rats (purchased from Charles River Japan) were used as subjects.
  • the rats were divided into groups according to body weight at the age of 5 weeks.
  • the rats in each test group were orally administered with a 5% gum arabic suspension in an amount of 5 ml/kg of body weight, the suspension containing the test compound of the invention in such an amount that the dose of the compound of the invention became 30 mg/kg of body weight in one group and 100 mg/kg of body weight in another group.
  • the rats in a control group were orally administered with a 5% gum arabic suspension (not containing the test compound of the invention) in an amount of 5 ml/kg of body weight.
  • Each sample suspension was orally administered every day at a specific time of day for 1 week starting when the rats reached the age of 6 weeks.
  • LPL activity in the skeletal muscle tissues was measured by the following method.
  • the soleus muscle was homogenized in a chilled solution of 0.05 mol/L NH 4 OH—NH 4 Cl buffer (pH 8.5) containing 0.5 U/mL heparin at 1 mL/100 mg of tissue wet weight. After standing on ice for 60 min with vigorous mixing at intervals of 15 min, the homogenate was centrifuged at 3000 rpm and 4° C. for 10 min and the supernatant was separated.
  • the substrate solution was prepared by mixing 2 ⁇ Ci of glycerol tri[1- 14 C]oleate, 0.133 g of unlabeled triolein, 0.9 mL of 1% Triton X-100, and 0.9 mL of 4% bovine serum albumin. in 0.2 mol/L Tris-HCl buffer (pH 8.6) and 10.2 mL of 0.2 mol/L Tris-HCl buffer (pH 8.6). The mixture was emulsified by sonication on ice for 3 min.
  • tissue extract 0.1 mL of the tissue extract, 0.05 mL of heat-inactivated rat serum and 0.15 mL of 4% bovine serum albumin in 0.2 mol/L Tris-HCl buffer (pH 7.4) were mixed. Enzyme reaction was started by adding 0.2 mL of the substrate solution and was carried out for 30 min. at 37° C.
  • the reaction was stopped by addition of 2 mL of 1.5 mol/L H 2 SO 4 /2-propanol (1:40, v/v), and 1 mL of distilled water and 3 mL of hexane were added into the test tube. After vigorously shaking for 10 min. at room temperature, the test tube was centrifuged for 10 min. at 3000 rpm.
  • the upper layer (3.5 mL) was collected in a new test tube and mixed with 1 mL of 0.1 mol/L KOH.
  • test tube was vigorously shaken for 10 min. at room temperature and then centrifuged for 10 min. at 3000 rpm.
  • the LPL activity increase (%) was calculated from the measured values of LPL activity in the control group and test groups according to the following formula:
  • TABLE 6 Result Increase of skeletal muscle LPL activity compared to control Example Dose (%) 30 mg/kg 56 100 mg/kg 75 10 30 mg/kg 22 100 mg/kg 55 23 30 mg/kg 18 100 mg/kg 15 30 30 mg/kg 22 100 mg/kg 31 85 30 mg/kg 9 100 mg/kg 36 95 30 mg/kg 13 100 mg/kg 25
  • Example Compound 1 Using Example Compound 1 as an active ingredient, tablets (10000 tablets) each containing 300 mg of the active ingredient were prepared according to the following formulation:
  • Example Compound 1 3000 g Lactose (Japanese Pharmacopoeia) 335 g Corn starch (Japanese Pharmacopoeia) 165 g Carboxymethylcellulose calcium 125 g (Japanese Pharmacopoeia) Methylcellulose (Japanese Pharmacopoeia) 60 g Magnesium stearate (Japanese Pharmacopoeia) 15 g
  • Example Compound 1 lactose, corn starch and carboxymethylcellulose calcium were sufficiently mixed, the mixture was granulated using the methylcellulose aqueous solution, the granules were passed through a 24-mesh sieve and mixed with magnesium stearate, and the resulting mixture was pressed to form tablets.
  • Example Compound 95 Using the Example Compound 95 as an active ingredient, hard gelatin capsules (10000 capsules) each containing 200 mg of the active ingredient were prepared according to the following formulation.
  • each ingredient was finely powdered and thoroughly mixed to give a uniform mixture.
  • the desired capsules were then prepared by encapsulating the mixture into gelatin capsules having a size appropriate for oral administration.

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Publication number Priority date Publication date Assignee Title
US8329739B2 (en) 2009-02-04 2012-12-11 Otsuka Pharmaceutical Factory, Inc. Phenylimidazole compounds

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201302927D0 (en) 2013-02-20 2013-04-03 Cancer Therapeutics Crc Pty Ltd Compounds
US10494376B2 (en) 2014-09-03 2019-12-03 Ctxt Pty. Ltd. Tetrahydroisoquinoline derived PRMT5-inhibitors
EP3189048B1 (en) 2014-09-03 2021-03-17 Ctxt Pty Ltd Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived prmt5-inhibitors
GB201415573D0 (en) 2014-09-03 2014-10-15 Cancer Therapeutics Crc Pty Ltd Compounds
EP3355699B1 (en) * 2015-09-29 2021-03-31 OncoTherapy Science, Inc. Bicyclic compound and use thereof for inhibiting suv39h2
US10570117B2 (en) * 2015-12-25 2020-02-25 Otsuka Pharmaceutical Factory, Inc. Phenylimidazole compound
GB201604029D0 (en) 2016-03-09 2016-04-20 Ctxt Pty Ltd Compounds
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EP3453706A1 (en) 2017-09-08 2019-03-13 Basf Se Pesticidal imidazole compounds

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4714762A (en) * 1986-10-31 1987-12-22 Warner-Lambert Company Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof
US4716169A (en) * 1984-12-21 1987-12-29 Dr. Karl Thomae Gmbh Imidazo[1,2a]pyridines and their use as cardiotonic agents
US5179117A (en) * 1991-12-20 1993-01-12 Du Pont Merck Pharmaceutical Company Antihypercholesterolemic 2-substituted imidazoles
US20090075938A1 (en) * 2006-02-10 2009-03-19 Graham Michael Wynne Treatment of duchenne muscular dystrophy
US20090176773A1 (en) * 2005-05-18 2009-07-09 Forschungsverbund Berlin E.V. Non-Peptidic Inhibitors of AKAP/PKA Interaction
US20100113412A1 (en) * 2007-02-28 2010-05-06 Sanofi-Aventis IMIDAZO[1,2-a]PYRIDINES AND THEIR USE AS PHARMACEUTICALS
US20110275823A1 (en) * 2009-02-04 2011-11-10 Otsuka Pharmaceutical Factory, Inc. Phenylimidazole compounds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH483276A (de) 1959-09-23 1969-12-31 Ciba Geigy Verwendung von 2-Phenyl-benzazolen als Schutzmittel vor ultravioletter Strahlung ausserhalb der Textilindustrie
US3669979A (en) 1967-12-14 1972-06-13 Gaf Corp Novel process for the production of 2-benzothiazolyl-phenol and derivatives thereof employing phosphorus trichloride as a catalyst
US3647812A (en) 1969-04-22 1972-03-07 Richard F Smith Halogenated 2(2'-hydroxyphenyl benzothiazoles
US3876791A (en) 1973-11-30 1975-04-08 Uniroyal Inc Control of acarids using certain benzothiazoles or benzothiazolines
PT77844B (en) 1982-12-27 1986-05-08 Lilly Co Eli Process for preparing substituted imidazopyrimidines -pyrazines and -triazines
JPH07291976A (ja) * 1994-04-27 1995-11-07 Otsuka Pharmaceut Factory Inc イミダゾ〔２，１−ｂ〕チアゾール誘導体
JP3477238B2 (ja) * 1994-04-27 2003-12-10 株式会社大塚製薬工場 イミダゾ〔１，２−ａ〕ピリジン誘導体
IL113472A0 (en) 1994-04-29 1995-07-31 Lilly Co Eli Non-peptidyl tachykinin receptor antogonists
JPH10324688A (ja) 1997-03-21 1998-12-08 Takeda Chem Ind Ltd イミダゾピリジン誘導体およびその製造法
JP2001226358A (ja) * 1999-10-12 2001-08-21 Japan Tobacco Inc Ｌｐｌ活性増強剤
JP2001163861A (ja) 1999-12-07 2001-06-19 Nippon Soda Co Ltd ジフェニルイミダゾール化合物および農園芸用殺菌剤
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
JP2006182668A (ja) * 2004-12-27 2006-07-13 Dainippon Sumitomo Pharma Co Ltd 高脂質症、動脈硬化、および／またはメタボリックシンドローム治療剤
WO2008029152A2 (en) * 2006-09-08 2008-03-13 Summit Corporation Plc Treatment of duchenne muscular dystrophy

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4716169A (en) * 1984-12-21 1987-12-29 Dr. Karl Thomae Gmbh Imidazo[1,2a]pyridines and their use as cardiotonic agents
US4714762A (en) * 1986-10-31 1987-12-22 Warner-Lambert Company Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof
US5179117A (en) * 1991-12-20 1993-01-12 Du Pont Merck Pharmaceutical Company Antihypercholesterolemic 2-substituted imidazoles
US20090176773A1 (en) * 2005-05-18 2009-07-09 Forschungsverbund Berlin E.V. Non-Peptidic Inhibitors of AKAP/PKA Interaction
US20090075938A1 (en) * 2006-02-10 2009-03-19 Graham Michael Wynne Treatment of duchenne muscular dystrophy
US20100113412A1 (en) * 2007-02-28 2010-05-06 Sanofi-Aventis IMIDAZO[1,2-a]PYRIDINES AND THEIR USE AS PHARMACEUTICALS
US20110275823A1 (en) * 2009-02-04 2011-11-10 Otsuka Pharmaceutical Factory, Inc. Phenylimidazole compounds
US8329739B2 (en) * 2009-02-04 2012-12-11 Otsuka Pharmaceutical Factory, Inc. Phenylimidazole compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8329739B2 (en) 2009-02-04 2012-12-11 Otsuka Pharmaceutical Factory, Inc. Phenylimidazole compounds

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