US20090155176A1 - Compositions and methods for treatment of diabetic retinopathy - Google Patents

Compositions and methods for treatment of diabetic retinopathy Download PDF

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Publication number
US20090155176A1
US20090155176A1 US12/288,330 US28833008A US2009155176A1 US 20090155176 A1 US20090155176 A1 US 20090155176A1 US 28833008 A US28833008 A US 28833008A US 2009155176 A1 US2009155176 A1 US 2009155176A1
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United States
Prior art keywords
alkyl
aryl
lfa
substituted
amino
Prior art date
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Abandoned
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US12/288,330
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English (en)
Inventor
John Burnier
Thomas Gadek
Charles Semba
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Novartis AG
Original Assignee
Sarcode Corp
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Priority to US12/288,330 priority Critical patent/US20090155176A1/en
Application filed by Sarcode Corp filed Critical Sarcode Corp
Assigned to SARCODE CORPORATION reassignment SARCODE CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BURNIER, JOHN, GADEK, THOMAS, SEMBA, CHARLES
Publication of US20090155176A1 publication Critical patent/US20090155176A1/en
Assigned to SARCODE BIOSCIENCE INC. reassignment SARCODE BIOSCIENCE INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: SARCODE CORPORATION
Assigned to SILICON VALLEY BANK reassignment SILICON VALLEY BANK SECURITY AGREEMENT Assignors: SARCODE BIOSCIENCE INC.
Assigned to SARCODE BIOSCIENCE INC. reassignment SARCODE BIOSCIENCE INC. RELEASE OF SECURITY INTEREST Assignors: SILICON VALLEY BANK
Priority to US14/491,333 priority patent/US9447077B2/en
Priority to US14/659,789 priority patent/US10960087B2/en
Priority to US15/235,572 priority patent/US11028077B2/en
Assigned to NOVARTIS AG reassignment NOVARTIS AG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SARCODE BIOSCIENCE INC.
Priority to US17/181,187 priority patent/US20210338839A1/en
Abandoned legal-status Critical Current

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  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
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US12/288,330 2007-10-19 2008-10-17 Compositions and methods for treatment of diabetic retinopathy Abandoned US20090155176A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US12/288,330 US20090155176A1 (en) 2007-10-19 2008-10-17 Compositions and methods for treatment of diabetic retinopathy
US14/491,333 US9447077B2 (en) 2008-04-15 2014-09-19 Crystalline pharmaceutical and methods of preparation and use thereof
US14/659,789 US10960087B2 (en) 2007-10-19 2015-03-17 Compositions and methods for treatment of diabetic retinopathy
US15/235,572 US11028077B2 (en) 2008-04-15 2016-08-12 Crystalline pharmaceutical and methods of preparation and use thereof
US17/181,187 US20210338839A1 (en) 2007-10-19 2021-02-22 Compositions and methods for treatment of diabetic retinopathy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99957107P 2007-10-19 2007-10-19
US12/288,330 US20090155176A1 (en) 2007-10-19 2008-10-17 Compositions and methods for treatment of diabetic retinopathy

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US14/659,789 Continuation US10960087B2 (en) 2007-10-19 2015-03-17 Compositions and methods for treatment of diabetic retinopathy

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US20090155176A1 true US20090155176A1 (en) 2009-06-18

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US14/659,789 Active US10960087B2 (en) 2007-10-19 2015-03-17 Compositions and methods for treatment of diabetic retinopathy
US17/181,187 Abandoned US20210338839A1 (en) 2007-10-19 2021-02-22 Compositions and methods for treatment of diabetic retinopathy

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Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060281739A1 (en) * 2005-05-17 2006-12-14 Thomas Gadek Compositions and methods for treatment of eye disorders
US20080176896A1 (en) * 2003-11-05 2008-07-24 Wang Shen Modulators of cellular adhesion
US20090257957A1 (en) * 2008-04-15 2009-10-15 John Burnier Aerosolized LFA-1 antagonists for use in localized treatment of immune related disorders
US20090258069A1 (en) * 2008-04-15 2009-10-15 John Burnier Delivery of LFA-1 antagonists to the gastrointestinal system
US20090258070A1 (en) * 2008-04-15 2009-10-15 John Burnier Topical LFA-1 antagonists for use in localized treatment of immune related disorders
US20090298869A1 (en) * 2008-04-15 2009-12-03 John Burnier Crystalline pharmaceutical and methods of preparation and use thereof
US20110092707A1 (en) * 2009-10-21 2011-04-21 Sarcode Corporation Crystalline Pharmaceutical and Methods of Preparation and Use Thereof
US20110104206A1 (en) * 2009-10-30 2011-05-05 Intratus, Inc. Methods and compositions for sustained delivery of drugs
US20110189174A1 (en) * 2010-02-01 2011-08-04 Afshin Shafiee Compositions and methods for treating, reducing, ameliorating, alleviating, or inhibiting progression of, pathogenic ocular neovascularization
US20110281901A1 (en) * 2010-05-05 2011-11-17 Glaxo Wellcome Manufacturing Pte Ltd. Pharmaceutical compositions and methods of making same
US20130324603A1 (en) * 2012-06-05 2013-12-05 Olatec Industries Llc Pharmaceutical composition for treating inflammation and pain
US9085553B2 (en) 2012-07-25 2015-07-21 SARcode Bioscience, Inc. LFA-1 inhibitor and methods of preparation and polymorph thereof
US10960087B2 (en) 2007-10-19 2021-03-30 Novartis Ag Compositions and methods for treatment of diabetic retinopathy
US11018173B2 (en) 2018-06-18 2021-05-25 Samsung Electronics Co., Ltd. Image sensor
US11753382B2 (en) 2019-06-25 2023-09-12 Translatum Medicus Inc. Processes of making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012024380A2 (pt) 2010-03-25 2015-09-15 Glaxosmithkline Llc compostos químicos
EP2817018A4 (en) * 2012-02-22 2015-09-23 Stealth Peptides Int Inc METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING OPHTHALMIC CONDITIONS
MA37756B1 (fr) 2012-06-13 2018-09-28 Hoffmann La Roche Nouveaux composés diazaspirocycloalcane et azaspirocycloalcane
EP3590940B1 (en) 2012-09-25 2021-06-09 F. Hoffmann-La Roche AG Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
MA38982A1 (fr) 2013-11-26 2017-09-29 Hoffmann La Roche Nouvel octahydro-cyclobuta [1,2-c; 3,4-c'] dipyrrol-2-yl
JP6272604B2 (ja) * 2013-12-27 2018-01-31 日本サプリメント株式会社 糖取り込み促進剤
MX2016010675A (es) 2014-03-26 2016-11-10 Hoffmann La Roche Compuestos condensados de [1,4]diazepina como inhibidores de produccion de la autotaxina (atx) y acido lisofosfatidico (lpa).
CN106103446B (zh) 2014-03-26 2019-07-30 豪夫迈·罗氏有限公司 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物
AR104177A1 (es) * 2015-04-03 2017-07-05 Santen Pharmaceutical Co Ltd Sistema para la administración de fármacos en la glándula lagrimal
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WO2017050792A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
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WO2021247900A1 (en) * 2020-06-05 2021-12-09 Occurx Pty. Ltd. Compounds and methods for the treatment of eye disorders
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JP2024042677A (ja) * 2022-09-15 2024-03-28 日油株式会社 コンタクトレンズ用溶液

Citations (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4316893A (en) * 1975-06-19 1982-02-23 Nelson Research & Development Co. Vehicle composition containing 1-substituted azacycloalkan-2-ones
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
US4668506A (en) * 1985-08-16 1987-05-26 Bausch & Lomb Incorporated Sustained-release formulation containing and amino acid polymer
US4908202A (en) * 1988-02-02 1990-03-13 Cassella Aktiengesellschaft Use of 2-oxo-1-pyrrolidineacetamide for the determination of the glomerular filtration rate in humans
US4931279A (en) * 1985-08-16 1990-06-05 Bausch & Lomb Incorporated Sustained release formulation containing an ion-exchange resin
US4992445A (en) * 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US5001139A (en) * 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US5023252A (en) * 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5134122A (en) * 1989-07-28 1992-07-28 Debiopharm S.A. Method for preparing a pharmaceutical composition in the form of microparticles
US5192741A (en) * 1987-09-21 1993-03-09 Debiopharm S.A. Sustained and controlled release of water insoluble polypeptides
US5288854A (en) * 1990-11-28 1994-02-22 Center For Blood Research, Inc. Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1
US5298492A (en) * 1992-08-04 1994-03-29 Schering Corporation Diamino acid derivatives as antihypertensives
US5397791A (en) * 1993-08-09 1995-03-14 Merck & Co., Inc. Fibrinogen receptor antagonists
US5424289A (en) * 1993-07-30 1995-06-13 Alza Corporation Solid formulations of therapeutic proteins for gastrointestinal delivery
US5424399A (en) * 1988-06-28 1995-06-13 The Children's Medical Center Corporation Human CR3α/β heterodimers
US5597567A (en) * 1991-10-04 1997-01-28 The United States Of America As Represented By The Department Of Health And Human Services Blocking cell adhesion molecules and treating animals with ocular inflammation
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US5622700A (en) * 1992-08-21 1997-04-22 Genentech, Inc. Method for treating a LFA-1-mediated disorder
US5624837A (en) * 1994-03-03 1997-04-29 Alexion Pharmaceuticals, Inc. Nucleic acid encoding chimeric complement inhibitor proteins
US5747035A (en) * 1995-04-14 1998-05-05 Genentech, Inc. Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor
US5863910A (en) * 1996-01-12 1999-01-26 Bolonick; Joel Treatment of chronic inflammatory disorders of the gastrointestinal tract
US5877224A (en) * 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
US5893985A (en) * 1997-03-14 1999-04-13 The Lincoln Electric Company Plasma arc torch
US5922356A (en) * 1996-10-09 1999-07-13 Sumitomo Pharmaceuticals Company, Limited Sustained release formulation
US6011011A (en) * 1992-09-21 2000-01-04 Pharmacia & Upjohn Company Sustained-release protein formulations
US6180608B1 (en) * 1996-12-11 2001-01-30 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US6204280B1 (en) * 1994-11-02 2001-03-20 Merck Patent Gesellschaft Mit Berschrankter Haftung Adhesion receptor antagonists
US6203793B1 (en) * 1992-02-28 2001-03-20 Board Of Regents Of The University Of Texas System Compositions and methods for treating thermal injury
US20010006656A1 (en) * 1999-02-17 2001-07-05 University Of Washington Methods and compositions for inhibiting inflammation associated with pulmonary disease
US6340679B1 (en) * 1999-02-13 2002-01-22 Aventis Pharma Deutschland Gmbh Guanidine derivatives as inhibitors of cell adhesion
US6358976B1 (en) * 1996-11-27 2002-03-19 John Wityak Integrin receptor antagonists
US20020045582A1 (en) * 1997-12-31 2002-04-18 Alexey L. Margolin Stabilized protein crystals formulations containing them and methods of making them
US6515124B2 (en) * 2000-02-09 2003-02-04 Hoffman-La Roche Inc. Dehydroamino acids
US6521619B2 (en) * 2000-06-29 2003-02-18 Icos Corporation Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
US6524581B1 (en) * 1998-12-30 2003-02-25 The Children's Medical Center Corporation Prevention and treatment of retinal ischemia and edema
US20030044406A1 (en) * 2001-03-02 2003-03-06 Christine Dingivan Methods of preventing or treating inflammatory or autoimmune disorders by administering CD2 antagonists in combination with other prophylactic or therapeutic agents
US20030064105A1 (en) * 2000-08-25 2003-04-03 Myung-Jin Kim Lipophilic-coated microparticle containing a protein drug and formulation comprising same
US20030069560A1 (en) * 2001-05-03 2003-04-10 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
US20030138488A1 (en) * 1999-12-31 2003-07-24 Kohn Joachim B Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix
US20040006236A1 (en) * 1998-10-13 2004-01-08 Nader Fotouhi Diaminopropionic acid derivatives
US20040009998A1 (en) * 2001-10-01 2004-01-15 Dhar T. G. Murali Spiro-hydantoin compounds useful as anti-inflammatory agents
US20040038973A1 (en) * 2002-08-13 2004-02-26 Joe Nahra Phthalimide derivatives as matrix metalloproteinase inhibitors
US6710064B2 (en) * 2000-12-01 2004-03-23 Bristol-Myers Squibb Co. Hydantoin compounds useful as anti-inflammatory agents
US20040058968A1 (en) * 2000-11-28 2004-03-25 Genentech, Inc. LFA-1 antagonist compounds
US20040122047A1 (en) * 2001-06-06 2004-06-24 Aventis Pharma Limited Substituted tetrahydroisoquinolines
US6764681B2 (en) * 1991-10-07 2004-07-20 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
US6867203B2 (en) * 1998-12-29 2005-03-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
US6872382B1 (en) * 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
US20050107399A1 (en) * 2003-09-11 2005-05-19 Kemia, Inc. Cytokine inhibitors
US20050119279A1 (en) * 2003-10-02 2005-06-02 Dhar T. G. M. Spiro-cyclic compounds useful as anti-inflammatory agents
US20050142066A1 (en) * 2002-06-06 2005-06-30 Dana Farber Cancer Institute, Inc Compounds or agents that inhibit and induce the formation of focal microvessel dilatations
US20060052434A1 (en) * 2004-08-18 2006-03-09 Dhar T G M Pyrrolizine compounds useful as anti-inflammatory agents
US20060074099A1 (en) * 2004-10-01 2006-04-06 Delmonte Albert J Crystalline forms and process for preparing spiro-hydantoin compounds
US20060142319A1 (en) * 2004-12-14 2006-06-29 Bang-Chi Chen Pyridyl-substituted spiro-hydantoin crystalline forms and process
US20060148836A1 (en) * 2004-12-14 2006-07-06 Dhar T G M Pyridyl-substituted spiro-hydantoin compounds and use thereof
US7166568B1 (en) * 1998-02-09 2007-01-23 Oklahoma Medical Research Foundation Compositions and methods to inhibit formation of the C5b-9 complex of complement
US20070027101A1 (en) * 2001-11-09 2007-02-01 Guyer David R Methods for treating ocular neovascular diseases
US20070048216A1 (en) * 2005-08-23 2007-03-01 Norenberg Jeffrey P Non-invasive diagnostic agents of cancer and methods of diagnosing cancer, especially leukemia and lymphoma
US20070066585A1 (en) * 2000-06-29 2007-03-22 Wang Gary T Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
US20070090205A1 (en) * 2005-06-24 2007-04-26 Boehringer Ingelheim International Gmbh Nebuliser and container
US20070105824A1 (en) * 2003-04-29 2007-05-10 Erickson-Miller Connie L Methods for treating degenerative diseases/injuries
US20070142317A1 (en) * 2003-12-29 2007-06-21 Qlt Usa, Inc. Topical composition for treatment of skin disorders
US20070149593A1 (en) * 2005-12-23 2007-06-28 Alcon, Inc. PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
US7314938B2 (en) * 2003-11-05 2008-01-01 Sunesis Pharmaceuticals, Inc. Modulators of cellular adhesion
US20080108677A1 (en) * 2004-08-30 2008-05-08 Karyon-Ctt Ltd Thioxothiazolidinone Compounds For Use As Pharmaceuticals
US7396530B2 (en) * 2004-06-09 2008-07-08 Genentech, Inc. Method of treating granuloma annulare or sarcoid
US20100092541A1 (en) * 2005-05-17 2010-04-15 John Burnier Compositions and methods for treatment of eye disorders
US20110092707A1 (en) * 2009-10-21 2011-04-21 Sarcode Corporation Crystalline Pharmaceutical and Methods of Preparation and Use Thereof
US20120107404A1 (en) * 2008-04-15 2012-05-03 Sarcode Bioscience Inc. Crystalline Pharmaceutical and Methods of Preparation and Use Thereof

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US735A (en) 1838-05-10 Rtjftjg porter
US6872A (en) 1849-11-13 Means of changing the combination in bevolving tumbler-locks
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4405616A (en) 1975-06-19 1983-09-20 Nelson Research & Development Company Penetration enhancers for transdermal drug delivery of systemic agents
US3989816A (en) 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4557934A (en) 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
US4713244A (en) 1985-08-16 1987-12-15 Bausch & Lomb Incorporated Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent
ES2064327T3 (es) 1987-11-02 1995-02-01 Baylor College Medicine Uso de icam-1 o de sus derivados funcionales para el tratamiento de una inflamacion no especifica.
ATE90570T1 (de) 1988-01-29 1993-07-15 Sumitomo Pharma Verbesserte formulierungen mit kontrollierter abgabe.
EP0362526B1 (en) 1988-08-23 1995-06-14 Dana Farber Cancer Institute The Alpha-subunit of the LFA-1 leukocyte adhesion receptor
DE68929096T2 (de) 1988-09-01 2000-05-11 Bayer Ag Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt
AU4412889A (en) 1988-09-28 1990-04-18 Dana-Farber Cancer Institute Intercellular adhesion molecules, and their binding ligands
US5149780A (en) 1988-10-03 1992-09-22 The Scripps Research Institute Peptides and antibodies that inhibit integrin-ligand binding
EP0462184A4 (en) 1989-03-09 1992-01-08 Dana Farber Cancer Institute Method of treating viral infections using lfa-1
WO1990013316A1 (en) 1989-04-28 1990-11-15 Baylor College Of Medicine Dissemination of hiv-1 infected cells
US5135916A (en) 1989-06-12 1992-08-04 Oklahoma Medical Research Foundation Inhibition of complement mediated inflammatory response
WO1991019511A1 (en) 1990-06-18 1991-12-26 The General Hospital Corporation CONTROLLING CELLULAR IMMUNE/INFLAMMATORY RESPONSES WITH β2 INTEGRINS
CA2046830C (en) 1990-07-19 1999-12-14 Patrick P. Deluca Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer
US5318965A (en) 1990-08-24 1994-06-07 Abbott Laboratories Quinobenzoxazine, antineoplastic agents
EP0546077A1 (en) 1990-08-27 1993-06-16 Chiron Corporation Cd18 peptide medicaments for the treatment of disease
CH683149A5 (fr) 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US6162432A (en) 1991-10-07 2000-12-19 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
GB9211268D0 (en) 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
WO1994011400A1 (en) 1992-11-18 1994-05-26 Helsinki University Licensing Ltd. Oy Peptides from human icam-2 and from human icam-1 and their analogs for use in therapy and diagnosis
WO1994015587A2 (en) 1993-01-06 1994-07-21 Kinerton Limited Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
US5672659A (en) 1993-01-06 1997-09-30 Kinerton Limited Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
ATE192430T1 (de) 1993-12-03 2000-05-15 Hoffmann La Roche Essigsäurederivate als arzneimittel
US5470953A (en) 1993-12-23 1995-11-28 Icos Corporation Human β2 integrin α subunit
JPH09512021A (ja) 1994-04-19 1997-12-02 ザ ユニバーシティ オブ カンサス Ｉｃａｍ−１／ｌｆａ−１ 短鎖ペプチドおよび該ペプチドの使用方法
US5849327A (en) 1994-07-29 1998-12-15 Advanced Polymer Systems, Inc. Delivery of drugs to the lower gastrointestinal tract
US5585359A (en) 1994-09-29 1996-12-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US20020028798A1 (en) 1995-12-12 2002-03-07 Omeros Medical Systems Irrigation solution and method for inhibition of pain and inflammation
EP0828754B1 (en) 1995-05-29 2005-02-02 Pfizer Inc. Dipeptides which promote release of growth hormone
US5843884A (en) 1995-11-15 1998-12-01 Oklahoma Medical Research Foundation C9 complement inhibitor
US5980945A (en) 1996-01-16 1999-11-09 Societe De Conseils De Recherches Et D'applications Scientifique S.A. Sustained release drug formulations
US5840332A (en) 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
US6319897B1 (en) 1996-03-13 2001-11-20 John D. Lambris Peptides which inhibit complement activation
IL126422A (en) 1996-04-23 2004-02-19 Kinerton Ltd Biodegradable acidic polylactic polymers and methods for their preparation
HRP970493A2 (en) 1996-09-23 1998-08-31 Wienman E. Phlips Oral delayed immediate release medical formulation and method for preparing the same
AR012443A1 (es) 1997-04-16 2000-10-18 Uriach & Cia Sa J Nuevas carboxamidas como inhibidores de la agregacion plaquetaria, procedimiento para su preparacion, composiciones farmaceuticas que loscontienen y uso de los mismos en la manufactura de medicamentos
DE69839399T2 (de) 1997-08-28 2009-05-20 Novartis Ag Lymphozyten funktion antigen-1 antagonisten
IL138297A0 (en) 1998-03-27 2001-10-31 Genentech Inc Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders
CA2352389C (en) 1998-11-27 2009-01-20 Kanji Takada An oral formulation for gastrointestinal drug delivery
IT1304152B1 (it) 1998-12-10 2001-03-08 Mediolanum Farmaceutici Srl Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato
WO2000040262A1 (en) 1999-01-05 2000-07-13 The Flinders University Of South Australia Novel agents and methods for treatment and diagnosis of ocular disorders
WO2000044731A1 (en) 1999-01-27 2000-08-03 G.D. Searle & Co. Novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors
CO5140104A1 (es) 1999-02-16 2002-03-22 Novartis Ag Derivados de mevinolina y preparacion farmaceuticas que los contienen
CA2371940C (en) 1999-03-31 2008-07-15 Janssen Pharmaceutica N.V. Pregelatinized starch in a controlled release formulation
WO2000072883A2 (en) 1999-06-02 2000-12-07 Aviana Biopharm Pharmaceutical transdermal compositions
EP1194128A2 (en) 1999-06-23 2002-04-10 Sedum Laboratories Ionically formulated biomolecule microcarriers
ATE252915T1 (de) 1999-08-18 2003-11-15 Sod Conseils Rech Applic Formulierung zur verzögerten freisetzung von peptiden
ECSP003707A (es) 1999-10-13 2002-05-23 Novartis Ag Diazepanes
US6605597B1 (en) 1999-12-03 2003-08-12 Cv Therapeutics, Inc. Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives
US6294522B1 (en) 1999-12-03 2001-09-25 Cv Therapeutics, Inc. N6 heterocyclic 8-modified adenosine derivatives
ATE403437T1 (de) 1999-12-14 2008-08-15 Genentech Inc Lfa-1 antagonisten und tnf-alpha antagonisten zur behandlung von rheumatoiden arthritis
EP1251864A4 (en) 1999-12-31 2006-02-22 Univ Rutgers PHARMACEUTICAL FORMULATION COMPRISING A POLYMERIC MIXTURE AND AN ACTIVE COMPOUND FOR TIME-RELEASED RELEASE
EP1263453A4 (en) 1999-12-31 2008-02-20 Univ Rutgers PHARMACEUTICAL FORMULATION CONSISTING OF A POLYMERMATRIX, FOR REGULATING THE TIME-CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES
DE60110396T2 (de) 2000-01-14 2006-01-19 Larson, Richard S., Albuquerque Peptidische inhibitoren der lfa-1/icam-1 interaktion
US6821986B2 (en) 2000-05-05 2004-11-23 Societe De Conseils De Recherchet Et E'applications Scientifiques (S.C.R.A.S.) Amino acid derivatives and their use as medicines
GB0011817D0 (en) 2000-05-16 2000-07-05 Pharmacia & Upjohn Spa Antagonists of integrin receptors
AR030817A1 (es) 2000-10-02 2003-09-03 Novartis Ag Derivados de diazacicloalcanodiona
GB0025208D0 (en) 2000-10-13 2000-11-29 Euro Celtique Sa Delayed release pharmaceutical formulations
US6653478B2 (en) 2000-10-27 2003-11-25 Ortho-Mcneil Pharmaceutical, Inc. Substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide Y modulators
DE10055857A1 (de) 2000-11-10 2002-08-22 Creative Peptides Sweden Ab Dj Neue pharmazeutische Depotformulierung
GB0028367D0 (en) 2000-11-21 2001-01-03 Celltech Chiroscience Ltd Chemical compounds
WO2002050080A1 (en) 2000-12-19 2002-06-27 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
WO2002058672A2 (en) 2001-01-26 2002-08-01 Debio Recherche Pharmaceutique S.A. Microparticles of biodegradable polymer encapsulating a biologically active substance
DE60216830T2 (de) 2001-02-06 2007-06-14 Pfizer Products Inc., Groton Pharmazeutische Zusammensetzungen zur Behandlung von Störungen des ZNS oder anderen Erkrankungen
AU2002258563A1 (en) 2001-03-19 2002-10-03 Praecis Pharmaceuticals Incorporated Pharmaceutical formulations for sustained release
US6391290B1 (en) 2001-03-21 2002-05-21 Schering-Plough Healthcare Products, Inc. Skin care compositions
CN1511151A (zh) 2001-05-24 2004-07-07 ֮����ҩ��ʽ���� 3-喹啉-2(1h)-亚基二氢吲哚-2-酮衍生物
AU2002320352A1 (en) 2001-07-24 2003-02-17 Biogen Idec Ma Inc. Methods for treating or preventing sclerotic disorders using cd2-binding agents
MXPA04006026A (es) 2001-12-19 2005-03-31 Alza Corp Formulacion y forma de dosificacion para aumentar la biodisponibilidad oral de macromoleculas hidrofilitas.
BR0308137A (pt) 2002-03-04 2005-01-04 Sod Conseils Rech Applic Formulações de droga de liberação constante contendo um peptìdeo veìculo
WO2004026406A1 (en) 2002-09-20 2004-04-01 Alcon, Inc. Use of cytokine synthesis inhibitors for the treatment of dry eye disorders
US7785578B2 (en) 2002-10-11 2010-08-31 Aciont, Inc. Non-invasive ocular drug delivery
EP2251434B1 (en) * 2003-01-16 2014-07-30 The Trustees of The University of Pennsylvania Compositions and methods for siRNA inhibition of ICAM-1
WO2004073701A1 (ja) * 2003-02-19 2004-09-02 Kuniyasu Soda Lfa-1抑制剤、及びその用途
US20050119186A1 (en) 2003-07-22 2005-06-02 Larson Richard S. Potent peptide inhibitors and methods of use
WO2005014534A1 (en) 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
CA2531796A1 (en) 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
GB0323684D0 (en) 2003-10-09 2003-11-12 Jagotec Ag Improvements in or relating to organic compounds
WO2005042710A1 (en) 2003-10-28 2005-05-12 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of statin to kill ebv-transformed b cells
UA86051C2 (en) 2004-02-04 2009-03-25 Пфайзер Продактс Инк. Substituted quinoline compounds
KR100799802B1 (ko) * 2004-02-04 2008-01-31 화이자 프로덕츠 인크. 치환된 퀴놀린 화합물
WO2005105766A2 (en) 2004-04-28 2005-11-10 Icos Corporation Arylphenylamino-and arylphenylether-sulfide derivatives, useful for the treatment of inflammatory and immune diseases, and pharmaceutical compositions containing them
GT200500139A (es) 2004-06-08 2005-07-25 Metodo para la preparacion de acidos hidroxamicos
US20060089590A1 (en) 2004-10-27 2006-04-27 John Higuchi Methods and devices for sustained in-vivo release of an active agent
US7943660B2 (en) 2005-04-15 2011-05-17 Dominion Pharmakine S.L. Inhibitors of the LFA-1/ICAM-1 interaction and uses thereof
US20060286108A1 (en) 2005-06-16 2006-12-21 Bell Katherine A Topical compositions for the treatment of chronic wounds
JP2007099641A (ja) * 2005-09-30 2007-04-19 Tsumura & Co インドールキノキサリン類化合物、その製造方法およびそれを用いた医薬組成物
CA2624488A1 (en) * 2005-10-06 2007-04-12 Novartis Ag Tetrahydro-pyrrolizinone compounds as lfa-i mediators
GB0520378D0 (en) 2005-10-06 2005-11-16 Novartis Ag Organic compounds
ES2830024T3 (es) 2007-10-19 2021-06-02 Novartis Ag Composiciones y métodos para el tratamiento del edema macular
ES2763703T3 (es) 2008-04-15 2020-05-29 Sarcode Bioscience Inc Antagonistas de LFA-1 tópicos utilizados en el tratamiento localizado de trastornos inmunes
WO2009128932A1 (en) 2008-04-15 2009-10-22 Sarcode Corporation Delivery of lfa-1 antagonists to the gastrointestinal system

Patent Citations (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4316893A (en) * 1975-06-19 1982-02-23 Nelson Research & Development Co. Vehicle composition containing 1-substituted azacycloalkan-2-ones
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
US4668506A (en) * 1985-08-16 1987-05-26 Bausch & Lomb Incorporated Sustained-release formulation containing and amino acid polymer
US4931279A (en) * 1985-08-16 1990-06-05 Bausch & Lomb Incorporated Sustained release formulation containing an ion-exchange resin
US5023252A (en) * 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US4992445A (en) * 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US5001139A (en) * 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US5192741A (en) * 1987-09-21 1993-03-09 Debiopharm S.A. Sustained and controlled release of water insoluble polypeptides
US4908202A (en) * 1988-02-02 1990-03-13 Cassella Aktiengesellschaft Use of 2-oxo-1-pyrrolidineacetamide for the determination of the glomerular filtration rate in humans
US5424399A (en) * 1988-06-28 1995-06-13 The Children's Medical Center Corporation Human CR3α/β heterodimers
US5134122A (en) * 1989-07-28 1992-07-28 Debiopharm S.A. Method for preparing a pharmaceutical composition in the form of microparticles
US5288854A (en) * 1990-11-28 1994-02-22 Center For Blood Research, Inc. Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1
US5597567A (en) * 1991-10-04 1997-01-28 The United States Of America As Represented By The Department Of Health And Human Services Blocking cell adhesion molecules and treating animals with ocular inflammation
US6764681B2 (en) * 1991-10-07 2004-07-20 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
US7323171B2 (en) * 1991-10-07 2008-01-29 Astellas Us Llc Methods of treating skin conditions using inhibitors of the CD2/LFA-3 interaction
US6203793B1 (en) * 1992-02-28 2001-03-20 Board Of Regents Of The University Of Texas System Compositions and methods for treating thermal injury
US5298492A (en) * 1992-08-04 1994-03-29 Schering Corporation Diamino acid derivatives as antihypertensives
US5622700A (en) * 1992-08-21 1997-04-22 Genentech, Inc. Method for treating a LFA-1-mediated disorder
US20040120960A1 (en) * 1992-08-21 2004-06-24 Genentech, Inc. Method for treating multiple sclerosis
US6011011A (en) * 1992-09-21 2000-01-04 Pharmacia & Upjohn Company Sustained-release protein formulations
US5424289A (en) * 1993-07-30 1995-06-13 Alza Corporation Solid formulations of therapeutic proteins for gastrointestinal delivery
US5397791A (en) * 1993-08-09 1995-03-14 Merck & Co., Inc. Fibrinogen receptor antagonists
US5624837A (en) * 1994-03-03 1997-04-29 Alexion Pharmaceuticals, Inc. Nucleic acid encoding chimeric complement inhibitor proteins
US6204280B1 (en) * 1994-11-02 2001-03-20 Merck Patent Gesellschaft Mit Berschrankter Haftung Adhesion receptor antagonists
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US5747035A (en) * 1995-04-14 1998-05-05 Genentech, Inc. Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor
US5877224A (en) * 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
US20030068384A1 (en) * 1995-07-28 2003-04-10 Stephen Brocchini Polymeric drug formulations
US20020019446A1 (en) * 1995-07-28 2002-02-14 Stephen Brocchini Polymeric drug formulations
US5863910A (en) * 1996-01-12 1999-01-26 Bolonick; Joel Treatment of chronic inflammatory disorders of the gastrointestinal tract
US5922356A (en) * 1996-10-09 1999-07-13 Sumitomo Pharmaceuticals Company, Limited Sustained release formulation
US6358976B1 (en) * 1996-11-27 2002-03-19 John Wityak Integrin receptor antagonists
US6180608B1 (en) * 1996-12-11 2001-01-30 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US5893985A (en) * 1997-03-14 1999-04-13 The Lincoln Electric Company Plasma arc torch
US20020045582A1 (en) * 1997-12-31 2002-04-18 Alexey L. Margolin Stabilized protein crystals formulations containing them and methods of making them
US7166568B1 (en) * 1998-02-09 2007-01-23 Oklahoma Medical Research Foundation Compositions and methods to inhibit formation of the C5b-9 complex of complement
US20070155671A1 (en) * 1998-10-13 2007-07-05 Nader Fotouhi Diaminopropionic acid derivatives
US20050080119A1 (en) * 1998-10-13 2005-04-14 Nader Fotouhi Diaminopropionic acid derivatives
US20040006236A1 (en) * 1998-10-13 2004-01-08 Nader Fotouhi Diaminopropionic acid derivatives
US7217728B2 (en) * 1998-10-13 2007-05-15 Hoffmann-La Roche Inc. Diaminopropionic acid derivatives
US6867203B2 (en) * 1998-12-29 2005-03-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
US20080019977A1 (en) * 1998-12-30 2008-01-24 The Children's Medical Center Corporation Prevention and treatment of retinal ischemia and edema
US6524581B1 (en) * 1998-12-30 2003-02-25 The Children's Medical Center Corporation Prevention and treatment of retinal ischemia and edema
US20040028648A1 (en) * 1998-12-30 2004-02-12 The Children's Medical Center Corporation Prevention and treatment of retinal ischemia and edema
US6340679B1 (en) * 1999-02-13 2002-01-22 Aventis Pharma Deutschland Gmbh Guanidine derivatives as inhibitors of cell adhesion
US20010006656A1 (en) * 1999-02-17 2001-07-05 University Of Washington Methods and compositions for inhibiting inflammation associated with pulmonary disease
US20030138488A1 (en) * 1999-12-31 2003-07-24 Kohn Joachim B Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix
US6515124B2 (en) * 2000-02-09 2003-02-04 Hoffman-La Roche Inc. Dehydroamino acids
US20070066585A1 (en) * 2000-06-29 2007-03-22 Wang Gary T Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
US6521619B2 (en) * 2000-06-29 2003-02-18 Icos Corporation Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
US20030064105A1 (en) * 2000-08-25 2003-04-03 Myung-Jin Kim Lipophilic-coated microparticle containing a protein drug and formulation comprising same
US20040058968A1 (en) * 2000-11-28 2004-03-25 Genentech, Inc. LFA-1 antagonist compounds
US6872735B2 (en) * 2000-11-28 2005-03-29 Genentech, Inc. LFA-1 antagonist compounds
US20050148588A1 (en) * 2000-11-28 2005-07-07 Genentech, Inc. LFA-1 antagonist compounds
US6710064B2 (en) * 2000-12-01 2004-03-23 Bristol-Myers Squibb Co. Hydantoin compounds useful as anti-inflammatory agents
US20030044406A1 (en) * 2001-03-02 2003-03-06 Christine Dingivan Methods of preventing or treating inflammatory or autoimmune disorders by administering CD2 antagonists in combination with other prophylactic or therapeutic agents
US20070025990A1 (en) * 2001-03-02 2007-02-01 Medimmune, Inc. Methods of administering/dosing CD2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders
US20030068320A1 (en) * 2001-03-02 2003-04-10 Christine Dingivan Methods of administering/dosing CD2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders
US20030069560A1 (en) * 2001-05-03 2003-04-10 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
US6872382B1 (en) * 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
US20040122047A1 (en) * 2001-06-06 2004-06-24 Aventis Pharma Limited Substituted tetrahydroisoquinolines
US7211586B2 (en) * 2001-06-06 2007-05-01 Aventis Pharma Limited Substituted tetrahydroisoquinolines
US20050004153A1 (en) * 2001-10-01 2005-01-06 Dhar T.G. Murali Spiro-hydantoin compounds useful as anti-inflammatory agents
US7078420B2 (en) * 2001-10-01 2006-07-18 Bristol-Myers Squibb Company Spiro-hydantoin compounds useful as anti-inflammatory agents
US20040009998A1 (en) * 2001-10-01 2004-01-15 Dhar T. G. Murali Spiro-hydantoin compounds useful as anti-inflammatory agents
US20070027101A1 (en) * 2001-11-09 2007-02-01 Guyer David R Methods for treating ocular neovascular diseases
US20050142066A1 (en) * 2002-06-06 2005-06-30 Dana Farber Cancer Institute, Inc Compounds or agents that inhibit and induce the formation of focal microvessel dilatations
US20040038973A1 (en) * 2002-08-13 2004-02-26 Joe Nahra Phthalimide derivatives as matrix metalloproteinase inhibitors
US20070105824A1 (en) * 2003-04-29 2007-05-10 Erickson-Miller Connie L Methods for treating degenerative diseases/injuries
US20050107399A1 (en) * 2003-09-11 2005-05-19 Kemia, Inc. Cytokine inhibitors
US7199125B2 (en) * 2003-10-02 2007-04-03 Bristol-Myers Squibb Company Spiro-cyclic compounds useful as anti-inflammatory agents
US20050119279A1 (en) * 2003-10-02 2005-06-02 Dhar T. G. M. Spiro-cyclic compounds useful as anti-inflammatory agents
US20080182839A1 (en) * 2003-11-05 2008-07-31 Sunesis Pharmaceuticals, Inc. Modulators of cellular adhesion
US20080176896A1 (en) * 2003-11-05 2008-07-24 Wang Shen Modulators of cellular adhesion
US20100093693A1 (en) * 2003-11-05 2010-04-15 Wang Shen Modulators of cellular adhesion
US7928122B2 (en) * 2003-11-05 2011-04-19 Sarcode Corporation Modulators of cellular adhesion
US20110124669A1 (en) * 2003-11-05 2011-05-26 Sarcode Corporation Modulators of Cellular Adhesion
US7314938B2 (en) * 2003-11-05 2008-01-01 Sunesis Pharmaceuticals, Inc. Modulators of cellular adhesion
US20070142317A1 (en) * 2003-12-29 2007-06-21 Qlt Usa, Inc. Topical composition for treatment of skin disorders
US7396530B2 (en) * 2004-06-09 2008-07-08 Genentech, Inc. Method of treating granuloma annulare or sarcoid
US20060052434A1 (en) * 2004-08-18 2006-03-09 Dhar T G M Pyrrolizine compounds useful as anti-inflammatory agents
US7375237B2 (en) * 2004-08-18 2008-05-20 Bristol-Myers Squibb Company Pyrrolizine compounds useful as anti-inflammatory agents
US20080108677A1 (en) * 2004-08-30 2008-05-08 Karyon-Ctt Ltd Thioxothiazolidinone Compounds For Use As Pharmaceuticals
US20060074099A1 (en) * 2004-10-01 2006-04-06 Delmonte Albert J Crystalline forms and process for preparing spiro-hydantoin compounds
US7381737B2 (en) * 2004-10-01 2008-06-03 Bristol-Myers Squibb Company Crystalline forms and process for preparing spiro-hydantoin compounds
US20060142319A1 (en) * 2004-12-14 2006-06-29 Bang-Chi Chen Pyridyl-substituted spiro-hydantoin crystalline forms and process
US20060148836A1 (en) * 2004-12-14 2006-07-06 Dhar T G M Pyridyl-substituted spiro-hydantoin compounds and use thereof
US7186727B2 (en) * 2004-12-14 2007-03-06 Bristol-Myers Squibb Company Pyridyl-substituted spiro-hydantoin compounds and use thereof
US20100092541A1 (en) * 2005-05-17 2010-04-15 John Burnier Compositions and methods for treatment of eye disorders
US20100092542A1 (en) * 2005-05-17 2010-04-15 John Burnier Compositions and methods for treatment of eye disorders
US8168655B2 (en) * 2005-05-17 2012-05-01 Sarcode Bioscience Inc. Compositions and methods for treatment of eye disorders
US20070090205A1 (en) * 2005-06-24 2007-04-26 Boehringer Ingelheim International Gmbh Nebuliser and container
US20070048216A1 (en) * 2005-08-23 2007-03-01 Norenberg Jeffrey P Non-invasive diagnostic agents of cancer and methods of diagnosing cancer, especially leukemia and lymphoma
US20070149593A1 (en) * 2005-12-23 2007-06-28 Alcon, Inc. PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
US20120107404A1 (en) * 2008-04-15 2012-05-03 Sarcode Bioscience Inc. Crystalline Pharmaceutical and Methods of Preparation and Use Thereof
US20130144063A1 (en) * 2008-04-15 2013-06-06 Sarcode Bioscience Inc. Crystalline Pharmaceutical and Methods of Preparation and Use Thereof
US20110092707A1 (en) * 2009-10-21 2011-04-21 Sarcode Corporation Crystalline Pharmaceutical and Methods of Preparation and Use Thereof
US20130150585A1 (en) * 2009-10-21 2013-06-13 SARcode Bioscience, Inc. Crystalline Pharmaceutical and Methods of Preparation and Use Thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Adamis AP. Is diabetic retinopathy an inflammatory disease? Br J Ophthalmol. 2002 Apr;86(4):363-5. *
Devine L, Lightman SL, Greenwood J. Role of LFA-1, ICAM-1, VLA-4 and VCAM-1 in lymphocyte migration across retinal pigment epithelial monolayers in vitro. Immunology. 1996 Jul;88(3):456-62. *
King, F.D. (Ed.), "Bioisosteres, conformational restriction and pro-drugs--case history: an example of a conformational restriction approach," Medical Chemistry: Principles and Practice, 1994, Chapter 14, 206-209. *
Meleth AD, Agrón E, Chan CC, Reed GF, Arora K, Byrnes G, Csaky KG, Ferris FL 3rd, Chew EY. Serum inflammatory markers Diabetologia. 2002 Dec;45(12):1617-34. in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4295-301. *
Nam K1, Maiorov V, Feuston B, Kearsley S. Dynamic control of allosteric antagonism of leukocyte function antigen-1 and intercellular adhesion molecule-1 interaction. Proteins. 2006 Aug 1;64(2):376-84. *
Porta M, Bandello F. Diabetic retinopathyA clinical update.Diabetologia. 2002 Dec;45(12):1617-34. *

Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110124669A1 (en) * 2003-11-05 2011-05-26 Sarcode Corporation Modulators of Cellular Adhesion
US20080182839A1 (en) * 2003-11-05 2008-07-31 Sunesis Pharmaceuticals, Inc. Modulators of cellular adhesion
US20110124625A1 (en) * 2003-11-05 2011-05-26 Sarcode Corporation Modulators of Cellular Adhesion
US8071617B2 (en) 2003-11-05 2011-12-06 Sarcode Bioscience Inc. Modulators of cellular adhesion
US9216174B2 (en) 2003-11-05 2015-12-22 Sarcode Bioscience Inc. Modulators of cellular adhesion
US9248126B2 (en) 2003-11-05 2016-02-02 Sarcode Bioscience Inc. Modulators of cellular adhesion
US20080176896A1 (en) * 2003-11-05 2008-07-24 Wang Shen Modulators of cellular adhesion
US20100093693A1 (en) * 2003-11-05 2010-04-15 Wang Shen Modulators of cellular adhesion
US7745460B2 (en) 2003-11-05 2010-06-29 Sarcode Corporation Modulators of cellular adhesion
US7790743B2 (en) 2003-11-05 2010-09-07 Sarcode Corporation Modulators of cellular adhesion
US7928122B2 (en) 2003-11-05 2011-04-19 Sarcode Corporation Modulators of cellular adhesion
US7989626B2 (en) 2003-11-05 2011-08-02 SAR code Corporation Modulators of cellular adhesion
US9045457B2 (en) 2005-05-17 2015-06-02 Sarcode Bioscience Inc. Compositions and methods for treatment
US8592450B2 (en) 2005-05-17 2013-11-26 Sarcode Bioscience Inc. Compositions and methods for treatment of eye disorders
US9045458B2 (en) 2005-05-17 2015-06-02 Sarcode Bioscience Inc. Compositions and methods for treatment
US8771715B2 (en) 2005-05-17 2014-07-08 Sarcode Bioscience Inc. Compositions and methods for treatment
US8758776B2 (en) 2005-05-17 2014-06-24 Sarcode Bioscience Inc. Compositions and methods for treatment
US9051297B2 (en) 2005-05-17 2015-06-09 Sarcode Bioscience Inc. Compositions and methods for treatment
US10188641B2 (en) 2005-05-17 2019-01-29 Sarcode Bioscience Inc. Compositions and methods for treatment
US20060281739A1 (en) * 2005-05-17 2006-12-14 Thomas Gadek Compositions and methods for treatment of eye disorders
US8168655B2 (en) 2005-05-17 2012-05-01 Sarcode Bioscience Inc. Compositions and methods for treatment of eye disorders
US8084047B2 (en) 2005-05-17 2011-12-27 Sarcode Bioscience Inc. Compositions and methods for treatment of eye disorders
US10960087B2 (en) 2007-10-19 2021-03-30 Novartis Ag Compositions and methods for treatment of diabetic retinopathy
US8080562B2 (en) 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US8367701B2 (en) 2008-04-15 2013-02-05 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US20090257957A1 (en) * 2008-04-15 2009-10-15 John Burnier Aerosolized LFA-1 antagonists for use in localized treatment of immune related disorders
US20090258069A1 (en) * 2008-04-15 2009-10-15 John Burnier Delivery of LFA-1 antagonists to the gastrointestinal system
US20090258070A1 (en) * 2008-04-15 2009-10-15 John Burnier Topical LFA-1 antagonists for use in localized treatment of immune related disorders
US20090298869A1 (en) * 2008-04-15 2009-12-03 John Burnier Crystalline pharmaceutical and methods of preparation and use thereof
US11028077B2 (en) 2008-04-15 2021-06-08 Novartis Pharmaceuticals Corporation Crystalline pharmaceutical and methods of preparation and use thereof
US8871935B2 (en) 2008-04-15 2014-10-28 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US8378105B2 (en) 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US9353088B2 (en) * 2009-10-21 2016-05-31 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US8927574B2 (en) 2009-10-21 2015-01-06 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US20110092707A1 (en) * 2009-10-21 2011-04-21 Sarcode Corporation Crystalline Pharmaceutical and Methods of Preparation and Use Thereof
US9890141B2 (en) 2009-10-21 2018-02-13 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US20110104206A1 (en) * 2009-10-30 2011-05-05 Intratus, Inc. Methods and compositions for sustained delivery of drugs
US20110104083A1 (en) * 2009-10-30 2011-05-05 Intratus, Inc. Methods and cosmetic preparations for the sustained delivery of therapeutic agents to the eye
US9034830B2 (en) 2009-10-30 2015-05-19 Intratus, Inc. Methods and compositions for sustained delivery of drugs
US20110189174A1 (en) * 2010-02-01 2011-08-04 Afshin Shafiee Compositions and methods for treating, reducing, ameliorating, alleviating, or inhibiting progression of, pathogenic ocular neovascularization
US20110281901A1 (en) * 2010-05-05 2011-11-17 Glaxo Wellcome Manufacturing Pte Ltd. Pharmaceutical compositions and methods of making same
US10751316B2 (en) 2012-06-05 2020-08-25 Olatec Therapeutics Llc Pharmaceutical composition for treating inflammation and pain
US20130324603A1 (en) * 2012-06-05 2013-12-05 Olatec Industries Llc Pharmaceutical composition for treating inflammation and pain
US9085553B2 (en) 2012-07-25 2015-07-21 SARcode Bioscience, Inc. LFA-1 inhibitor and methods of preparation and polymorph thereof
US10214517B2 (en) 2012-07-25 2019-02-26 Sarcode Bioscience Inc. LFA-1 inhibitor and methods of preparation and polymorph thereof
US10906892B2 (en) 2012-07-25 2021-02-02 Novartis Pharmaceuticals Corporation LFA-1 inhibitor and methods of preparation and polymorph thereof
US11018173B2 (en) 2018-06-18 2021-05-25 Samsung Electronics Co., Ltd. Image sensor
US11753382B2 (en) 2019-06-25 2023-09-12 Translatum Medicus Inc. Processes of making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives

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