US20070081950A1 - Solid oral tooth whitening confectionary composition - Google Patents

Solid oral tooth whitening confectionary composition Download PDF

Info

Publication number
US20070081950A1
US20070081950A1 US10/582,223 US58222303A US2007081950A1 US 20070081950 A1 US20070081950 A1 US 20070081950A1 US 58222303 A US58222303 A US 58222303A US 2007081950 A1 US2007081950 A1 US 2007081950A1
Authority
US
United States
Prior art keywords
composition
composition according
weight
agents
tooth whitening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/582,223
Other languages
English (en)
Inventor
Edith Sorensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gumlink AS
Original Assignee
Cadbury Schweppes Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadbury Schweppes Ltd filed Critical Cadbury Schweppes Ltd
Assigned to CADBURY SCHWEPPES PLC reassignment CADBURY SCHWEPPES PLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SORENSEN, EDITH TROST
Publication of US20070081950A1 publication Critical patent/US20070081950A1/en
Assigned to CADBURY HOLDING LIMITED reassignment CADBURY HOLDING LIMITED CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: CADBURY SCHWEPPES LIMITED
Assigned to CADBURY SCHWEPPES LIMITED reassignment CADBURY SCHWEPPES LIMITED CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: CADBURY SCHWEPPES PUBLIC LIMITED COMPANY
Assigned to CADBURY HOLDINGS LIMITED reassignment CADBURY HOLDINGS LIMITED CORRECTIVE ASSIGNMENT TO CORRECT THE NAME OF THE ASSIGNEE PREVIOUSLY RECORDED ON REEL 021631 FRAME 0646. ASSIGNOR(S) HEREBY CONFIRMS THE NAME OF THE ASSIGNEE IDENTIFIED AS CADBURY HOLDINGS LIMITED. Assignors: CADBURY SCHWEPPES LIMITED
Assigned to MONDELEZ UK HOLDINGS & SERVICES LIMITED reassignment MONDELEZ UK HOLDINGS & SERVICES LIMITED CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: CADBURY HOLDINGS LIMITED
Assigned to GUMLINK A/S reassignment GUMLINK A/S ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MONDELEZ UK HOLDINGS & SERVICES LIMITED
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the invention relates to solid, oral tooth whitening compositions.
  • the invention further relates to the use of such compositions to whiten tooth surfaces.
  • Tooth whitening or stain removing agents are known to be added to dentifrice compositions such as toothpaste, mouthwash, chewing gum, confectionary compositions and the like.
  • dentifrice compositions such as toothpaste, mouthwash, chewing gum, confectionary compositions and the like.
  • the use of such compositions for reducing stains and discolouration of tooth surfaces thereby improving the general cosmetic appearance of the teeth is likewise well-known.
  • Teeth with extrinsic stains are objectionable both on the basis of cosmetic appearance and also socially as indication of poor oral hygiene.
  • Another approach to tooth whitening products is to add abrasives—known mainly from dentifrices. Not all of these are legal in confectionary.
  • abrasive agents have been used for tooth whitening purposes and these are known to the person skilled in the art.
  • abrasive agents include calcium carbonate, sodium bicarbonate, sodium metaphosphate, potassium metaphosphate, tricalcium phosphate, dihydrated dicalcium phosphate, bentonite, zirconium silicate or other siliceous materials.
  • Other suitable abrasives are described in U.S. Pat. No. 4,170,633 and U.S. Pat. No. 4,891,211, incorporated herein by reference.
  • US Patent Application US 2002/0142068 discloses chewing gum formulations including sodium pyrophosphate and encapsulated aspartame.
  • U.S. Pat. No. 4,233,288 discloses a gum emulsified liquid composition for delivering and preserving the liquid content in the mouth.
  • the herein disclosed examples describe a gum emulsified liquid composition comprising 5% of calcium pyrophosphate and more than 50% of liquid components.
  • U.S. Pat. No. 3,590,120 discloses a chewing gum comprising a polishing agent comprising a mixture of fine and coarse zirconium silicate particles.
  • a polishing agent comprising a mixture of fine and coarse zirconium silicate particles.
  • reference chewing gum compositions containing 10% of calcium pyrophosphate or 10% of calcium carbonate, respectively. The cleaning/polishing effects of said compositions are shown to decrease in the order ZrSiO 4 , CaCO 3 and CaP 2 O 7 .
  • zirconium silicate Attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite, Int. J Toxicol. 2003; 22 Suppl. 1:37-102) and the use of zirconium compounds in solid oral compositions is prohibited in a number of countries.
  • the present invention relates to a solid, oral tooth whitening composition comprising more than 75% by weight of solid materials, said composition comprising:
  • the present invention relates to the use of a composition according to the present invention to whiten tooth surfaces.
  • the present invention relates to a method of whitening tooth surfaces.
  • FIG. 1 shows the release percentage as a function of time for calcium carbonate and calcium pyrophosphate, respectively, present in a chewing gum composition.
  • solid, oral tooth whitening compositions are intended to comprise a recommended daily dose of tooth whitening agent of about 40 to 700 mg.
  • this dose may be divided into multiple sub-doses, such as 8 units of the composition, each unit weighing approximately 900-1000 mg, excluding any coating.
  • a content of 0.5% to 9% of tooth whitening agent corresponds to a composition unit content of approximately 4.5 to 90 mg of tooth whitening agent.
  • compositions of the invention are essentially solid and comprise more than 75%, preferably more than 85%, even more preferably more than 95%, by weight of the composition of solid materials.
  • calcium pyrophosphate is present in an amount of between 3% and 8%, preferably between 4.5% and 7.5%, even more preferably between 5.5% and 7%, by weight of the composition, respectively, excluding any coating.
  • the composition according to the invention may be formulated as a chewing gum composition, said chewing gum composition preferably comprising a gum base constituting from 10% to 99%, particularly from 15% to 80%, preferably 25% to 60% by weight of the composition.
  • a gum base refers in general to the water insoluble part of the chewing gum.
  • Chewing gum base formulations typically comprise one or more elastomeric compounds which may be of synthetic or natural origin, one or more resin compounds which may be of synthetic or natural origin, fillers, softening compounds and minor amounts of miscellaneous ingredients such as antioxidants and colorants, etc.
  • useful synthetic elastomers include, but are not limited to, synthetic elastomers listed in Food and Drug Administration, CFR, Title 21, Section 172,615, the Masticatory Substances, Synthetic) such as polyisobutylene with a gas pressure chromatography (GPC) average molecular weight in the range of about 10,000 to about 1,000,000 including the range of 50,000 to 80,000, isobutylene-isoprene copolymer (butyl elastomer), styrene-butadiene copolymers e.g.
  • styrene-butadiene ratios of about 1:3 to about 3:1, polyisoprene, polyethylene, vinyl acetate-vinyl laurate copolymer e.g. having a vinyl laurate content of about 5 to about 50% by weight such as 10 to 45% by weight of the copolymer, and combinations hereof.
  • Useful natural non-degradable elastomers include the elastomers listed in Food and Drug Administration, CFR, Title 21, Section 172,615, as “Masticatory Substances of Natural Vegetable Origin” including natural rubber compounds such as smoked or liquid latex and guayule and other natural gums including jelutong, lechi caspi, massaranduba balata, sorva, perillo, rosindinha, massaranduba chocolate, chicle, nispero, gutta hang kang, and combinations thereof.
  • the preferred synthetic elastomer and natural elastomer concentrations vary depending on whether the chewing gum in which the base is used is adhesive or conventional, bubble gum or regular gum.
  • Presently preferred natural elastomers include jelutong, chicle, massaranduba balata and sorva.
  • Resin in conventional chewing gum bases typically include synthetic resins such as poly(vinyl acetate) (PVAc) and natural resins such as rosin esters which are often referred to as ester gums. Additionally, natural resins such as glycerol esters of partially hydrogenated rosins, glycerol esters of polymerised rosins, glycerol esters of partially dimerised rosins, glycerol esters of tally oil rosins, pentaerythritol esters of partially hydrogenated rosins, methyl esters of rosins, partially hydrogenated methyl esters of rosins and pentaerythritol esters of rosins are typically applied in chewing gum bases.
  • Other resinous compounds typically applied in chewing gum bases indclude synthetic resins such as terpene resins derived from alpha-pinene, beta-pinene, and/or d-limonene and natural terpene resins
  • a chewing gum base formulation may, if desired, include one or more fillers/texturisers including as examples, magnesium and calcium carbonate, sodium sulphate, ground limestone, silicate compounds such as magnesium and aluminium silicate, kaolin and clay, aluminium oxide, silicium oxide, talc, titanium oxide, mono-, di- and tri-calcium phosphates, cellulose polymers, such as wood, and combinations thereof.
  • fillers/texturisers including as examples, magnesium and calcium carbonate, sodium sulphate, ground limestone, silicate compounds such as magnesium and aluminium silicate, kaolin and clay, aluminium oxide, silicium oxide, talc, titanium oxide, mono-, di- and tri-calcium phosphates, cellulose polymers, such as wood, and combinations thereof.
  • a gum base formulation may, in accordance with the present invention comprise one or more softening agents e.g. sucrose polyesters including those disclosed in WO 00/25598, which is incorporated herein by reference, tallow, hydrogenated tallow, hydrogenated and partially hydrogenated vegetable oils, cocoa butter, glycerol monostearate, glycerol triacetate, lecithin, mono-, di- and triglycerides, acetylated monoglycerides, fatty acids (e.g. stearic, palmitic, oleic and linoleic acids), and combinations thereof.
  • softener designates an ingredient, which softens the gum base or chewing gum formulation and encompasses waxes, fats, oils, emulsifiers, surfactants and solubilisers.
  • one or more emulsifiers is/are usually added to the composition, typically in an amount of 0 to 18% by weight, preferably 0 to 12% by weight of the gum base.
  • Mono- and diglycerides of edible fatty acids, lactic acid esters and acetic acid esters of mono- and diglycerides of edible fatty acids, acetylated mono and diglycerides, sugar esters of edible fatty acids, Na—, K—, Mg— and Ca-stearates, lecithin, hydroxylated lecithin and the like are examples of conventionally used emulsifiers which can be added to the chewing gum base.
  • the formulation may comprise certain specific emulsifiers and/or solubilisers in order to disperse and release the active ingredient.
  • Waxes and fats are conventionally used for the adjustment of the consistency and for softening of the chewing gum base when preparing chewing gum bases.
  • any conventionally used and suitable type of wax and fat may be used, such as for instance rice bran wax, polyethylene wax, petroleum wax (refined paraffin and microcrystalline wax), paraffin, bees' wax, carnauba wax, candelilla wax, cocoa butter, degreased cocoa powder and any suitable oil or fat, as e.g. completely or partially hydrogenated vegetable oils or completely or partially hydrogenated animal fats.
  • the gum base is wax-free.
  • the gum base formulation may, in accordance with the present invention, comprise colourants and whiteners such as FD&C-type dyes and lakes, fruit and vegetable extracts, titanium dioxide and combinations thereof.
  • Further useful chewing gum base components include antioxidants, e.g. butylated hydroxytoluene (BHT), butyl hydroxyanisol (BHA), propylgallate and tocopherols, and preservatives.
  • composition of chewing gum base formulations which are admixed with chewing gum additives as defined below can vary substantially depending on the particular product to be prepared and on the desired masticatory and other sensory characteristics of the final product.
  • typical ranges (weight %) of the above gum base components are: 5 to 50% by weight elastomeric compounds, 5 to 55% by weight elastomer plasticizers, 0 to 50% by weight filler/texturiser, 5 to 35% by weight softener and 0 to 1% by weight of miscellaneous ingredients such as anti-oxidants, colorants, etc.
  • Chewing gum compositions may be formulated as sticks or pellets, and may be coated with a suitable coating. Concentrations given throughout this disclosure are based on weight excluding coating unless specifically indicated.
  • compositions of the invention are formulated as confectionary compositions comprising a confectionary base, said confectionary base preferably comprising from 0% to 99%, particularly from 15% to 98%, preferably 30% to 97% by weight of the composition.
  • confectionary compositions according to the invention include high boiling, grained sugar confectionary, chocolate, compressed tablets, gummy confectionary and jellies.
  • compositions comprised by the present invention may also contain one or more conventional additives such as sweeteners, high intensity sweeteners, taste enhancers, flavouring agents and the like.
  • Sweeteners, high intensity sweeteners and taste enhancers are well known to the skilled person.
  • Non-limiting examples of sweeteners comprise sugar sweeteners including saccharides such as sucrose, dextrose, glucose, maltose, dextrins, D-tagatose, trehalose, dried invert sugar, fructose, levulose, galactose, corn syrup solids, and the like, alone or in combination.
  • sweeteners comprise sugarless sweeteners including polyhydric alcohols such as sorbitol, mannitol, xylitol, glycerol, hydrogenated starch hydrolysates, maltitol, isomaltitol, erythritol, lactitol and the like, alone or in combination. Sugarless sweeteners are preferred.
  • Preferred high intensity sweeteners include but are not limited to sucralose, aspartame, salts of acesulfame, alitame, saccharin or salts herof, neotame, cyclamic acid and salts thereof, glycyrrhizin, dihydrochalcones thaumatin, monnelin, sterioside and the like, alone or in combination.
  • flavours known in the art may be used, such as cinnamon, wintergreen, eucalyptus, spearmint, peppermint, menthol, anise as well as fruit flavours such as apple, pear, peach, strawberry, cherry, apricot, orange, watermelon, banana and the like; bean-derived flavours, such as coffee, cocoa and the like.
  • Flavouring agents are incorporated in the chewing gum formulation at a concentration of about 0.5 to about 5% by weight and preferably 1 to 3% by weight.
  • compositions of the invention may or may not contain sugar.
  • Sugar-free compositions are preferred.
  • additional tooth whitening agents may be included.
  • additional tooth whitening agents are well known in the art and include abrasives as well as bleaching agents.
  • Abrasive materials comprise as non-limiting examples silica, alumina, calcium carbonate, dicalcium phosphate, hydroxyapatite, trimetaphosphates and insoluble hexametaphosphates.
  • Bleaching agents comprise agents such as peroxy compounds, e.g. potassium peroxydiphosphate and urea-peroxid.
  • Effervescing systems such as sodium bicarbonate, alone or in combination with citric acid as well as colour change systems may also be incorporated into compositions comprised by the present invention.
  • said additional whitening agents are usually present in between 0.01% and 10.0%, preferably between 0.1 and 2.0%, more preferably between 0.25% and 1.0% by weight of the composition, excluding any coating.
  • a preferred additional tooth whitening agent comprises a bicarbonate salt.
  • said bicarbonate salt comprises sodium bicarbonate in an amount of between 0.3% and 0.4% by weight of the compositions excluding any coating.
  • a range of active agents may be added to the compositions of the invention.
  • Such agents may comprise one or more of the following; oral hygiene promoting agents, anti-calculus agents, anti-microbial agents, anti-inflammatory agents, desensitising agents, therapeutically active agents, remineralising agents.
  • Non-limiting examples comprise anti-caries agents such as sodium, calcium, magnesium and stannous fluoride, amine fluorides, disodium monofluorophosphate, sodium trimetaphosphate and casein; antimicrobial agents, e.g.
  • Triclosan chlorhexidine, copper, zinc and stannous salts such as zinc citrate, zinc sulphate, zinc glycinate, sodium zinc citrate and stannous pyrophosphate, sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; bis-guanides, such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; and halogenated bisphenolic compounds, such as 2,2′ methylenebis-(4-chloro-6-bromophenol); anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc.; plaque acid buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates; desensitising agents, e.g.
  • Other agents which may be incorporated in the chewable compositions of the present invention are agents to counter breath malodour and include water soluble zinc salts (at least 1% soluble) particularly zinc chloride, zinc acetate, zinc citrate and zinc gluconate.
  • the additives, the whitening agents and the optional active agents comprised by the present invention may be encapsulated. This may be done in order to achieve a slow release of the encapsulated agents upon entering the oral environment. For example, a longer lasting sweetening of the compounds comprised by the present invention may be achieved by encapsulating the sweetening agents. A longer release time of the whitening agents as well as any therapeutic compound may likewise be achieved.
  • Another advantage of encapsulating the agents comprised by the invention may be to obtain an increased stability of the agents, thus lending a longer storage life at a greater range of storage conditions to the compositions of the invention.
  • Suitable methods include, but are not limited to, spray drying, spray chilling, fluid-bed coating, and coacervation. These methods can be used individually or in any combination in a single step process or multiple step process.
  • compositions of high organic solubility, good film forming properties, and low water solubility provide a suitable encapsulation.
  • These compositions include acrylic polymers and copolymers, carboxyvinyl polymers, polyamides, polystyrene, polyvinyl acetate, polyvinyl acetate phthalate, polyvinyl pyrrolidine, and waxes.
  • Two standard food grade coating materials which are good formers, but not water soluble, are shellac and Zein. Others which are more water soluble, but also good film formers, are materials such as agar, alginates, a wide range of cellulose derivatives like ethyl cellulose and hydroxypropylmethyl cellulose, dextrin, gelatin and modified starches. It is also possible to use other encapsulants like acacia or maltodextrin for encapsulation.
  • Vitamins are preferably added in concentrations of between 10%-100% of the recommended daily allowance (RDA).
  • Especially vitamin C may be added to the compositions of the invention.
  • urea may be added as a plaque acid neutralising agent.
  • urea is added to chewable compositions in between 0.15% and 25%, particularly between 0.4% and 10%, preferably between 0.8% and 5.0%, even more preferably between 1.5% and 2.5% by weight.
  • the present invention relates to the use of the compositions of the invention to whiten tooth surfaces and/or prevent discolouration of tooth surfaces.
  • the compositions of the invention may be used to remove or prevent discolouration of teeth due to the use of tobacco-related products and/or coffee-related products.
  • compositions are based on a standard chewing gum composition in addition to the specified ingredients.
  • the standard chewing gum composition used herein consists essentially of the following ingredients: Gum base 29.64% Sweeteners 60.98% High intensity sweeteners 0.12% Flavours 1.80% Buffers/stabilizer 2.28% Softeners 0.07% Colourants 0.35%
  • the experiments were conducted using a modification of the laboratory method described by Stookey, G K: Burkhart, T. A: and Schemehom, B. R; In vitro removal of stain with dentifrices, J Dent Res 61(11):1236-1239, November 1982, which has been shown to correlate with the cleaning/whitening properties of dentrifrices in clinical trials.
  • the general experimental design consists of the use of a specially designed mechanical mastication device to treat stained teeth with the test chewing gums (Kleber, C J; Schimmele R G, Putt, M S, Muhler J C: A mastication device designed for the evaluation of chewing gums, J Dent Res 60: 109-114, 1981).
  • the amount of stain on the teeth before and after treatment is measured quantitatively using a colorimeter.
  • Example 1 The chewing gum compositions disclosed in Example 1 were assayed for the effect on the inhibition of extrinsic stain formation on tooth surfaces.
  • the experiments were conducted using a special laboratory method that has been developed to determine the potential of chewing gum to inhibit the formation of dental stains and maintain white teeth. This method is based on a model that is used to evaluate the tooth whitening properties of toothpastes and is predictive of findings in human clinical studies.
  • the general experimental design consists of the use of a specially designed mechanical mastication device to treat teeth with chewing gum while they undergo a daily staining process (Kleber, C J; Schimmele R G, Putt, M S, Muhler J C: A mastication device designed for the evaluation of chewing gums, J Dent Res 60: 109-114). The amount of stain which accumulates on the teeth is measured quantitatively using a colorimeter.
  • Standard chewing gum compositions were assayed for the effect on the removal of stains on tooth surfaces, said compositions containing, by weight of the core, excluding any coating, 6.5% of calcium pyrophosphate and 0.38% of sodium bicarbonate, 4.5% of calcium carbonate and 0.38% of sodium bicarbonate, 0.38% of sodium bicarbonate and a no gum control, respectively.
  • a group of test persons were divided into four test groups and instructed to chew 2 pieces of chewing gum compositions as specified above, 4 times per day, each for 15 minutes, and allowed one brush per day (morning) with an assigned brush and dentrifrice.
  • the test persons were then examined by persons skilled in the art using the modified lobene stain index (MLSI), well known to the person skilled in the art.
  • MLSI modified lobene stain index
  • Tables 4 and 5 show the results from the above mentioned clinical trials in per cent of stains removed after 8 weeks of treatment presented for different areas of the teeth.
  • the total (column 3) shows the total removal of stains whereas the remaining columns specify the percentage of removed stain on specific teeth areas.
  • TABLE 6 Whitening agent N Baseline Week 4 Week 8 6.5% CaP 2 O 7 + 11 4.06 ⁇ 1.22 2.71 ⁇ 0.33 a 2.01 ⁇ 0.34 a 0.38% NaHCO 3 4.5% CaCO 3 + 11 3.95 ⁇ 0.98 2.89 ⁇ 0.33 a 2.63 ⁇ 0.34 a,b 0.38% NaHCO 3 0.38% NaHCO 3 17 3.85 ⁇ 1.18 3.12 ⁇ 0.26 a 3.09 ⁇ 0.27 b No gum control 15 3.65 ⁇ 1.43 2.73 ⁇ 0.28 a 2.52 ⁇ 0.29 a,b
  • FIG. 1 The result is shown in FIG. 1 . It is shown that within 5 minutes more than 80% of calcium pyrophosphate is released from the composition whereas less than 20% of calcium carbonate is released after more than 15 min. of chewing the two otherwise identical chewing gum compositions.
  • This non-limiting example discloses the inventive composition formulated as a confectionary composition, wherein the sweeteners constitute the confectionary base.
  • the composition is based on a standard confectionary composition in addition to the specified tooth whitening agent comprising calcium pyrophosphate.
  • the standard confectionary composition used herein consists essentially of the following ingredients: Sweeteners 97.49% High intensity sweeteners 0.13% Flavours 0.18% Sodium bicarbonate 0.12% Calcium pyrophosphate 2.08%

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)
  • Confectionery (AREA)
US10/582,223 2003-12-08 2003-12-08 Solid oral tooth whitening confectionary composition Abandoned US20070081950A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2003/013873 WO2005058263A1 (fr) 2003-12-08 2003-12-08 Composition orale solide de blanchiment des dents

Publications (1)

Publication Number Publication Date
US20070081950A1 true US20070081950A1 (en) 2007-04-12

Family

ID=34684482

Family Applications (2)

Application Number Title Priority Date Filing Date
US10/582,223 Abandoned US20070081950A1 (en) 2003-12-08 2003-12-08 Solid oral tooth whitening confectionary composition
US10/582,079 Expired - Fee Related US8388938B2 (en) 2003-12-08 2004-12-08 Solid oral tooth whitening confectionary composition

Family Applications After (1)

Application Number Title Priority Date Filing Date
US10/582,079 Expired - Fee Related US8388938B2 (en) 2003-12-08 2004-12-08 Solid oral tooth whitening confectionary composition

Country Status (11)

Country Link
US (2) US20070081950A1 (fr)
EP (2) EP1691770A1 (fr)
JP (2) JP2007515382A (fr)
KR (1) KR20120102817A (fr)
CN (2) CN1878526B (fr)
AU (2) AU2003294811A1 (fr)
BR (2) BR0318646A (fr)
CA (2) CA2547329A1 (fr)
MX (1) MXPA06006424A (fr)
RU (2) RU2006124548A (fr)
WO (2) WO2005058263A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100015068A1 (en) * 2006-07-06 2010-01-21 Massachusetts Institute Of Technology Methods and Compositions For Altering Biological Surfaces
US8388938B2 (en) 2003-12-08 2013-03-05 Cadbury Holdings Limited Solid oral tooth whitening confectionary composition
RU2580636C1 (ru) * 2014-12-23 2016-04-10 Аркадий Анатольевич Козлов Порошковая композиция для профессиональной гигиены полости рта и способ её использования
WO2017194901A1 (fr) * 2016-05-13 2017-11-16 Bochenek Stéphane Gel de blanchiment sans peroxydes

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070237729A1 (en) 2006-04-05 2007-10-11 Cadbury Adams Usa, Llc. Impact of calcium phosphate complex on dental caries
ES2619161T3 (es) 2006-04-05 2017-06-23 Intercontinental Great Brands Llc Complejo de fosfato de calcio y sales en sistemas de suministro oral
US8133475B2 (en) 2006-04-05 2012-03-13 Cadbury Adams Usa, Llc Calcium phosphate complex in acid containing chewing gum
IL183818A0 (en) 2007-06-10 2007-10-31 Shimon Harpaz Uniformly abrasive confectionery product and process therefor
SE534627C2 (sv) * 2010-02-17 2011-11-01 Swedish Match North Europe Ab Orala rökfria tobaksprodukter och orala rökfria icke tobaksinnehållande snusprodukter innehållande karbamid
CN103140214B (zh) * 2010-10-01 2015-09-23 宝洁公司 具有改善甜味的口腔护理组合物
US20140105948A1 (en) * 2011-04-21 2014-04-17 Intercontinental Great Brands Llc Stability of peroxide in oral care compostions
RU2670443C2 (ru) 2014-07-21 2018-10-23 Колгейт-Палмолив Компани Абразивная композиция для ухода за полостью рта
WO2019084255A1 (fr) * 2017-10-26 2019-05-02 Reynoso Bernardino Compositions de soins bucco-dentaires et leurs procédés d'utilisation
CN111436520A (zh) * 2019-01-16 2020-07-24 南昌登特科技有限公司 一种用于牙齿增白的口香糖
CH718673A1 (fr) * 2021-05-28 2022-11-30 Vixelia Compositions de soins bucco-dentaires.

Citations (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2876167A (en) * 1954-11-24 1959-03-03 Colgate Palmolive Co Fluoride dentifrice stabilized by a water-soluble acid phosphate compound
US3590120A (en) * 1969-04-16 1971-06-29 Indiana University Foundation Chewing gum
US3897548A (en) * 1973-04-09 1975-07-29 Indiana University Foundation Oral compositions for retarding the formation of dental plaque and methods of utilization thereof
US3928618A (en) * 1972-04-10 1975-12-23 Colgate Palmolive Co Oral compositions
US3957967A (en) * 1973-07-27 1976-05-18 Blendax-Werke R. Schneider & Co. Agent for the care and the cleaning of teeth and dentures
US3989814A (en) * 1975-01-28 1976-11-02 Colgate-Palmolive Company Calcium pyrophosphate abrasive system for dentifrice
US4170633A (en) * 1977-11-28 1979-10-09 General Mills, Inc. Plaque inhibiting composition and method
US4233288A (en) * 1979-03-12 1980-11-11 Cornell John A Gum emulsified liquid package for delivering and preserving liquid content in the mouth
US4400372A (en) * 1981-03-05 1983-08-23 Indiana University Foundation Chewing gum
US4627977A (en) * 1985-09-13 1986-12-09 Colgate-Palmolive Company Anticalculus oral composition
US4806340A (en) * 1985-09-13 1989-02-21 Colgate-Palmolive Company Anticalculus oral composition
US4891211A (en) * 1988-06-29 1990-01-02 Church & Dwight Co., Inc. Stable hydrogen peroxide-releasing dentifice
US4975270A (en) * 1987-04-21 1990-12-04 Nabisco Brands, Inc. Elastomer encased active ingredients
US5147632A (en) * 1990-10-31 1992-09-15 Warner-Lambert Company Anti-plaque compositions comprising a combination of morpholinoamino alcohol and chelating agent
US5156845A (en) * 1990-05-04 1992-10-20 Colgate-Palmolive Company Dry mouth lozenge
US5470566A (en) * 1985-05-10 1995-11-28 Fertin Laboratories A/S (Dansk Tyggegummi Fabrik A/S) Solid oral anticariogenic composition
US5496541A (en) * 1993-01-19 1996-03-05 Pilot Research & Development Co. Tasteful toothpaste and other dental products
US5851514A (en) * 1995-09-26 1998-12-22 Colgate Palmolive Company Stable aqueous abrasive peroxide tooth whitening dentifrice
US5861169A (en) * 1994-04-22 1999-01-19 Dibona Holding Ag Hard candy with tooth plaque-neutralizing effect comprising an ammonium salt
US6174516B1 (en) * 1999-02-16 2001-01-16 Colgate-Palmolive Company Method to enhance peroxide tooth whitening
US6294154B1 (en) * 1994-12-22 2001-09-25 Procter And Gamble Company Oral compositions containing dimethicone copolyols
US6294155B1 (en) * 1998-04-08 2001-09-25 W. R. Grace & Co. -Conn. Abrasive silica compositions and dentifrice compositions prepared therefrom
US6331291B1 (en) * 1996-05-30 2001-12-18 William R. Glace Dentifrice gel/paste compositions
US6355229B1 (en) * 2001-06-27 2002-03-12 Church & Dwight Co., Inc. Oral composition containing cetylpyridinium chloride and guar hydroxypropyltrimonium chloride and method of using the same
US20020061282A1 (en) * 2000-10-11 2002-05-23 Constantine Georgiades Tooth whitening composition and method employing dicarboxylic acid whitening agent
US6416744B1 (en) * 2001-06-21 2002-07-09 Colgate Palmolive Company Tooth whitening chewing gum
US20020142068A1 (en) * 2000-09-12 2002-10-03 Savage William D. Chewing gum formulations including encapsulated aspartame and sodium pyrophosphate
US20020187108A1 (en) * 2001-03-19 2002-12-12 Jayanth Rajaiah Oral care kits and compositions
US6500406B1 (en) * 2001-03-19 2002-12-31 The Procter & Gamble Company Denture care compositions and kits
US20030068282A1 (en) * 2001-08-24 2003-04-10 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Composition
US20030068283A1 (en) * 2001-08-24 2003-04-10 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Composition
US20030072722A1 (en) * 2001-08-02 2003-04-17 Nathoo Salim A. Tooth whitening hydrogels
US20030072841A1 (en) * 2001-03-19 2003-04-17 The Procter & Gamble Campany Polybutene containing chewing gum and confection
US20030082112A1 (en) * 2001-08-24 2003-05-01 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Composition
US20030099740A1 (en) * 2000-04-26 2003-05-29 Roberto Colle Chewing gum containing encapsulated abrasive filler substance
US6682722B2 (en) * 2001-09-19 2004-01-27 The Procter & Gamble Company Oral compositions providing enhanced overall cleaning
US6685916B1 (en) * 2002-10-31 2004-02-03 Cadbury Adams Usa Llc Compositions for removing stains from dental surfaces, and methods of making and using the same
US6703000B2 (en) * 2001-05-15 2004-03-09 The Procter & Gamble Co. Confectionery compositions
US6926916B1 (en) * 1999-11-12 2005-08-09 The Procter & Gamble Company Chewing gum compositions
US20070190086A1 (en) * 2003-12-08 2007-08-16 Edith Sorensen Solid oral tooth whitening confectionary composition

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB234870A (en) 1924-02-08 1925-06-08 Karl Oskar Leon Improvements in and relating to advertising devices
DE1250970B (de) * 1961-11-29 1967-09-28 UNILEVER NV, Rotterdam (Niederlande) , Oscar Walter Neiditch Fair Lawn NJ (V St A) I Zahnremigungsmittel
US3511914A (en) * 1967-01-31 1970-05-12 Schering Corp Throat lozenge vehicle
CA1243959A (fr) * 1983-03-14 1988-11-01 Anthony Winston Poudre a dents contenant du bicarbonate de sodium
JPS61180710A (ja) * 1985-02-05 1986-08-13 Kazuhiko Suzuki チユ−インガム
JPS61225115A (ja) * 1985-03-29 1986-10-06 Lion Corp ２重カプセル及び該カプセルを含有する口腔用組成物
DE3645147C2 (de) * 1985-09-13 2000-11-09 Colgate Palmolive Co Zahnpflegemittel
US4765984A (en) * 1986-01-22 1988-08-23 Colgate-Palmolive Company Stable single unit dose oral product
DK111187D0 (da) * 1986-03-05 1987-03-04 Monsanto Co Tandbehandlingsmiddel
AU2090488A (en) 1987-08-28 1989-03-02 Avantgarde S.P.A. Chewing gum having antitartar activity
JP2580661B2 (ja) 1987-12-26 1997-02-12 ライオン株式会社 口腔用組成物
MX170421B (es) 1988-11-15 1993-08-20 Colgate Palmolive Co Mejoras a composicion oral antibacterial
US5079868A (en) * 1990-06-25 1992-01-14 Union Oil Company Of California Plant treatment with urea peroxide
GB9425939D0 (en) * 1994-12-22 1995-02-22 Procter & Gamble Oral composition
EP0736544B1 (fr) * 1995-04-05 2001-10-24 Unilever Plc Compositions poursoins buccaux
MX9504922A (es) * 1995-11-27 1997-05-31 Jorge Isaac Tame Said Dentifrico y enjuague bucal en pastillas.
AU9300998A (en) * 1997-09-09 1999-03-29 Smithkline Beecham Corporation Tooth whitening preparations
US6350438B1 (en) * 1998-02-27 2002-02-26 The Procter & Gamble Company Oral care compositions comprising chlorite and methods
WO2000025598A1 (fr) 1998-11-03 2000-05-11 Dandy A/S Esters d'acide gras de saccharose prevus pour augmenter la liberation d'ingredients actifs
JP4267830B2 (ja) 1999-03-25 2009-05-27 キャドバリー・アダムズ・ユーエスエイ・エルエルシー 口内保護チューインガムおよび糖菓
GB2348370A (en) * 1999-03-30 2000-10-04 Gerwyn Tudor Hodges Chewing gum for oral hygiene containing magnesium trisilicate
WO2001056399A1 (fr) 2000-02-04 2001-08-09 The Procter & Gamble Company Compositions de chewing-gum
WO2002019834A1 (fr) 2000-09-01 2002-03-14 Wm. Wrigley Jr. Company Gomme a macher enrobee
WO2002074409A1 (fr) 2001-03-21 2002-09-26 Heco Filtration A/S Systeme filtrant
JP4762429B2 (ja) * 2001-04-03 2011-08-31 日本ゼトック株式会社 口腔用組成物
ITMI20012322A1 (it) * 2001-11-06 2003-05-06 Perfetti Van Melle Spa Composizioni orali solide anti-tartaro e anti-placca batterica, utilicome coadiuvanti nell'igiene odont-stomatologica

Patent Citations (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2876167A (en) * 1954-11-24 1959-03-03 Colgate Palmolive Co Fluoride dentifrice stabilized by a water-soluble acid phosphate compound
US3590120A (en) * 1969-04-16 1971-06-29 Indiana University Foundation Chewing gum
US3928618A (en) * 1972-04-10 1975-12-23 Colgate Palmolive Co Oral compositions
US3897548A (en) * 1973-04-09 1975-07-29 Indiana University Foundation Oral compositions for retarding the formation of dental plaque and methods of utilization thereof
US3957967A (en) * 1973-07-27 1976-05-18 Blendax-Werke R. Schneider & Co. Agent for the care and the cleaning of teeth and dentures
US3989814A (en) * 1975-01-28 1976-11-02 Colgate-Palmolive Company Calcium pyrophosphate abrasive system for dentifrice
US4170633A (en) * 1977-11-28 1979-10-09 General Mills, Inc. Plaque inhibiting composition and method
US4233288A (en) * 1979-03-12 1980-11-11 Cornell John A Gum emulsified liquid package for delivering and preserving liquid content in the mouth
US4400372A (en) * 1981-03-05 1983-08-23 Indiana University Foundation Chewing gum
US5470566A (en) * 1985-05-10 1995-11-28 Fertin Laboratories A/S (Dansk Tyggegummi Fabrik A/S) Solid oral anticariogenic composition
US4806340A (en) * 1985-09-13 1989-02-21 Colgate-Palmolive Company Anticalculus oral composition
US4627977A (en) * 1985-09-13 1986-12-09 Colgate-Palmolive Company Anticalculus oral composition
US4975270A (en) * 1987-04-21 1990-12-04 Nabisco Brands, Inc. Elastomer encased active ingredients
US4891211A (en) * 1988-06-29 1990-01-02 Church & Dwight Co., Inc. Stable hydrogen peroxide-releasing dentifice
US5156845A (en) * 1990-05-04 1992-10-20 Colgate-Palmolive Company Dry mouth lozenge
US5147632A (en) * 1990-10-31 1992-09-15 Warner-Lambert Company Anti-plaque compositions comprising a combination of morpholinoamino alcohol and chelating agent
US5496541A (en) * 1993-01-19 1996-03-05 Pilot Research & Development Co. Tasteful toothpaste and other dental products
US5496541C1 (en) * 1993-01-19 2001-06-26 Squigle Inc Tasteful toothpaste and other dental products
US5861169A (en) * 1994-04-22 1999-01-19 Dibona Holding Ag Hard candy with tooth plaque-neutralizing effect comprising an ammonium salt
US6294154B1 (en) * 1994-12-22 2001-09-25 Procter And Gamble Company Oral compositions containing dimethicone copolyols
US5851514A (en) * 1995-09-26 1998-12-22 Colgate Palmolive Company Stable aqueous abrasive peroxide tooth whitening dentifrice
US6331291B1 (en) * 1996-05-30 2001-12-18 William R. Glace Dentifrice gel/paste compositions
US6294155B1 (en) * 1998-04-08 2001-09-25 W. R. Grace & Co. -Conn. Abrasive silica compositions and dentifrice compositions prepared therefrom
US6174516B1 (en) * 1999-02-16 2001-01-16 Colgate-Palmolive Company Method to enhance peroxide tooth whitening
US6926916B1 (en) * 1999-11-12 2005-08-09 The Procter & Gamble Company Chewing gum compositions
US20030099740A1 (en) * 2000-04-26 2003-05-29 Roberto Colle Chewing gum containing encapsulated abrasive filler substance
US20020142068A1 (en) * 2000-09-12 2002-10-03 Savage William D. Chewing gum formulations including encapsulated aspartame and sodium pyrophosphate
US20020061282A1 (en) * 2000-10-11 2002-05-23 Constantine Georgiades Tooth whitening composition and method employing dicarboxylic acid whitening agent
US20020187108A1 (en) * 2001-03-19 2002-12-12 Jayanth Rajaiah Oral care kits and compositions
US20030086878A1 (en) * 2001-03-19 2003-05-08 The Procter & Gamble Company Denture care compositions and kits
US6500406B1 (en) * 2001-03-19 2002-12-31 The Procter & Gamble Company Denture care compositions and kits
US20030082113A1 (en) * 2001-03-19 2003-05-01 The Proctor & Gamble Company Oral care kits and compositions
US20030072841A1 (en) * 2001-03-19 2003-04-17 The Procter & Gamble Campany Polybutene containing chewing gum and confection
US6703000B2 (en) * 2001-05-15 2004-03-09 The Procter & Gamble Co. Confectionery compositions
US6416744B1 (en) * 2001-06-21 2002-07-09 Colgate Palmolive Company Tooth whitening chewing gum
US6355229B1 (en) * 2001-06-27 2002-03-12 Church & Dwight Co., Inc. Oral composition containing cetylpyridinium chloride and guar hydroxypropyltrimonium chloride and method of using the same
US20030072722A1 (en) * 2001-08-02 2003-04-17 Nathoo Salim A. Tooth whitening hydrogels
US20050019276A1 (en) * 2001-08-02 2005-01-27 Nathoo Salim A. Tooth whitening hydrogels
US20030077232A1 (en) * 2001-08-24 2003-04-24 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Composition
US20030068283A1 (en) * 2001-08-24 2003-04-10 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Composition
US20030082112A1 (en) * 2001-08-24 2003-05-01 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Composition
US20030068282A1 (en) * 2001-08-24 2003-04-10 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Composition
US6682722B2 (en) * 2001-09-19 2004-01-27 The Procter & Gamble Company Oral compositions providing enhanced overall cleaning
US6685916B1 (en) * 2002-10-31 2004-02-03 Cadbury Adams Usa Llc Compositions for removing stains from dental surfaces, and methods of making and using the same
US20070190086A1 (en) * 2003-12-08 2007-08-16 Edith Sorensen Solid oral tooth whitening confectionary composition

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8388938B2 (en) 2003-12-08 2013-03-05 Cadbury Holdings Limited Solid oral tooth whitening confectionary composition
US20100015068A1 (en) * 2006-07-06 2010-01-21 Massachusetts Institute Of Technology Methods and Compositions For Altering Biological Surfaces
RU2580636C1 (ru) * 2014-12-23 2016-04-10 Аркадий Анатольевич Козлов Порошковая композиция для профессиональной гигиены полости рта и способ её использования
WO2017194901A1 (fr) * 2016-05-13 2017-11-16 Bochenek Stéphane Gel de blanchiment sans peroxydes
FR3051113A1 (fr) * 2016-05-13 2017-11-17 Stephane Bochenek Gel de blanchiment sans peroxydes.

Also Published As

Publication number Publication date
BRPI0417416A (pt) 2007-04-10
RU2006124548A (ru) 2008-01-20
RU2009140130A (ru) 2011-05-10
BR0318646A (pt) 2006-11-28
JP2007515382A (ja) 2007-06-14
US8388938B2 (en) 2013-03-05
CA2547333C (fr) 2013-02-12
WO2005058264A1 (fr) 2005-06-30
JP4827741B2 (ja) 2011-11-30
CN1889917B (zh) 2010-08-11
EP1691770A1 (fr) 2006-08-23
EP1755405A1 (fr) 2007-02-28
KR20120102817A (ko) 2012-09-18
MXPA06006424A (es) 2007-01-31
AU2004298328A1 (en) 2005-06-30
CN1878526A (zh) 2006-12-13
US20070190086A1 (en) 2007-08-16
CN1889917A (zh) 2007-01-03
CN1878526B (zh) 2010-09-08
AU2003294811A1 (en) 2005-07-05
CA2547333A1 (fr) 2005-06-30
CA2547329A1 (fr) 2005-06-30
WO2005058263A1 (fr) 2005-06-30
JP2007522102A (ja) 2007-08-09

Similar Documents

Publication Publication Date Title
CA2493514C (fr) Compositions permettant d'eliminer les taches sur des surfaces dentaires, procedes d'elaboration et d'utilisation correspondants
US6436369B2 (en) Anti-plaque emulsions and products containing same
US4828820A (en) Chewable tooth cleaning composition
US20070081950A1 (en) Solid oral tooth whitening confectionary composition
MXPA02004792A (es) Composiciones de goma de mascar.
RU2226060C2 (ru) Не содержащая сахара жевательная резинка для реминерализации зубной эмали (варианты) и способ реминерализации зубов
RU2320315C1 (ru) Твердая композиция для полости рта для отбеливания зубов
WO1997002009A1 (fr) Gomme a macher pour l'hygiene buccale, et gomme de base pour son elaboration
KR20070031270A (ko) 고형 구강 치아 미백 조성물
US20080008663A1 (en) Method of reducing inflammation
US20240122824A1 (en) Oral compositions
AU2004201045B2 (en) Chewing Gum with Dental Health Benefits Employing Calcium Lactate
MXPA06006144A (es) Composicion de confiteria blanqueadora dental, bucal, solida

Legal Events

Date Code Title Description
AS Assignment

Owner name: CADBURY SCHWEPPES PLC, UNITED KINGDOM

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SORENSEN, EDITH TROST;REEL/FRAME:018001/0786

Effective date: 20050620

AS Assignment

Owner name: CADBURY HOLDINGS LIMITED, UNITED KINGDOM

Free format text: CORRECTIVE ASSIGNMENT TO CORRECT THE NAME OF THE ASSIGNEE PREVIOUSLY RECORDED ON REEL 021631 FRAME 0646;ASSIGNOR:CADBURY SCHWEPPES LIMITED;REEL/FRAME:022093/0137

Effective date: 20080705

Owner name: CADBURY HOLDING LIMITED, UNITED KINGDOM

Free format text: CHANGE OF NAME;ASSIGNOR:CADBURY SCHWEPPES LIMITED;REEL/FRAME:021631/0646

Effective date: 20080705

Owner name: CADBURY SCHWEPPES LIMITED, UNITED KINGDOM

Free format text: CHANGE OF NAME;ASSIGNOR:CADBURY SCHWEPPES PUBLIC LIMITED COMPANY;REEL/FRAME:021631/0550

Effective date: 20080205

AS Assignment

Owner name: MONDELEZ UK HOLDINGS & SERVICES LIMITED, UNITED KI

Free format text: CHANGE OF NAME;ASSIGNOR:CADBURY HOLDINGS LIMITED;REEL/FRAME:031523/0692

Effective date: 20130429

AS Assignment

Owner name: GUMLINK A/S, DENMARK

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MONDELEZ UK HOLDINGS & SERVICES LIMITED;REEL/FRAME:031897/0332

Effective date: 20140106

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION