ITMI20012322A1 - Composizioni orali solide anti-tartaro e anti-placca batterica, utilicome coadiuvanti nell'igiene odont-stomatologica - Google Patents
Composizioni orali solide anti-tartaro e anti-placca batterica, utilicome coadiuvanti nell'igiene odont-stomatologica Download PDFInfo
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- ITMI20012322A1 ITMI20012322A1 IT2001MI002322A ITMI20012322A ITMI20012322A1 IT MI20012322 A1 ITMI20012322 A1 IT MI20012322A1 IT 2001MI002322 A IT2001MI002322 A IT 2001MI002322A IT MI20012322 A ITMI20012322 A IT MI20012322A IT MI20012322 A1 ITMI20012322 A1 IT MI20012322A1
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- formulations according
- extracts
- formulations
- polyphosphates
- tartar
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Description
Descrizione del brevetto per invenzione industriale avente per titolo:
"COMPOSIZIONI ORALI SOLIDE ANTI-TARTARO E ANTI-PLACCA BATTERICA, UTILI COME COADIUVANTI NELL’IGIENE ODONTO-STOMATOLOGICA"
La presente invenzione ha per oggetto composizioni orali anti-tartaro e anti-placca batterica, utili come coadiuvanti nell’igiene odontostomatologica.
SFONDO DELL’INVENZIONE
Il problema della formazione della placca batterica e del tartaro dentale è da tempo oggetto di studio e la ricerca di agenti che possano essere utilizzati per contrastare e ritardare tale formazione è particolarmente attiva.
Sono ben noti in particolare i meccanismi che portano al deposito del tartaro, costituito da cristalli di fosfato di calcio che precipitano nella matrice extracellulare della placca batterica così come altrettanto noto è il ruolo patogenetico del tartaro nelle malattie periodontali quali piorrea, periodontiti, gengiviti e patologie correlate.
Diverse sostanze si sono dimostrate efficaci nel ridurre o impedire la formazione e il deposito di tartaro sui denti: fra queste, pirofosfati e polifosfati solubili, sali di zinco, fluoruri, difosfonati, agenti antibatterici quali triclosan, agenti abrasivi quali, ad esempio, silice o allumina, che, variamente combinati fra loro, rientrano nella composizione della maggior parte dei dentifrici anti-tartaro oggi disponibili in commercio. L’efficacia clinica di tali dentifrici è stata oggetto di numerosi studi, passati in rassegna in J. Clin. Dent. Voi IV(3) ,71-81, 1993.
I dentifrici più comuni contengono in particolare polifosfati solubili associati a fluoruri e silice ed eventualmente a polimeri dotati di proprietà bioadesive, come descritti ad esempio in US 4327977, US 4889713, US5017362, US 5139769, US 4921693, EP 492997.
Composizioni analoghe, in cui sono stati aggiunti anche agenti antibatterici quali il triclosan, sono descritte ad esempio in GB 2200551. Oltre ai dentifrici propriamente detti, sono inoltre proposte anche gomme da masticare o caramelle di analoga composizione.
L’efficacia di tali dentifrici, oggetto di numerosi studi (J.Clin. Dent. Voi. X(3), 99-102, 1999;Oral Surg.Oral Med.Oral Pathol., Voi 70(4), 529-536,1990; J.Clin. Dent. Voi. IX(4), 101-104, 1998), è dovuta alla inibizione della precipitazione di fosfato di calcio da parte dei polifosfati che complessano gli ioni calcio nella saliva, all’azione abrasiva della silice, all’effetto di rinforzo dello smalto dei fluoruri e, ove presenti polimeri bioadesivi, alla loro azione protettiva nei confronti delle mucose e all’effetto di lento rilascio degli altri ingredienti.
E’ sempre più diffuso il consumo di caramelle o gomme da masticare proposte come coadiuvanti nell’igiene dentale e buccale in genere, dotate di proprietà che possono essere a seconda dei casi definite anti-tartaro, anticarie, sbiancanti e/o rinfrescanti. Il vantaggio connesso a tali forme di somministrazione è soprattutto quello di poter essere assunte con assoluta libertà e comodità nel corso della giornata in qualunque luogo e in qualsiasi occasione, oltre al rilascio più lento e costante degli elementi attivi (ingredienti funzionali) rispetto a un comune dentifricio.
DESCRIZIONE DELL’INVENZIONE
Oggetto della presente invenzione sono appunto formulazioni orali in forma solida, preferibilmente in forma di gomme da masticare, che presentano un’efficacia migliorata rispetto alle formulazioni simili note.
Le composizioni dell’ invenzione contengono quantità efficaci di: a. polifosfati, preferibilmente una miscela di pirofosfati e trifosfati di metalli alcalini;
b. un agente abrasivo (preferibilmente silice idrata);
c. una fonte di ioni fluoruro;
d. estratti o principi attivi di origine vegetale ;
e. eventualmente disinfettanti o antibatterici.
Oltre agli ingredienti attivi sopra citati, le composizioni dell’invenzione conterranno opportuni eccipienti per la definizione della forma finale di somministrazione.
Così, ad esempio, una formulazione in gomma da masticare richiederà una opportuna base costituita da gomma base, edulcoranti, polialcoli quali xilitolo, sorbitolo e mannitolo, aromi, coloranti, ammorbidenti, plastificanti, stabilizzanti, addensanti etc.
I polifosfati presenti nelle composizioni possono essere pirofosfati (difosfati), esametafosfati, tripolifosfati di metalli alcalini o loro miscele. E preferita in particolare una miscela di difosfato diacido disodico e trifosfato pentasodico o pentapotassico. È stato infatti dimostrato che un dentifricio contenente tale miscela consente una più netta riduzione del tartaro rispetto a quella ottenibile con un dentifricio contenente pirofosfati non associati a trifosfati (J.Clin. Dent. Voi. IX(4), 101-104,1998).
La percentuale in peso dei polifosfati sul totale della composizione oggetto dell’invenzione è in linea di massima compreso fra 0,5 e 5%.
L'agente abrasivo ha funzione di incrementare l'azione di rimozione della placca che un normale chewing gum già possiede. Esso può essere formato da silice idrata (in una forma adeguata allo scopo), carbonato di calcio (in una forma adeguata allo scopo), talco, singolarmente od in miscela tra loro. Tali abrasivi possono essere anche presenti, totalmente, parzialmente, singolarmente o in combinazione fra loro in forma incapsulata, in particolar modo in alginato di calcio. Chewing gum contenenti microgranuli di silice idrata incapsulata in alginato di calcio si sono rivelati più efficaci nel rimuovere la placca rispetto a chewing gum di stessa formulazione, ma senza microgranuli (Doc. Os 06.2001 779-781). Nella presente invenzione all'interno dei microgranuli incapsulati possono essere presenti coloranti, aromi, ingredienti funzionali ed estratti di erbe. Tale agente abrasivo è generalmente presente in percentuali in peso tra 0,5 e 7%.
Fonti adatte di ioni fluoruro comprendono fluoruro di sodio, fluoruro di potassio, fluoruro di ammonio, sodio monofluoro-fosfato e altri noti sali non tossici contenenti fluoro, in concentrazioni tali da fornire percentuali in peso di fluoruro comprese fra 0.005 e 0.2 %.
Gli estratti vegetali presenti nelle composizioni dell’ invenzione sono scelti preferibilmente fra estratti di Centella asiatica, Malva sylvestris, Melaleuca alternifolia, Commìphora abyssinica (mirra,), Krameria triandra (Ratani3⁄4), Acacia catechu, Medicago sativa (Alfa-Alfa), resine del genus Styrax es. Styrax Benzoin (Benzoino), Matrìcaria recutita (Camomilla), Echinacea purpurea (Echinacea), Croton lechleri (Sangue di drago). Estratti di queste piante, la cui attività è nota da tempo, sono disponibili in commercio.
L’associazione di tali estratti consente di impartire alle formulazioni proprietà antiinfiammatorie/decongestionanti, emollienti, cicatrizzanti, antisettiche e astringenti. Tali proprietà sono desiderabili per almeno due aspetti nell'ambito della presente invenzione.
In primo luogo per coadiuvare e rafforzare l'effetto di diminuzione delle condizioni patologiche della mucosa orale dato dalla diminuzione del tartaro.
In secondo luogo, per controllare e scongiurare, in persone particolarmente predisposte, eventuali stomatiti da contatto simili a quelle che si manifestano con l'uso di dentifrici, definite "stomatiti da dentifricio".
Tali estratti possono essere presenti, nelle formulazioni dell'invenzione, anche in forma incapsulata in alginato insieme all'agente abrasivo.
Tali estratti possono essere aggiunti alle formulazioni in percentuali in peso comprese fra 0.01 e 2 %.
La preparazione delle formulazioni oggetto dell’invenzione può avvenire con tecniche convenzionali, aggiungendo e miscelando i vari ingredienti alla gomma base nel caso delle gomme da masticare, che saranno poi eventualmente sottoposte a operazioni di rivestimento/confettatura secondo tecniche altrettanto convenzionali.
Nella presente invenzione possono essere presenti anche degli agenti disinfettanti o antibatterici quali, ad esempio Triclosan, sali di Zinco o ossido di Zinco, da soli o in combinazione tra loro, in concentrazioni tra 0.1 e 5% in peso. Tali agenti sono volti a combattere la formazione della placca batterica, che favorisce il deposito del tartaro.
Nella presente invenzione possono, in aggiunta, essere presenti dei cristalli decorativi, composti preferibilmente di gomma arabica e coloranti, depositati sulla superficie del prodotto con funzione prettamente estetica.
L’assunzione giornaliera di gomme da masticare secondo l’invenzione comporta una riduzione del deposito di tartaro e altri benefici effetti sulle condizioni della mucosa orale e gengivale.
Il seguente Esempio illustra l’invenzione in maggior dettaglio. ESEMPIO
Gomma da masticare rivestita del peso di 1.4 g. con estratti vegetali
Composizione percentuale (in peso)
Claims (10)
- RIVENDICAZIONI 1. Formulazioni orali in forma solida comprendenti: a. polifosfati; b. un agente abrasivo; c. una fonte di ioni fluoruro; d. estratti o principi attivi di origine vegetale; e. eventualmente disinfettanti/antibatterici.
- 2. Formulazioni secondo la rivendicazione 1 in cui i polifosfati sono scelti fra tripolifosfati , pirofosfati o loro miscele.
- 3. Formulazioni secondo la rivendicazione 2 comprendenti una miscela di tripolifosfati e di pirofosfati di metalli alcalini.
- 4. Formulazioni secondo una delle rivendicazioni precedenti contenenti inoltre eccipienti scelti fra gomma base, edulcoranti, polialcoli, aromi, coloranti, ammorbidenti, plastificanti, stabilizzanti, addensanti.
- 5. Formulazioni secondo le rivendicazioni precedenti in cui l'agente abrasivo è costituito da: silice idrata, carbonato di calcio, talco, singolarmente od in miscela tra loro.
- 6. Formulazioni secondo le rivendicazioni precedenti contenti estratti ad attività antinfiammatorie, cicatrizzanti, antiemorragiche, lenitive, emollienti, anticogenstionanti, antisettiche.
- 7. Formulazioni secondo la rivendicazione 6 in cui gli estratti vegetali sono scelti fra estratti di Centella asiatica, Malva sylvestris, Melaleuca alternifolia, Commiphora abyssinica (mirrai Krameria triandra (Ratania,), Acacia catechu, Medicago sativa (Alfa-Alfa), resine del genus Styrax es. Styrax Benzoin (Benzoino), Matricaria recutita (Camomilla), Echinacea purpurea (Echinacea), Croton lechleri (Sangue di drago).
- 8. Formulazioni secondo le rivendicazioni precedenti contenenti da 0,5 a 5 % in peso di polifosfati, da 0.5 a 7 % in peso di un agente abrasivo (eventualmente, in parte o totalmente incapsulato), una fonte di ioni fluoruro in grado di garantire un apporto da 0.005 a 0.2% di fluoro e da 0.01 a 2 % in peso di estratti vegetali.
- 9. Formulazioni secondo le rivendicazioni precedenti comprendenti disinfettanti e/o antibatterici scelti fra triclosan, ossido di zinco, sali di zinco da soli o in combinazione tra loro nelle concentrazioni fra 0,1% e 5%.
- 10. Formulazioni secondo le rivendicazioni precedenti in cui tali formulazioni sono chewing gum o caramelle.
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI002322A ITMI20012322A1 (it) | 2001-11-06 | 2001-11-06 | Composizioni orali solide anti-tartaro e anti-placca batterica, utilicome coadiuvanti nell'igiene odont-stomatologica |
| EP02787567A EP1441689B1 (en) | 2001-11-06 | 2002-11-05 | Solid oral compositions |
| CA002465700A CA2465700A1 (en) | 2001-11-06 | 2002-11-05 | Solid oral compositions |
| PCT/EP2002/012330 WO2003039504A1 (en) | 2001-11-06 | 2002-11-05 | Solid oral compositions |
| AT02787567T ATE322883T1 (de) | 2001-11-06 | 2002-11-05 | Feste mundpflegezusammensetzungen |
| JP2003541795A JP2005511584A (ja) | 2001-11-06 | 2002-11-05 | 固形口腔用組成物 |
| RU2004113652/15A RU2308938C2 (ru) | 2001-11-06 | 2002-11-05 | Твердые оральные композиции |
| US10/494,567 US20050063917A1 (en) | 2001-11-06 | 2002-11-05 | Solid oral compositions |
| DE60210651T DE60210651T2 (de) | 2001-11-06 | 2002-11-05 | Feste mundpflegezusammensetzungen |
| ES02787567T ES2261761T3 (es) | 2001-11-06 | 2002-11-05 | Composiciones orales solidas. |
| DK02787567T DK1441689T3 (da) | 2001-11-06 | 2002-11-05 | Orale sammensætninger i fast form |
| BR0213934-0A BR0213934A (pt) | 2001-11-06 | 2002-11-05 | Composições orais sólidas |
| CNB028242718A CN1327825C (zh) | 2001-11-06 | 2002-11-05 | 固体口腔用组合物 |
| PT02787567T PT1441689E (pt) | 2001-11-06 | 2002-11-05 | Compostos orais solidos |
| HK05103763A HK1070838A1 (en) | 2001-11-06 | 2005-05-04 | Solid oral compositions |
| CY20061100592T CY1106082T1 (el) | 2001-11-06 | 2006-05-05 | Συνθεσεις που χορηγουνται απο το στομα σε στepεα μορφη |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI002322A ITMI20012322A1 (it) | 2001-11-06 | 2001-11-06 | Composizioni orali solide anti-tartaro e anti-placca batterica, utilicome coadiuvanti nell'igiene odont-stomatologica |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITMI20012322A1 true ITMI20012322A1 (it) | 2003-05-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2001MI002322A ITMI20012322A1 (it) | 2001-11-06 | 2001-11-06 | Composizioni orali solide anti-tartaro e anti-placca batterica, utilicome coadiuvanti nell'igiene odont-stomatologica |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20050063917A1 (it) |
| EP (1) | EP1441689B1 (it) |
| JP (1) | JP2005511584A (it) |
| CN (1) | CN1327825C (it) |
| AT (1) | ATE322883T1 (it) |
| BR (1) | BR0213934A (it) |
| CA (1) | CA2465700A1 (it) |
| CY (1) | CY1106082T1 (it) |
| DE (1) | DE60210651T2 (it) |
| DK (1) | DK1441689T3 (it) |
| ES (1) | ES2261761T3 (it) |
| HK (1) | HK1070838A1 (it) |
| IT (1) | ITMI20012322A1 (it) |
| PT (1) | PT1441689E (it) |
| RU (1) | RU2308938C2 (it) |
| WO (1) | WO2003039504A1 (it) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0318646A (pt) * | 2003-12-08 | 2006-11-28 | Cadbury Schweppes Plc | composição de branqueamento de dentes oral sólida |
| IT1400386B1 (it) * | 2010-05-27 | 2013-05-31 | Roberto Logi | Kit di parti per il trattamento e/o prevenzione delle ulcere cutanee |
| CN101912025B (zh) * | 2010-08-31 | 2012-11-14 | 许荧 | 洋甘菊口香糖组合物及其口香糖制备方法 |
| CN101971908A (zh) * | 2010-11-18 | 2011-02-16 | 林国军 | 洁牙口香糖 |
| EP3233206B1 (en) * | 2014-12-26 | 2021-12-01 | Colgate-Palmolive Company | Zinc phosphate complex for oral care |
| BR112017012806B1 (pt) * | 2014-12-26 | 2020-11-17 | Colgate-Palmolive Company | complexo de polifosfato de zinco solúvel e método de produção de polifosfato de zinco |
| US12005076B2 (en) | 2014-12-26 | 2024-06-11 | Colgate-Palmolive Company | Zinc phosphate complex |
| CN107205892B (zh) * | 2015-03-20 | 2021-01-05 | 株式会社爱茉莉太平洋 | 有效抑制牙石形成的口腔用组合物 |
| CN105997743A (zh) * | 2016-07-17 | 2016-10-12 | 张学健 | 一种天然植物成份抗过敏牙膏 |
| CN108606939B (zh) * | 2018-03-14 | 2020-07-07 | 弘美制药（中国）有限公司 | 一种具有口腔保健功能的组合物及其应用和制备方法 |
| JP7368858B2 (ja) * | 2018-09-21 | 2023-10-25 | 株式会社山田養蜂場本社 | バイオフィルム形成抑制剤 |
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| US5000944A (en) * | 1989-06-09 | 1991-03-19 | Colgate-Palmolive Company | Zinc-containing oral products with reduced astringency |
| US5958380A (en) * | 1997-07-07 | 1999-09-28 | Enamelon, Inc. | Chewing gum products and the use thereof for remineralizing subsurface dental lesions and for mineralizing exposed dentinal tubules |
| WO2000025598A1 (en) * | 1998-11-03 | 2000-05-11 | Dandy A/S | Sucrose fatty acid esters for use as increased release of active ingredients |
| CN1367663A (zh) * | 1999-09-08 | 2002-09-04 | Amt技术公司 | 眼睛生物计 |
| US6491540B1 (en) * | 1999-09-20 | 2002-12-10 | Jack Barreca | Center-filled supplement gum |
| AU3478001A (en) * | 2000-02-04 | 2001-08-14 | Procter & Gamble Company, The | Chewing gum compositions |
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2001
- 2001-11-06 IT IT2001MI002322A patent/ITMI20012322A1/it unknown
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2002
- 2002-11-05 ES ES02787567T patent/ES2261761T3/es not_active Expired - Lifetime
- 2002-11-05 DE DE60210651T patent/DE60210651T2/de not_active Expired - Lifetime
- 2002-11-05 BR BR0213934-0A patent/BR0213934A/pt not_active IP Right Cessation
- 2002-11-05 JP JP2003541795A patent/JP2005511584A/ja active Pending
- 2002-11-05 DK DK02787567T patent/DK1441689T3/da active
- 2002-11-05 CA CA002465700A patent/CA2465700A1/en not_active Abandoned
- 2002-11-05 AT AT02787567T patent/ATE322883T1/de not_active IP Right Cessation
- 2002-11-05 EP EP02787567A patent/EP1441689B1/en not_active Expired - Lifetime
- 2002-11-05 US US10/494,567 patent/US20050063917A1/en not_active Abandoned
- 2002-11-05 RU RU2004113652/15A patent/RU2308938C2/ru not_active IP Right Cessation
- 2002-11-05 PT PT02787567T patent/PT1441689E/pt unknown
- 2002-11-05 WO PCT/EP2002/012330 patent/WO2003039504A1/en active IP Right Grant
- 2002-11-05 CN CNB028242718A patent/CN1327825C/zh not_active Expired - Fee Related
-
2005
- 2005-05-04 HK HK05103763A patent/HK1070838A1/xx not_active IP Right Cessation
-
2006
- 2006-05-05 CY CY20061100592T patent/CY1106082T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE322883T1 (de) | 2006-04-15 |
| CY1106082T1 (el) | 2011-06-08 |
| BR0213934A (pt) | 2004-08-31 |
| EP1441689A1 (en) | 2004-08-04 |
| DK1441689T3 (da) | 2006-08-07 |
| WO2003039504A1 (en) | 2003-05-15 |
| RU2004113652A (ru) | 2005-04-10 |
| PT1441689E (pt) | 2006-08-31 |
| DE60210651D1 (de) | 2006-05-24 |
| US20050063917A1 (en) | 2005-03-24 |
| ES2261761T3 (es) | 2006-11-16 |
| RU2308938C2 (ru) | 2007-10-27 |
| EP1441689B1 (en) | 2006-04-12 |
| JP2005511584A (ja) | 2005-04-28 |
| HK1070838A1 (en) | 2005-06-30 |
| CN1327825C (zh) | 2007-07-25 |
| CN1599594A (zh) | 2005-03-23 |
| CA2465700A1 (en) | 2003-05-15 |
| DE60210651T2 (de) | 2007-01-11 |
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