CN1599594A - 固体口腔用组合物 - Google Patents

固体口腔用组合物 Download PDF

Info

Publication number
CN1599594A
CN1599594A CNA028242718A CN02824271A CN1599594A CN 1599594 A CN1599594 A CN 1599594A CN A028242718 A CNA028242718 A CN A028242718A CN 02824271 A CN02824271 A CN 02824271A CN 1599594 A CN1599594 A CN 1599594A
Authority
CN
China
Prior art keywords
preparation
formulations
extract
polyphosphate
abrasive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA028242718A
Other languages
English (en)
Other versions
CN1327825C (zh
Inventor
R·库勒
G·萨尔莫里拉奇
A·巴里卡
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Perfetti Van Melle SpA
Original Assignee
Perfetti Van Melle SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perfetti Van Melle SpA filed Critical Perfetti Van Melle SpA
Publication of CN1599594A publication Critical patent/CN1599594A/zh
Application granted granted Critical
Publication of CN1327825C publication Critical patent/CN1327825C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/362—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/064—Chewing gum characterised by the composition containing organic or inorganic compounds containing inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G4/126—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Botany (AREA)
  • Nutrition Science (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • Mycology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Confectionery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

口香糖形式的口腔用制剂，其包含：a.多磷酸盐；b.水合二氧化硅；c.氟离子源；d.植物来源的提取物或活性成分；e.任选地，抗菌剂/消毒剂。本发明的组合物可在牙齿卫生中用作辅助药，特别是用于减少牙垢沉积。

Description

固体口腔用组合物
本发明涉及可在牙齿口腔医学卫生(odontostomatological hygiene)中用作辅助药的口腔用抗牙垢和抗牙菌斑组合物。
发明背景
人们已经对牙菌斑和牙垢形成问题进行了长期研究，且正在积极研究可用于抵抗和延缓上述牙菌斑和牙垢形成的活性剂。
导致牙垢沉积的机制众所周知；这些沉积物由沉淀在牙菌斑细胞外基质中的磷酸钙晶体构成。牙垢在牙周病如脓溢、牙周炎、龈炎以及相关疾病中的致病作用同样是众所周知的。
已证实有多种物质可有效减少或预防牙齿上的牙垢形成和沉积，包括可溶性焦磷酸盐和多磷酸盐、锌盐、氟化物、二膦酸盐、抗菌剂如三氯生以及磨擦剂如二氧化硅或氧化铝。目前市售的大部分抗牙垢牙膏的组成中均包括以各种方式相互组合的这些物质。这些牙膏的临床功效已在多项研究中进行了检验，综述于J.Clin.Dent.IV卷(3)，71-81，1993中。
大部分普通牙膏均含有可溶性多磷酸盐以及氟化物和二氧化硅，还可能含有具有生物粘附性的聚合物，如例如US4327977、US4889713、US5017362、US5139769、US4921693和EP492997中所述。
例如在GB2200551中描述了添加了抗菌剂如三氯生的类似组合物。除牙膏以外，已经开发了含有类似组成的口香糖和糖果。
这些牙膏的功效已成为多项研究的目的(J.Clin.Dent.X卷(3)，99-102，1999；Oral Surg.Oral Med.Oral Pathol.，70卷(4)，529-536，1990；J.Clin.Dent.IX卷(4)，101-104，1998)，该功效的原因是与唾液中的钙离子络合的多磷酸盐对磷酸钙沉淀的抑制作用、二氧化硅的磨擦作用、氟化物对牙釉质的加固作用以及生物粘附性聚合物的作用，使用时，该聚合物保护粘膜并引起其它成分的缓慢释放。
旨在通常在牙齿卫生和口腔卫生中用作辅助药的糖果和口香糖正变得越来越流行，这些糖果和口香糖具有可描述为抗牙垢、抗腐蚀、洁白和/或清凉的性质。除了活性成分(功能成分)的释放比普通牙膏更缓慢和更规律这一事实以外，这些施用形式的主要优势是它们在全天中、任何地点以及任何场合均可自由地和方便地使用。
发明内容
本发明涉及固体形式、优选口香糖形式的口腔用制剂，其功效优于类似的已知制剂。
本发明的组合物含有有效量的：
a.多磷酸盐，优选碱金属焦磷酸盐和三聚磷酸盐的混合物；
b.磨擦剂(优选水合二氧化硅)；
c.氟离子源；
d.植物来源的提取物或活性成分；
e.任选地，抗菌剂或消毒剂。
除了以上提及的活性成分外，本发明的组合物还含有适合用于确定最终施用形式的赋形剂。
因此，例如，口香糖制剂将需要由胶基、甜味剂、多元醇如木糖醇、山梨醇和甘露醇、芳香剂、染料、软化剂、增塑剂、稳定剂、增稠剂等组成的适合的基质。
用于组合物的多磷酸盐可以是碱金属焦磷酸盐(二磷酸盐)、六偏磷酸盐或三聚磷酸盐或其混合物。特别优选二磷酸二氢二钠(disodium diaciddiphosphate)和三聚磷酸钠或三聚磷酸钾的混合物。已经证明含有该混合物的牙膏比含有焦磷酸盐但不含三聚磷酸盐的牙膏能更显著地减少牙垢(J.Clin.Dent.IX卷(4)，101-104，1998)。
一般而言，多磷酸盐占本发明整个组合物的重量比总计为0.5至5％。
磨擦剂的作用是增强普通口香糖已具有的除牙菌斑作用。其可以由单独的(适合形式的)水合二氧化硅、(适合形式的)碳酸钙或滑石粉，或由其混合物形成。这些磨擦剂也可以全部或部分地、单独或相互组合地、以囊化形式、特别是囊化于藻酸钙中的形式存在。已证明含有囊化于藻酸钙中的水合二氧化硅微粒的口香糖比不含微粒的相同配方的口香糖能更有效地去除牙菌斑(Doc.Os 06.2001 779-781)。根据本发明，囊化微粒可以含有染料、芳香剂、功能成分和草药提取物。所述磨擦剂通常以0.5至7％的重量百分比存在。
适合的氟离子源包括氟化钠、氟化钾、氟化铵、单氟磷酸钠和其它已知的无毒含氟盐，其浓度应能提供重量百分比0.005至0.2％的氟化物。
可存在于本发明组合物中的植物提取物将优选选自以下物质的提取物：积雪草(Centella asiatica)、锦葵(Malva sylvestris)、互叶白千层(Melaleucaalternifolia)、没药(Commiphora abyssinica)、秘鲁拉坦尼(Krameriatriandra)、儿茶(Acacia catechu)、紫苜蓿(Medicago sativa)、安息香(Styrax)属如安息香(Styrax benzoin)的树脂、母菊(Matricaria recutita)、紫锥菊(Echinacea purpurea)和血竭(Croton lechleri)。这些植物提取物是市售可得的，其活性一段时间以来已经为人们所熟知。
这些提取物的组合产生了具有抗炎/减轻充血、润滑、愈合伤口、抗菌防腐和收敛性质的制剂。在本发明范围内这些性质在至少两方面是有利的：
第一，帮助和加强由牙垢减少导致的口腔粘膜疾病的减少，和
第二，在特别易患病的人中，控制和预防与使用牙膏所出现的称为“牙膏口炎”类似的接触性毒性口炎。
在本发明的制剂中，这些提取物可以与磨擦剂一起囊化于藻酸盐中。
所述提取物可以以0.01至2％的重量百分比加入制剂中。
本发明的制剂可用常规技术制备，对于口香糖而言是将各种成分加入胶基中并混合，然后可根据同样常规的技术对其进行包衣操作。
本发明的制剂可以以重量比0.1至5％的浓度包含单独的或相互组合的消毒剂或抗菌剂如三氯生、锌盐或氧化锌。这些活性剂旨在对抗导致牙垢沉积的牙菌斑的形成。
本发明的制剂还可以包含美饰性晶体，该晶体优选由沉积于产品表面的具有纯粹美学作用的阿拉伯胶和染料组成。
每天使用本发明的口香糖可以减少牙垢沉积，并对口腔和齿龈粘膜状况具有其它的有益作用。
以下实施例更详细地阐述了本发明。
实施例
含有植物提取物的重1.4g的包衣口香糖。
百分比组成(以重量计)
成分   ％
胶基   25.5
木糖醇   23.5
山梨醇   23.2
甘露醇   16
芳香剂   1.8
二氧化硅   3
阿拉伯胶   1
甘油   1
二磷酸二氢二钠   1
三聚磷酸钠   1
锦葵、没药、积雪草、白千层、秘鲁拉坦尼和儿茶提取物   0.05
麦芽糖醇糖浆   0.93
二氧化钛(E171)   0.7
Quick Coat   0.6
阿司帕坦   0.6
丁磺氨   0.05
巴西棕榈蜡   0.05
氟化钾   0.02
总计   100

Claims (10)

1.固体形式的口腔用制剂，其包含：
a.多磷酸盐；
b.磨擦剂；
c.氟离子源；
d.植物来源的提取物或活性成分；
e.任选地，抗菌剂或消毒剂。
2.权利要求1的制剂，其中的多磷酸盐选自三聚磷酸盐、焦磷酸盐或其混合物。
3.权利要求2的制剂，其包含碱金属焦磷酸盐和三聚磷酸盐的混合物。
4.以上权利要求中任意一项的制剂，其还含有选自胶基、甜味剂、多元醇、芳香剂、染料、软化剂、增塑剂、稳定剂和增稠剂的赋形剂。
5.以上权利要求的制剂，其中的磨擦剂是单独的水合二氧化硅、碳酸钙和滑石粉，或其混合物。
6.以上权利要求的制剂，其含有具有抗炎、愈合伤口、抗出血、缓解、润滑、减轻充血和抗菌防腐性质的提取物。
7.权利要求6的制剂，其中的植物提取物选自以下物质的提取物：积雪草、锦葵、互叶白千层、没药、秘鲁拉坦尼、儿茶、紫苜蓿、安息香属如安息香的树脂、母菊、紫锥菊和血竭。
8.以上权利要求的制剂，其含有重量比0.5至5％的多磷酸盐、重量比0.5至7％的磨擦剂(可为全部或部分囊化的)、能保证0.005至0.2％的氟化物摄入量的氟离子源以及重量比0.01至2％的植物提取物。
9.以上权利要求的制剂，其以0.1％至5％的浓度包含单独的或相互组合的选自三氯生、氧化锌和锌盐的消毒剂和/或抗菌剂。
10.以上权利要求的制剂，其中所述的制剂是口香糖或糖果。
CNB028242718A 2001-11-06 2002-11-05 固体口腔用组合物 Expired - Fee Related CN1327825C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2001A002322 2001-11-06
IT2001MI002322A ITMI20012322A1 (it) 2001-11-06 2001-11-06 Composizioni orali solide anti-tartaro e anti-placca batterica, utilicome coadiuvanti nell'igiene odont-stomatologica

Publications (2)

Publication Number Publication Date
CN1599594A true CN1599594A (zh) 2005-03-23
CN1327825C CN1327825C (zh) 2007-07-25

Family

ID=11448573

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028242718A Expired - Fee Related CN1327825C (zh) 2001-11-06 2002-11-05 固体口腔用组合物

Country Status (16)

Country Link
US (1) US20050063917A1 (zh)
EP (1) EP1441689B1 (zh)
JP (1) JP2005511584A (zh)
CN (1) CN1327825C (zh)
AT (1) ATE322883T1 (zh)
BR (1) BR0213934A (zh)
CA (1) CA2465700A1 (zh)
CY (1) CY1106082T1 (zh)
DE (1) DE60210651T2 (zh)
DK (1) DK1441689T3 (zh)
ES (1) ES2261761T3 (zh)
HK (1) HK1070838A1 (zh)
IT (1) ITMI20012322A1 (zh)
PT (1) PT1441689E (zh)
RU (1) RU2308938C2 (zh)
WO (1) WO2003039504A1 (zh)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101912025A (zh) * 2010-08-31 2010-12-15 许荧 洋甘菊口香糖组合物及其口香糖制备方法
CN101971908A (zh) * 2010-11-18 2011-02-16 林国军 洁牙口香糖
CN102917719A (zh) * 2010-05-27 2013-02-06 罗伯托·洛吉 用于治疗和/或预防皮肤溃疡的套药盒
CN107205892A (zh) * 2015-03-20 2017-09-26 株式会社爱茉莉太平洋 有效抑制牙石形成的口腔用组合物
CN108606939A (zh) * 2018-03-14 2018-10-02 弘美制药（中国）有限公司 一种具有口腔保健功能的组合物及其应用和制备方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005058263A1 (en) * 2003-12-08 2005-06-30 Cadbury Schweppes Plc A solid oral tooth whithening composition
EP3223914B1 (en) * 2014-12-26 2020-05-06 Colgate-Palmolive Company Zinc phosphate complex
RU2690157C2 (ru) * 2014-12-26 2019-05-31 Колгейт-Палмолив Компани Комплекс фосфата цинка для ухода за полостью рта
US12005076B2 (en) 2014-12-26 2024-06-11 Colgate-Palmolive Company Zinc phosphate complex
CN105997743A (zh) * 2016-07-17 2016-10-12 张学健 一种天然植物成份抗过敏牙膏
WO2020059828A1 (ja) * 2018-09-21 2020-03-26 株式会社山田養蜂場本社 バイオフィルム形成抑制剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5000944A (en) * 1989-06-09 1991-03-19 Colgate-Palmolive Company Zinc-containing oral products with reduced astringency
US5958380A (en) * 1997-07-07 1999-09-28 Enamelon, Inc. Chewing gum products and the use thereof for remineralizing subsurface dental lesions and for mineralizing exposed dentinal tubules
WO2000025598A1 (en) * 1998-11-03 2000-05-11 Dandy A/S Sucrose fatty acid esters for use as increased release of active ingredients
CN1367663A (zh) * 1999-09-08 2002-09-04 Amt技术公司 眼睛生物计
AU3885201A (en) * 1999-09-20 2001-04-24 Mastercare Diet and weight control gum and sucker
AU3478001A (en) * 2000-02-04 2001-08-14 Procter & Gamble Company, The Chewing gum compositions

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102917719A (zh) * 2010-05-27 2013-02-06 罗伯托·洛吉 用于治疗和/或预防皮肤溃疡的套药盒
CN102917719B (zh) * 2010-05-27 2015-11-25 罗伯托·洛吉 用于治疗和/或预防皮肤溃疡的套药盒
CN101912025A (zh) * 2010-08-31 2010-12-15 许荧 洋甘菊口香糖组合物及其口香糖制备方法
CN101912025B (zh) * 2010-08-31 2012-11-14 许荧 洋甘菊口香糖组合物及其口香糖制备方法
CN101971908A (zh) * 2010-11-18 2011-02-16 林国军 洁牙口香糖
CN107205892A (zh) * 2015-03-20 2017-09-26 株式会社爱茉莉太平洋 有效抑制牙石形成的口腔用组合物
CN107205892B (zh) * 2015-03-20 2021-01-05 株式会社爱茉莉太平洋 有效抑制牙石形成的口腔用组合物
CN108606939A (zh) * 2018-03-14 2018-10-02 弘美制药（中国）有限公司 一种具有口腔保健功能的组合物及其应用和制备方法

Also Published As

Publication number Publication date
EP1441689A1 (en) 2004-08-04
CY1106082T1 (el) 2011-06-08
DE60210651D1 (de) 2006-05-24
WO2003039504A1 (en) 2003-05-15
ITMI20012322A1 (it) 2003-05-06
BR0213934A (pt) 2004-08-31
JP2005511584A (ja) 2005-04-28
RU2308938C2 (ru) 2007-10-27
EP1441689B1 (en) 2006-04-12
ES2261761T3 (es) 2006-11-16
CN1327825C (zh) 2007-07-25
DE60210651T2 (de) 2007-01-11
HK1070838A1 (en) 2005-06-30
US20050063917A1 (en) 2005-03-24
RU2004113652A (ru) 2005-04-10
ATE322883T1 (de) 2006-04-15
CA2465700A1 (en) 2003-05-15
DK1441689T3 (da) 2006-08-07
PT1441689E (pt) 2006-08-31

Similar Documents

Publication Publication Date Title
CN1270689C (zh) 固体口腔用抗牙垢和抗牙菌斑组合物
EP1387662B1 (en) Oral care compositions
US6706256B2 (en) Oral care compositions
US6491899B1 (en) Anti-inflammatory dental care agents
CN1327825C (zh) 固体口腔用组合物
SK279232B6 (sk) Ústny prípravok proti tvorbe zubného kameňa
SK284210B6 (en) Anticalculus dentifrice containing highly soluble pyrophosphate
US9005587B2 (en) Anti-bacterial and mineralizing calcium phosphate compositions
US10022309B2 (en) Composition, comprising hydrofluoric acid, for inhibiting dental erosion
US20190008746A1 (en) Oral Hygiene Products and Method of Using the Same
JP2979444B2 (ja) 口腔用組成物
AU1707699A (en) Compositions for inhibiting gingivitis
KR20120136140A (ko) 잔토리졸의 구강 내 흡착 및/또는 잔류 증진용 조성물

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1070838

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070725

Termination date: 20101105