CN100344273C - 洁牙剂 - Google Patents

洁牙剂 Download PDF

Info

Publication number
CN100344273C
CN100344273C CNB028082753A CN02808275A CN100344273C CN 100344273 C CN100344273 C CN 100344273C CN B028082753 A CNB028082753 A CN B028082753A CN 02808275 A CN02808275 A CN 02808275A CN 100344273 C CN100344273 C CN 100344273C
Authority
CN
China
Prior art keywords
dentifrice
salt
ascorbic acid
sodium
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028082753A
Other languages
English (en)
Other versions
CN1646088A (zh
Inventor
霍斯特·韦斯坦菲尔德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of CN1646088A publication Critical patent/CN1646088A/zh
Application granted granted Critical
Publication of CN100344273C publication Critical patent/CN100344273C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

一种含有抗坏血酸衍生物和乙二胺四乙酸或其盐的洁牙剂。

Description

洁牙剂
本发明涉及洁牙剂(dentifrice)，具体地，本发明涉及含抗坏血酸衍生物的洁牙剂。此处所用的术语“洁牙剂”是指用于口腔护理(oral care)的组合物，其含有基本上为固体或糊状的配方，例如：牙膏、牙乳(dental cream)、凝胶或牙粉。
抗坏血酸衍生物，例如抗坏血酸磷酸盐(ascorbic acid phosphates)，例如抗坏血酸磷酸钠(sodium ascorbyl phosphate)被用来在洁牙剂中发挥有利的生理作用，如预防齿龈炎或牙周炎。但是，含有抗坏血酸衍生物例如抗坏血酸磷酸或硫酸酯及其盐的洁牙剂在储藏时出现变色现象。
根据本发明，已经发现含有抗坏血酸衍生物的洁牙剂的变色可以通过加入乙二胺四乙酸(EDTA)或其盐来抑制。
因此，一方面，本发明涉及乙二胺四乙酸或其盐在抑制含有抗坏血酸衍生物的洁牙剂变色中的应用。
合适的乙二胺四乙酸盐为例如碱金属或碱土金属盐，例如钠、钾、钙或镁的乙二胺四乙酸盐。也可以用乙二胺四乙酸及其盐的混合物，优选乙二胺四乙酸或乙二胺四乙酸钠或钙。
乙二胺四乙酸或其盐的用量合适地占整个洁牙剂组合物重量的约0.05～约5％，优选约0.1～约1％重量，或占洁牙剂组合物中的抗坏血酸衍生物重量的约0.1～约2％。一般地，洁牙剂中抗坏血酸衍生物占整个洁牙剂组合物重量的约0.01～约10％，优选约0.1～约5％重量。
洁牙剂中抗坏血酸衍生物的例子为抗坏血酸酯，特别是磷酸酯和硫酸酯及其盐，或抗坏血酸葡萄糖酸盐(gluconate)。
盐的例子为碱金属和碱土金属盐，特别是钠盐和镁盐。特别是抗坏血酸磷酸钠和抗坏血酸磷酸镁。
另一方面，本发明涉及含有上述说明的抗坏血酸衍生物和乙二胺四乙酸或其盐的洁牙剂，下述洁牙剂除外：其中所述抗坏血酸衍生物为抗坏血酸磷酸镁，所述乙二胺四乙酸为乙二胺四乙酸钙。
本发明洁牙剂的其它组分可以是通常用于洁牙剂组合物中的成分，例如二氧化硅、碳酸钙、磷酸二钙、磷酸三钙、氧化铝、偏磷酸钠和钾、焦磷酸钠和钾、三偏磷酸(trimetaphosphate)钠和六偏磷酸(hexametaphosphate)钠等；增稠剂，例如瓜尔胶、黄原胶、caraya gum、羧甲基纤维素、羟甲基纤维素和胶态硅酸铝镁等；表面活性剂，例如氢化椰子脂肪酸单甘油酯单硫酸钠、十二烷基硫酸钠、十二烷基苯磺酸钠、N-月桂酰肌氨酸和脱水山梨(糖)醇单硬脂酸酯等；氟化物和提供氟的化合物，例如钠、铵。钙、锌、铜和锡的氟化物，氟硅酸钠和铵以及单氟代磷酸钠等；润湿剂，例如甘油、1，4-丁二醇、山梨(糖)醇、甘露醇和木糖醇等；金属盐，例如氟化亚铜、氯化亚铜、氟硅酸亚铜和氟化亚锡等；调味剂，例如薄荷、桉、桂皮和柠檬油等；甜味剂，例如蔗糖、木糖醇、环己烷氨基磺酸钠和糖精等；抗菌剂，例如三氯苯氧氯酚和洗必太等，以及各种其它的助剂，例如增白剂或脱敏剂。上述成分可以以本领域技术人员普遍公知的量包含在所述洁牙剂组合物中。
下面通过实施例进一步举例说明本发明。
实施例1
可以用下列成分制备牙膏：
  A)   水   加至100(ad.100)
  甘油   30.00
  山梨(糖)醇   20.00
  EDTA   0.01-1.00
  抗坏血酸磷酸钠   0.01-5.0
  B)   羧甲基纤维素   1.2
  C)   二氧化钛   0.50
  环己烷氨基磺酸钠   0.10
  糖精钠   0.01
  单-氟磷酸钠   0.85
  水合二氧化硅   20.00
  三氯苯氧氯酚
  D)   十二烷基硫酸钠   1.00
  香料(aroma)   0.80
实施例2
用下列成分制备透明牙膏：
  A)   水   加至100
  甘油   5.00
  山梨(糖)醇   60.00
  EDTA   0.01-1.00
  抗坏血酸磷酸钠   0.01-5.00
  B)   羧甲基纤维素   1.0
  C)   PEG-12   3.00
  糖精   0.20
  氟化钠   0.85
  水合二氧化硅   20.00
  D)   十二烷基硫酸钠   1.20
  香料(aroma)   1.00

Claims (6)

1.乙二胺四乙酸或其盐在抑制含抗坏血酸磷酸盐和增稠剂的固体或糊状洁牙剂变色中的用途。
2.权利要求1的用途，其中所述抗坏血酸磷酸盐为抗坏血酸磷酸钠。
3.权利要求1或2的用途，其中所述洁牙剂含有0.01％重量～5％重量的抗坏血酸磷酸盐。
4.权利要求1或2任意一项的用途，其中乙二胺四乙酸或其盐的量为0.01％重量～5％重量。
5.权利要求3的用途，其中乙二胺四乙酸或其盐的量为0.01％重量～5％重量。
6.一种含有抗坏血酸磷酸盐和乙二胺四乙酸或其盐以及增稠剂的固体或糊状洁牙剂，下述洁牙剂除外：其中所述抗坏血酸磷酸盐为抗坏血酸磷酸镁，所述乙二胺四乙酸盐为乙二胺四乙酸钙。
CNB028082753A 2001-05-10 2002-05-04 洁牙剂 Expired - Fee Related CN100344273C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01111421.2 2001-05-10
EP01111421 2001-05-10

Publications (2)

Publication Number Publication Date
CN1646088A CN1646088A (zh) 2005-07-27
CN100344273C true CN100344273C (zh) 2007-10-24

Family

ID=8177380

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028082753A Expired - Fee Related CN100344273C (zh) 2001-05-10 2002-05-04 洁牙剂

Country Status (9)

Country Link
US (1) US20040175332A1 (zh)
EP (1) EP1387663A1 (zh)
JP (1) JP3813126B2 (zh)
KR (1) KR100618736B1 (zh)
CN (1) CN100344273C (zh)
AU (1) AU2002319161B2 (zh)
BR (1) BR0209455A (zh)
CA (1) CA2444100A1 (zh)
WO (1) WO2002089756A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5022625B2 (ja) * 2006-04-28 2012-09-12 花王株式会社 歯磨剤
CN104853719B (zh) 2012-12-19 2017-11-03 高露洁-棕榄公司 口腔护理组合物
MX2023006361A (es) * 2020-12-09 2023-06-13 Colgate Palmolive Co Composiciones para el cuidado bucal que comprenden derivados de acido ascorbico.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4457909A (en) * 1982-09-27 1984-07-03 Tames Theobaldo Oral rinse formulation and method of treating mouth and throat irritations therewith
US5496541A (en) * 1993-01-19 1996-03-05 Pilot Research & Development Co. Tasteful toothpaste and other dental products
US5900230A (en) * 1997-08-18 1999-05-04 Squigle, Inc. Dental products to treat and prevent periodontal disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2846317A (en) * 1954-01-14 1958-08-05 Dow Chemical Co Preservation of foods
US4348378A (en) * 1979-08-09 1982-09-07 Kosti Carl M Plaque disclosing dentifrice compositions with semi-solid microcapsules of dye
JP2814549B2 (ja) * 1989-05-08 1998-10-22 ライオン株式会社 口腔用組成物
JP2936579B2 (ja) * 1989-05-08 1999-08-23 ライオン株式会社 口腔用組成物
JP4519961B2 (ja) * 1998-05-29 2010-08-04 株式会社カネカ 皮膚外用剤用界面活性剤及びそれを含有する皮膚外用剤
JP4304681B2 (ja) * 1998-07-09 2009-07-29 西日本旅客鉄道株式会社 軌道の曲線線形データ作成方法
JP2000256153A (ja) * 1999-03-05 2000-09-19 Lion Corp 口腔用組成物
US6379654B1 (en) * 2000-10-27 2002-04-30 Colgate Palmolive Company Oral composition providing enhanced tooth stain removal
EP1370226A2 (en) * 2001-01-24 2003-12-17 Oraceutical LLC Topical oral care compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4457909A (en) * 1982-09-27 1984-07-03 Tames Theobaldo Oral rinse formulation and method of treating mouth and throat irritations therewith
US5496541A (en) * 1993-01-19 1996-03-05 Pilot Research & Development Co. Tasteful toothpaste and other dental products
US5496541C1 (en) * 1993-01-19 2001-06-26 Squigle Inc Tasteful toothpaste and other dental products
US5900230A (en) * 1997-08-18 1999-05-04 Squigle, Inc. Dental products to treat and prevent periodontal disease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
维生素C注射液生产中应该注意的几个问题 王建国，产销园地，第7卷第5期 1998 *

Also Published As

Publication number Publication date
WO2002089756A1 (en) 2002-11-14
JP3813126B2 (ja) 2006-08-23
BR0209455A (pt) 2004-07-06
AU2002319161B2 (en) 2006-08-24
KR100618736B1 (ko) 2006-08-31
EP1387663A1 (en) 2004-02-11
KR20040025918A (ko) 2004-03-26
US20040175332A1 (en) 2004-09-09
JP2004528357A (ja) 2004-09-16
CA2444100A1 (en) 2002-11-14
CN1646088A (zh) 2005-07-27

Similar Documents

Publication Publication Date Title
EP1061892B1 (en) Remineralization of teeth
EP1437126B1 (en) Compositions used to alleviate xerostomia and to treat disorders associated with same
US6248310B1 (en) Anti-tartar dental product and method
US5281412A (en) Oral compositions
US9539445B2 (en) Type of anion-containing calcium phosphate compound for dental remineralization
US6491899B1 (en) Anti-inflammatory dental care agents
US4826675A (en) Anticalculus oral composition
CA1330047C (en) Oral compositions
GB2172202A (en) Anticalculus oral composition
CN100344273C (zh) 洁牙剂
CN1327825C (zh) 固体口腔用组合物
DE1956016A1 (de) Praeparat zur Zahn- und Mundpflege
EP0176249B1 (en) Stain removal toothpaste
Martu et al. TOOTHPASTES COMPOSITION AND THEIR ROLE IN ORAL CAVITY HYGIENE
Pader Dental products
EP3952829B1 (en) Process for producing an oral care composition comprising gingerdiol
AU2002319161A1 (en) Dentrifice
KR20030088737A (ko) 동해 해양 심층수가 함유된 치약
JPH01153621A (ja) 歯磨組成物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CI01 Correction of invention patent gazette

Correction item: Applicant

Correct: D Sm IP asset company

False: D Sm ZP asset company

Number: 30

Page: 467

Volume: 21

CI02 Correction of invention patent application

Correction item: Applicant

Correct: D Sm IP asset company

False: D Sm ZP asset company

Number: 30

Page: The title page

Volume: 21

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: DSM ZP CAPITAL CO., LTD. TO: DSM IP CAPITAL CO., LTD.

ERR Gazette correction

Free format text: CORRECT: APPLICANT; FROM: DSM ZP CAPITAL CO., LTD. TO: DSM IP CAPITAL CO., LTD.

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1076607

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20071024

Termination date: 20100504

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1076607

Country of ref document: HK