US20060177502A1 - Sustained release pharmaceutical formulations - Google Patents

Sustained release pharmaceutical formulations Download PDF

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Publication number
US20060177502A1
US20060177502A1 US11/326,965 US32696506A US2006177502A1 US 20060177502 A1 US20060177502 A1 US 20060177502A1 US 32696506 A US32696506 A US 32696506A US 2006177502 A1 US2006177502 A1 US 2006177502A1
Authority
US
United States
Prior art keywords
formulation
ranolazine
magnesium stearate
angina
hydroxypropyl methylcellulose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/326,965
Other languages
English (en)
Inventor
Srikonda Sastry
Janaki Nyshadham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
CV Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CV Therapeutics Inc filed Critical CV Therapeutics Inc
Priority to US11/326,965 priority Critical patent/US20060177502A1/en
Assigned to CV THERAPEUTICS, INC. reassignment CV THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: NYSHADHAM, JANAKI, SASTRY, SRIKONDA
Publication of US20060177502A1 publication Critical patent/US20060177502A1/en
Assigned to GILEAD PALO ALTO, INC. reassignment GILEAD PALO ALTO, INC. MERGER (SEE DOCUMENT FOR DETAILS). Assignors: APEX MERGER SUB, INC., CV THERAPEUTICS, INC.
Assigned to GILEAD SCIENCES, INC. reassignment GILEAD SCIENCES, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GILEAD PALO ALTO, INC.
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
US11/326,965 2005-01-06 2006-01-05 Sustained release pharmaceutical formulations Abandoned US20060177502A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/326,965 US20060177502A1 (en) 2005-01-06 2006-01-05 Sustained release pharmaceutical formulations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64216805P 2005-01-06 2005-01-06
US11/326,965 US20060177502A1 (en) 2005-01-06 2006-01-05 Sustained release pharmaceutical formulations

Publications (1)

Publication Number Publication Date
US20060177502A1 true US20060177502A1 (en) 2006-08-10

Family

ID=36648222

Family Applications (1)

Application Number Title Priority Date Filing Date
US11/326,965 Abandoned US20060177502A1 (en) 2005-01-06 2006-01-05 Sustained release pharmaceutical formulations

Country Status (16)

Country Link
US (1) US20060177502A1 (fr)
EP (1) EP1841411A2 (fr)
JP (1) JP2008526879A (fr)
KR (1) KR20070093988A (fr)
CN (1) CN101098682A (fr)
AU (1) AU2006203890A1 (fr)
BR (1) BRPI0606403A2 (fr)
CA (1) CA2593593A1 (fr)
GE (1) GEP20094784B (fr)
IL (1) IL184460A0 (fr)
MX (1) MX2007008162A (fr)
NO (1) NO20074037L (fr)
RU (1) RU2384332C2 (fr)
UA (1) UA90875C2 (fr)
WO (1) WO2006074398A2 (fr)
ZA (1) ZA200705530B (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080009503A1 (en) * 2002-05-21 2008-01-10 Andrew Wolff Method of treating diabetes
US20080193530A1 (en) * 2007-02-13 2008-08-14 Brent Blackburn Use of ranolazine for the treatment of non-coronary microvascular diseases
US20080214555A1 (en) * 2007-02-13 2008-09-04 Markus Jerling Use of ranolazine for the treatment of cardiovascular diseases
US20080233191A1 (en) * 2007-03-22 2008-09-25 Brent Blackburn Use of ranolazine for elevated brain-type natriuretic peptide
US20080248112A1 (en) * 2007-02-13 2008-10-09 Brent Blackburn Use of ranolazine for the treatment of coronary microvascular diseases
US20080299195A1 (en) * 2007-05-31 2008-12-04 Brent Blackburn Use of ranolazine for elevated brain-type natriuretic peptide
US20090012103A1 (en) * 2007-07-05 2009-01-08 Matthew Abelman Substituted heterocyclic compounds
US20090111826A1 (en) * 2007-02-13 2009-04-30 Louis Lange Use of ranolazine for the treatment of cardiovascular diseases
US20090203707A1 (en) * 2008-02-06 2009-08-13 Sridharan Rajamani Methods for treating pain
US20100197701A1 (en) * 2002-05-21 2010-08-05 Gilead Palo Alto, Inc. Method of treating diabetes
US20100292217A1 (en) * 2009-05-14 2010-11-18 Gilead Palo Alto, Inc. Ranolazine for the treatment of cns disorders
WO2010137040A2 (fr) 2009-05-28 2010-12-02 Lupin Limited Nouvelles compositions pharmaceutiques de ranolazine
WO2011036677A2 (fr) 2009-09-25 2011-03-31 Lupin Limited Composition de ranolazine à libération prolongée
WO2011084733A1 (fr) 2009-12-21 2011-07-14 Gilead Sciences, Inc. Méthode de traitement de la fibrillation atriale
WO2011159706A1 (fr) 2010-06-16 2011-12-22 Gilead Sciences, Inc. Ranolazine destinée à être utilisée pour le traitement de l'hypertension pulmonaire

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2139480A1 (fr) * 2007-04-12 2010-01-06 CV Therapeutics Inc. Ranolazine utilisée pour améliorer la sécrétion d'insuline
BRPI0721741A2 (pt) * 2007-05-31 2013-02-13 Cv Therapeutics Inc mÉtodo de tratamento de diabetes
CN101066253B (zh) * 2007-06-07 2011-01-05 北京本草天源药物研究院 一种雷诺嗪缓释片
ES2414384T3 (es) 2011-05-11 2013-07-19 Ratiopharm Gmbh Composición de liberación modificada que comprende ranolazina
CN104758265B (zh) * 2014-01-07 2019-05-17 四川海思科制药有限公司 一种雷诺嗪缓释片药物组合物及其制备方法
WO2016144855A1 (fr) * 2015-03-07 2016-09-15 Innophos, Inc. Composition de levage pour remplacer des acides de levage à base d'aluminium
TW201717919A (zh) 2015-07-02 2017-06-01 國際藥品股份公司 雷諾多重壓縮錠劑
WO2018001582A1 (fr) 2016-06-30 2018-01-04 Interquim, S.A. Comprimés multiples à base de ranolazine
CN110859843A (zh) * 2019-12-17 2020-03-06 卓和药业集团有限公司 一种治疗动脉硬化合并心绞痛的药物组合物及制备方法
CN111000818A (zh) * 2020-01-04 2020-04-14 东莞市东阳光仿制药研发有限公司 一种雷诺嗪组合物及其制备方法
GR1010345B (el) * 2021-12-16 2022-11-28 Φαρματεν Α.Β.Ε.Ε., Δισκια παρατεταμενης αποδεσμευσης που περιλαμβανουν ρανολαζινη και μεθοδος παραγωγης αυτων

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567264A (en) * 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
US5209933A (en) * 1990-01-10 1993-05-11 Syntex (U.S.A.) Inc. Long acting calcium channel blocker composition
US5403593A (en) * 1991-03-04 1995-04-04 Sandoz Ltd. Melt granulated compositions for preparing sustained release dosage forms
US5472707A (en) * 1993-05-13 1995-12-05 Syntex (U.S.A.) Inc. High dose ranolazine formulations
US5506229A (en) * 1989-06-23 1996-04-09 Syntex Pharmaceuticals, Ltd. Methods of treatment using ranolazine and related piperazine derivatives
US5670171A (en) * 1989-09-18 1997-09-23 Recordati S.A. Chemical And Pharmaceutical Company Liquid-suspension controlled-release pharmaceutical composition
US6303607B1 (en) * 1998-09-10 2001-10-16 Cv Therapeutics, Inc. Method for administering a sustained release ranolanolazine formulation
US6479496B1 (en) * 1998-09-10 2002-11-12 Cv Therapeutics, Inc. Methods for treating angina with ranolazine
US20030220344A1 (en) * 2002-04-04 2003-11-27 Luiz Belardinelli Method of treating arrhythmias
US20040063717A1 (en) * 2002-05-21 2004-04-01 Andrew Wolff Method of treating diabetes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6242918A (ja) * 1985-08-20 1987-02-24 Kaken Pharmaceut Co Ltd 持続性製剤
AU622254B2 (en) * 1989-01-03 1992-04-02 Sterling Drug Inc. Controlled-release, low dose aspirin
US6083532A (en) * 1995-03-01 2000-07-04 Duramed Pharmaceuticals, Inc. Sustained release formulation containing three different types of polymers and tablet formed therefrom

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567264A (en) * 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
US5506229A (en) * 1989-06-23 1996-04-09 Syntex Pharmaceuticals, Ltd. Methods of treatment using ranolazine and related piperazine derivatives
US5906988A (en) * 1989-06-23 1999-05-25 Syntex (U.S.A.) Inc. Methods of treatment using ranolazine and related piperazine derivatives
US5670171A (en) * 1989-09-18 1997-09-23 Recordati S.A. Chemical And Pharmaceutical Company Liquid-suspension controlled-release pharmaceutical composition
US5209933A (en) * 1990-01-10 1993-05-11 Syntex (U.S.A.) Inc. Long acting calcium channel blocker composition
US5403593A (en) * 1991-03-04 1995-04-04 Sandoz Ltd. Melt granulated compositions for preparing sustained release dosage forms
US5472707A (en) * 1993-05-13 1995-12-05 Syntex (U.S.A.) Inc. High dose ranolazine formulations
US6369062B1 (en) * 1998-09-10 2002-04-09 Cv Therapeutics, Inc. Sustained release ranolazine formulations
US6303607B1 (en) * 1998-09-10 2001-10-16 Cv Therapeutics, Inc. Method for administering a sustained release ranolanolazine formulation
US6479496B1 (en) * 1998-09-10 2002-11-12 Cv Therapeutics, Inc. Methods for treating angina with ranolazine
US6503911B2 (en) * 1998-09-10 2003-01-07 Cv Therapeutics, Inc. Sustained release ranolazine formulations
US6525057B2 (en) * 1998-09-10 2003-02-25 Cv Therapeutics, Inc. Sustained release ranolazine formulations
US6562826B1 (en) * 1998-09-10 2003-05-13 Cv Therapeutics, Inc. Sustained release ranolazine formulations
US6617328B2 (en) * 1998-09-10 2003-09-09 Cv Therapeutics, Inc Sustained release ranolazine formulations
US6852724B2 (en) * 1998-09-10 2005-02-08 Cv Therapeutics, Inc. Sustained release ranolazine formulations
US6864258B2 (en) * 1998-09-10 2005-03-08 Andrew A. Wolff Sustained release ranolazine formulations
US20030220344A1 (en) * 2002-04-04 2003-11-27 Luiz Belardinelli Method of treating arrhythmias
US20040063717A1 (en) * 2002-05-21 2004-04-01 Andrew Wolff Method of treating diabetes

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080009503A1 (en) * 2002-05-21 2008-01-10 Andrew Wolff Method of treating diabetes
US8883750B2 (en) 2002-05-21 2014-11-11 Gilead Sciences, Inc. Method of treating diabetes
US8822473B2 (en) 2002-05-21 2014-09-02 Gilead Sciences, Inc. Method of treating diabetes
US8314104B2 (en) 2002-05-21 2012-11-20 Gilead Sciences, Inc. Method of treating diabetes
US20100197701A1 (en) * 2002-05-21 2010-08-05 Gilead Palo Alto, Inc. Method of treating diabetes
EP2216024A2 (fr) 2007-02-13 2010-08-11 Cv Therapeutics, Inc. Utilisation de ranolazine pour le traitement de maladies cardiovasculaires
US20080193530A1 (en) * 2007-02-13 2008-08-14 Brent Blackburn Use of ranolazine for the treatment of non-coronary microvascular diseases
US20080214555A1 (en) * 2007-02-13 2008-09-04 Markus Jerling Use of ranolazine for the treatment of cardiovascular diseases
US20080214556A1 (en) * 2007-02-13 2008-09-04 Markus Jerling Use of ranolazine for the treatment of cardiovascular diseases
US20080248112A1 (en) * 2007-02-13 2008-10-09 Brent Blackburn Use of ranolazine for the treatment of coronary microvascular diseases
US20090111826A1 (en) * 2007-02-13 2009-04-30 Louis Lange Use of ranolazine for the treatment of cardiovascular diseases
US20080233191A1 (en) * 2007-03-22 2008-09-25 Brent Blackburn Use of ranolazine for elevated brain-type natriuretic peptide
US20080299195A1 (en) * 2007-05-31 2008-12-04 Brent Blackburn Use of ranolazine for elevated brain-type natriuretic peptide
US20100197684A1 (en) * 2007-07-05 2010-08-05 Gilead Palo Alto, Inc. Substituted heterocyclic compounds
US9045428B2 (en) 2007-07-05 2015-06-02 Gilead Sciences, Inc. Substituted heterocyclic compounds
US20090012103A1 (en) * 2007-07-05 2009-01-08 Matthew Abelman Substituted heterocyclic compounds
US8716319B2 (en) 2007-07-05 2014-05-06 Gilead Sciences, Inc. Substituted heterocyclic compounds
US20090203707A1 (en) * 2008-02-06 2009-08-13 Sridharan Rajamani Methods for treating pain
US20100292217A1 (en) * 2009-05-14 2010-11-18 Gilead Palo Alto, Inc. Ranolazine for the treatment of cns disorders
US8901128B2 (en) 2009-05-28 2014-12-02 Lupin Limited Pharmaceutical compositions of ranolazine
WO2010137040A2 (fr) 2009-05-28 2010-12-02 Lupin Limited Nouvelles compositions pharmaceutiques de ranolazine
EP2515880B1 (fr) * 2009-05-28 2019-11-27 Lupin Limited Nouvelles compositions pharmaceutiques de ranolazine
US20120177729A1 (en) * 2009-09-25 2012-07-12 Lupin Limited Sustained release composition of ranolazine
WO2011036677A2 (fr) 2009-09-25 2011-03-31 Lupin Limited Composition de ranolazine à libération prolongée
WO2011084733A1 (fr) 2009-12-21 2011-07-14 Gilead Sciences, Inc. Méthode de traitement de la fibrillation atriale
EP2749282A1 (fr) 2009-12-21 2014-07-02 Gilead Sciences, Inc. Méthode de traitement de la fibrillation auriculaire
WO2011159706A1 (fr) 2010-06-16 2011-12-22 Gilead Sciences, Inc. Ranolazine destinée à être utilisée pour le traitement de l'hypertension pulmonaire

Also Published As

Publication number Publication date
WO2006074398A2 (fr) 2006-07-13
JP2008526879A (ja) 2008-07-24
UA90875C2 (ru) 2010-06-10
IL184460A0 (en) 2007-10-31
NO20074037L (no) 2007-08-03
WO2006074398A3 (fr) 2007-02-22
AU2006203890A1 (en) 2006-07-13
CA2593593A1 (fr) 2006-07-13
ZA200705530B (en) 2008-10-29
KR20070093988A (ko) 2007-09-19
CN101098682A (zh) 2008-01-02
RU2384332C2 (ru) 2010-03-20
BRPI0606403A2 (pt) 2009-06-23
GEP20094784B (en) 2009-09-25
EP1841411A2 (fr) 2007-10-10
MX2007008162A (es) 2007-07-24
RU2007125656A (ru) 2009-01-20

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Legal Events

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AS Assignment

Owner name: CV THERAPEUTICS, INC., CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SASTRY, SRIKONDA;NYSHADHAM, JANAKI;REEL/FRAME:017634/0852;SIGNING DATES FROM 20060418 TO 20060424

AS Assignment

Owner name: GILEAD PALO ALTO, INC., CALIFORNIA

Free format text: MERGER;ASSIGNORS:APEX MERGER SUB, INC.;CV THERAPEUTICS, INC.;REEL/FRAME:024838/0650

Effective date: 20090417

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION

AS Assignment

Owner name: GILEAD SCIENCES, INC., CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:GILEAD PALO ALTO, INC.;REEL/FRAME:026426/0553

Effective date: 20110511