Classifications

• • C—CHEMISTRY; METALLURGY
  • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
  • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
  • C09J4/00—Adhesives based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; adhesives, based on monomers of macromolecular compounds of groups C09J183/00 - C09J183/16
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K6/00—Preparations for dentistry
  • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
  • A61K6/69—Medicaments

Definitions

• the present invention relates to self-adhesive dental materials featuring a high level of adhesion to hard tooth substances, simplicity in use, and good mechanical properties.
• the compositions of the invention can be used in the dental segment as fillings, cements, core buildups, fissure sealants and as dental engineering materials.
• GICs glass ionomer cements
• the glass ionomer cements exhibit weak adhesion to the hard tooth substances.
• the adhesion levels are in the very low region of 1 MPa and are generally achieved only by a conditioning step beforehand.
• a further disadvantage of the GICs are the low mechanical values, in particular the low flexural strengths, which limit use in the area exposed to masticatory pressure.
• Composites feature very good mechanical properties and excellent esthetics.
• composites are composed essentially of a crosslinked polymeric resin matrix based on (meth)acrylate monomers and a fraction of fillers.
• composites are generally given an apolar, hydrophobic formulation. A consequence of this is that composites do not exhibit self-adhesion to the hard tooth substances and in particular not to dentine. Additionally, composites exhibit shrinkage in the course of curing, which allows marginal gaps to form and secondary caries to develop.
• additional pretreatments and/or worksteps involving what is known as bonding are required. In accordance with the present state of the art it is necessary in this case for the practitioner to carry out the following worksteps:
• Compomers are chemically related to the composites. They are given a more hydrophilic formulation, however, through the use of acid-functional (meth)acrylates in the monomer mixture. With use of these materials, in contrast to the composites, there is no longer any need for absolute dryness (no placement of rubber dam). Nevertheless, these materials as well require the use of a bonding material in order to achieve an effective adhesive bond with the hard tooth substances.
• the RMGICs are composed essentially of a basic filler, acids, water, (meth)acrylate-based monomers, and initiators for a free-radical polymerization.
• the RMGICs cure both by way of an acid/base reaction and by way of a free-radical polymerization.
• the esthetics of the RMGICs are improved as compared with those of the conventional GICs.
• a conditioning step is generally necessary for adhesion—albeit minimal—to the hard tooth substances.
• the formulations of the products on the market include hydroxyethyl methacrylate (HEMA), which functions as a solubilizer for the water-soluble acids and remaining (meth)acrylates.
• HEMA is toxicologically objectionable and adversely affects the swelling characteristics and hence the mechanical properties, such as the flexural strength, of the RMGICs.
• One object of the present invention can therefore be seen as being to provide dental materials which do not have the described disadvantages of the state of the art and which in particular feature simple application, a high level of adhesion to hard tooth substances without pretreatment such as the use of a conditioner, bonding material, primer or etching agent, for example, and also good mechanical properties.
• filler(s) from 22.8 to 85% by weight of filler(s), including at least one filler capable of reacting with component (A) in an ion exchange, neutralization, acid-forming and/or chelate-forming reaction,
• formulations with the above composition exhibit an adhesion to bovine dental enamel or dentine of at least 2.0 MPa, preferably of at least 2.5 MPa, more preferably at least 3.0 MPa, measured in accordance with the adhesion determination method indicated below, “Determination of adhesion”, without the need for pretreatment of the hard tooth substance.
• the formulations of the invention moreover, have good mechanical properties and are easy to handle.
• low water absorbency of ⁇ 50 ⁇ g/mm 3 preferably ⁇ 40 ⁇ g/mm 3 , more preferably ⁇ 30 ⁇ g/mm 3
• pretreatment encompasses steps such as etching, priming, bonding, and conditioning, for example.
• At least one monomer of component (A) contains at least one P—OH group, such as a phosphoric, phosphonic or phosphinic acid group, for example. This monomer is present preferably in a concentration of at least about 5% by weight, more preferably at least about 10% by weight, based on constituents (A) to (E).
• P—OH group such as a phosphoric, phosphonic or phosphinic acid group
• this monomer is present preferably in an amount of at least 30%, more preferably at least 50% by weight.
• Component (A) comprises compounds which possess at least one ethylenically unsaturated group and also at least one acid-functional group.
• the polymerizable groups are acrylic, methacrylic, vinyl and/or styryl groups, with acrylic and methacrylic groups being particularly preferred.
• Suitable acid groups are carboxylic acid residues, acid residues of phosphorus (e.g., phosphoric, phosphonic, phosphinic acids), of sulfur (e.g., sulfuric, sulfonic, sulfinic acids) and of boron.
• a feature of the acid groups is that they are able to enter into ion exchange, neutralization, salt-forming and/or chelate-forming reactions with reactive inorganic fillers. It is also possible for the acid residues of component (A) to be present not completely in free form but also, in part, in derivatized form, for instance as a salt, acid halide, acid hydride or readily hydrolyzable esters.
• Suitable components (A) and their preparation are described for example in DE 35 36 076 A1, EP 0 237 233 A, and WO 95/22956.
• HEMA hydroxyethyl
• glyceryl di(meth)acrylate and/or pentaerythrityl tri(meth)acrylate chloro- and bromophosphoric esters of bisphenol A glycidyl (meth)acrylate.
• nucleophilic acrylates and methacrylates such as 2-hydroxyethyl methacrylate (HEMA) or glycerol methacrylate esters, for example, with reactive phosphonic or phosphinic or phosphoric acid derivatives such as POCl 3 , P 2 O 5 or PCl 3 , for example.
• HEMA 2-hydroxyethyl methacrylate
• glycerol methacrylate esters for example
• reactive phosphonic or phosphinic or phosphoric acid derivatives such as POCl 3 , P 2 O 5 or PCl 3 , for example.
• the abovementioned ethylenically unsaturated acids and/or derivatives thereof have a molecular weight in the range from 70 to 5 000, preferably in the range from 90 to 2 500, more preferably in the range from 100 to 1 000 g/mol.
• Compounds suitable as component (B) are those which possess at least one ethylenically unsaturated group.
• the polymerizable groups are acrylic, methacrylic, vinyl and/or styryl groups, with acrylic and methacrylic groups being particularly preferred.
• Suitable mono- and polyfunctional (meth)acrylates and also further ethylenically unsaturated compounds are described for example in EP 0 480 472 A, DE 39 41 629 C2 and in G. Webster (Ed.), Chemistry & Technology of UV & EB Formulation for Coatings, Inks and Paints, Vol. II Prepolymers & Reactive Diluents, J. Wiley and Sons, Chichester, N.Y., Weinheim, Brisbane, Toronto, Singapore, 1997.
• the ethylenically unsaturated compounds can be used in solitary form or in mixtures in the formulations.
• Suitable monomers are the acrylic and methacrylic esters of mono-, di- or higher polyfunctional alcohols.
• diacrylic and dimethacrylic esters of bis(hydroxymethyl)tricyclo[5.2.1.0 2,6 ]decane specified in DE 28 168 23 C and the diacrylic and dimethacrylic esters of the compounds of bis(hydroxymethyl)tricyclo[5.2.1.0 2,6 ]decane extended with from 1 to 3 ethylene oxide and/or propylene oxide units.
• urethane (meth)acrylates such as 7,7,9-trimethyl-4,13-dioxo-5,12-diazahexadecane-1,16-dioxydi(meth)acrylate (UDMA, Plex 6661) can be a constituent of component (B).
• the stated compounds and their derivatives preferably have a molecular weight in the range from 70 to 5 000, preferably in the range from 90 to 2 500, more preferably in the range from 100 to 1 000 g/mol.
• component (C) it is possible to use inorganic fillers such as glasses or ceramics and/or organic fillers.
• the fillers can be used in solitary form or in mixtures.
• the fillers can be incorporated in different particle sizes into the formulas, i.e., the fillers can have a unimodal or polymodal distribution, bimodal for example.
• At least one filler must be used which is able to react with component (A) in an ion exchange, neutralization, salt-forming and/or chelate-forming reaction (reactive filler).
• reactive filler ion exchange, neutralization, salt-forming and/or chelate-forming reaction
• those fillers which are inert toward the acid functions of component (A) nonreactive fillers.
• reinforcing materials such as fibers or fibrous compounds, can also be added.
• Fillers capable of reacting with the acid groups of component (A) are used, for example, to produce polycarboxylate cements and glass-ionomer cements and are described, for example, in D. C. Smith, Biomaterials 19, 467-478 (1998), DE 20 61 513 A, and WO 95/22956.
• Suitable in principle are finely divided metals such as finely divided zinc, metal compounds such as the oxides and/or hydroxides of calcium, magnesium, strontium, and zinc.
• finely divided metals such as finely divided zinc, metal compounds such as the oxides and/or hydroxides of calcium, magnesium, strontium, and zinc.
• basic glass powders having a high fraction of divalent and trivalent ions, and also silicates which release metal cations, such as phyllosilicates, bentonites or calcium silicates, sodium aluminum silicates, and zeolites, including the molecular sieves, and also apatite.
• glasses reactive toward component (A) are the borate, phosphate, and fluoroaluminosilicate glasses specified in WO 93/12759.
• Particularly preferred reactive fillers are the fluoroaluminosilicate glasses and also hydroxides of the alkaline earth metals.
• Suitable inert inorganic fillers are, for example, quartz, zirconium silicates, precipitated silicates (HDKH) and low-solubility metal salts such as barium sulfate or calcium fluoride. Further inert inorganic fillers are described in WO 95/22956. Particularly preferred inert inorganic fillers are quartz and zirconium silicates. Component (C) here does not include, in the sense of the invention, any pyrogenic silicas.
• organic fillers examples include bead polymers and copolymers based on methyl methacrylate, which are available commercially under the designation “Plexidon” or “Plex” from the company Röhm. Also particularly suitable are the polyurethane-based organic fillers described in DE 19 941 738.
• initiators in accordance with component (D) are meant initiator systems which effect the free-radical polymerization of the monomers, examples being photoinitiators and/or what are called redox initiatory systems and/or thermal initiators.
• Suitable photoinitiators are described for example in J. -P. Fouassier, Photoinitiation, Photopolymerization and Photocuring, Hanser Publishers, Kunststoff, Vienna, N.Y. 1995 or else J. F. Rabek (ed.), Radiation Curing in Polymer Science and Technology, Vol. II, Elsevier Applied Science, London, N.Y., 1993 and also in the patent publications EP 0 073 413 A, EP 0 007 508 A, EP 0 047 902 A, EP 0 057 474 A, and EP 0 184 095 A. Examples that may be mentioned include benzoin alkyl ethers, benzil ketals, and acylphosphine oxides. Particularly suitable are aliphatic and aromatic 1,2-diketone compounds such as camphorquinone in combination with activators such as tertiary amines.
• Suitable redox initiator systems include organic compounds with an oxidative action, such as peroxide compounds, together with what are termed activators.
• Suitable organic peroxide compounds include, in particular, compounds such as lauroyl peroxide, benzoyl peroxide, and also p-chlorobenzoyl and p-methylbenzoyl peroxide.
• Suitable activators include tertiary aromatic amines, such as the N,N-bis(hydroxyalkyl)-3,5-xylidines known from U.S. Pat. No. 3,541,068 A and the N,N-bis(hydroxyalkyl)-3,5-di-t-butylanilines known from DE 26 58 538 A, especially N,N-bis( ⁇ -oxybutyl)-3,5-di-t-butylaniline, and also N,N-bis(hydroxyalkyl)-3,4,5-trimethylaniline.
• tertiary aromatic amines such as the N,N-bis(hydroxyalkyl)-3,5-xylidines known from U.S. Pat. No. 3,541,068 A and the N,N-bis(hydroxyalkyl)-3,5-di-t-butylanilines known from DE 26 58 538 A, especially N,N-bis( ⁇ -oxybutyl)-3,5-di-t-butylani
• activators are compounds of sulfur in oxidation state +2 or +4 such as sodium benzenesulfinate or sodium para-toluenesulfinate or the barbituric acids or barbituric acid derivatives described in DE 14 955 20 B and also the malonylsulfamides described in EP 0 059 451 A.
• Preferred malonylsulfamides are 2,6-dimethyl-4-iso-butylmalonylsulfamide, 2,6-diisobutyl-4-propylmalonylsulfamide, 2,6-dibutyl-4-propylmalonylsulfamide, 2,6-dimethyl-4-ethylmalonylsulfamide and 2,6-dioctyl-4-isobutylmalonylsulfamide.
• the polymerization can be conducted in the presence of heavy metal compounds based on, for example, Ce, Fe, Cu, Mn, Co, Sn or Zn, with copper compounds being particularly suitable.
• the heavy metal compounds are used preferably in the form of soluble organic compounds.
• One particularly suitable redox system comprises the following components:
• the dental compositions of the invention are cured by photopolymerization it is possible to formulate one-component systems.
• the dental compositions of the invention comprise a redox initiator system, comprising for example organic peroxide and activator, then for reasons of storage stability peroxide and activator are present in spatially separate parts of the dental composition of the invention, which are not mixed with one another until immediately prior to application.
• a redox initiator system comprising for example organic peroxide and activator
• peroxide and activator are present in spatially separate parts of the dental composition of the invention, which are not mixed with one another until immediately prior to application.
• the constituents of the initiator system of the invention may be microencapsulated.
• Methods of microencapsulation are described for example in U.S. Pat. No. 5,154,762 and EP 0 588 878 B1.
• component (E) In order to set specific properties it is possible as component (E) to introduce additional additives or modifiers into the formulations. Possible additives and their functions are described in U. Zorll (ed.), Lehrbuch der Lacktechnologie, Vincentz Verlag, Hanover 1998 and P. Nanetti, Lackrohstofftechnik, Vincentz Verlag, Hanover 1997. With no claim to completeness, representative mention may be made of some additives and/or modifiers:
• plasticizers such as phthalates, adipates, sebacates, phosphates or citrates, for example to increase the flexibility of the compositions;
• organic and inorganic pigments and/or dyes such as white pigments based on titanium dioxide or zinc sulfide (lithopones), red iron oxide 3395, Bayferrox 920 Z Yellow, Neozapon Blue 807 (copper phthalocyanine-based dye) or Helio Fast Yellow ER, for individual coloring of the dental compositions;
• stabilizers especially free-radical scavengers, such as substituted and unsubstituted hydroxyaromatics (e.g., para-methoxyphenol), phenothiazine, HALS (hindered amine light stabilizers) and/or heavy metal scavengers such as EDTA;
• free-radical scavengers such as substituted and unsubstituted hydroxyaromatics (e.g., para-methoxyphenol), phenothiazine, HALS (hindered amine light stabilizers) and/or heavy metal scavengers such as EDTA;
• thixotropic assistants such as pyrogenic silicas (Aerosil) or else modified phyllosilicates;
• ion donor substances particularly those which release fluoride ions, such as the fluoride salts of metals from main groups one and/or two such as sodium fluoride.
• fluoride ions such as the fluoride salts of metals from main groups one and/or two such as sodium fluoride.
• Particularly suitable are complex inorganic fluorides of the general formula A n MF m as described in EP 0 717977 A.
• A is a mono- or polyvalent cation
• M is a metal from main or transition group III
• IV, V
• n is an integer from 1 to 3
• m is an integer from 3 to 6.
• calcium zinc fluoride and potassium hexafluorotitanate are examples of calcium zinc fluoride and potassium hexafluorotitanate.
• Bactericidal or antibiotic substances such as chlorhexidine, pyridinium salts or the customary pharmaceutical substances such as ⁇ -lactam antibiotics (penicillins), cephalosporins, tetracyclines, chloramphenicol, fosfomycin, antibacterial macrolides or polypeptide antibiotics, for example, may likewise be used.
• solvents as flow improvers and to improve the mixing characteristics.
• Particularly preferred in this context are water, acetone, methyl ethyl ketone and/or short-chain alcohols having less than 10 carbon atoms such as ethanol or isopropanol, for example.
• component (E) in order to set specific properties, it is also possible as component (E) to use soluble organic polymers such as polyvinyl acetate, polyacrylic acid and/or polyvinyl ethers.
• compositions of the invention can be used in the dental segment, for example, as filling materials, fissure sealants, cements, core buildups and as dental engineering materials and/or bone substitute compositions.
• Ketac Molar (GIC from 3M ESPE AG)
• Fuji II LC (RMGIC from GC)
• Ketac Cem (GIC from 3M ESPE AG)
• Fuji Plus (RMGIC from GC)
• Panavia 21 Composite from Kuraray
• Adhesion tests were carried out using bovine teeth. For each test, five bovine teeth deep frozen following extraction are thawed, cleaned to remove the remaining gum, and separated from the roots by sawing with a diamond saw. The remaining pulp is removed with the aid of a pulp needle and the teeth are then rinsed with mains water. Planar dentine is obtained by labial sanding of the teeth on a water-cooled diamond sanding disk. The teeth are then embedded in silicone in such a way that the sanded-off surface, which is kept well moistened, points upward, and are subsequently aftertreated wet with a fine silicon carbide sandpaper.
• each tooth has stuck to it a small wax plate which has a round cutout of 6 mm in diameter (test area).
• This test area is filled in a planar fashion with the material, mixed according to the manufacturer's instructions, and cured in accordance with the manufacturer's instructions for 10 to 40 seconds with Elipar II (600-800 mW/cm 2 ). Autopolymerizing materials are cured for 1 h at 36° C. and 100% relative humidity. After curing, the small wax plate is removed, a screw is bonded adhesively to the protruding filling at right angles to the surface of the tooth, and after storage for one day at 36° C. and 100% relative humidity the adhesion is measured in a take-off test on a Zwick UPM 1455 with a take-off rate of 1 mm/min.
• the flexural strength was determined in accordance with EN ISO 4049: 2000 (3-point bending test).
• the water absorption was determined on standardized test specimens in accordance with EN ISO 4049: 2000.
• the example formulas 1 to 3 of the invention exhibit without pretreatment a much higher adhesion to bovine dentine than all other materials.
• the flexural strengths are greatly increased.
• the water absorptions are within the range of the compomers and composites and are much lower than in the case of the glass ionomer cements and resin-modified glass ionomer cements.
• the example formula 4 of the invention exhibits without pretreatment a very high adhesion to bovine dentine.
• the water absorptions are within the range of the composites and are much lower than in the case of the compomers, glass ionomer cements, and resin-modified glass ionomer cements.
• a laboratory kneader was used to produce a paste from the following constituents:

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• 2001
  • 2001-05-16 DE DE10124028A patent/DE10124028B4/de not_active Expired - Lifetime
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