US20020193685A1 - Guided Radiation Therapy System - Google Patents

Guided Radiation Therapy System Download PDF

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Publication number
US20020193685A1
US20020193685A1 US09/877,498 US87749801A US2002193685A1 US 20020193685 A1 US20020193685 A1 US 20020193685A1 US 87749801 A US87749801 A US 87749801A US 2002193685 A1 US2002193685 A1 US 2002193685A1
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United States
Prior art keywords
target
marker
isocenter
relative
sensors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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US09/877,498
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English (en)
Inventor
Timothy Mate
Steven Dimmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Varian Medical Systems Inc
Calypso Medical Inc
Original Assignee
Calypso Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US09/877,498 priority Critical patent/US20020193685A1/en
Application filed by Calypso Medical Inc filed Critical Calypso Medical Inc
Assigned to CALYPSO MEDICAL, INC. reassignment CALYPSO MEDICAL, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DIMMER, STEVEN C., MATE, TIMOTHY P.
Priority to EP10185676A priority patent/EP2289597A1/en
Priority to CA002449967A priority patent/CA2449967A1/en
Priority to PCT/US2002/017876 priority patent/WO2002100485A1/en
Priority to EP10185512.0A priority patent/EP2314348B1/en
Priority to EP02741866.4A priority patent/EP1392397B1/en
Priority to JP2003503301A priority patent/JP4446335B2/ja
Publication of US20020193685A1 publication Critical patent/US20020193685A1/en
Priority to US10/721,491 priority patent/US7657301B2/en
Priority to US10/722,015 priority patent/US7657302B2/en
Priority to US10/743,531 priority patent/US7657303B2/en
Assigned to CALYPSO MEDICAL TECHNOLOGIES, INC. reassignment CALYPSO MEDICAL TECHNOLOGIES, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DIMMER, STEVEN C., MATE, TIMOTHY P.
Priority to JP2009229945A priority patent/JP5682868B2/ja
Priority to US12/891,742 priority patent/US9072895B2/en
Assigned to VARIAN MEDICAL SYSTEMS, INC. reassignment VARIAN MEDICAL SYSTEMS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CALYPSO MEDICAL TECHNOLOGIES, INC.
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2046—Tracking techniques
    • A61B2034/2051—Electromagnetic tracking systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2072—Reference field transducer attached to an instrument or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3954—Markers, e.g. radio-opaque or breast lesions markers magnetic, e.g. NMR or MRI
    • A61B2090/3958—Markers, e.g. radio-opaque or breast lesions markers magnetic, e.g. NMR or MRI emitting a signal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/105—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using a laser alignment system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1051—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using an active marker
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
    • A61N5/1069—Target adjustment, e.g. moving the patient support
    • A61N5/107—Target adjustment, e.g. moving the patient support in real time, i.e. during treatment

Definitions

  • This invention relates generally to radiation therapy systems, and more particularly to systems and methods for accurately locating and tracking a target in a body to which guided radiation therapy is delivered.
  • Recent advances in radiation therapy are providing new avenues of effective treatment for localized cancer. These include three-dimensional conformal external beam radiation, intensity modulated radiation therapy (IMRT), and stereotactic radiosurgery and brachytherapy. These newer treatment modalities deliver greater doses of radiation to the tumor, which accounts for their increased effectiveness when compared to standard external beam radiation therapy.
  • IMRT intensity modulated radiation therapy
  • stereotactic radiosurgery and brachytherapy These newer treatment modalities deliver greater doses of radiation to the tumor, which accounts for their increased effectiveness when compared to standard external beam radiation therapy.
  • the margin may encompass some rectal, bladder and bulbar urethral tissues. It is highly desirable to provide a margin that does not encompass these important tissues.
  • a tumor is identified within a patient's body with an imaging system, such as an X-ray, computerized tomography (CT), magnetic resonance imaging (MRI), or ultrasound system.
  • CT computerized tomography
  • MRI magnetic resonance imaging
  • ultrasound system The approximate location of a tumor in the body is aligned with two or more alignment points on the exterior of the patient's body, and external marks are written on the patient's skin to mark the alignment points.
  • the external marks are aligned with a reference system of the radiation delivery devices.
  • This setup process attempts to accurately position the treatment target (or patient) isocenter within the body at a position in space where the radiation beam is focused, known as the machine isocenter.
  • the effective patient treatment volume within the body is accurately registered (or positioned) to the radiation therapy treatment plan location. If, however, the target has moved relative to the external marks, then the target may be offset from the machine's isocenter, even when the external aligning devices and marks are properly aligned. Accordingly, the doctors and technicians cannot tell how far the target has actually moved relative to the machine's isocenter.
  • a system and methods are provided for accurately locating and tracking the actual position of a target within a body in preparation for and during radiation therapy.
  • the system is usable with a radiation delivery source that delivers a selected dose of radiation to the target in the body when the target is positioned at the machine isocenter of the radiation delivery source.
  • the system includes a marker fixable in or on the body at a selected position relative to the target, such as in or near the target.
  • the marker is excitable by an external excitation source to produce an identifiable signal while affixed in or on the body.
  • a sensor array with a plurality of sensors is provided external of the body, and the sensors are spaced apart in a known geometry relative to each other.
  • a data-processing unit is coupled to the sensor array and is configured to use the measurements from the sensors to determine the actual location of the marker and a target isocenter within the target relative to the sensors.
  • a reference marker is also coupled to the radiation delivery device at a known position relative to the device's machine isocenter. The reference marker provides a measurable signal for determining the position of the reference marker and the machine isocenter relative to the sensor array.
  • the data-processing unit is configured to compare the position of the target isocenter with the position of the machine isocenter in real time to determine whether the patient is properly setup for the radiation therapy.
  • a monitoring system is coupled to the data-processing unit and has a feedback portion configured to provide feedback information about the actual position of the target isocenter relative to the machine isocenter.
  • the feedback portion provides a visual and/or numeric representation of the positions of the machine isocenter and target isocenter relative to each other. This representation may then be used to adjust the position of the target isocenter before or during therapy.
  • the feedback portion provides a visual and/or numeric display of the real-time movement of the target isocenter relative to the machine isocenter.
  • the feedback data may be used to automatically alert the operator of patient or target movement beyond acceptable limits.
  • the feedback data may be used to automatically adjust, gate or shutoff the radiation therapy treatment for normal (i.e. respiration) or unplanned patient motion.
  • an adjustable patient support assembly is combined with the tracking and monitoring system for use with the radiation delivery system.
  • the support assembly includes a base, a support structure movably attached to the base, and a movement control device connected to the support structure in order to selectively move the support structure relative to the base.
  • the plurality of sensors spaced apart from each other are coupled to the base in a fixed location relative to the base.
  • the data-processing unit is coupled to the sensors to receive the signal measurement data from one or more markers in or next to the target.
  • the data-processing unit is configured to use the signal measurement data for each marker to determine the actual location of the marker and target isocenter within the target.
  • the data-processing unit is configured to identify the location of the target isocenter relative to the machine isocenter.
  • the movement control device is coupled to the data-processing unit and is adapted to position the target isocenter coincident with the machine isocenter in response to data from the data processing unit.
  • a method for delivering radiation therapy on a selected target within a body.
  • the method includes positioning an excitable marker at a selected position relative to the target, exciting the implanted marker with an excitation source external of the body to produce an identifiable marker signal and measuring the marker signal from the marker with a plurality of sensors exterior of the body, positioned in a known geometry relative to each other.
  • the method also includes determining the location of the marker and a target isocenter in the body relative to the sensors based upon the measurements of the marker signal from the sensors.
  • the method further includes determining the location of a machine isocenter of the radiation delivery assembly relative to the sensors and relative to the target isocenter, and positioning the body relative to the radiation delivery device so the target isocenter is coincident with the machine isocenter. Radiation therapy is then applied from the radiation delivery device to the treatment volume about the target isocenter.
  • a method for positioning a body relative to a radiation delivery device for delivering radiation therapy to a treatment volume at a target isocenter within the body.
  • the body has a selected target therein, and at least one excitable marker is positioned in a known position relative to the target.
  • the method includes positioning the body on a movable support assembly adjacent to a plurality of sensors, and energizing the excitable marker with an excitation source exterior of the body.
  • the excited marker provides an identifiable marker signal.
  • the marker signal is measured with the plurality of sensors positioned exterior of the body and in a known geometry relative to each other and relative to the movable support assembly.
  • the location of the marker and a target isocenter within the treatment volume is determined based on the measurements by the sensors of the marker signal.
  • the location of the target isocenter is also determined relative to the plurality of sensors and relative to the machine isocenter.
  • the location of the target isocenter is compared to the location of the machine isocenter, and if the two isocenters are not coincident with each other, a portion of the support assembly moves the body and target to position the target isocenter coincident with the machine isocenter.
  • Figure 1 is a schematic side elevation view of a target locating and monitoring system in accordance with an embodiment of the present invention.
  • Excitable markers are shown implanted in or adjacent to a target in a patient's body, a sensor array is shown exterior of the patient, and a radiation delivery device is shown in a position to apply radiation therapy to the target within the body.
  • Figure 2 is a schematic top plan view of the patient on a movable support table, with the implanted markers, the target, and the sensor array shown in hidden lines.
  • Figure 3 is an enlarged side elevation view of one embodiment of a single-axis marker usable in the system illustrated in Figure 1.
  • Figure 4 is an enlarged side elevation view of one embodiment of a three-axis marker usable in the system of Figure 1.
  • Figure 5 is an enlarged isometric view of another embodiment of a three-axis marker usable in the system of Figure 1.
  • Figure 6 is an enlarged partial schematic isometric view of the target, three markers implanted in or near the target, an external excitation source, the sensor array, and a computer controller in the system of Figure 1.
  • Figure 7 is a schematic isometric view of an alternate embodiment of the sensor array in the system of Figure 1.
  • Figure 8 is a geometric representation of two intersecting spheres representing data for determining a marker's position relative to two sensors.
  • Figure 9 is a geometric representation of four intersecting spheres representing data for determining a marker's position relative to four sensors.
  • Figure 10 is a schematic isometric view of a target in a body shown in phantom lines in a first position and shown in solid lines in a second, different position within the body.
  • Figure 11 is an enlarged isometric view of the monitoring system of Figure 1 showing a simulated target, simulated markers, and a simulated target isocenter shown in phantom lines on a display screen, and actual marker locations and target isocenter locations shown in solid lines on the display screen.
  • Figure 12 is an isometric view of the monitoring system of Figure 11 with the simulated and actual markers shown aligned with each other, and the machine isocenter and target isocenter coincident with each other.
  • Figure 13 is a simulated isometric view of a target and markers illustrated on the monitoring system, and the target is shown in a first target condition.
  • Figure 14 is a simulated isometric view of the target and markers of Figure 13, and the target is shown in a second condition representing a change in the target size or condition relative to the markers.
  • Figure 15 is a side elevation view of an alternate embodiment of the present invention with surface markers mounted to an external surface of the patient's body and in alignment with each other and the target.
  • Figure 16 is a top plan view of all of the patient with the surface-mounted markers of Figure 15 mounted thereon.
  • Figure 17 is a schematic flow diagram of a radiation delivery process for delivering radiation treatment to a target utilizing the system of Figure 1.
  • Figures 1-17 illustrate a system and several components for locating, tracking and monitoring a target within a body in accordance with embodiments of the present invention.
  • the system and components are usable to locate, track, monitor, and evaluate a target for application of a selected therapy to the target, such as guided radiation therapy.
  • a selected therapy such as guided radiation therapy.
  • one aspect of the present invention provides a system 10 configured for use in applying guided radiation therapy to a target 12, such as a tumor, within the body 14 of a patient 16.
  • the system 10 allows the target 12 to be located within the patient's body 14 and the actual position monitored in real time while applying ionizing radiation therapy to the target from a radiation delivery source 18.
  • the target 12 may move within the body 14 because of breathing, organ filling or emptying, or other internal movement.
  • the target motion is tracked and monitored relative to the radiation beam to insure accurate delivery of radiation to the target 12 and, if needed, only a minimum margin around the target.
  • the system 10 is discussed below in connection with guided radiation therapy for radiation of a tumor or other target, the system can be used for tracking and monitoring other targets within a body, such as for other therapeutic or diagnostic purposes.
  • the radiation delivery source 18 of the illustrated embodiment is an ionizing radiation device, known as a linear accelerator, but could be any radiation therapy delivery device.
  • Other radiation therapy delivery devices can be used, including such devices manufactured by Varian Medical Systems, Inc. of Palo Alto, California; Siemans Medical Systems, Inc. of Iselin, New Jersey; Electa Instruments, Inc. of Iselin, New Jersey; or Mitsubishi Denki Kabushik Kaisha of Japan.
  • Such devices are used to deliver conventional single or multi-field radiation therapy, 3D conformal radiation therapy (3D CRT), inverse modulated radiation therapy (IMRT), stereotactic radiotherapy, and tomo therapy. This is done in conjunction with a variety of treatment planning software systems.
  • the radiation delivery source 18 delivers a gated, contoured or shaped beam 19 of ionizing radiation from a movable gantry 20 to a area or volume referenced to a point at a location away from the gantry.
  • This point in space referred to as a machine isocenter 22, is the point to which the ionizing radiation beam 19 is configured about as determined by industry standard treatment planning processes.
  • the system 10 allows the target 12 to be accurately positioned at the machine isocenter 22 so the ionizing radiation is accurately delivered to the target 12.
  • the system also allows the target's actual position relative to the machine isocenter 22 to be monitored during the radiation therapy so as to minimize collateral damage to healthy tissue surrounding the target.
  • the illustrated system 10 includes a plurality of markers 30 positioned in or adjacent to the target 12 to mark the target's actual location in the body 14. Accordingly, the markers 30 are markers in, on or near the body. In one example, the markers 30 may be attached to patient-immobilization devices at known locations relative to the treatment isocenter.
  • the markers 30 are energized or excited by an excitation source 32 positioned exterior of the patient's body 14. When the markers 30 are excited, they each resonate at a selected unique frequency and generate a low energy radio-frequency magnetic signal measurable from outside of the body 14.
  • the signals from the markers 30 are detected and measured by an array 34 of sensors 36 located exterior of the patient's body 14.
  • the sensors 36 are positioned in a fixed, selected geometry relative to each other, so the array 34 defines a fixed reference coordinate system from which location and movement are calculated.
  • the sensors 36 are operatively coupled to a computer controller 38 that receives the measurement information from each sensor and determines the actual location of the markers 30 within the patient's body 14 relative to the sensors.
  • the computer controller 38 includes algorithms used to define and determine the location of the target isocenter 40 within the target 12, based upon the signal measurements by the sensors 36 from the resonating markers.
  • the location of the target isocenter 40 within the target 12 is selected, and the computer controller 38 utilizes position information about the position and/or orientation of each marker 30 relative to the selected target isocenter.
  • the target isocenter 40 is the point or position within the target to which the shaped dose of radiation is configured around or referenced to as determined by a treatment planning process.
  • the sensors 36 are polled twelve or more times per minute to track the actual position of the target isocenter 40 within the patient's body 14 relative to the sensor array 34. Accordingly, the actual position of the target 12 and the target isocenter 40 can be monitored in real time when the patient is positioned adjacent to the sensor array 34.
  • the actual position of the target isocenter 40 is compared to the position of the machine isocenter 22 relative to the sensor array 34.
  • the illustrated system 10 has a reference device 42 positioned on the gantry 20 of the linear actuator or another selected position on a radiation therapy delivery device used in alternate embodiments.
  • the other radiation therapy delivery device can include cobalt machines, a Gamma Knife, a Cyberknife, specialized stereostatic radiotherapy devices, or a TomoCT assembly (which utilizes a linear actuator in a CT scanner).
  • the reference device 42 is positioned at a known spatial or geometric relationship relative to the machine isocenter 22.
  • the reference device 42 in one embodiment is a resonating, three axis, single frequency marker that provides a measurable signal detectable by the sensors 36 in the array 34.
  • the reference device 42 in alternate embodiments can be positioned in a remote location away from the gantry 20. In either embodiment, the location of the machine isocenter 22 relative to the sensor array 34 can be calculated upon determining the position of the reference device 42 relative to the sensor array.
  • the sensors 36 provide the measurement data about the reference device 42 to the computer controller 38, and the computer controller calculates the location of the machine isocenter 22 relative to the sensor array 34.
  • the location of the target isocenter 40 relative to the sensor array 34 is compared to the position of the machine isocenter 22 relative to the sensor array. If the target isocenter 40 and machine isocenter 22 are spatially misaligned such that the two isocenters are not three-dimensionally coincident with each other, the patient 16, and/or target 12 can be moved relative to the machine isocenter 22. The target 12 position is moved until the target isocenter 40 is coincident with the machine isocenter 22.
  • the radiation delivery source 18 can be activated to provide the ionizing radiation beam 19 referenced to the target isocenter, thereby irradiating the target according to a radiation treatment plan, while minimizing or eliminating collateral damage to healthy tissue surrounding the target 12.
  • the actual location of the target isocenter 40 can also be monitored in real time during the radiation therapy to ensure that the target isocenter does not move an unacceptable amount relative to the machine isocenter 22 and allow for treatment when the treatment isocenter and the machine isocenter are within acceptable displacement limits.
  • the system 10 also includes a monitoring assembly 44 coupled to the computer controller 38 that provides feedback data to a user interface for the doctor or technician operating the system and/or the radiation delivery device 18.
  • the monitoring assembly 44 can provide the feedback data as a visual representation of the target isocenter's position in three-dimensional space relative to the machine isocenter's position in real time as the patient is being set up and positioned for the radiation therapy.
  • the monitoring assembly 44 can also provide other feedback data to the user interface including, for example, confirmation of setup completion, graphical information, patient information, radiation treatment plan information, or other information that can be utilized during the guided radiation therapy process.
  • FIGs 3-5 illustrate excitable markers 30 of alternate embodiments usable in the system 10.
  • One of the markers 30 shown in Figure 3 is an implantable, single-axis, resonating marker 31 having a ferrite core 46 wrapped by a conductive winding 48, and the winding is connected to a small capacitor 50.
  • the marker 31 is configured to be energized by the external excitation source 32, which produces an electromagnetic field. This electromagnetic field causes the marker 31 to resonate at a predetermined frequency, thereby providing a signal of sufficient intensity to be measured by the sensors 36 ( Figure 1) from outside of the body.
  • a biologically inert coating 52 encapsulates the ferrite core 46, the winding 48, and the capacitor 50 so as to provide a small, self-contained, wireless excitable marker 31 that can be permanently implanted into the patient.
  • the marker 31 is "wireless" because it need not be physically connected via wires to an outside energy source for generation or communication of the marker signal.
  • the marker 31 has a length of only approximately 5 mm and diameter sized to fit through an applicator needle. The marker 31 in other embodiments can have different sizes as needed for the desired configuration of the marker signal.
  • another one of the excitable markers 30 includes a three-axis, wireless, resonating marker 52 with three signaling portions 54.
  • Each signaling portion 54 is positioned axially perpendicular to the other two signaling portions. Accordingly, the three signaling portions 54 define an X, Y, Z reference coordinate.
  • Each of the signaling portions 54 includes a ferrite core 46, a winding 48 around the ferrite core, and a small capacitor 50 connected to each winding.
  • Each signaling portion is configured to be energized by the external excitation source 32, and to resonate at a frequency different than the resonating frequency of the other two signaling portions.
  • the three-axis marker 52 includes a biologically inert coating 56 that encapsulates all three of the signaling portions 54, so the marker can be permanently implanted in the patient's body.
  • each of the marker's signaling portions resonates at its selected frequency and provides the measurable marker signal at an intensity so it can each be measured by the sensor array 34 ( Figure 1).
  • Frequency multiplexing by the computer controller allows the computer controller 38 to differentiate between the marker signals from the different signaling portions of the marker when calculating the marker's position and orientation relative to the sensor array.
  • another embodiment of the marker 30 includes a cube-shaped marker 58 with a single ferrite core 60 and three sets of windings 62 axially oriented perpendicular to each other to define the X, Y, and Z axes for the marker.
  • Each winding 62 is connected to a small capacitor 64 and configured to resonate at a frequency different than the other two windings.
  • the cube-shaped marker 58 is also a wireless, three-axis, resonating marker.
  • the wireless, excitable markers 30 are configured to resonate and provide a measurable signal within the frequency range of approximately 10kHz to 200kHz, inclusive.
  • the markers 30 can be self-contained, powered markers that include a power source, such as a battery, that provides sufficient power to produce the measurable identifiable marker signal.
  • the markers 30 can be "wired" markers connectable via wires to a selected power or excitation source to allow the markers to generate the unique marker signal.
  • the marker signal can be unique as a function of frequency (i.e., frequency multiplexing) as a function of time or time multiplexing.
  • two, three, or more markers 30 are implanted at known locations in or adjacent to the target. Each marker 30 produces its unique signal relative to the other markers, so the sensor array 34 differentiates between the markers by frequency multiplexing. The sensor array 34 measures the intensity of the unique signals from the markers 30.
  • the signal intensity measurements are converted for use in geometric calculations (discussed in greater detail below) to accurately determine the actual three-dimensional location (X, Y, Z) and possibly the angular orientation (pitch, yaw, roll) of the marker relative to the sensor array 34.
  • the system 10 includes the excitation source 32 that generates a magnetic field for exciting the markers 30.
  • the excitation source is positioned in a selected location relative to the target 12 and close enough to the markers 30 so the emitted magnetic field has sufficient intensity to acceptably energize the markers.
  • a plurality of markers 30 are permanently implanted within the patient's body 14 in or adjacent to the target 12.
  • the computer controller 38 provides a separate driver circuit for the excitation source 32 for each marker 30, so as to selectively excite the respective marker at the selected frequency.
  • the excitation source 32 in one embodiment is a three-dimensional, AC magnetic field source that generates three-dimensional magnetic fields in the X, Y, and Z axes.
  • This excitation source 32 provides one source coil for each marker 30, and the electric current driven through the source coil generates the AC magnetic waveform tuned for the respective markers.
  • the source coil (or coils) in the excitation source 32 is provided by a coil configured to generate the multiple or scanned excitation frequency fields for the respective markers 30.
  • Figures 6 and 7 are schematic isometric views of sensor arrays 34 positionable exterior of the body ( Figure 6) and spaced apart from the markers 30 positioned in or near the target 12. In these illustrated embodiments, three markers 30 are shown implanted in or near the target 12.
  • the sensor array 34 includes a frame 70 that supports a plurality of sensors 36 in a fixed and known geometry relative to each other along X, Y, or Z axes of a reference coordinate system 72. The position of each sensor 36 on the frame 70 relative to the reference coordinate system 72 is fixed and defines fixed reference points for obtaining measurement data used by the computer controller 38.
  • the frame 70 supports the sensors 36 so the sensors are positioned in a single plane.
  • the frame 70 is shaped to support the sensors 36 in two orthogonal planes, so the sensors 36 are oriented along the X, Y, and Z axes of the reference coordinate system 72. Accordingly, the sensor array 34 provides the fixed reference structure from which measurements are taken and calculations performed to determine the relative positions of the target 12, the target isocenter 40 and the machine isocenter 22.
  • Each sensor 36 is a three-axis sensor that measures the absolute marker signal strengths from a respective one of the markers 30 relative to the X, Y, and Z axes.
  • the absolute signal strength of the marker signal along each axis in the reference coordinate system 72 is measured by the sensors 36 for each marker in order to determine the X, Y, and Z position of each marker.
  • the distance of the marker from the sensor can be determined based upon the marker's signal strength.
  • the geometric relationship from the marker to a series of sensors that are spaced at known locations relative to each other is used to solve a series of equations with one unique result. Accordingly, the distance between the marker 30 and the sensor 36 calculated by the computer controller 38 based on the marker's signal strength measured by the respective sensors and iterated for a best fit solution to the geometric equations.
  • the precise location of a marker 30 in space relative to the sensor array 34 can be calculated based upon the distances between that marker and at least four separate three-axis sensors spaced apart from each other in the array.
  • the absolute magnitude of the distance from the three-axis sensor is determined by squaring the each of the three axis magnitudes (x, y, and z orientations), adding the results and finally taking the square root for the distance resultant.
  • the distance between one sensor 36 and one of the markers 30 corresponds geometrically to the radius of a sphere.
  • Figure 8 shows two illustrative spheres 100 with the center points 102 each defined by a separate sensor 36. When two spheres 100 intersect, the intersection defines a circle 104.
  • the marker is located at some point on that circle.
  • three spheres 100 intersect shown in Figure 9
  • the intersection defines one of two points 105 where the marker is located on that line.
  • four spheres 100 intersect the intersection defines a single point 108 in space corresponding to the precise position of the marker 30 in space relative to the sensor array 34.
  • the sensor array 34 can include only four three-axis sensors 36 to determine that marker's position in space. Since the signals are frequency multiplexed and multiple frequencies may be received with each sensor coil and each individual frequency component may be examined by processing the combined signal with a fast Fourier transform (FFT) in the control electronics, multiple markers may be located with the same sensors.
  • FFT fast Fourier transform
  • the sensor array 34 is configured at known geometric orientations relative to the reference coordinate system 72, so that the marker signal measurements can be used by the computer controller 38 to calculate the angular orientation of the treatment volume (i.e., the pitch, yaw and roll) in space relative to the reference coordinate system 72 by using the three sets of three dimensional data (x, y, and z from the single axis markers). Based upon the position of the markers 30 relative to the target, the location and angular orientation of the target 12 can be determined by the computer controller 38.
  • the marker signal may be separated from the signal generated by the excitation source 32 via signal processing software or electronics in a number of ways.
  • the excitation source 32 is turned or gated “on” to excite the marker and then turned or gated “off” to allow for measurement of the marker response without interference by the signal from the excitation source.
  • the marker 30 will continue to resonate after the excitation source 32 is gated “off” for a period determined by the sensor's electric inductance, capacitance and series resistance.
  • the system is operated in continuous wave (CW) mode where the excitation source 32 remains “on” during measurement of the markers 30.
  • the marker signal is 90 degrees “out of phase” with the signal from the excitation source, so the marker signal is removed from the excitation signal.
  • the output frequency of the excitation source's signal is continuously varied or scanned to maximize the excitation of the markers 30 which results in a maximum marker signal while minimizing or eliminating unwanted excitation signal.
  • the position of each marker 30 relative to the target 12 and relative to the target isocenter 40 is also calculated or determined.
  • the target isocenter 40 in the target 12 is chosen first based upon imaging data about the target provided by an imaging system, such as a CT scan, MRI, ultrasound system, or nuclear imaging system (e.g. positron emission tomography). Once the target isocenter 40 is selected, the position of each implanted marker 30 is measured relative to the target isocenter 40. The position of the target isocenter 40 is then determined relative to the reference coordinate system 72 based upon defining the location of each marker 12 relative to the reference coordinate system.
  • an imaging system such as a CT scan, MRI, ultrasound system, or nuclear imaging system (e.g. positron emission tomography).
  • the target isocenter 40 is defined as a function of the marker locations relative to the target 12.
  • the markers 30 are selectively positioned in or near the target 12 and the orientation of the markers is used to define and calculate the target isocenter.
  • the target isocenter 40 within the target 12 can be defined and its position determined relative to markers 30 and the reference coordinate system 72 even if the markers 30 are not actually implanted within or even immediately adjacent to the target 12.
  • the markers 30 are, however, positioned close enough to the target 12 so that if the target moves, the target and markers move together substantially as a unit. Therefore, movement of the target 12 is monitored by tracking movement of the markers 30 relative to the sensor array 34.
  • the system 10 is configured to track motion of the target 12 in real time.
  • the computer controller 38 acquires data from each sensor 36 and outputs a result approximately 12 times per second.
  • the computer controller obtains measurement data from the sensors 36 and calculates the location of the target isocenter 40 relative to the sensor array every five seconds.
  • the computer controller 38 can measure the sensors 36 to monitor in real time the motion of the particular target isocenter 40 relative to the sensor array 34.
  • the measurement update rate may be reduce as to allow for sufficient data averaging to reduce the measurement noise at the same time allowing for an adequate update rate for the user.
  • Figure 10 is a partial isometric view illustrating an aspect of the present invention that includes a support table 76 that movably supports the patient's body 14 under the gantry 20 and adjacent to the sensor array 34.
  • the support table 76 is positionable below the machine isocenter 22.
  • the support table 76 is movable to adjust the position of the patient 16 relative to the machine isocenter 22 until the target isocenter 40 is coincident with the machine isocenter.
  • the sensor array 34 may be placed on, under, or connected to the support table 76. Alternatively, it may be mounted to the linear accelerator's gantry at a location sufficiently close to any markers 30 (implanted, external or gantry) that are to be located. In this alternate embodiment with the sensor array 34 mounted to the linear accelerator, the position from the machine isocenter 22 to the sensor array will be known, so that a separate gantry marker 42 may not be used.
  • the support table 76 has a base 88 and a tabletop 90 movably supported to the base for linear and angular movement relative to the sensor array 34.
  • a movement control system 78 is connected to the tabletop 90 to control movement of the tabletop and the patient 16 relative to the machine isocenter 22 and the sensor array 34.
  • the control system 78 is also coupled to the computer controller 38, and the computer controller 38 is programmed to activate the control system 78 to adjust the linear or angular position of the patient.
  • the tabletop's position moves in response to an authorized user such as doctor, physicist or technician activating the control system, or automatically in response to instructions provided by the computer controller 38.
  • ionizing radiation can be selectively and very accurately delivered directly to the target area or volume.
  • Application of the radiation therapy to the target 12 can be provided at the selected dosage and intensity with precise accuracy, while potentially minimizing the margin needed around the target.
  • the actual position of the target isocenter 40 is substantially continuously monitored and tracked relative to the machine isocenter 22 during delivery of the radiation therapy. If the target isocenter 40 moves away from the machine isocenter 22 beyond an acceptable range of displacement distances, the computer controller 38 provides a signal to the radiation delivery device to interrupt the radiation therapy to the target.
  • the target's position can then be adjusted manually or automatically until the target isocenter 40 is again coincident with the machine isocenter 22, and radiation therapy can resume.
  • the computer controller 38 is programmed so that if the target isocenter 40 moves from the machine isocenter 22, but the distance of movement does not exceed the acceptable range, the computer controller 38 will not interrupt the radiation therapy. This range of movement is dependent upon many factors, such as the target type (e.g., prostate, lung, liver), target size, target location, beam shape/size, and the radiation treatment plan.
  • FIG. 11 and 12 illustrate a feedback portion 80 of the monitoring assembly 44 that provides feedback data to an operator about, as an example, the position of the markers 30, the target isocenter 40 and the machine isocenter 22.
  • the feedback portion 80 is a display monitor that provides pictorial, graphical, or textual information to the operator.
  • Other feedback portions 80 such as graphical display devices, auditory feedback devices, or visual feedback devices can be used in alternate embodiments.
  • the computer controller 38 contains imaging data, such as from a CT, MRI, or ultrasound imaging system, that defines the shape and size of the target 12 within the body 14.
  • the imaging data also defines the locations of each marker 30 in or around the target 12.
  • the computer controller 38 uses the imaging data to provide a simulated model of the target, the markers, and the target isocenter.
  • This simulated model is displayed on the feedback portion 80 as shown in Figure 11 in phantom lines.
  • the simulated model is also displayed overlaying the machine isocenter 22, so the simulated target isocenter 40 is coincident with the machine isocenter.
  • the simulated target and simulated markers can also display how the actual target needs to be positioned and oriented three-dimensionally for the particular radiation therapy to be applied to the target.
  • the monitoring assembly 44 also receives and displays information from the computer controller 38 to show the actual locations of the markers 30 and target isocenter 40 relative to the machine isocenter 22, and relative to the simulated target and markers. Accordingly, the feedback portion 80 allows the operator to determine the actual position of the markers relative to the simulated markers, and the target isocenter 40 relative to the machine isocenter 22 substantially in real time while the patient 16 is on the support table 76 ( Figure 1). The patient 16 and support table 76 can be repositioned until the target 12 is properly oriented for the selected radiation therapy.
  • the system 10 is also usable to monitor the status of the target, such as a tumor or the like, in a patient's body 14 over time.
  • Figures 13 and 14 are schematic views showing a tumor 90 in a body 92. Three markers 30 are shown for this embodiment permanently implanted in or adjacent to the tumor 90. Images of the tumor 90 and markers 30 are obtained by CT, MRI, ultrasound, or other imaging technique over time. From these multiple images of the tumor 90 and markers 30, the position of the markers relative to the tumor can be compared and tracked. Accordingly, a doctor can use the markers 30 in the multiple images as a reference tool to determine whether the tumor has shrunk, grown, moved, or otherwise changed within the patient's body.
  • Figure 13 illustrates an image of a tumor 90 in a first condition with three markers 30 implanted therein
  • Figure 14 illustrates a second image of the tumor taken later in time.
  • the second image shows the same markers 30 in the same location within the patient's body, and from the position of the tumor relative to the markers, one can see that the tumor has shrunk.
  • doctors can track the status of tumors or other targets within the body over time to determine, as an example, the effectiveness of radiation therapy, whether additional treatments are needed, or whether a change in tumor growth has occurred or whether the radiation treatment plan needs to be altered.
  • the markers 30 are described and shown as being subcutaneously implanted in or next to a target 12. This implantation of the markers 30 is performed when needed to ensure that, if the target 12 moves, the markers will move with the target as a unit.
  • the markers are surface-mounted markers 110 adhered to the exterior surface 112 of the patient's body 14 substantially adjacent to and in alignment with a target 12, in or on the body.
  • the surface-mounted markers 110 can be removably adhered with an adhesive, such as tape or the like, in a substantially fixed location on the body's exterior surface 112 relative to the target 12.
  • These surface-mounted markers 110 are particularly suitable for targets 12 known not to substantially move within the body 14 relative to the exterior surface.
  • the surface-mounted markers 30 are also suitable for use when the target's size or location in the body 14 is such that some motion of the target isocenter is not critical for effective radiation therapy or treatment. Accordingly, the surface-mounted markers 110 provide reference points for accurate alignment and orientation of the target 12 and the machine isocenter 22. Alternatively, markers 30 may be mounted on or in patient immobilization devices at known locations relative to the treatment isocenter.
  • the surface-mounted markers 110 in one embodiment are wireless markers, so that the markers can remain adhered on the patient's body 14 after a radiation treatment session so that the patient 16 can come and go from the treatment area without disrupting the position of the markers 110 relative to the target 12.
  • the markers 110 remain adhered to the patient 16 and are connectable to lead wires of a "wired" marker system in the treatment area.
  • the lead wires can be disconnected from the markers 110 to allow the patient 16, to leave the treatment area while the markers remain fixed in place on the patient's body.
  • the surface-mounted markers 110 are also usable to monitor a patient's base-line girth (anterior-posterior and lateral dimensions) during a radiation treatment program.
  • the base-line girth measurements referred to as patient separations, are initially obtained by CT, MRI, or physical measurements. Patient separations are used when preparing a radiation treatment plan for the patient.
  • the surface-mounted markers 100 can be utilized alone or in combination with implanted markers to provide data about changes in the patient separations that may occur during chemo or radiotherapy.
  • Each surface-mounted marker 110 has an identifiable initial position in space relative to, as an example, the target isocenter or relative to each other.
  • the sensor array 34 and computer controller 38 are configured to determine the distances between each surface-mounted marker and/or the target isocenter.
  • the computer controller 38 calculates and monitors the distances, corresponding to the patient separations.
  • the treatment plan may become invalid because less patient tissue is available to alternate the radiation beam, thereby resulting in higher than planned doses of radiation.
  • the surface-mounted markers 110 are usable to facilitate and speed up patient set-up procedures before and/or during the radiation therapy procedure.
  • the surface mounted markers 110 are positioned at selected locations on the patient's body 14 at known positions. The markers 110 are excited and the locations relative to the sensor array are determined. The marker's location information can then be used to calculate the Target Skin Distance or Source Skin Distance, which is the distance between the exterior skin of the patient and the linear actuator or the tabletop.
  • the markers 110 can also be used to determine the tabletop-to-isocenter, which is the distance between the tabletop to the marker or other alignment means, such as laser cross-hairs projected on to the patient's skin. Accordingly, the surface mounted markers 110 can be used to automatically calculate the relevant distances during the set up procedure to quickly determine if the patient is properly positioned in accordance with the radiation therapy treatment plan.
  • the surface-mounted markers 110 can be used in conjunction with one or more markers 30 implanted in or near the target 12.
  • the relative location of each marker 110 or 30 can be calculated and used for any combination of patient set-up, target locating, target positioning, target motion tracking, and/or target evaluation, as discussed above.
  • the system 10 is also adapted for use in an automated patient setup process prior to delivery of the radiation therapy.
  • the automated setup process of one embodiment is shown schematically as a flow chart in Figure 17.
  • the tumor or other target in the patient's body is identified (reference block 150).
  • Images of the target are obtained (reference block 152), such as by X-rays, CT, MRI, nuclear imaging, or ultrasound imaging.
  • the doctor and/or technicians then determine a treatment plan for the particular tumor (reference block 154).
  • One or more markers are implanted in or on the body in selected positions relative to the target (reference block 156), and the location of the treatment isocenter relative to the markers is determined or calculated (reference block 158).
  • the patient is positioned on the movable support table so the target and markers are generally adjacent to the sensor array (reference block 160).
  • the excitation source is activated to energize the markers (reference block 162), and the sensors measure the strength of the signals from the markers (reference block 164).
  • the computer controller calculates location of the markers and the target isocenter relative to the sensor array and the machine isocenter (reference block 166).
  • the computer compares the position of the target isocenter and machine isocenter (reference block 168), and if the two isocenters are misaligned, the computer automatically activates the control system of the support table to move the tabletop relative to the machine isocenter until the target isocenter is coincident with the machine isocenter (reference block 170).
  • the computer controller also determines the position and orientation of the markers relative to the position and orientation of simulated markers. If the markers are not properly aligned and oriented with the simulated markers, the support table is adjusted linearly and angularly as needed for proper marker alignment. This marker alignment properly positions the target volume along 6 dimensions, namely X, Y, Z, pitch, yaw, and roll. Accordingly, the patient is automatically positioned in the correct position relative to the machine isocenter for precise delivery of radiation therapy to the target.
  • the computer restricts the radiation delivery device from delivering the radiation beam until the target isocenter is coincident with the machine isocenter.
  • the computer monitors the position of the target isocenter during delivery of the radiation treatment (reference block 172). If the target isocenter's position is outside a permitted degree or range of dislocation, the computer interrupts the delivery of the radiation isocenter (reference block 174).
  • the computer can then automatically reposition the tabletop and the patient (as a unit) so the target is properly positioned with the target isocenter and is coincident with the machine isocenter (reference block 176), and the radiation therapy can be reactivated for continued irradiation of the target (reference block 178).
  • the process returns to reference block 172 to monitor the target's position relative to the machine isocenter as the radiation is being delivered. Accordingly, adjustments can be made automatically to ensure that the radiation is accurately delivered to the target without requiring a large margin around the target.

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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
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US09/877,498 US20020193685A1 (en) 2001-06-08 2001-06-08 Guided Radiation Therapy System
EP10185676A EP2289597A1 (en) 2001-06-08 2002-06-05 Guided radiation therapy system
CA002449967A CA2449967A1 (en) 2001-06-08 2002-06-05 Guided radiation therapy system
PCT/US2002/017876 WO2002100485A1 (en) 2001-06-08 2002-06-05 Guided radiation therapy system
EP10185512.0A EP2314348B1 (en) 2001-06-08 2002-06-05 Guided radiation therapy system
EP02741866.4A EP1392397B1 (en) 2001-06-08 2002-06-05 Guided radiation therapy system
JP2003503301A JP4446335B2 (ja) 2001-06-08 2002-06-05 誘導放射線療法システム
US10/721,491 US7657301B2 (en) 2001-06-08 2003-11-25 Guided radiation therapy system
US10/722,015 US7657302B2 (en) 2001-06-08 2003-11-25 Guided radiation therapy system
US10/743,531 US7657303B2 (en) 2001-06-08 2003-12-22 Guided radiation therapy system
JP2009229945A JP5682868B2 (ja) 2001-06-08 2009-10-01 誘導放射線療法システム
US12/891,742 US9072895B2 (en) 2001-06-08 2010-09-27 Guided radiation therapy system

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US10/743,531 Continuation US7657303B2 (en) 2001-06-08 2003-12-22 Guided radiation therapy system
US12/891,742 Continuation US9072895B2 (en) 2001-06-08 2010-09-27 Guided radiation therapy system

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US10/721,491 Expired - Lifetime US7657301B2 (en) 2001-06-08 2003-11-25 Guided radiation therapy system
US10/743,531 Expired - Lifetime US7657303B2 (en) 2001-06-08 2003-12-22 Guided radiation therapy system
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US10/743,531 Expired - Lifetime US7657303B2 (en) 2001-06-08 2003-12-22 Guided radiation therapy system
US12/891,742 Expired - Fee Related US9072895B2 (en) 2001-06-08 2010-09-27 Guided radiation therapy system

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US20040133101A1 (en) 2004-07-08
EP2289597A1 (en) 2011-03-02
US20110046481A1 (en) 2011-02-24
WO2002100485A1 (en) 2002-12-19
JP2005514969A (ja) 2005-05-26
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EP2314348B1 (en) 2016-12-21
US9072895B2 (en) 2015-07-07
JP5682868B2 (ja) 2015-03-11
EP2314348A2 (en) 2011-04-27
US7657302B2 (en) 2010-02-02
CA2449967A1 (en) 2002-12-19
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US7657303B2 (en) 2010-02-02
EP2314348A3 (en) 2011-08-03
US20050261570A1 (en) 2005-11-24
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JP4446335B2 (ja) 2010-04-07
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