US20130296883A1 - Automated detection, diagnostic and therapeutic method and system - Google Patents
Automated detection, diagnostic and therapeutic method and system Download PDFInfo
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- US20130296883A1 US20130296883A1 US13/859,336 US201313859336A US2013296883A1 US 20130296883 A1 US20130296883 A1 US 20130296883A1 US 201313859336 A US201313859336 A US 201313859336A US 2013296883 A1 US2013296883 A1 US 2013296883A1
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Definitions
- Cancer diagnosis and treatment can require the medical practitioner to be able to pin point a suspicious lesion within the patient.
- the next step in a typical treatment process can include a biopsy procedure to identify the pathology, which can be performed in the operating room, with the patient under general anesthetic.
- biopsy procedures can include the implementation of core needle biopsy procedures using minimally invasive core needle extraction methods.
- a medical insertion device which includes a mounting arm, an interface connected to the mounting arm for interfacing with a medical instrument, a mechanism for movement of the medical instrument or a part of the medical instrument in an insertion direction, a carriage connected to a distal end of the mounting arm, and a pivot connection between the carriage and the distal end of the mounting arm to permit pitch or yaw of the mounting arm.
- a method for facilitating insertion of a medical instrument which includes: interfacing the medical instrument with an interface, the interface being connected to a mounting arm, pivoting the mounting arm at a pivot connection connected between a carriage and a distal end of the mounting arm to effect pitch or yaw of the mounting arm, and moving the medical instrument or a part of the medical instrument in an insertion direction.
- FIG. 1A shows an isometric view of a medical insertion device in accordance with an example embodiment
- FIG. 1D shows a rear side view of the medical insertion device shown in FIG. 1A ;
- FIG. 3B shows an exploded isometric view of the rotary drive unit shown in FIG. 3A ;
- FIG. 4A shows a left side view of the medical insertion device shown in FIG. 1A in a pitch up configuration
- FIG. 5A shows a left side view of the medical insertion device shown in FIG. 1A in a straight insertion configuration
- FIG. 6A shows a rear side view of the medical insertion device shown in FIG. 1A in a translated configuration
- FIG. 7B shows a rear side view of the medical insertion device shown in FIG. 7A in the yaw configuration
- FIG. 8A shows an isometric front view of a dispenser system in accordance with an example embodiment
- FIG. 9A shows an isometric view of a robotic surgical system including a magnetic resonance imaging (MRI) system in accordance with an example embodiment
- FIG. 9B shows an isometric view of the robotic surgical system shown in FIG. 9A in another mode of operation.
- FIG. 10C shows an isometric view of the robotic surgical system shown in FIG. 10A in an insertion mode of operation.
- FIG. 12 shows an example interface in accordance with an example embodiment.
- Some example embodiments relate to an image guided, automated surgical robotic system having a manipulator, and associated workstations for the purpose of obtaining a biopsy sample and/or treating an identified lesion/pathology.
- the system can interface with existing clinical diagnostic imaging systems such as magnetic resonance imaging (MRI) to help chose a specific target and then automatically or semi-automatically drive a medical instrument such as a percutaneous coring needle biopsy device or ablation tool, under real-time or near-real-time image guidance.
- MRI magnetic resonance imaging
- a dispenser system for use with an imaging system, which includes a dispenser frame adjoined to the imaging system, the dispenser frame including or defining at least one instrument holder for holding and releasably providing of a medical instrument.
- FIGS. 1A and 1B show a medical insertion device 100 in accordance with an example embodiment.
- the medical insertion device 100 may be used with or installed within an imaging system (not shown here), such as a magnetic resonance imaging (MRI) system, during scanning.
- the medical insertion device 100 can generally be used to retain, position and effect insertion of a medical instrument 102 , for example a biopsy device 103 as shown, or for example a treatment device.
- the device 100 can generally provide linear, angular and/or rotational degrees of freedom for positioning of the medical instrument 102 prior to insertion of the medical instrument 102 .
- the frame 104 includes a baseplate 112 and a drive support plate 114 connected thereto to at least partially form a housing of the medical insertion device 100 .
- Other sidewalls or plates may also form part of the frame 104 .
- the frame 104 also includes a drive plate strengthening bracket 116 for strengthening of the connection between the baseplate 112 and the drive support plate 114 .
- Other strengthening brackets may also be used.
- the baseplate 112 may also include alignment fiducials 113 or other alignment markers for correlating the physical world with an imaging system (not shown here).
- An additional alignment fiducial 113 a or fiducials may be placed on the elongate mounting arm 120 (e.g. device holder 126 ), or on the medical instrument 102 itself (not shown), for correlating or registration purposes.
- the alignment fiducials can include MR molecular tagging.
- the frame 104 encloses almost an entirety of the medical insertion device 100 , save for the frame 104 further including or defining an opening at the front for passage of the medical instrument 102 there through.
- the frame 104 is integrated into or forms part of a same frame (not shown here) of the particular imaging system (not shown here).
- the frame 104 can be panel shaped to fit within restricted environments having a limited height.
- the carriage assembly 110 includes an elongate mounting arm 120 , wherein the mounting arm 120 includes an insertion track 122 which runs along a length of the mounting arm 120 .
- An insertion carriage 124 includes a mechanism such as a pneumatic or piezoelectric motor which can move or step the carriage 124 along the insertion track 122 .
- the insertion carriage 124 is therefore slideably mounted to the insertion track 122 .
- a device holder 126 is connected to the carriage 124 .
- the device holder 126 is generally tubular shaped and acts as an interface to receive or interface with the medical instrument 102 . As shown in FIG.
- FIG. 2 shows the medical instrument 102 in a retraction configuration or orientation.
- the insertion carriage 124 is located at a proximal end of the insertion track 122 , which therefore has retracted the medical instrument 102 backwards along the insertion direction 127 (with respect to FIG. 1A ). From this position, the insertion carriage 124 can move along the insertion track 122 to the distal end of the insertion track 122 , resulting in the medical instrument 102 moving in the insertion direction 127 to an insertion configuration or orientation as shown in FIG. 1A .
- the first carriage 134 also itself includes a pivoting (e.g. hinged) connection 148 with the first sway arm 135 at the linear slide assembly 106 .
- the first sway arm 135 is also hingedly connected to a first coupling arm 146 .
- the first coupling arm 146 is hingedly connected to the second carriage 136 .
- the third carriage 138 is connected to a proximal end of the mounting arm 120 via a second sway arm 139 , using a pivoting connection 150 such as a first hinge coupled with a second hinge, as shown.
- the second sway arm 139 is hingedly connected to a second coupling arm 152 .
- the second coupling arm 152 is hingedly connected to the fourth carriage 140 .
- the third carriage 138 also includes a pivoting (e.g. hinged) connection 154 to the second sway arm 139 at the linear slide assembly 106 .
- the linear slide assembly 106 provides a support for the carriage assembly 110 , and includes a first track system 160 and a second track system 162 having mechanisms for individually or collectively controlling of the positioning of the carriages 134 , 136 , 138 , 140 .
- the first track system 160 supports the first carriage coupling 131 and the second track system 162 supports the second carriage coupling 132 .
- the first and second track systems 160 , 162 include straightly moveable or slideable connections with the respective carriages 134 , 136 , 138 , 140 for facilitating linear translation of the carriages 134 , 136 , 138 , 140 .
- first track system 160 this includes four rails 164 a - d , which correspond respectively to channels 166 a - d defined by the first carriage 134 and channels 168 a - d defined by the second carriage 136 , as shown in FIG. 1B .
- first and fourth rails 164 a and 164 d are smooth rails which act as guide rails for sliding of the first carriage 134 and the second carriage 136 .
- channels 166 a , 166 d , 168 a , and 168 d may also have smooth inner surfaces.
- Second rail 164 b includes a lengthwise screw thread definition which engages corresponding anti-backlash nut (not shown) within channel 166 b of the first carriage 134 .
- Channel 168 b of second carriage 136 has a smooth inner surface.
- rotation of second rail 164 b results in horizontal translation of first carriage 134 while not affecting the second carriage 136 .
- third rail 164 c includes a lengthwise screw thread definition which engages corresponding anti-backlash nut (not shown) within channel 168 c of the second carriage 136 .
- Channel 166 c of first carriage 134 has a smooth inner surface.
- rotation of the third rail 164 c results in horizontal translation of the second carriage 136 along the first rail system 160 while not affecting the first carriage 134 .
- rotary drive unit 180 a is coupled to rail 164 b
- rotary drive unit 180 b is coupled to rail 164 c
- rotary drive unit 180 c is coupled to rail 170 b
- rotary drive unit 180 d is coupled to rail 170 c.
- ultrasonic motors 222 can be used to drive the drive shaft 210 , which are controllable by the encoder 220 .
- An example suitable ultrasonic motor 222 is a HR2 motor by Nanomotion Ltd., as would be understood in the art.
- vacuum-actuated drivers or hydraulic drivers may be used.
- various modes of operation of the medical insertion device 100 can be effected to position the medical instrument 102 by slideably moving at least one of the carriages 134 , 136 , 138 , 140 .
- the individual carriages may be moved so that relative motion (left or right) between two carriages will raise one end of the mounting arm 120 up or down, either linearly or in a slightly curved trajectory.
- the slightly curved trajectory also results in axial rotation of the medical instrument 102 .
- Translation of the two carriages couplings 131 , 132 in unison results in a linear translation left and right.
- the medical insertion device 100 can effect various insertion angles of the medical instrument 102 which vary from a straight insertion. It may be appreciated that the various insertion angles may provide flexibility in performing the particular procedure. Further, it may be appreciated that the medical insertion device 100 may provide a stable insertion angle for the subsequent insertion step. In addition, the medical instrument 102 may for example be able to reach additional target regions such as those near the edges of the frame 104 (e.g. at regions beyond the linear slide assembly 106 closer to the baseplate 112 ).
- the device holder 126 can be reversed, in that the body 128 of the medical instrument 102 can be inserted into the other opening 184 of the device holder 126 .
- the configuration shown in FIG. 1B may be used for superior (from the head) insertion at the right breast in a “right side” configuration.
- the entire medical instrument 102 e.g. the frame 104
- the entire medical instrument 102 can then be reversed with the body 128 of the medical instrument 102 inserted into the other opening 184 of the device holder 126 for superior insertion at the left breast in a “left side” configuration.
- the references herein to proximal and distal would be reversed. It may be appreciated that such a reversible configuration could provide operation of the device 100 in a limited space environment such as within an MRI (not shown here).
- the dispenser system 300 can also include a receiver 308 which can receive the desired medical instrument 302 for dispensing, in this example medical instrument 302 a .
- the receiver 308 can include a mechanism or a vacuum or air pump (not shown) for obtaining the medical instrument 302 a from the particular instrument holder 306 a .
- the receiver 308 can also include appropriate sterilization mechanisms (not shown) such as an alcohol spray, etc.
- each instrument holder 306 is arranged on the dispenser frame 304 around a centre of rotation 310 of the dispenser frame 304 .
- the dispenser frame 304 can further include a rotating mechanism (not shown) for rotating of the dispenser frame 304 around the centre of rotation 310 .
- rotation of the dispenser frame 304 can be effected until the desired medical instrument 302 is aligned with the receiver 308 for dispensing.
- each of the medical instruments 302 a - h can have a universal body which can each interchangeably be used with the medical insertion device 100 .
- the medical instruments 302 a - h can each have a similar elongate cylindrical body for interfacing with a corresponding shape of the device holder 126 ( FIG. 1A ). It can be appreciated that the dispenser system 300 therefore generally acts as a holster for the medical instruments 302 a - h.
- the medical insertion device 100 can be dimensioned to be positioned in the limited space located between the head support 408 and the patient support table 406 , typically having a restricted height as shown.
- the compression plates 412 are oriented along the lateral direction and the medical insertion device 100 is positioned laterally for procedures to be performed outside of the magnet bore hole of the MRI system 402 .
- the position of the alignment fiducials 113 ( FIG. 1B ) relative to the tumor is measured or located on the MR images.
- the appropriate position and/or angle of the medical instrument 102 can then be determined, and the medical instrument 102 is moved to that position and/or angle using the medical insertion device 100 .
- a proper needle entry hole can be determined by determining which hole in the compression plate 412 is closest to the desired entry point, as would be understood in the art.
- closed geometry RF coils may be used with a plurality of windings, which can interfere with a lateral or medial biopsy approach direction in some existing conventional systems.
- the tip of the biopsy device (or ablative device) may be seen in the image and can be accurately steered towards a suspected lesion location as imaging continues. This will allow adjustments to the trajectory of the biopsy device which are necessary if the lesion location moves for any reason.
- the robotic manipulation system allows the tool to be repositioned as necessary, in-situ, in order to achieve the goals of the intervention.
- alignment fiducials (not shown) may also be placed onto the medical instrument 102 to assist in registration.
- FIGS. 10A to 10C show a robotic surgical system 500 including a mammography system 502 in accordance with an example embodiment.
- the mammography system 502 can, for example, include an X-Ray based system, an MBI system, or a positron emission mammography (PEM) based system.
- PEM/MBI prior to imaging, an agent is injected into the patient which assists in detection of the lesion.
- Compression plates 504 a , 504 b are used to provide stability and immobilization of the breasts.
- the compression plates 504 a , 504 b can also include PEM detectors mounted thereon.
- a robotic arm 506 has one end mounted to the mammography system 502 and the other end has the medical insertion device 100 mounted thereon.
- the robotic arm 506 can, for example, place the medical insertion device 100 between the compression plates 504 a , 504 b at the appropriate time of the procedure.
- the robotic arm 506 can place the medical insertion device 100 for superior insertion (e.g., from the head) with the compression plates 504 a , 504 b mounted transversely (for transverse compression) or otherwise suitably modified.
- grid marks 510 may be shown in the virtual image to guide the medical insertion device 100 to the target site.
- the surgical robot 12 includes a controller 20 for controlling operation of the surgical robot 12 , a communications module or subsystem 22 for communicating with the control station 16 over the network 18 , and robotic surgical instruments 24 which are controllable by the control station 16 over the network 18 .
- the robotic surgical instruments may be haptically controllable which can include force-feedback or touch-feedback control.
- the controller 20 can include one or more microprocessors or processors that are coupled to a storage 21 (e.g. computer readable storage medium) that includes persistent and/or transient memory.
- the storage 21 stores information and software enabling the microprocessor(s) of controller 20 to control the subsystems and implement the functionality described herein.
- the surgical robot 12 includes a detector subsystem 28 for determining spatial information relating to a surgical environment of the surgical robot 12 (including a subject patient) and sending/relaying said information to the control station 16 over the network 18 .
- the detector 28 may include a camera 30 (for capturing video and/or audio information), an x-ray system 32 , an ultrasound system 34 , an MRI 36 , or others such as Positron Emission Tomography (PET), Positron Emission Mammography (PEM), CT laser mammography, or a GE (TM) molecular biological imager.
- the controller 20 is configured to operate or provide a local control loop between at least one of the subsystems and the robotic surgical instruments 24 .
- the control station 16 includes a controller 40 for controlling operation of the control station 16 and a communications subsystem 42 for communicating with the surgical robot 12 over the network 18 .
- the controller 40 is coupled to a storage 41 .
- a control console 44 provides an interface for interaction with a user, for example a surgeon.
- the control console 44 includes a display 46 (or multiple displays), and a user input 48 .
- the user input 48 may further include haptic controllers (not shown) for allowing the user to haptically control the robotic surgical instruments 24 of the surgical robot 12 , for example with force-feedback or touch control.
- haptic controllers not shown
- FIG. 12 An example interface is shown in FIG. 12 , which in example embodiments includes a graphical user interface (GUI) for interfacing with the user.
- GUI graphical user interface
- the system 10 can be used to perform a procedure by breaking down a procedure into a series of interconnected sub-tasks. Some of the sub-tasks are performed automatically by the surgical robot 12 to control the robotic instruments 24 and the subsystems to perform the particular sub-task. Some of the other sub-tasks are “semi-automated”, meaning having some control from the control station 16 as well as some local control from the controller 20 .
- Each defined sub-task may for example be stored in a storage 21 accessible by the controller 20 , the storage 21 including a library.
- the library includes a sequence of sub-tasks (both automated and “semi-automated”). Specifically, some of the sub-tasks have instructions to automatically control the robotic instruments 24 and the subsystems to perform the sub-task.
- the controller 20 may automatically perform the surgical functions by providing the local control loop with the subsystems.
- Some of the other sub-tasks may be “semi-automated”, meaning having some control from the control station 16 as well as some local automation (with the controller 20 providing local control loops as described herein).
- the control station 16 and the subsystems may be in a master-slave relationship. In example embodiments, such semi-automated control may be configured in an external control loop as between the subsystems and the robotic instruments 24 , which are facilitated by the control station 16 .
- a first sub-task may be the semi-automated positioning of the medical insertion tool 100 by the surgeon in front of the desired insertion region, while the second sub-task may be the automated insertion of the biopsy needle subcutaneously into the target site.
- the robotic surgical instruments 24 may include any number or combination of controllable mechanisms.
- the robotic surgical instruments 24 include end effectors such as grippers, cutters, manipulators, forceps, bi-polar cutters, ultrasonic grippers & probes, cauterizing tools, suturing devices, etc.
- the robotic surgical instruments 24 generally include small lightweight actuators and components.
- the robotic surgical instruments 24 include pneumatic and/or hydraulic actuators. Such actuators may further assist in providing motion stability, as further described below.
- various lightweight radiolucent materials for robotic arms as well as the range joint torques, forces, frequency response, ROM, weight and size of different actuators to achieve the maximum function in the surgical robot 12 .
- One aspect of such image-guided surgery in accordance with example embodiments is registering multiple images to each other and to the patient, tracking instruments intra-operatively and subsequently translating this imagery for real time use in the robot space.
- the incorporation of medical imagery into surgical planning for the system 10 facilitates the identification of a defined work envelope for single or multiple robotic arms.
- Intra-operative tracking of the position of the robotic surgical instruments 24 within the defined work envelope can be utilized to develop local control loop systems between the detector 28 and the robotic surgical instruments 24 to define keep-out and work within zones for surgical tasks. This data is incorporated into known algorithms developed for collision avoidance of the multiple robotic arms and optimization of the position of instrumentation for completion of the surgical task.
- a physical marker such as MR, X-Ray, IR (Infrared) markers or RF (Radiofrequency) devices, or chemical markers
- image-based registration is less sensitive to calibration and tracking errors as it provides a direct transformation between the image space and the instrument space.
- the information from anatomical landmarks can be registered with the diagnostic imagery used to plan the surgical procedure and subsequently translated into the robotic space for completion of an image guided surgical procedure. This translation is performed using a registration procedure between the robot and the imaging device.
- the incorporation of real-time intra-operative tracking of anatomical landmarks provides a mechanism of incorporating compensatory motion of the robotic arm to accommodate patient movement thereby enhancing the precision of the robotic task.
- Imagery can also be incorporated as one of many parameters used to provide local control loop feedback in performing autonomous robotic tasks.
- the control station 16 and the surgical robot 12 operate in a master slave relationship.
- Such embodiments may incorporate semi-autonomous surgical robotics wherein the surgical robot 12 may autonomously perform some specified surgical tasks that are part of a sequence of a larger task comprising the surgical procedure, for example using a locally controlled loop implemented by the controller 20 .
- This may for example enables the surgeon to selectively perform techniques best undertaken with a master slave relationship while using automated robotics to perform specific tasks that require the enhanced precision of a surgical robot.
- such tasks may include the precision placement of brachytherapy for cancer treatment or the precision drilling and intra-operative positioning of hardware in orthopaedic surgery.
- the control station 16 calculates the linear and angular motions necessary to move the surgical robotic manipulator over the planned trajectory and send appropriate commands to plurality of motors to move the medical instrument.
- the communications network 18 may further include a direct wireless connection, a satellite connection, a wide area network such as the Internet, a wireless wide area packet data network, a voice and data network, a public switched telephone network, a wireless local area network (WLAN), or other networks or combinations of the forgoing.
- a direct wireless connection such as the Internet
- a satellite connection such as the Internet
- a wireless wide area packet data network such as the Internet
- a voice and data network such as a PSTN network
- public switched telephone network such as PSTN
- WLAN wireless local area network
- additional procedures can be performed using several imaging modalities such as MRI, CT, PET, PEM, BSGI, X-ray, or sonography, or other modalities where there is an advantage to accurately target a pathology for biopsy or ablation. It would also be appreciated that in some example embodiments other areas of the body can be targeted other than the breast. Such applications include liver, axilla (sentinel node biopsy), lung, kidney, prostate, uterus, and neurological.
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Abstract
Description
- This application is a continuation of U.S. patent application Ser. No. 13/512,198, which claims the benefit of U.S. Provisional Patent Application No. 61/264,761 filed Nov. 27, 2009 and U.S. Provisional Patent Application No. 61/334,851 filed May 14, 2010, the disclosures of all the foregoing of which are incorporated by reference herein in their entirety as if fully set forth herein.
- Some example embodiments described herein relate to surgical robotics, and in particular to control of medical instruments which have an insertion action, such as a biopsy needle or ablation tool.
- Cancer diagnosis and treatment can require the medical practitioner to be able to pin point a suspicious lesion within the patient. After the area is located, the next step in a typical treatment process can include a biopsy procedure to identify the pathology, which can be performed in the operating room, with the patient under general anesthetic. In other instances, biopsy procedures can include the implementation of core needle biopsy procedures using minimally invasive core needle extraction methods.
- Difficulties can arise in performing of a conventional procedure. As an example, for breast biopsy with magnetic resonance imaging (MRI) systems, the patient may have to be shuttled in and out of the magnet several times before a biopsy is actually performed. During this time, the contrast agent could have already lost some of its effect and image quality could suffer. This process itself may be time consuming and cumbersome, especially in a time-sensitive environment.
- In addition, contrast laden blood from a hematoma as well as an air pocket at the biopsy site can make it difficult to subsequently verify that the correct site identified from the imaging system was biopsied, or to rapidly confirm that the sample obtained has a suspect morphology. This practice could also require removal of a relatively large volume of tissue, with a fraction of that assumed to be from the lesion.
- It would be advantageous to provide a medical insertion device which may be used within an imaging system in real-time or near real-time.
- Example embodiments relate to a method for detecting, diagnosing, and treating an area of interest in a patient, said method comprising the steps of (i) placing a patient in a position for retrieving medical information from the patient; (ii) retrieving the medical information from the patient while in the position; (iii) analyzing the medical information to determine an area of interest; (iv) while maintaining the position of the patient, assessing the area of interest to determine a medical intervention for the area; and (v) while maintaining the position of the patient, performing the medical intervention on the patient in the area of interest.
- In the example embodiment, the area of interest is a lesion, such as a tumor. The medical information can comprise image guidance registration information, diagnostic information, or combinations thereof. The image guidance registration information or diagnostic information can be obtained from at least one of magnetic resonance imaging, X-ray, computed tomography, radioimaging, sonography, or a radiofrequency device. The medical intervention can comprise at least one of cryotherapy, radiofrequency ablative therapy, ultrasonic ablative therapy, or combinations thereof. The medical intervention can also comprise at least one of radioactive seed implantation, genomics therapy, including therapy targeting brca1 or brca2, targeted anti-cancer agent delivery, or anti-seeding agents delivery to block proliferation of cancer cells.
- In the example embodiment, the area of interest can be assessed with information obtained by insertion of a medical instrument into or near the area of interest, and the medical instrument can be interfaced with an insertion device. The insertion device can assist in at least one of a core needle biopsy, fine needle aspiration, or vacuum assisted biopsy and can be configured to provide at least one of a tissue marker sensing device, a tissue repair mechanism, or a diagnostic procedure. The diagnostic procedure can comprise at least one of gamma detection, spectroscopy imaging, ultrasound, positron emission tomography, magnetic resonance imaging, optical spectroscopy, or fluorescence.
- In the example embodiment, the analysis conducted in step (iii) can determine real-time parameters of the area of interest. The real-time parameters can be used to assist the assessment of the area of interest in step (iv) and/or to assist the performance of the medical intervention in step (v).
- In the example of the embodiment, the insertion device can be used to perform the medical intervention on the patient. The insertion device can generally be controlled by a robotic device, which can be controlled by a control station through a communications network. The control station can comprise a user interface for receiving inputs from a user. In an example embodiment, the robotic device can respond to the user inputs provided to the user interface.
- Further example embodiments relate to a medical insertion device which may be used with or installed within an imaging system, such as a magnetic resonance imaging (MRI) system to plan the best approach to the target tissue. The medical insertion device can generally be used to retain, position and effect insertion of a medical instrument, for example a biopsy device or an ablation treatment device. The device can generally provide linear, rotational and/or angular degrees of freedom for positioning of the medical instrument prior to an insertion of the medical instrument. Embodiments include performance in real-time imaging environment (i.e. “in-bore” imaging). Additional embodiments include data/software integration into the system, allowing a user to pull images taken and employ a 2D or 3D target planning algorithm to provide co-ordinates for device positioning.
- In an example embodiment, there is provided a robotic system, including an insertion device having an interface for interfacing with a medical instrument, one or more mechanisms for effecting insertion of the medical instrument or a part of the medical instrument in an insertion direction, and for effecting pitch and yaw of the insertion device, and a controller in communication with the detector subsystem and configured to automatically control the one or more mechanisms based on the received spatial information.
- In another example embodiment, there is provided a medical insertion device which includes a mounting arm, an interface connected to the mounting arm for interfacing with a medical instrument, a mechanism for movement of the medical instrument or a part of the medical instrument in an insertion direction, a carriage connected to a distal end of the mounting arm, and a pivot connection between the carriage and the distal end of the mounting arm to permit pitch or yaw of the mounting arm.
- In another example embodiment, there is provided a method for facilitating insertion of a medical instrument, which includes: interfacing the medical instrument with an interface, the interface being connected to a mounting arm, pivoting the mounting arm at a pivot connection connected between a carriage and a distal end of the mounting arm to effect pitch or yaw of the mounting arm, and moving the medical instrument or a part of the medical instrument in an insertion direction.
- In another example embodiment, there is provided a dispenser system for use with an imaging system, which includes a dispenser frame adjoined to the imaging system, the dispenser frame including or defining at least one instrument holder for holding and releasably providing of a medical instrument.
- Reference will now be made, by way of example, to the accompanying drawings which show example embodiments, and in which:
-
FIG. 1A shows an isometric view of a medical insertion device in accordance with an example embodiment; -
FIG. 1B shows an exploded isometric view of the medical insertion device shown inFIG. 1A ; -
FIG. 1C shows a left side view of the medical insertion device shown inFIG. 1A ; -
FIG. 1D shows a rear side view of the medical insertion device shown inFIG. 1A ; -
FIG. 1E shows a plan view of the medical insertion device shown inFIG. 1A ; -
FIG. 2 shows an isometric view of the medical insertion device in a retraction configuration; -
FIG. 3A shows a detail isometric view of a rotary drive unit in accordance with an example embodiment; -
FIG. 3B shows an exploded isometric view of the rotary drive unit shown inFIG. 3A ; -
FIG. 4A shows a left side view of the medical insertion device shown inFIG. 1A in a pitch up configuration; -
FIG. 4B shows a rear side view of the medical insertion device shown inFIG. 4A in the pitch up configuration; -
FIG. 5A shows a left side view of the medical insertion device shown inFIG. 1A in a straight insertion configuration; -
FIG. 5B shows a plan view of the medical insertion device shown inFIG. 5A in the straight insertion configuration; -
FIG. 6A shows a rear side view of the medical insertion device shown inFIG. 1A in a translated configuration; -
FIG. 6B shows a rear side view of the medical insertion device shown inFIG. 6A in the translated configuration; -
FIG. 7A shows a left side view of the medical insertion device shown inFIG. 1A in a yaw configuration; -
FIG. 7B shows a rear side view of the medical insertion device shown inFIG. 7A in the yaw configuration; -
FIG. 7C shows a plan view of the medical insertion device shown inFIG. 7A in the yaw configuration; -
FIG. 8A shows an isometric front view of a dispenser system in accordance with an example embodiment; -
FIG. 8B shows an isometric exploded side view of the dispenser system shown inFIG. 8A ; -
FIG. 8C shows an isometric view of a dispenser assembly in accordance with another example embodiment in a lateral mode of dispensing; -
FIG. 8D shows an isometric view of the dispenser assembly shown inFIG. 8C in an upper mode of dispensing; -
FIG. 9A shows an isometric view of a robotic surgical system including a magnetic resonance imaging (MRI) system in accordance with an example embodiment; -
FIG. 9B shows an isometric view of the robotic surgical system shown inFIG. 9A in another mode of operation. -
FIG. 9C shows a detail isometric view of the robotic surgical system shown inFIG. 9A in another mode of operation. -
FIG. 10A shows an isometric view of a robotic surgical system including a mammography system in accordance with an example embodiment; -
FIG. 10B shows an isometric view of the robotic surgical system shown inFIG. 10A in a dispensing mode of operation. -
FIG. 10C shows an isometric view of the robotic surgical system shown inFIG. 10A in an insertion mode of operation. -
FIG. 11 shows a block diagram of a robotic surgical system in which example embodiments may be applied. -
FIG. 12 shows an example interface in accordance with an example embodiment. - Similar reference numerals may be used in different figures to denote similar components.
- Cancer diagnosis or procedures can include using a biopsy tool to retrieve a tissue sample for further analysis. A difficulty with some existing medical systems is that the health practitioner may not be able to work within a CT or MRI system during scanning for procedures such as biopsy or ablation therapy.
- Many imaging systems may also have limited space constraints for placement of robotic systems.
- Some example embodiments relate to an image guided, automated surgical robotic system having a manipulator, and associated workstations for the purpose of obtaining a biopsy sample and/or treating an identified lesion/pathology. The system can interface with existing clinical diagnostic imaging systems such as magnetic resonance imaging (MRI) to help chose a specific target and then automatically or semi-automatically drive a medical instrument such as a percutaneous coring needle biopsy device or ablation tool, under real-time or near-real-time image guidance.
- In an example embodiment, there is provided a robotic system, including an insertion device having an interface for interfacing with a medical instrument, one or more mechanisms for effecting insertion of the medical instrument or a part of the medical instrument in an insertion direction, and for effecting pitch and yaw of the insertion device, a detector subsystem for determining spatial information, and a controller in communication with the detector subsystem and configured to automatically control the one or more mechanisms based on the received spatial information.
- In another example embodiment, there is provided a medical insertion device which includes a mounting arm, an interface connected to the mounting arm for interfacing with a medical instrument, a mechanism for movement of the medical instrument or a part of the medical instrument in an insertion direction, a carriage connected to a distal end of the mounting arm, and a pivot connection between the carriage and the distal end of the mounting arm to permit pitch or yaw of the mounting arm.
- In another example embodiment, there is provided a method for facilitating insertion of a medical instrument, or the use of the medical instrument, which includes: interfacing the medical instrument with an interface, the interface being connected to a mounting arm, pivoting the mounting arm at a pivot connection connected between a carriage and a distal end of the mounting arm to effect pitch or yaw of the mounting arm, and moving the medical instrument or a part of the medical instrument in an insertion direction.
- In another example embodiment, there is provided a dispenser system for use with an imaging system, which includes a dispenser frame adjoined to the imaging system, the dispenser frame including or defining at least one instrument holder for holding and releasably providing of a medical instrument.
- Reference is first made to
FIGS. 1A and 1B , which show amedical insertion device 100 in accordance with an example embodiment. Generally, themedical insertion device 100 may be used with or installed within an imaging system (not shown here), such as a magnetic resonance imaging (MRI) system, during scanning. Themedical insertion device 100 can generally be used to retain, position and effect insertion of a medical instrument 102, for example abiopsy device 103 as shown, or for example a treatment device. Thedevice 100 can generally provide linear, angular and/or rotational degrees of freedom for positioning of the medical instrument 102 prior to insertion of the medical instrument 102. - As shown in
FIG. 1B , themedical insertion device 100 includes aframe 104 which acts to house themedical insertion device 100. Themedical insertion device 100 further includes alinear slide assembly 106 mounted or connected to theframe 104. The medical insertion device further includes arotary drive assembly 108 for generally driving thelinear slide assembly 106, and acarriage assembly 110 for moving along thelinear slide assembly 106. Thecarriage assembly 110 also generally supports the medical instrument 102 for positioning and insertion thereof. - Referring still to
FIG. 1B , theframe 104 will now be described in greater detail. Theframe 104 includes abaseplate 112 and adrive support plate 114 connected thereto to at least partially form a housing of themedical insertion device 100. Other sidewalls or plates (not shown) may also form part of theframe 104. Theframe 104 also includes a driveplate strengthening bracket 116 for strengthening of the connection between thebaseplate 112 and thedrive support plate 114. Other strengthening brackets (not shown) may also be used. Thebaseplate 112 may also includealignment fiducials 113 or other alignment markers for correlating the physical world with an imaging system (not shown here). An additional alignment fiducial 113 a or fiducials may be placed on the elongate mounting arm 120 (e.g. device holder 126), or on the medical instrument 102 itself (not shown), for correlating or registration purposes. In some example embodiments, the alignment fiducials can include MR molecular tagging. In some example embodiments, theframe 104 encloses almost an entirety of themedical insertion device 100, save for theframe 104 further including or defining an opening at the front for passage of the medical instrument 102 there through. In yet further embodiments, theframe 104 is integrated into or forms part of a same frame (not shown here) of the particular imaging system (not shown here). Theframe 104 can be panel shaped to fit within restricted environments having a limited height. - Referring still to
FIG. 1B , thecarriage assembly 110 includes an elongate mountingarm 120, wherein the mountingarm 120 includes aninsertion track 122 which runs along a length of the mountingarm 120. Aninsertion carriage 124 includes a mechanism such as a pneumatic or piezoelectric motor which can move or step thecarriage 124 along theinsertion track 122. Theinsertion carriage 124 is therefore slideably mounted to theinsertion track 122. Adevice holder 126 is connected to thecarriage 124. Thedevice holder 126 is generally tubular shaped and acts as an interface to receive or interface with the medical instrument 102. As shown inFIG. 1B , thedevice holder 126 includes a sheath to receive a corresponding tubular-shapedmain body 128 of the medical instrument 102. Thus, movement of theinsertion carriage 124 along theinsertion track 122 causes the medical instrument 102 to move in aninsertion direction 127. In the example shown, the mountingarm 120 also defines theinsertion direction 127. In some example embodiments, the mountingarm 120 and/or thedevice holder 126 includes a force sensor(s) to detect the tissue being penetrated, and for prevention of accidental excursion into the incorrect tissue (e.g. chest wall). - Referring still to
FIG. 1B , the medical instrument 102 typically includes themain body 128 and anelongate member 130 such as a needle which extends from themain body 128. In example embodiments, theelongate member 130 is formed from MR compatible materials such as carbon fibre, ceramic, or tritanium. One example of the medical instrument 102 is abiopsy tool 103, such as a vacuum assisted biopsy (VAB) device available from ATEC (TM), as would be understood in the art. Theelongate member 130 can also include an ablative tool such as Radio Frequency (RF) ablation, focused ultrasound, cryotherapy, laser and other ablative technologies that are administered within the cancerous region causing cell destruction with minimal damage to surrounding tissues. In some example embodiments, the medical instrument 102 may also include a detector such as a probe, ultrasound probe, or fiber optic probe. The detector can also include an MRI coil to provide higher resolution in situ imaging. In yet further example embodiments, the medical instrument 102 may be integrated with thedevice holder 126 to result in a dedicated-purpose insertion device. In yet further example embodiments, the medical instrument 102 can include an end effector or end effectors. - Reference is now made to
FIG. 2 , which shows the medical instrument 102 in a retraction configuration or orientation. As shown, theinsertion carriage 124 is located at a proximal end of theinsertion track 122, which therefore has retracted the medical instrument 102 backwards along the insertion direction 127 (with respect toFIG. 1A ). From this position, theinsertion carriage 124 can move along theinsertion track 122 to the distal end of theinsertion track 122, resulting in the medical instrument 102 moving in theinsertion direction 127 to an insertion configuration or orientation as shown inFIG. 1A . - In example embodiments, referring again to
FIG. 1B , thecarriage assembly 110 generally includes one or more carriages which including pivot connections and/or slideable connections for effecting positioning of the mountingarm 120, and therefore positioning of the medical instrument 102. Once at the desired position, the next step is typically an insertion step through the skin which includes movement of theinsertion carriage 124 along theinsertion track 122 in theinsertion direction 127. - In the example shown in
FIG. 1B , thecarriage assembly 110 includes afirst carriage coupling 131 and asecond carriage coupling 132. Thefirst carriage coupling 131 includes afirst carriage 134 and asecond carriage 136. Thesecond carriage coupling 132 includes athird carriage 138 and afourth carriage 140. As shown, thefirst carriage 134 viafirst sway arm 135 is connected to a distal end of the mountingarm 120 using a ball-and-socket pivot connection, which is defined by aball 142 of the mountingarm 120 and acorresponding socket 144 of thefirst sway arm 135. Such a pivot connection therefore permits pitch or yaw of the mountingarm 120 in operation. Thefirst carriage 134 also itself includes a pivoting (e.g. hinged)connection 148 with thefirst sway arm 135 at thelinear slide assembly 106. Thefirst sway arm 135 is also hingedly connected to afirst coupling arm 146. Thefirst coupling arm 146 is hingedly connected to thesecond carriage 136. - The
third carriage 138 is connected to a proximal end of the mountingarm 120 via asecond sway arm 139, using apivoting connection 150 such as a first hinge coupled with a second hinge, as shown. Thesecond sway arm 139 is hingedly connected to a second coupling arm 152. The second coupling arm 152 is hingedly connected to thefourth carriage 140. Thethird carriage 138 also includes a pivoting (e.g. hinged)connection 154 to thesecond sway arm 139 at thelinear slide assembly 106. - Referring still to
FIG. 1B , thelinear slide assembly 106 provides a support for thecarriage assembly 110, and includes afirst track system 160 and asecond track system 162 having mechanisms for individually or collectively controlling of the positioning of thecarriages first track system 160 supports thefirst carriage coupling 131 and thesecond track system 162 supports thesecond carriage coupling 132. The first andsecond track systems respective carriages carriages - Referring to the
first track system 160, this includes four rails 164 a-d, which correspond respectively to channels 166 a-d defined by thefirst carriage 134 and channels 168 a-d defined by thesecond carriage 136, as shown inFIG. 1B . In the example embodiment shown, first andfourth rails first carriage 134 and thesecond carriage 136. Thus,channels Second rail 164 b includes a lengthwise screw thread definition which engages corresponding anti-backlash nut (not shown) withinchannel 166 b of thefirst carriage 134. Channel 168 b ofsecond carriage 136 has a smooth inner surface. Thus, rotation ofsecond rail 164 b results in horizontal translation offirst carriage 134 while not affecting thesecond carriage 136. Similarly,third rail 164 c includes a lengthwise screw thread definition which engages corresponding anti-backlash nut (not shown) withinchannel 168 c of thesecond carriage 136.Channel 166 c offirst carriage 134 has a smooth inner surface. Thus, rotation of thethird rail 164 c results in horizontal translation of thesecond carriage 136 along thefirst rail system 160 while not affecting thefirst carriage 134. - In example embodiments, a similar configuration may be used for the
second track system 162, which includes four rails 170 a-d, which correspond respectively to channels 172 a-d defined by thethird carriage 138 and channels 174 a-d defined by the fourth carriage 176, as shown inFIG. 1B . In the example embodiment shown, first andfourth rails third carriage 138 and thesecond carriage 140. Thus,channels channel 172 b of thethird carriage 138.Channel 174 b offourth carriage 140 has a smooth inner surface. Thus, rotation ofsecond rail 170 b results in horizontal translation ofthird carriage 138 while not affecting thefourth carriage 140. Similarly,third rail 170 c includes a lengthwise screw thread definition which engages corresponding screw threads ofchannel 174 c of thefourth carriage 140.Channel 172 c ofthird carriage 138 has a smooth inner surface. Thus, rotation of thethird rail 170 c results in horizontal translation of thefourth carriage 140 along thesecond rail system 162 while not affecting thethird carriage 138. - Referring still to
FIG. 1B , reference is now made to therotary drive assembly 108, which acts to drive the various tracks of thelinear slide assembly 106, for driving of thevarious carriages carriage assembly 110. In the example embodiment shown, therotary drive assembly 108 includes fourrotary drive units 180 a-d (each or individually referred to as 180) each corresponding to a respective rotary drive belt 182 a-d. As shown,rotary drive unit 180 a is coupled to rail 164 b,rotary drive unit 180 b is coupled to rail 164 c,rotary drive unit 180 c is coupled to rail 170 b, androtary drive unit 180 d is coupled to rail 170 c. - Reference is now made to
FIGS. 3A and 3B , which show arotary drive unit 180 in greater detail, in accordance with an example embodiment. As shown inFIG. 3B , thedrive unit 180 includes, in sequential adjoining order, apulley 200 for engaging the drive belt 182 a-d, a retainingring 202, aceramic bearing 204, afront motor plate 206, aceramic ring 208, adrive shaft 210, a secondceramic ring 212, a secondceramic bearing 214, one or more spacer plates 216 (two shown), aback motor plate 218, and a controller such as a microcontroller orencoder 220. Four motors such asultrasonic motors 222 can be used to drive thedrive shaft 210, which are controllable by theencoder 220. An example suitableultrasonic motor 222 is a HR2 motor by Nanomotion Ltd., as would be understood in the art. In other example embodiments, vacuum-actuated drivers or hydraulic drivers may be used. - Referring still to
FIG. 1B , various modes of operation of themedical insertion device 100 can be effected to position the medical instrument 102 by slideably moving at least one of thecarriages carriage coupling arm 120 up or down, either linearly or in a slightly curved trajectory. The slightly curved trajectory also results in axial rotation of the medical instrument 102. Translation of the twocarriages couplings first carriage coupling 131 and thesecond carriage coupling 132 results in a horizontal angular motion (yaw), while a differential vertical motion between thefirst carriage coupling 131 and thesecond carriage coupling 132 results in a vertical angle (pitch). Raising or lowering thefirst carriage coupling 131 and thesecond carriage coupling 132 in unison results in a combined vertical motion. - Reference is thus made to
FIGS. 4A and 4B , which show themedical insertion device 100 in a pitch up configuration. As shown, to effect the pitch up configuration, thefirst carriage 134 and thesecond carriage 136 are slideably moved relatively towards each other. In some embodiments, only one of thefirst carriage 134 and thesecond carriage 136 is moved towards the other, resulting in a slightly curved pitch up trajectory. This slightly curved trajectory also results in axial rotation of the medical instrument 102. In another example embodiment (not shown), a pitch down may be effected by having thefirst carriage 134 and thesecond carriage 136 slideably moved relatively away from each other. - Reference is also made to
FIGS. 5A and 5B , which show themedical insertion device 100 in a straight insertion configuration. As shown, to effect the straight insertion configuration, at least one of thecarriages - Reference is now made to
FIGS. 6A and 6B , which show themedical insertion device 100 in a translated configuration. As shown, all of thecarriages - Reference is now made to
FIGS. 7A , 7B and 7C, which show themedical insertion device 100 in a yaw configuration. As best shown inFIG. 7C , thecarriages second carriage coupling 132 can be collectively moved leftwardly relative to thefirst carriage coupling 131 to result in the medical instrument 102 being angled in a yaw right direction. Similarly, thecarriages second carriage coupling 132 can be collectively moved rightwardly relative to thefirst carriage coupling 131 to result in the medical instrument 102 being angled in a yaw left direction (not shown). - Referring again to
FIG. 1B , it can be appreciated that themedical insertion device 100 can effect various insertion angles of the medical instrument 102 which vary from a straight insertion. It may be appreciated that the various insertion angles may provide flexibility in performing the particular procedure. Further, it may be appreciated that themedical insertion device 100 may provide a stable insertion angle for the subsequent insertion step. In addition, the medical instrument 102 may for example be able to reach additional target regions such as those near the edges of the frame 104 (e.g. at regions beyond thelinear slide assembly 106 closer to the baseplate 112). - It may also be appreciated that a difficulty with some existing conventional systems is that conventional articulated or snake-like robotic arms may not be able to provide the required stability or control for performing such a procedure within an imaging system, and especially for the final subcutaneous insertion step of the needle through the skin and tissue.
- Referring again to
FIG. 1B , in another mode of operation, it can be appreciated that thedevice holder 126 can be reversed, in that thebody 128 of the medical instrument 102 can be inserted into theother opening 184 of thedevice holder 126. For example, the configuration shown inFIG. 1B may be used for superior (from the head) insertion at the right breast in a “right side” configuration. The entire medical instrument 102 (e.g. the frame 104) can then be reversed with thebody 128 of the medical instrument 102 inserted into theother opening 184 of thedevice holder 126 for superior insertion at the left breast in a “left side” configuration. Of course, in the “left side” configuration the references herein to proximal and distal would be reversed. It may be appreciated that such a reversible configuration could provide operation of thedevice 100 in a limited space environment such as within an MRI (not shown here). - Suitable materials for the various described assemblies and subsystems of the
device 100 include magnetic resonance (MR) compatible materials, ceramics, thermo-plastics and thermo-sets. Additional example materials may also include carbon fiber, ceramic, composites, nanoparticle composites, aluminium, titanium, and stainless steel. Examples of MR compatible motors include piezoelectric motors, pneumatic, vacuum-actuated drivers or hydraulic drivers. - Variations may be made to the
device 100 in example embodiments. For example, in some example embodiment, an insertion mechanism may be used to move the entirelinear slide assembly 106 in theinsertion direction 127 to provide the insertion step (rather than from the insertion track 122). In some additional embodiments, some medical instruments 102 may include their own insertion or injection mechanism, which may be automated or manually controlled. For example, in some example embodiments, only a part of the medical instrument 102 such as the elongate member 130 (e.g. a needle) is independently controllable by a mechanism for insertion. - Reference is now made to
FIGS. 8A and 8B , which shows adispenser system 300 in accordance with an example embodiment. Thedispenser system 300 can for example be used with an imaging system (not shown here) to dispense one or more medical instruments 302 a-h (each or individually referred to as 302) to the medical insertion device 100 (FIG. 1A ). As shown, thedispenser system 300 includes adispenser frame 304 which can be adjoined or attached to the particular imaging system. Thedispenser frame 304 includes or defines a plurality of instrument holders 306 a-h (each or individually referred to as 306) for respectively holding the medical instruments 302 a-h. The instrument holders 306 a-h can also releasably secure the medical instruments 302 a-h using a retaining mechanism (not shown). - As shown in
FIG. 8A , thedispenser system 300 can also include areceiver 308 which can receive the desired medical instrument 302 for dispensing, in this examplemedical instrument 302 a. Thereceiver 308 can include a mechanism or a vacuum or air pump (not shown) for obtaining themedical instrument 302 a from theparticular instrument holder 306 a. Thereceiver 308 can also include appropriate sterilization mechanisms (not shown) such as an alcohol spray, etc. - As shown in
FIG. 8A , each instrument holder 306 is arranged on thedispenser frame 304 around a centre ofrotation 310 of thedispenser frame 304. Thedispenser frame 304 can further include a rotating mechanism (not shown) for rotating of thedispenser frame 304 around the centre ofrotation 310. Thus, for example, rotation of thedispenser frame 304 can be effected until the desired medical instrument 302 is aligned with thereceiver 308 for dispensing. - In some example embodiments, each of the medical instruments 302 a-h can have a universal body which can each interchangeably be used with the
medical insertion device 100. In the example embodiments shown, the medical instruments 302 a-h can each have a similar elongate cylindrical body for interfacing with a corresponding shape of the device holder 126 (FIG. 1A ). It can be appreciated that thedispenser system 300 therefore generally acts as a holster for the medical instruments 302 a-h. - Reference is now made to
FIGS. 8C and 8D , which show adispenser assembly 320 in accordance with another example embodiment.FIG. 8C shows a lateral mode of dispensing whileFIG. 8D shows an upper mode of dispensing. In the lateral mode (FIG. 8C ) the instrument holders 306 are directed laterally (sideways) for accessing of the medical instruments 302. In the upper mode (FIG. 8D ) the instrument holders 306 are directed upwardly for accessing of the medical instruments 302. As shown, thedispenser system 300 is mounted onto astand 322. Thestand 322 includes a plurality of wheels 324 (e.g. five), which are lockable once wheeled to the desired position. Thestand 322 also includes aswivel mechanism 324, which can swivel and lock thedispenser system 300 between the lateral mode (FIG. 8C ) and the upper mode (FIG. 8D ). - Reference is now made to
FIGS. 9A to 9C , which show a roboticsurgical system 400 including a magnetic resonance imaging (MRI)system 402 in accordance with an example embodiment. As shown, abreast imaging assembly 404 can be used with a patient support table 406. The patient lies prone on top of theassembly 404 with the sternum resting on a central support beam (not shown). The patient's head is supported byhead support 408. The patient's shoulders are supported by shoulder supports 410. The patient's breasts extend down into thebreast imaging assembly 404. As shown, the patient may be put into the magnet bore hole of theMRI system 402 head first. Alternatively, the patient may be inserted feet first into theMRI system 402. - The breasts are compressed by
compression plates 412, wherein thecompression plates 412 may compress the breast either in a head/feet direction or a lateral direction. When compressing, thecompression plates 412 act as a breast stabilization mechanism. In other example embodiments, thecompression plates 412 can include a plastic plate with a grid of finely-spaced needle guide holes. In the example embodiment shown inFIG. 9A , thecompression plates 412 are oriented along the head/feet direction. Thecompression plates 412 can further include a plastic plate with large rectangular access windows, which is advantageous when used for positioning of the medical instruments 302. In yet further embodiments, a non-compressive stabilization device may be used. - As best shown in
FIG. 9C , themedical insertion device 100 can be dimensioned to be positioned in the limited space located between thehead support 408 and the patient support table 406, typically having a restricted height as shown. - In an alternate embodiment, the
compression plates 412 are oriented along the lateral direction and themedical insertion device 100 is positioned laterally for procedures to be performed outside of the magnet bore hole of theMRI system 402. - The position of the alignment fiducials 113 (
FIG. 1B ) relative to the tumor is measured or located on the MR images. The appropriate position and/or angle of the medical instrument 102 can then be determined, and the medical instrument 102 is moved to that position and/or angle using themedical insertion device 100. In another example embodiment, a proper needle entry hole can be determined by determining which hole in thecompression plate 412 is closest to the desired entry point, as would be understood in the art. - It can be appreciated that the closed geometry RF coils may be used with a plurality of windings, which can interfere with a lateral or medial biopsy approach direction in some existing conventional systems.
- Generally, the tip of the biopsy device (or ablative device) may be seen in the image and can be accurately steered towards a suspected lesion location as imaging continues. This will allow adjustments to the trajectory of the biopsy device which are necessary if the lesion location moves for any reason. In the case of ablative therapy, the robotic manipulation system allows the tool to be repositioned as necessary, in-situ, in order to achieve the goals of the intervention. As mentioned, alignment fiducials (not shown) may also be placed onto the medical instrument 102 to assist in registration.
- Referring to
FIG. 9A , in some example embodiments, thedispenser system 300 can be mounted onto a front of the frame of theMRI system 402. In such embodiments, themedical insertion device 100 can be swung out or otherwise controlled to access thedispenser system 300. In another example embodiment, also shown inFIG. 9A , thedispenser assembly 320 can be rolled and locked into position adjacent to the front of theMRI system 402. In other example embodiments, thedispenser system 300 can be integrated within or attached to the patient support table 406 for dispensing of the various medical instruments 302. In such embodiments, themedical insertion device 100 may, for example, pitch down into the table 406 to obtain or replace the medical instrument 102. - As shown in
FIG. 9B , in some example embodiments, thedispenser system 300 can be mounted onto a rear side of the frame of theMRI system 402, for example in the upper mode of dispensing. In another example embodiment, also shown inFIG. 9B , thedispenser assembly 320 can be rolled and locked into position adjacent to the rear side of theMRI system 402. - Reference is now made to
FIGS. 10A to 10C , which show a roboticsurgical system 500 including amammography system 502 in accordance with an example embodiment. Themammography system 502 can, for example, include an X-Ray based system, an MBI system, or a positron emission mammography (PEM) based system. In PEM/MBI, prior to imaging, an agent is injected into the patient which assists in detection of the lesion.Compression plates compression plates - As shown in
FIG. 10C , there is a limited space in the region transverse to the patient between thecompression plates medical insertion device 100 is dimensioned to fit in this transverse region between thecompression plates FIG. 1A , a height of thedrive support plate 114 of theframe 104 can be dimensioned to fit within the transverse space between thecompression plates medical insertion device 100 is mounted onto thelower compression plate 504 b within this transverse region. - As shown, a
robotic arm 506 has one end mounted to themammography system 502 and the other end has themedical insertion device 100 mounted thereon. Therobotic arm 506 can, for example, place themedical insertion device 100 between thecompression plates robotic arm 506 can place themedical insertion device 100 for superior insertion (e.g., from the head) with thecompression plates - In some example embodiments, as shown in
FIG. 10B , thedispenser system 300 can be mounted within the frame of themammography system 502. In such embodiments, themedical insertion device 100 can controlled or maneuvered to access thedispenser system 300 using therobotic arm 506. In some example embodiments, thedispenser system 300 does not rotate but rather therobotic arm 506 is used to retrieve the medical instrument 302 from the appropriate instrument holder 306. - As shown in
FIG. 10C , grid marks 510 may be shown in the virtual image to guide themedical insertion device 100 to the target site. - After the core biopsy is performed, the
medical insertion device 100 provides an opportunity for other minimally invasive diagnostic procedures and treatments. Examples include: (1) gamma detectors; (2) energized tunneling tips to reduce tunneling forces; (3) inserts to aid in reconstruction of removed tissue (e.g., one or two sided shaver inserts); (4) spectroscopy imaging devices; (5) general tissue characterization sensors {e.g., (a) mammography; (b) ultrasound, sonography, contrast agents, power Doppler; (c) PET and FDG ([Flourine-18]-2-deoxy-2-fluoro-glucose); (d) MRI or NMR, breast coil; (e) mechanical impedance or elastic modulus; (f) electrical impedance; (g) optical spectroscopy, raman spectroscopy, phase, polarization, wavelength/frequency, reflectance; (h) laser-induced fluorescence or auto-fluorescence; (i) radiation emission/detection, radioactive seed implantation; (j) flow cytometry; (k) genomics, PCR (polymerase chain reaction)-brca1, brca2; (I) proteomics, protein pathway}; (6) tissue marker sensing device; (7) inserts or devices for MRI enhancement; (8) bishops on-a-stick; (9) endoscope; (10) diagnostic pharmaceutical agents delivery devices; (11) therapeutic anti-cancer pharmaceutical agents delivery devices; (12) radiation therapy delivery devices, radiation seeds; (13) anti-seeding agents for therapeutic biopsies to block the release of growth factors and/or cytokines (e.g., chlorpheniramine (CPA) is a protein that has been found to reduce proliferation of seeded cancer sells by 75% in cell cultures.); (14) fluorescent tagged antibodies, and a couple fiber optics to stimulate fluorescence from a laser source and to detect fluorescence signals for detecting remaining cancer cells; (15) positive pressure source to supply fluid to the cavity to aid with ultrasound visualization or to inflate the cavity to under the shape or to reduce bleeding; (16) biological tagging delivery devices (e.g., (a) functional imaging of cellular proliferation, neovacularity, mitochondrial density, glucose metabolism; (b) immunohistochemistry of estrogen receptor, her2neu; (c) genomics, PCR (polymerase chain reaction)-brca1, brca2; (d) proteomics, protein pathway); (17) marking clips; (18) mammotome; and (19) obturator trocar; (20) ablative therapies (cryo, RF, laser, etc.). - Reference is now made to
FIG. 11 , which shows a block diagram of a roboticsurgical system 10 to which example embodiments may be applied. Thesystem 10 includes asurgical robot 12 for use in a surgical environment. Thesurgical robot 12 is in communication with acontrol station 16 either over a communications network 18 (as shown), or via a direct connection. Generally, thesurgical robot 12 includes one or more robotic instrument(s) 24 which can be operational in a limited size operating environment defined by an imaging system such as magnetic resonance imaging (MRI). At least one of the roboticsurgical instruments 24 may include themedical insertion device 100 as shown inFIG. 1A . - Referring still to
FIG. 11 , thesurgical robot 12 includes acontroller 20 for controlling operation of thesurgical robot 12, a communications module orsubsystem 22 for communicating with thecontrol station 16 over thenetwork 18, and roboticsurgical instruments 24 which are controllable by thecontrol station 16 over thenetwork 18. In an example embodiment, the robotic surgical instruments may be haptically controllable which can include force-feedback or touch-feedback control. Thecontroller 20 can include one or more microprocessors or processors that are coupled to a storage 21 (e.g. computer readable storage medium) that includes persistent and/or transient memory. Thestorage 21 stores information and software enabling the microprocessor(s) ofcontroller 20 to control the subsystems and implement the functionality described herein. Thesurgical robot 12 includes adetector subsystem 28 for determining spatial information relating to a surgical environment of the surgical robot 12 (including a subject patient) and sending/relaying said information to thecontrol station 16 over thenetwork 18. As shown, in some example embodiments thedetector 28 may include a camera 30 (for capturing video and/or audio information), anx-ray system 32, anultrasound system 34, anMRI 36, or others such as Positron Emission Tomography (PET), Positron Emission Mammography (PEM), CT laser mammography, or a GE (TM) molecular biological imager. In some example embodiments, thecontroller 20 is configured to operate or provide a local control loop between at least one of the subsystems and the roboticsurgical instruments 24. - The
control station 16 includes acontroller 40 for controlling operation of thecontrol station 16 and acommunications subsystem 42 for communicating with thesurgical robot 12 over thenetwork 18. Thecontroller 40 is coupled to astorage 41. Acontrol console 44 provides an interface for interaction with a user, for example a surgeon. Thecontrol console 44 includes a display 46 (or multiple displays), and auser input 48. In some embodiments, theuser input 48 may further include haptic controllers (not shown) for allowing the user to haptically control the roboticsurgical instruments 24 of thesurgical robot 12, for example with force-feedback or touch control. Although only onecontrol station 16 is shown, in other embodiments two or more control stations may be used, each configured for controlling at least part of thesurgical robot 12. An example interface is shown inFIG. 12 , which in example embodiments includes a graphical user interface (GUI) for interfacing with the user. - Generally, the
system 10 can be used to perform a procedure by breaking down a procedure into a series of interconnected sub-tasks. Some of the sub-tasks are performed automatically by thesurgical robot 12 to control therobotic instruments 24 and the subsystems to perform the particular sub-task. Some of the other sub-tasks are “semi-automated”, meaning having some control from thecontrol station 16 as well as some local control from thecontroller 20. - Each defined sub-task may for example be stored in a
storage 21 accessible by thecontroller 20, thestorage 21 including a library. The library includes a sequence of sub-tasks (both automated and “semi-automated”). Specifically, some of the sub-tasks have instructions to automatically control therobotic instruments 24 and the subsystems to perform the sub-task. During automated control, thecontroller 20 may automatically perform the surgical functions by providing the local control loop with the subsystems. Some of the other sub-tasks may be “semi-automated”, meaning having some control from thecontrol station 16 as well as some local automation (with thecontroller 20 providing local control loops as described herein). During semi-automated control, thecontrol station 16 and the subsystems may be in a master-slave relationship. In example embodiments, such semi-automated control may be configured in an external control loop as between the subsystems and therobotic instruments 24, which are facilitated by thecontrol station 16. - The sub-task may be selectively retrieved from the library and combined into a defined sequence or sequences to perform the surgical procedure. The flow from one sub-task to another is stored in the library. Each sub-task may use imagery and other parameters to verify sub-task completion. In some example embodiments, each of the sub-tasks in a particular entire procedure may be automatically performed by the
surgical robot 12. - For example, for a breast biopsy a first sub-task may be the semi-automated positioning of the
medical insertion tool 100 by the surgeon in front of the desired insertion region, while the second sub-task may be the automated insertion of the biopsy needle subcutaneously into the target site. - Referring again to
FIG. 11 , the roboticsurgical instruments 24 may include any number or combination of controllable mechanisms. The roboticsurgical instruments 24 include end effectors such as grippers, cutters, manipulators, forceps, bi-polar cutters, ultrasonic grippers & probes, cauterizing tools, suturing devices, etc. The roboticsurgical instruments 24 generally include small lightweight actuators and components. In some example embodiments, the roboticsurgical instruments 24 include pneumatic and/or hydraulic actuators. Such actuators may further assist in providing motion stability, as further described below. In some example embodiments, various lightweight radiolucent materials for robotic arms as well as the range joint torques, forces, frequency response, ROM, weight and size of different actuators to achieve the maximum function in thesurgical robot 12. In another example embodiment, the roboticsurgical instrument 24 may be configured to include a therapeutic tool utilizing the administration of high intensity focused ultrasound (HIFU) to control haemorrhage and treat solid tumours. Both the HIFU and the ultrasound 34 (for detecting the surgical environment) may be implemented within the same roboticsurgical instrument 24. - Referring still to
FIG. 11 , thedetector subsystem 28 will now be described in greater detail. The incorporation of intra-operative image guidance into surgical robotics provides an additional capability to refine the precision of a surgical procedure. Pre-operative diagnostic imagery may be utilized to plan surgical procedures with the assumption that these diagnostic images will represent tissue morphology at the time of surgery. Along with this pre-operative planning, intra-operative imagery may also be used to modify or refine a present surgical procedure or administer minimally invasive treatment such as HIFU ultrasound therapy used to control bleeding. - One aspect of such image-guided surgery in accordance with example embodiments is registering multiple images to each other and to the patient, tracking instruments intra-operatively and subsequently translating this imagery for real time use in the robot space. The incorporation of medical imagery into surgical planning for the
system 10 facilitates the identification of a defined work envelope for single or multiple robotic arms. Intra-operative tracking of the position of the roboticsurgical instruments 24 within the defined work envelope can be utilized to develop local control loop systems between thedetector 28 and the roboticsurgical instruments 24 to define keep-out and work within zones for surgical tasks. This data is incorporated into known algorithms developed for collision avoidance of the multiple robotic arms and optimization of the position of instrumentation for completion of the surgical task. - Different technologies that incorporate a physical marker, such as MR, X-Ray, IR (Infrared) markers or RF (Radiofrequency) devices, or chemical markers, may be used for image registration of specific anatomical landmarks for both the intra-operative tracking of the
surgical robot 12 in relation to the patient as well as tracking the surgical instrumentation. Image-based registration is less sensitive to calibration and tracking errors as it provides a direct transformation between the image space and the instrument space. The information from anatomical landmarks can be registered with the diagnostic imagery used to plan the surgical procedure and subsequently translated into the robotic space for completion of an image guided surgical procedure. This translation is performed using a registration procedure between the robot and the imaging device. The incorporation of real-time intra-operative tracking of anatomical landmarks provides a mechanism of incorporating compensatory motion of the robotic arm to accommodate patient movement thereby enhancing the precision of the robotic task. - In another example embodiment, the
detector subsystem 28 includes the incorporation of image guidance into the robotic surgery, including predetermined marker shapes and positions that provide optimal accuracy for fiducial marker monitoring and tracking of anatomical landmarks, instrument position and the position of the robotic arms under the constraints imposed by the imaging device and the limited volume available in the surgical work envelope. - Imagery can also be incorporated as one of many parameters used to provide local control loop feedback in performing autonomous robotic tasks. In some example embodiments, the
control station 16 and thesurgical robot 12 operate in a master slave relationship. Such embodiments may incorporate semi-autonomous surgical robotics wherein thesurgical robot 12 may autonomously perform some specified surgical tasks that are part of a sequence of a larger task comprising the surgical procedure, for example using a locally controlled loop implemented by thecontroller 20. This may for example enables the surgeon to selectively perform techniques best undertaken with a master slave relationship while using automated robotics to perform specific tasks that require the enhanced precision of a surgical robot. For example, such tasks may include the precision placement of brachytherapy for cancer treatment or the precision drilling and intra-operative positioning of hardware in orthopaedic surgery. - In another aspect the
control station 16 displays diagnostic images, uploaded from a diagnostic workstation (such as CT, MRI, or the like), such that a clinician may select start (insertion point) and end (lesion) location points. A 3D representation of the 2D image slice data with controllable view angle enables the clinician to plan an optimal path avoiding blood vessels and other tissue structures. The avoidance of hematoma can be important with regard to post biopsy image quality for target confirmation. - The
control station 16 calculates the linear and angular motions necessary to move the surgical robotic manipulator over the planned trajectory and send appropriate commands to plurality of motors to move the medical instrument. - Referring still to
FIG. 11 , thecommunications network 18 may further include a direct wireless connection, a satellite connection, a wide area network such as the Internet, a wireless wide area packet data network, a voice and data network, a public switched telephone network, a wireless local area network (WLAN), or other networks or combinations of the forgoing. - In one aspect the
surgical robot 12 can move themedical instrument 100 while diagnostic images are being acquired. This can reduce the targeting confirmation time can be critical in light of contrast enhancement degradation issues. In addition, targeting errors as a result of lesion motion due to the force of the advancing needle, for example, can also be adjusted with the patient remaining within the magnet bore hole. The automated steering uses targeting software as well as force sensors to prevent accidental excursion into the wrong tissue. The software allows the medical practitioner to plan the full trajectory of the needle or ablation instrument from the skin surface down to the lesion and to steer themedical instrument 100 using real time MR. Again, MR fiducials as well as of MR molecular tagging may also be used to improve targeting accuracy. - In yet another aspect a
remote control station 16 can enable control of therobotic instruments 24 from a distance such that an expert in the breast biopsy and ablation procedures will direct the procedure from a distance. Theremote control station 16 can connect to one or more local workstations such that one physician may perform procedures at a plurality of remote sites (the master controller is at the remote site). Alternatively, the local workstation may control the procedure and a remote station will monitor the procedure for teaching purposes, for example. Examples of various systems which can use local and remote workstations collaboratively are described in the PCT Patent Application No. WO 2007/121,572, the contents of which are herein incorporated by reference. - In some example embodiments, rather than the breast biopsy or ablative procedures described herein, additional procedures can be performed using several imaging modalities such as MRI, CT, PET, PEM, BSGI, X-ray, or sonography, or other modalities where there is an advantage to accurately target a pathology for biopsy or ablation. It would also be appreciated that in some example embodiments other areas of the body can be targeted other than the breast. Such applications include liver, axilla (sentinel node biopsy), lung, kidney, prostate, uterus, and neurological.
- The various example embodiments described as systems would similarly apply to methods, and vice-versa.
- Variations may be made to some example embodiments, which may include combinations and sub-combinations of any of the above. The various embodiments presented above are merely examples and are in no way meant to limit the scope of this disclosure. Variations of the innovations described herein will be apparent to persons of ordinary skill in the art, such variations being within the intended scope of the present disclosure. In particular, features from one or more of the above-described embodiments may be selected to create alternative embodiments comprised of a sub-combination of features which may not be explicitly described above. In addition, features from one or more of the above-described embodiments may be selected and combined to create alternative embodiments comprised of a combination of features which may not be explicitly described above. Features suitable for such combinations and sub-combinations would be readily apparent to persons skilled in the art upon review of the described embodiments. The subject matter described herein intends to cover and embrace all suitable changes in technology.
Claims (19)
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CA2781788C (en) | 2015-11-03 |
WO2011063511A1 (en) | 2011-06-03 |
AU2010324494A1 (en) | 2012-06-14 |
WO2011063511A8 (en) | 2011-12-01 |
CA2901359A1 (en) | 2011-06-03 |
CA2901359C (en) | 2020-02-11 |
EP2503951A4 (en) | 2017-07-26 |
EP2503951A1 (en) | 2012-10-03 |
CA2781788A1 (en) | 2011-06-03 |
US9259271B2 (en) | 2016-02-16 |
AU2010324494B2 (en) | 2014-11-06 |
US20130158565A1 (en) | 2013-06-20 |
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