UA96916C2 - Конъюгат полипептида и синтетически сульфатованого пентасахарида, фармацевтическая композиция на его основе - Google Patents

Конъюгат полипептида и синтетически сульфатованого пентасахарида, фармацевтическая композиция на его основе

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Publication number
UA96916C2
UA96916C2 UAA200708223A UAA200708223A UA96916C2 UA 96916 C2 UA96916 C2 UA 96916C2 UA A200708223 A UAA200708223 A UA A200708223A UA A200708223 A UAA200708223 A UA A200708223A UA 96916 C2 UA96916 C2 UA 96916C2
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Ukraine
Prior art keywords
polypeptide
oligosaccharide
conjugate
pharmaceutical composition
composition based
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UAA200708223A
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English (en)
Ukrainian (uk)
Inventor
Эбо Сибрен Бос
Корт Мартин Де
Мертинус Йан Смит
Бекель Констант Адриаан Антон ван
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Н.В. Органон
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Application filed by Н.В. Органон filed Critical Н.В. Органон
Publication of UA96916C2 publication Critical patent/UA96916C2/ru

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    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract

Изобретение касается конъюгатов полипептида и олигосахарида, в которых полипептид конъюгирован до по меньшей мере одного остатка олигосахаридного спейсера, а олигосахарид является синтетически сульфатированным олигосахаридом, содержащим 4-18 моносахаридных единиц и, как такой, имеет родственность к антитромбину III, причем спейсер является связью или существенно фармакологически неактивным гибким связным остатком, или фармацевтически приемлемых солей этих конъюгатов. Конъюгаты согласно изобретению имеют улучшенные фармакокинетические свойства сравнительно с первоначальными полипептидами (т.е. неконъюгированными полипептидами как такими).
UAA200708223A 2005-02-01 2006-01-31 Конъюгат полипептида и синтетически сульфатованого пентасахарида, фармацевтическая композиция на его основе UA96916C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05100688 2005-02-01

Publications (1)

Publication Number Publication Date
UA96916C2 true UA96916C2 (ru) 2011-12-26

Family

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UAA200708223A UA96916C2 (ru) 2005-02-01 2006-01-31 Конъюгат полипептида и синтетически сульфатованого пентасахарида, фармацевтическая композиция на его основе

Country Status (20)

Country Link
US (2) US8106007B2 (ru)
EP (1) EP1976563A2 (ru)
JP (1) JP5134374B2 (ru)
KR (1) KR20070108535A (ru)
CN (1) CN101111268A (ru)
AR (1) AR052283A1 (ru)
AU (1) AU2006210230B2 (ru)
BR (1) BRPI0607248A2 (ru)
CA (1) CA2594970A1 (ru)
IL (1) IL184565A0 (ru)
MX (1) MX2007009243A (ru)
MY (1) MY148776A (ru)
NO (1) NO20073756L (ru)
NZ (1) NZ556581A (ru)
PE (1) PE20060880A1 (ru)
RU (1) RU2443713C2 (ru)
TW (1) TWI376234B (ru)
UA (1) UA96916C2 (ru)
WO (1) WO2006082184A2 (ru)
ZA (1) ZA200705904B (ru)

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US8106007B2 (en) 2012-01-31
KR20070108535A (ko) 2007-11-12
NZ556581A (en) 2011-06-30
AU2006210230B2 (en) 2011-09-15
TWI376234B (en) 2012-11-11
AR052283A1 (es) 2007-03-07
WO2006082184A3 (en) 2007-06-07
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AU2006210230A1 (en) 2006-08-10
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US20080139459A1 (en) 2008-06-12
BRPI0607248A2 (pt) 2010-10-19
US20120039843A1 (en) 2012-02-16
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IL184565A0 (en) 2007-10-31
WO2006082184A2 (en) 2006-08-10

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