NO20073756L - Konjugater av et polypeptid og et oligosakkarid - Google Patents

Konjugater av et polypeptid og et oligosakkarid

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Publication number
NO20073756L
NO20073756L NO20073756A NO20073756A NO20073756L NO 20073756 L NO20073756 L NO 20073756L NO 20073756 A NO20073756 A NO 20073756A NO 20073756 A NO20073756 A NO 20073756A NO 20073756 L NO20073756 L NO 20073756L
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NO
Norway
Prior art keywords
oligosaccharide
conjugates
polypeptide
conjugated
spacer
Prior art date
Application number
NO20073756A
Other languages
English (en)
Inventor
Martin De Kort
Constant Adriaan Anton Boeckel
Ebo Sybren Bos
Meertinus Jan Smit
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Organon Nv
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Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of NO20073756L publication Critical patent/NO20073756L/no

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
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  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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Abstract

Foreliggende oppfinnelse angår konjugater av et polypeptid og et oligosakkarid, hvor polypeptidet er konjugert til minst én oligosakkarid-spacer rest, idet oligosakkaridet er et syntetisk sulfatert oligosakkarid omfattende 4-18 monosakkaridenheter og per se som har affinitet til antithrombin III og spaceren er en binding eller en i det vesentlige farmakologisk inaktiv fleksibel linkingrest eller et farmasøytisk akseptabelt salt derav. Konjugatene ifølge oppfinnelsen har forbedrete farmakokinetiske egenskaper når sammenlignet med de opprinnelige polypeptidene (dvs. de tilsvarende ikke-konjugerte polypeptidene per se).
NO20073756A 2005-02-01 2007-07-19 Konjugater av et polypeptid og et oligosakkarid NO20073756L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05100688 2005-02-01
PCT/EP2006/050551 WO2006082184A2 (en) 2005-02-01 2006-01-31 Conjugates of a polypeptide and a pentasaccharide

Publications (1)

Publication Number Publication Date
NO20073756L true NO20073756L (no) 2007-08-29

Family

ID=35532856

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073756A NO20073756L (no) 2005-02-01 2007-07-19 Konjugater av et polypeptid og et oligosakkarid

Country Status (20)

Country Link
US (2) US8106007B2 (no)
EP (1) EP1976563A2 (no)
JP (1) JP5134374B2 (no)
KR (1) KR20070108535A (no)
CN (1) CN101111268A (no)
AR (1) AR052283A1 (no)
AU (1) AU2006210230B2 (no)
BR (1) BRPI0607248A2 (no)
CA (1) CA2594970A1 (no)
IL (1) IL184565A0 (no)
MX (1) MX2007009243A (no)
MY (1) MY148776A (no)
NO (1) NO20073756L (no)
NZ (1) NZ556581A (no)
PE (1) PE20060880A1 (no)
RU (1) RU2443713C2 (no)
TW (1) TWI376234B (no)
UA (1) UA96916C2 (no)
WO (1) WO2006082184A2 (no)
ZA (1) ZA200705904B (no)

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JP2008538200A (ja) 2008-10-16
US8106007B2 (en) 2012-01-31
IL184565A0 (en) 2007-10-31
MY148776A (en) 2013-05-31
CA2594970A1 (en) 2006-08-10
PE20060880A1 (es) 2006-09-23
TWI376234B (en) 2012-11-11
ZA200705904B (en) 2008-07-30
WO2006082184A2 (en) 2006-08-10
CN101111268A (zh) 2008-01-23
AU2006210230A1 (en) 2006-08-10
NZ556581A (en) 2011-06-30
EP1976563A2 (en) 2008-10-08
UA96916C2 (ru) 2011-12-26
US20080139459A1 (en) 2008-06-12
AU2006210230B2 (en) 2011-09-15
JP5134374B2 (ja) 2013-01-30
TW200638947A (en) 2006-11-16
RU2007132909A (ru) 2009-03-10
BRPI0607248A2 (pt) 2010-10-19
MX2007009243A (es) 2007-09-07
WO2006082184A3 (en) 2007-06-07
RU2443713C2 (ru) 2012-02-27
AR052283A1 (es) 2007-03-07
KR20070108535A (ko) 2007-11-12
US20120039843A1 (en) 2012-02-16

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