WO2008145721A3 - N-terminal modification of polypeptides for protection against degradation by aminopeptidases - Google Patents

N-terminal modification of polypeptides for protection against degradation by aminopeptidases Download PDF

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Publication number
WO2008145721A3
WO2008145721A3 PCT/EP2008/056673 EP2008056673W WO2008145721A3 WO 2008145721 A3 WO2008145721 A3 WO 2008145721A3 EP 2008056673 W EP2008056673 W EP 2008056673W WO 2008145721 A3 WO2008145721 A3 WO 2008145721A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
aminopeptidases
protection against
against degradation
terminal modification
Prior art date
Application number
PCT/EP2008/056673
Other languages
French (fr)
Other versions
WO2008145721A2 (en
Inventor
Ulrich Sensfuss
Frantisek Hubalek
Lauge Schaeffer
Thomas Hoeg-Jensen
Janos Tibor Kodra
Original Assignee
Novo Nordisk As
Ulrich Sensfuss
Frantisek Hubalek
Lauge Schaeffer
Thomas Hoeg-Jensen
Janos Tibor Kodra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As, Ulrich Sensfuss, Frantisek Hubalek, Lauge Schaeffer, Thomas Hoeg-Jensen, Janos Tibor Kodra filed Critical Novo Nordisk As
Publication of WO2008145721A2 publication Critical patent/WO2008145721A2/en
Publication of WO2008145721A3 publication Critical patent/WO2008145721A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/003—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

Abstract

N-terminally modified polypeptides comprising one or more N-terminal modifications consisting of an organic molecular substituent having a MW below 100 g per mol are ob- tained by the invention. Also compositions comprising such and the use thereof are com- prised by the invention.
PCT/EP2008/056673 2007-06-01 2008-05-30 N-terminal modification of polypeptides for protection against degradation by aminopeptidases WO2008145721A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07109440.3 2007-06-01
EP07109440 2007-06-01

Publications (2)

Publication Number Publication Date
WO2008145721A2 WO2008145721A2 (en) 2008-12-04
WO2008145721A3 true WO2008145721A3 (en) 2009-03-12

Family

ID=38473104

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/056673 WO2008145721A2 (en) 2007-06-01 2008-05-30 N-terminal modification of polypeptides for protection against degradation by aminopeptidases

Country Status (1)

Country Link
WO (1) WO2008145721A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009019027A (en) * 2007-07-16 2009-01-29 Hanmi Pharmaceutical Co Ltd Insulin secretion peptide derivative in which amino acid of amino terminal is varied
WO2011075430A1 (en) 2009-12-14 2011-06-23 University Of Massachusetts Methods of inhibiting cataracts and presbyopia
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
DE102010015123A1 (en) 2010-04-16 2011-10-20 Sanofi-Aventis Deutschland Gmbh New benzylamidic diphenylazetidinone compounds, useful for treating lipid disorders, hyperlipidemia, atherosclerotic manifestations or insulin resistance, and for reducing serum cholesterol levels
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2012049307A2 (en) 2010-10-15 2012-04-19 Novo Nordisk A/S Novel n-terminally modified insulin derivatives
CN103596584B (en) 2011-06-15 2016-12-14 诺沃—诺迪斯克有限公司 Polysubstituted insulin
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013093009A1 (en) 2011-12-21 2013-06-27 Novo Nordisk A/S N -terminally modified insulin derivatives
EP2968239B1 (en) * 2013-03-14 2019-04-24 The University of Massachusetts Methods of inhibiting cataracts and presbyopia
AR099569A1 (en) 2014-02-28 2016-08-03 Novo Nordisk As INSULIN DERIVATIVES AND THE MEDICAL USES OF THESE
CA2966765C (en) * 2014-11-21 2020-04-14 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
MX2018005903A (en) 2015-11-13 2019-04-04 Univ Massachusetts Bifunctional molecules containing peg for use in inhibiting cataracts and presbyopia.
EP3517544A4 (en) 2016-09-23 2020-06-03 Hanmi Pharm. Co., Ltd. Insulin analog having reduced binding force to insulin receptor, and use thereof
JP2020511513A (en) 2017-03-23 2020-04-16 ハンミ ファーマシューティカル カンパニー リミテッド Insulin analog conjugates having reduced binding to the insulin receptor and uses thereof
MX2023008330A (en) 2021-01-20 2024-01-18 Viking Therapeutics Inc Compositions and methods for the treatment of metabolic and liver disorders.

Citations (1)

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WO2003105677A2 (en) * 2002-06-01 2003-12-24 Praecis Pharmaceuticals, Inc. Methods for treating viral diseases using modulators of amyloidogenic peptide aggregation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003105677A2 (en) * 2002-06-01 2003-12-24 Praecis Pharmaceuticals, Inc. Methods for treating viral diseases using modulators of amyloidogenic peptide aggregation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GLIEMANN J ET AL: "The biological activity and the binding affinity of modified insulins determined on isolated rat fat cells.", DIABETOLOGIA APR 1974, vol. 10, no. 2, April 1974 (1974-04-01), pages 105 - 113, XP002453103, ISSN: 0012-186X *
HINDS KEN ET AL: "Synthesis and characterization of poly(ethylene glycol)-insulin conjugates", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 11, no. 2, 15 February 2000 (2000-02-15), pages 195 - 201, XP002391407, ISSN: 1043-1802 *
UCHIO T ET AL: "Site-specific insulin conjugates with enhanced stability and extended action profile", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, vol. 35, no. 2-3, 1999, pages 289 - 306, XP002363507, ISSN: 0169-409X *

Also Published As

Publication number Publication date
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