WO2008145721A3 - N-terminal modification of polypeptides for protection against degradation by aminopeptidases - Google Patents
N-terminal modification of polypeptides for protection against degradation by aminopeptidases Download PDFInfo
- Publication number
- WO2008145721A3 WO2008145721A3 PCT/EP2008/056673 EP2008056673W WO2008145721A3 WO 2008145721 A3 WO2008145721 A3 WO 2008145721A3 EP 2008056673 W EP2008056673 W EP 2008056673W WO 2008145721 A3 WO2008145721 A3 WO 2008145721A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polypeptides
- aminopeptidases
- protection against
- against degradation
- terminal modification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/003—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
N-terminally modified polypeptides comprising one or more N-terminal modifications consisting of an organic molecular substituent having a MW below 100 g per mol are ob- tained by the invention. Also compositions comprising such and the use thereof are com- prised by the invention.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07109440 | 2007-06-01 | ||
EP07109440.3 | 2007-06-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008145721A2 WO2008145721A2 (en) | 2008-12-04 |
WO2008145721A3 true WO2008145721A3 (en) | 2009-03-12 |
Family
ID=38473104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/056673 WO2008145721A2 (en) | 2007-06-01 | 2008-05-30 | N-terminal modification of polypeptides for protection against degradation by aminopeptidases |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008145721A2 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009019027A (en) * | 2007-07-16 | 2009-01-29 | Hanmi Pharmaceutical Co Ltd | Insulin secretion peptide derivative in which amino acid of amino terminal is varied |
WO2011075430A1 (en) | 2009-12-14 | 2011-06-23 | University Of Massachusetts | Methods of inhibiting cataracts and presbyopia |
WO2011107494A1 (en) | 2010-03-03 | 2011-09-09 | Sanofi | Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof |
DE102010015123A1 (en) | 2010-04-16 | 2011-10-20 | Sanofi-Aventis Deutschland Gmbh | New benzylamidic diphenylazetidinone compounds, useful for treating lipid disorders, hyperlipidemia, atherosclerotic manifestations or insulin resistance, and for reducing serum cholesterol levels |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
JP2013540771A (en) * | 2010-10-15 | 2013-11-07 | ノヴォ ノルディスク アー/エス | Novel N-terminally modified insulin derivative |
WO2012171994A1 (en) | 2011-06-15 | 2012-12-20 | Novo Nordisk A/S | Multi substituted insulins |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
CN104364262A (en) * | 2011-12-21 | 2015-02-18 | 诺沃—诺迪斯克有限公司 | N -terminally modified insulin derivatives |
WO2014152818A1 (en) * | 2013-03-14 | 2014-09-25 | The University Of Massachusetts | Methods of inhibiting cataracts and presbyopia |
AR099569A1 (en) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | INSULIN DERIVATIVES AND THE MEDICAL USES OF THESE |
JP6484337B2 (en) | 2014-11-21 | 2019-03-13 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Insulin receptor partial agonist |
AU2016354479B2 (en) | 2015-11-13 | 2021-10-07 | The University Of Massachusetts | Bifunctional molecules containing PEG for use in inhibiting cataracts and presbyopia |
KR20180033105A (en) | 2016-09-23 | 2018-04-02 | 한미약품 주식회사 | Insulin analogs with reduced affinity to insulin receptor and use thereof |
AU2018239037B2 (en) | 2017-03-23 | 2022-05-26 | Hanmi Pharm. Co., Ltd. | Insulin analog complex with reduced affinity for insulin receptor and use thereof |
CA3204051A1 (en) | 2021-01-20 | 2022-07-28 | Brian Lian | Compositions and methods for the treatment of metabolic and liver disorders |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003105677A2 (en) * | 2002-06-01 | 2003-12-24 | Praecis Pharmaceuticals, Inc. | Methods for treating viral diseases using modulators of amyloidogenic peptide aggregation |
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2008
- 2008-05-30 WO PCT/EP2008/056673 patent/WO2008145721A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003105677A2 (en) * | 2002-06-01 | 2003-12-24 | Praecis Pharmaceuticals, Inc. | Methods for treating viral diseases using modulators of amyloidogenic peptide aggregation |
Non-Patent Citations (3)
Title |
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GLIEMANN J ET AL: "The biological activity and the binding affinity of modified insulins determined on isolated rat fat cells.", DIABETOLOGIA APR 1974, vol. 10, no. 2, April 1974 (1974-04-01), pages 105 - 113, XP002453103, ISSN: 0012-186X * |
HINDS KEN ET AL: "Synthesis and characterization of poly(ethylene glycol)-insulin conjugates", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 11, no. 2, 15 February 2000 (2000-02-15), pages 195 - 201, XP002391407, ISSN: 1043-1802 * |
UCHIO T ET AL: "Site-specific insulin conjugates with enhanced stability and extended action profile", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, vol. 35, no. 2-3, 1999, pages 289 - 306, XP002363507, ISSN: 0169-409X * |
Also Published As
Publication number | Publication date |
---|---|
WO2008145721A2 (en) | 2008-12-04 |
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