UA84879C2 - Изотиазолохинолоны и родственные соединения с противомикробным действием - Google Patents

Изотиазолохинолоны и родственные соединения с противомикробным действием

Info

Publication number
UA84879C2
UA84879C2 UAA200602630A UAA200602630A UA84879C2 UA 84879 C2 UA84879 C2 UA 84879C2 UA A200602630 A UAA200602630 A UA A200602630A UA A200602630 A UAA200602630 A UA A200602630A UA 84879 C2 UA84879 C2 UA 84879C2
Authority
UA
Ukraine
Prior art keywords
formula
compounds
provides
compositions
contain
Prior art date
Application number
UAA200602630A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Бартон Джеймс Бредбери
Майлинд Деспанде
Майкл Джон Пуччи
Куипин Ван
Джейсон Алан Вайлс
Йоншен Сон
Акихиро Хасимото
Эдлен Люсьен
Original Assignee
Акилайон Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Акилайон Фармасьютикалз, Инк. filed Critical Акилайон Фармасьютикалз, Инк.
Publication of UA84879C2 publication Critical patent/UA84879C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
UAA200602630A 2003-08-12 2004-08-04 Изотиазолохинолоны и родственные соединения с противомикробным действием UA84879C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49465503P 2003-08-12 2003-08-12

Publications (1)

Publication Number Publication Date
UA84879C2 true UA84879C2 (ru) 2008-12-10

Family

ID=34215887

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200602630A UA84879C2 (ru) 2003-08-12 2004-08-04 Изотиазолохинолоны и родственные соединения с противомикробным действием

Country Status (14)

Country Link
US (2) US20050075363A1 (enExample)
EP (1) EP1664062B1 (enExample)
JP (1) JP5147237B2 (enExample)
KR (1) KR20060069836A (enExample)
CN (1) CN1867570A (enExample)
AU (1) AU2004267052B2 (enExample)
BR (1) BRPI0413528A (enExample)
CA (1) CA2535370C (enExample)
IL (1) IL173492A0 (enExample)
MX (1) MXPA06001645A (enExample)
NO (1) NO20060653L (enExample)
NZ (1) NZ545157A (enExample)
UA (1) UA84879C2 (enExample)
WO (1) WO2005019228A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006089054A1 (en) * 2005-02-16 2006-08-24 Achillion Pharmaceuticals, Inc. New isothiazoloquinolones and related compounds as anti-infective agents
EP1809639B1 (en) * 2004-11-11 2009-10-14 Achillion Pharmaceuticals, Inc. 8a, 9-dihydro-4a-h-isothiazolo[5,4-b] quinoline-3, 4-diones and related compounds as anti-infective agents
WO2006074317A1 (en) * 2005-01-05 2006-07-13 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]naphthalene-3,4-diones and related compounds as anti-infective agents
ES2352799T3 (es) 2005-07-27 2011-02-23 Achillion Pharmaceuticals, Inc. 8-metoxi-9h-isotiazolo[5,4-b]quinolina-3,4-dionas y compuestos relacionados.
WO2008021491A2 (en) * 2006-08-16 2008-02-21 Achillion Pharmaceuticals, Inc. Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones
WO2008036420A2 (en) * 2006-09-21 2008-03-27 Achillion Pharmaceuticals, Inc. 9-(heteroaryl)-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
US8173636B2 (en) * 2009-04-03 2012-05-08 Achillion Pharmaceuticals, Inc. Hydroxylthienoquinolones and related compounds as anti-infective agents
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
JP2013508299A (ja) 2009-10-16 2013-03-07 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法
NZ623384A (en) * 2009-10-16 2016-06-24 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
JP6274723B2 (ja) 2009-10-16 2018-02-07 メリンタ セラピューティクス，インコーポレイテッド 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法
CN102866153B (zh) * 2012-09-29 2014-08-13 郑州安图生物工程股份有限公司 前列腺炎联合检测试剂盒
US9937183B2 (en) 2013-09-09 2018-04-10 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
MX2016002975A (es) 2013-09-09 2016-10-21 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos.
CN104530034B (zh) * 2014-12-31 2017-02-22 西南大学 喹诺酮噻唑类化合物及其制备方法和应用
WO2016145417A1 (en) 2015-03-11 2016-09-15 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
US11098047B2 (en) 2016-05-06 2021-08-24 BioVersys AG Antimicrobials and methods of making and using same
KR101915550B1 (ko) 2016-10-20 2018-11-07 한국화학연구원 퀴놀린 4-온 유도체 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 폐렴의 예방 또는 치료용 약학적 조성물
KR101891315B1 (ko) 2017-08-01 2018-08-24 한국화학연구원 퀴놀린 4-온 유도체 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 폐렴의 예방 또는 치료용 약학적 조성물
CN113045589B (zh) * 2019-12-27 2024-08-23 广东东阳光药业股份有限公司 流感病毒复制抑制剂及其用途
CN122213010A (zh) * 2026-05-20 2026-06-16 山东丰金制药有限公司 一种苏泽曲林中间体4-氨基吡啶-2-甲酸甲酯的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62187472A (ja) * 1985-12-23 1987-08-15 アボツト　ラボラトリ−ズ イソオキサゾロ−ナフチリジン、イソオキサゾロキノリン、イソチアゾロ−ナフチリジン及びイソチアゾロ−キノリン誘導体
US4767762A (en) * 1985-12-23 1988-08-30 Abbott Laboratories Tricyclic quinoline and naphthyride antibacterials
JP2681190B2 (ja) * 1988-04-13 1997-11-26 塩野義製薬株式会社 ピリドン系抗菌剤
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US4945160A (en) * 1988-11-22 1990-07-31 Warner-Lambert Company Preparation of certain 7-substituted quinolones
JP2787713B2 (ja) * 1989-07-28 1998-08-20 富山化学工業株式会社 新規なイソチアゾローナフチリジンおよびイソチアゾローキノリン誘導体並びにそれらの塩
US5646163A (en) * 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
US20020103115A1 (en) * 2000-09-19 2002-08-01 Karl Guegler Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
WO2006089054A1 (en) * 2005-02-16 2006-08-24 Achillion Pharmaceuticals, Inc. New isothiazoloquinolones and related compounds as anti-infective agents
US7678235B2 (en) * 2005-10-19 2010-03-16 Sylvan Source, Inc. Water purification system

Also Published As

Publication number Publication date
JP2007502275A (ja) 2007-02-08
US20110223132A1 (en) 2011-09-15
MXPA06001645A (es) 2006-05-12
AU2004267052B2 (en) 2009-02-05
EP1664062A1 (en) 2006-06-07
KR20060069836A (ko) 2006-06-22
WO2005019228A1 (en) 2005-03-03
IL173492A0 (en) 2006-06-11
US20050075363A1 (en) 2005-04-07
EP1664062B1 (en) 2013-03-13
JP5147237B2 (ja) 2013-02-20
CN1867570A (zh) 2006-11-22
CA2535370A1 (en) 2005-03-03
BRPI0413528A (pt) 2006-10-10
AU2004267052A1 (en) 2005-03-03
CA2535370C (en) 2011-01-25
NZ545157A (en) 2009-03-31
NO20060653L (no) 2006-03-13

Similar Documents

Publication Publication Date Title
IL189017A (en) Derivatives of 8-methoxy-9 h-isothiazolo [4,5- b] quinoline-4,3-diones as bactericides
IL185164A0 (en) New isothiazoloquinolones and related compounds as anti-infective agents
NO20060653L (no) Isotiazolokinoloner og beslektede forbindelser som anti-infektive midler
DE602004021472D1 (en) Pyrimiidinverbindungen
MXPA05009611A (es) Piperidinas sustituidas como nuevos inhibidores de mdm2-p53.
AP2003002942A0 (en) New derivatives of oxazolidinones as bacterial agents
DE602004008959D1 (de) Benzoäbüä1,4üdioxepinderivate
DE60102171D1 (de) Ketolidantibiotika
BRPI0410669A (pt) inibidores de caspase e usos dos mesmo
WO2005054234A8 (en) Substituted piperidino phenyloxazolidinones having antimicriobial activity with improved in vivo efficacy
MXPA05009688A (es) Derivados de naftiridina como agentes antibacterianos.
EP1511472A4 (en) USEFUL COMPOUNDS FOR THE TREATMENT OF ANTHRAX AND INHIBITION OF THE LETAL FACTOR
WO2002100327A3 (en) Substituted 1-benzazepines and derivatives thereof
MXPA05010783A (es) Derivados antimicrobianos de [3.1.0] biciclohexilfenil-oxazolidinona y analogos.
IL183153A0 (en) 8a, 9-DIHYDRO-4a-H-ISOTHIAZOLO[5,4-b]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS
WO2008036420A3 (en) 9-(heteroaryl)-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
TW200640464A (en) Pharmaceutical composition comprising phenoxazinium compounds as an active ingredient
SV2003001058A (es) Agentes antibacterianos pca494-01
BR0307468A (pt) Derivados tiadiazinona antimicrobianos úteis no tratamento de infecções bacterianas
DE60326710D1 (de) Trizyklische antibakterielle makrolidderivate
WO2003068790A3 (en) Macrolide antibacterial compounds
WO2003090679A3 (en) 11-deoxy azalide antibacterials