AU2004267052B2 - Isothiazoloquinolones and related compounds as anti-infective agents - Google Patents

Isothiazoloquinolones and related compounds as anti-infective agents Download PDF

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Publication number
AU2004267052B2
AU2004267052B2 AU2004267052A AU2004267052A AU2004267052B2 AU 2004267052 B2 AU2004267052 B2 AU 2004267052B2 AU 2004267052 A AU2004267052 A AU 2004267052A AU 2004267052 A AU2004267052 A AU 2004267052A AU 2004267052 B2 AU2004267052 B2 AU 2004267052B2
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AU
Australia
Prior art keywords
cyclopropyl
fluoro
isothiazolo
alkyl
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004267052A
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English (en)
Other versions
AU2004267052A1 (en
Inventor
Barton James Bradbury
Milind Deshphande
Akihiro Hashimoto
Edlaine Lucien
Michael John Pucci
Yongsheng Song
Quiping Wang
Jason Allan Wiles
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Achillion Pharmaceuticals Inc
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Achillion Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Achillion Pharmaceuticals Inc filed Critical Achillion Pharmaceuticals Inc
Publication of AU2004267052A1 publication Critical patent/AU2004267052A1/en
Priority to AU2006214234A priority Critical patent/AU2006214234B2/en
Application granted granted Critical
Publication of AU2004267052B2 publication Critical patent/AU2004267052B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2004267052A 2003-08-12 2004-08-04 Isothiazoloquinolones and related compounds as anti-infective agents Ceased AU2004267052B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2006214234A AU2006214234B2 (en) 2003-08-12 2006-02-15 New isothiazoloquinolones and related compounds as anti-infective agents

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49465503P 2003-08-12 2003-08-12
US60/494,655 2003-08-12
PCT/US2004/025365 WO2005019228A1 (en) 2003-08-12 2004-08-04 Isothiazoloquinolones and related compounds as anti-infective agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2006214234A Division AU2006214234B2 (en) 2003-08-12 2006-02-15 New isothiazoloquinolones and related compounds as anti-infective agents

Publications (2)

Publication Number Publication Date
AU2004267052A1 AU2004267052A1 (en) 2005-03-03
AU2004267052B2 true AU2004267052B2 (en) 2009-02-05

Family

ID=34215887

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004267052A Ceased AU2004267052B2 (en) 2003-08-12 2004-08-04 Isothiazoloquinolones and related compounds as anti-infective agents

Country Status (14)

Country Link
US (2) US20050075363A1 (enExample)
EP (1) EP1664062B1 (enExample)
JP (1) JP5147237B2 (enExample)
KR (1) KR20060069836A (enExample)
CN (1) CN1867570A (enExample)
AU (1) AU2004267052B2 (enExample)
BR (1) BRPI0413528A (enExample)
CA (1) CA2535370C (enExample)
IL (1) IL173492A0 (enExample)
MX (1) MXPA06001645A (enExample)
NO (1) NO20060653L (enExample)
NZ (1) NZ545157A (enExample)
UA (1) UA84879C2 (enExample)
WO (1) WO2005019228A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006089054A1 (en) * 2005-02-16 2006-08-24 Achillion Pharmaceuticals, Inc. New isothiazoloquinolones and related compounds as anti-infective agents
EP1809639B1 (en) * 2004-11-11 2009-10-14 Achillion Pharmaceuticals, Inc. 8a, 9-dihydro-4a-h-isothiazolo[5,4-b] quinoline-3, 4-diones and related compounds as anti-infective agents
WO2006074317A1 (en) * 2005-01-05 2006-07-13 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]naphthalene-3,4-diones and related compounds as anti-infective agents
ES2352799T3 (es) 2005-07-27 2011-02-23 Achillion Pharmaceuticals, Inc. 8-metoxi-9h-isotiazolo[5,4-b]quinolina-3,4-dionas y compuestos relacionados.
WO2008021491A2 (en) * 2006-08-16 2008-02-21 Achillion Pharmaceuticals, Inc. Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones
WO2008036420A2 (en) * 2006-09-21 2008-03-27 Achillion Pharmaceuticals, Inc. 9-(heteroaryl)-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
US8173636B2 (en) * 2009-04-03 2012-05-08 Achillion Pharmaceuticals, Inc. Hydroxylthienoquinolones and related compounds as anti-infective agents
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
JP2013508299A (ja) 2009-10-16 2013-03-07 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法
NZ623384A (en) * 2009-10-16 2016-06-24 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
JP6274723B2 (ja) 2009-10-16 2018-02-07 メリンタ セラピューティクス，インコーポレイテッド 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法
CN102866153B (zh) * 2012-09-29 2014-08-13 郑州安图生物工程股份有限公司 前列腺炎联合检测试剂盒
US9937183B2 (en) 2013-09-09 2018-04-10 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
MX2016002975A (es) 2013-09-09 2016-10-21 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos.
CN104530034B (zh) * 2014-12-31 2017-02-22 西南大学 喹诺酮噻唑类化合物及其制备方法和应用
WO2016145417A1 (en) 2015-03-11 2016-09-15 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
US11098047B2 (en) 2016-05-06 2021-08-24 BioVersys AG Antimicrobials and methods of making and using same
KR101915550B1 (ko) 2016-10-20 2018-11-07 한국화학연구원 퀴놀린 4-온 유도체 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 폐렴의 예방 또는 치료용 약학적 조성물
KR101891315B1 (ko) 2017-08-01 2018-08-24 한국화학연구원 퀴놀린 4-온 유도체 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 폐렴의 예방 또는 치료용 약학적 조성물
CN113045589B (zh) * 2019-12-27 2024-08-23 广东东阳光药业股份有限公司 流感病毒复制抑制剂及其用途
CN122213010A (zh) * 2026-05-20 2026-06-16 山东丰金制药有限公司 一种苏泽曲林中间体4-氨基吡啶-2-甲酸甲酯的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0358992A (ja) * 1989-07-28 1991-03-14 Toyama Chem Co Ltd 新規なイソチアゾローナフチリジンおよびイソチアゾローキノリン誘導体並びにそれらの塩
US5387748A (en) * 1988-10-24 1995-02-07 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial dithiocarbamoyl quinolones
WO1995029894A1 (en) * 1994-04-28 1995-11-09 The Procter & Gamble Company Novel quinolone 5-(n-heterosubstituted amino) antimicrobials
US5631256A (en) * 1988-10-24 1997-05-20 The Procter & Gamble Company Antimicrobial quinolone thioureas

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JPS62187472A (ja) * 1985-12-23 1987-08-15 アボツト　ラボラトリ−ズ イソオキサゾロ−ナフチリジン、イソオキサゾロキノリン、イソチアゾロ−ナフチリジン及びイソチアゾロ−キノリン誘導体
US4767762A (en) * 1985-12-23 1988-08-30 Abbott Laboratories Tricyclic quinoline and naphthyride antibacterials
JP2681190B2 (ja) * 1988-04-13 1997-11-26 塩野義製薬株式会社 ピリドン系抗菌剤
US4945160A (en) * 1988-11-22 1990-07-31 Warner-Lambert Company Preparation of certain 7-substituted quinolones
US20020103115A1 (en) * 2000-09-19 2002-08-01 Karl Guegler Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
WO2006089054A1 (en) * 2005-02-16 2006-08-24 Achillion Pharmaceuticals, Inc. New isothiazoloquinolones and related compounds as anti-infective agents
US7678235B2 (en) * 2005-10-19 2010-03-16 Sylvan Source, Inc. Water purification system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387748A (en) * 1988-10-24 1995-02-07 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial dithiocarbamoyl quinolones
US5631256A (en) * 1988-10-24 1997-05-20 The Procter & Gamble Company Antimicrobial quinolone thioureas
JPH0358992A (ja) * 1989-07-28 1991-03-14 Toyama Chem Co Ltd 新規なイソチアゾローナフチリジンおよびイソチアゾローキノリン誘導体並びにそれらの塩
US5646163A (en) * 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
WO1995029894A1 (en) * 1994-04-28 1995-11-09 The Procter & Gamble Company Novel quinolone 5-(n-heterosubstituted amino) antimicrobials

Also Published As

Publication number Publication date
JP2007502275A (ja) 2007-02-08
US20110223132A1 (en) 2011-09-15
MXPA06001645A (es) 2006-05-12
EP1664062A1 (en) 2006-06-07
KR20060069836A (ko) 2006-06-22
WO2005019228A1 (en) 2005-03-03
IL173492A0 (en) 2006-06-11
US20050075363A1 (en) 2005-04-07
UA84879C2 (ru) 2008-12-10
EP1664062B1 (en) 2013-03-13
JP5147237B2 (ja) 2013-02-20
CN1867570A (zh) 2006-11-22
CA2535370A1 (en) 2005-03-03
BRPI0413528A (pt) 2006-10-10
AU2004267052A1 (en) 2005-03-03
CA2535370C (en) 2011-01-25
NZ545157A (en) 2009-03-31
NO20060653L (no) 2006-03-13

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired