UA82008C2 - Ингибиторы нейтральной эндопептидазы (nep) и растворимой человеческой эндопептидазы (hsep) для профилактики и лечения нейродегенеративных расстройств - Google Patents
Ингибиторы нейтральной эндопептидазы (nep) и растворимой человеческой эндопептидазы (hsep) для профилактики и лечения нейродегенеративных расстройств Download PDFInfo
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- UA82008C2 UA82008C2 UAA200609032A UAA200609032A UA82008C2 UA 82008 C2 UA82008 C2 UA 82008C2 UA A200609032 A UAA200609032 A UA A200609032A UA A200609032 A UAA200609032 A UA A200609032A UA 82008 C2 UA82008 C2 UA 82008C2
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- Prior art keywords
- alkyl
- pharmaceutically acceptable
- acceptable salts
- precursors
- formula
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53553804P | 2004-01-12 | 2004-01-12 | |
| EP04100067 | 2004-01-12 | ||
| PCT/EP2005/050075 WO2005067937A1 (en) | 2004-01-12 | 2005-01-10 | Neutral endopeptidase (nep) and human soluble endopeptidase (hsep) inhibitors for prophylaxis and treatment of neurodegenerative disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA82008C2 true UA82008C2 (ru) | 2008-02-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200609032A UA82008C2 (ru) | 2004-01-12 | 2005-10-01 | Ингибиторы нейтральной эндопептидазы (nep) и растворимой человеческой эндопептидазы (hsep) для профилактики и лечения нейродегенеративных расстройств |
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| EP (1) | EP1706121B1 (ru) |
| JP (1) | JP4951350B2 (ru) |
| KR (1) | KR101219580B1 (ru) |
| CN (1) | CN101076339B (ru) |
| AT (1) | ATE406899T1 (ru) |
| AU (1) | AU2005205067B2 (ru) |
| BR (1) | BRPI0506750A (ru) |
| CA (1) | CA2551789C (ru) |
| CY (1) | CY1108588T1 (ru) |
| DE (1) | DE602005009487D1 (ru) |
| DK (1) | DK1706121T3 (ru) |
| ES (1) | ES2313279T3 (ru) |
| HR (1) | HRP20080611T3 (ru) |
| IL (1) | IL176456A (ru) |
| NO (1) | NO20063623L (ru) |
| PL (1) | PL1706121T3 (ru) |
| PT (1) | PT1706121E (ru) |
| RU (1) | RU2362563C2 (ru) |
| SI (1) | SI1706121T1 (ru) |
| UA (1) | UA82008C2 (ru) |
| WO (1) | WO2005067937A1 (ru) |
| ZA (1) | ZA200605549B (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010207597A1 (en) * | 2009-01-24 | 2011-08-18 | Phytopharm Plc | Treatment of neurotrophic factor mediated disorders |
| AR079059A1 (es) | 2009-12-07 | 2011-12-21 | Abbott Healthcare Products Bv | Acido ((3s)-3-(((1-(((2r)-2-carboxi-4-(1-naftil) butil) ciclopentil)-carbonil) amino )-2-oxo-2,3,4,5-tetrahidro-1h-1-benzazepin-1-il) acetico cristalino, su preparacion y uso |
| CN106065006B (zh) * | 2015-04-22 | 2020-06-05 | 深圳信立泰药业股份有限公司 | 一种中性内肽酶抑制剂盐晶型及其制备方法 |
| PL424453A1 (pl) * | 2018-01-31 | 2019-08-12 | Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością | Sposoby zmniejszania szkodliwego działania niedoboru perfuzji narządów miąższowych przez inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) |
| PL424452A1 (pl) | 2018-01-31 | 2019-08-12 | Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu |
| CN110590695B (zh) * | 2019-10-22 | 2023-03-21 | 南华大学 | 苯并氮杂环类化合物及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19510566A1 (de) * | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE19750002A1 (de) * | 1997-11-12 | 1999-05-20 | Solvay Pharm Gmbh | Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| EP1073674A1 (en) * | 1998-04-23 | 2001-02-07 | Novartis AG | Thiol inhibitors of endothelin-converting enzyme |
| US20020013307A1 (en) * | 2000-05-23 | 2002-01-31 | Pablo Lapuerta | Use of vasopeptidase inhibitors to treat or slow the progression of cognitive dysfunction and to treat and/or prevent dementia |
| US6505135B2 (en) * | 2001-03-13 | 2003-01-07 | Micro Motion, Inc. | Initialization algorithm for drive control in a coriolis flowmeter |
| PL367093A1 (en) * | 2001-05-18 | 2005-02-21 | Solvay Pharmaceuticals Gmbh | Use of compounds with combined nep/mp-inhibitory activity in the preparation of medicaments |
| CL2004000545A1 (es) * | 2003-03-18 | 2005-01-28 | Pharmacia Corp Sa Organizada B | Uso de un antagonista de los receptores de aldosterona y un antagonista de receptores de endotelina para el tratamiento o profilaxis de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopatia y enfermedades cardiovascul |
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- 2005-01-10 SI SI200530457T patent/SI1706121T1/sl unknown
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- 2005-01-10 PL PL05701469T patent/PL1706121T3/pl unknown
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- 2006-07-05 ZA ZA200605549A patent/ZA200605549B/xx unknown
- 2006-08-10 NO NO20063623A patent/NO20063623L/no not_active Application Discontinuation
- 2006-08-11 KR KR1020067016297A patent/KR101219580B1/ko active IP Right Grant
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Also Published As
| Publication number | Publication date |
|---|---|
| JP4951350B2 (ja) | 2012-06-13 |
| AU2005205067B2 (en) | 2009-10-22 |
| PT1706121E (pt) | 2008-12-04 |
| AU2005205067A1 (en) | 2005-07-28 |
| DK1706121T3 (da) | 2009-01-05 |
| JP2007517834A (ja) | 2007-07-05 |
| HRP20080611T3 (en) | 2008-12-31 |
| SI1706121T1 (sl) | 2009-02-28 |
| ES2313279T3 (es) | 2009-03-01 |
| EP1706121A1 (en) | 2006-10-04 |
| IL176456A0 (en) | 2006-10-05 |
| KR20060123541A (ko) | 2006-12-01 |
| RU2006129288A (ru) | 2008-02-20 |
| WO2005067937A1 (en) | 2005-07-28 |
| CY1108588T1 (el) | 2014-04-09 |
| NO20063623L (no) | 2006-10-12 |
| EP1706121B1 (en) | 2008-09-03 |
| BRPI0506750A (pt) | 2007-05-22 |
| ATE406899T1 (de) | 2008-09-15 |
| CN101076339A (zh) | 2007-11-21 |
| PL1706121T3 (pl) | 2009-02-27 |
| CA2551789A1 (en) | 2005-07-28 |
| CA2551789C (en) | 2011-05-03 |
| KR101219580B1 (ko) | 2013-01-08 |
| ZA200605549B (en) | 2007-12-27 |
| CN101076339B (zh) | 2011-02-09 |
| IL176456A (en) | 2010-03-28 |
| DE602005009487D1 (de) | 2008-10-16 |
| RU2362563C2 (ru) | 2009-07-27 |
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