UA80085C2 - Oral liquid compositions - Google Patents
Oral liquid compositions Download PDFInfo
- Publication number
- UA80085C2 UA80085C2 UA2002010408A UA2002010408A UA80085C2 UA 80085 C2 UA80085 C2 UA 80085C2 UA 2002010408 A UA2002010408 A UA 2002010408A UA 2002010408 A UA2002010408 A UA 2002010408A UA 80085 C2 UA80085 C2 UA 80085C2
- Authority
- UA
- Ukraine
- Prior art keywords
- pharmaceutical composition
- agents
- composition according
- group
- acid
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims description 221
- 239000007788 liquid Substances 0.000 title abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 61
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 61
- 239000002775 capsule Substances 0.000 claims abstract description 41
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 50
- 239000002253 acid Substances 0.000 claims description 48
- 239000013543 active substance Substances 0.000 claims description 47
- 239000007903 gelatin capsule Substances 0.000 claims description 40
- 239000002904 solvent Substances 0.000 claims description 40
- 239000002270 dispersing agent Substances 0.000 claims description 36
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 36
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 33
- 241000124008 Mammalia Species 0.000 claims description 32
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 32
- 229920001223 polyethylene glycol Polymers 0.000 claims description 31
- 239000002202 Polyethylene glycol Substances 0.000 claims description 29
- 239000003795 chemical substances by application Substances 0.000 claims description 24
- 239000004014 plasticizer Substances 0.000 claims description 24
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 22
- 229960000381 omeprazole Drugs 0.000 claims description 22
- 239000004094 surface-active agent Substances 0.000 claims description 22
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 21
- -1 cervistatin Chemical compound 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 20
- 238000000576 coating method Methods 0.000 claims description 19
- HEMJJKBWTPKOJG-UHFFFAOYSA-N Gemfibrozil Chemical compound CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1 HEMJJKBWTPKOJG-UHFFFAOYSA-N 0.000 claims description 18
- 229960003627 gemfibrozil Drugs 0.000 claims description 18
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 claims description 17
- 229960000894 sulindac Drugs 0.000 claims description 17
- 230000002378 acidificating effect Effects 0.000 claims description 16
- 125000004185 ester group Chemical group 0.000 claims description 16
- 235000011187 glycerol Nutrition 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 229960000265 cromoglicic acid Drugs 0.000 claims description 14
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims description 14
- 239000012634 fragment Substances 0.000 claims description 14
- 231100000252 nontoxic Toxicity 0.000 claims description 14
- 230000003000 nontoxic effect Effects 0.000 claims description 14
- 239000011248 coating agent Substances 0.000 claims description 13
- 229960001259 diclofenac Drugs 0.000 claims description 13
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 238000010521 absorption reaction Methods 0.000 claims description 12
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 12
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims description 12
- 229960003592 fexofenadine Drugs 0.000 claims description 12
- 229960000905 indomethacin Drugs 0.000 claims description 11
- 229920000642 polymer Polymers 0.000 claims description 11
- 235000014633 carbohydrates Nutrition 0.000 claims description 9
- 150000001720 carbohydrates Chemical class 0.000 claims description 9
- 229930182555 Penicillin Natural products 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 8
- 150000002960 penicillins Chemical class 0.000 claims description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
- 229930186147 Cephalosporin Natural products 0.000 claims description 7
- 206010053155 Epigastric discomfort Diseases 0.000 claims description 7
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims description 7
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims description 7
- 150000007513 acids Chemical class 0.000 claims description 7
- 229940124587 cephalosporin Drugs 0.000 claims description 7
- 150000001780 cephalosporins Chemical class 0.000 claims description 7
- 229960004844 lovastatin Drugs 0.000 claims description 7
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims description 7
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims description 7
- 229940126409 proton pump inhibitor Drugs 0.000 claims description 7
- 239000000612 proton pump inhibitor Substances 0.000 claims description 7
- 229960002855 simvastatin Drugs 0.000 claims description 7
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims description 7
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims description 6
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims description 6
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims description 6
- KPSRODZRAIWAKH-JTQLQIEISA-N Ciprofibrate Natural products C1=CC(OC(C)(C)C(O)=O)=CC=C1[C@H]1C(Cl)(Cl)C1 KPSRODZRAIWAKH-JTQLQIEISA-N 0.000 claims description 6
- 208000002193 Pain Diseases 0.000 claims description 6
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims description 6
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims description 6
- 229960005370 atorvastatin Drugs 0.000 claims description 6
- 229960003395 carboprost Drugs 0.000 claims description 6
- DLJKPYFALUEJCK-MRVZPHNRSA-N carboprost Chemical compound CCCCC[C@](C)(O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C\CCCC(O)=O DLJKPYFALUEJCK-MRVZPHNRSA-N 0.000 claims description 6
- KPSRODZRAIWAKH-UHFFFAOYSA-N ciprofibrate Chemical compound C1=CC(OC(C)(C)C(O)=O)=CC=C1C1C(Cl)(Cl)C1 KPSRODZRAIWAKH-UHFFFAOYSA-N 0.000 claims description 6
- 229960002174 ciprofibrate Drugs 0.000 claims description 6
- 229960003405 ciprofloxacin Drugs 0.000 claims description 6
- 229960003765 fluvastatin Drugs 0.000 claims description 6
- ZEKZLJVOYLTDKK-UHFFFAOYSA-N lomefloxacin Chemical compound FC1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNC(C)C1 ZEKZLJVOYLTDKK-UHFFFAOYSA-N 0.000 claims description 6
- 229960002422 lomefloxacin Drugs 0.000 claims description 6
- 229960001699 ofloxacin Drugs 0.000 claims description 6
- 229960002965 pravastatin Drugs 0.000 claims description 6
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims description 6
- DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 claims description 6
- 229960003081 probenecid Drugs 0.000 claims description 6
- 239000002325 prokinetic agent Substances 0.000 claims description 6
- 229960001455 quinapril Drugs 0.000 claims description 6
- JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 claims description 6
- 229930002330 retinoic acid Natural products 0.000 claims description 6
- 229960001727 tretinoin Drugs 0.000 claims description 6
- 229920000858 Cyclodextrin Polymers 0.000 claims description 5
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 claims description 5
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical group CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 claims description 5
- 229960004503 metoclopramide Drugs 0.000 claims description 5
- 229940035722 triiodothyronine Drugs 0.000 claims description 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
- 230000027119 gastric acid secretion Effects 0.000 claims description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 230000001387 anti-histamine Effects 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 230000005764 inhibitory process Effects 0.000 claims description 3
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- RDJGLLICXDHJDY-NSHDSACASA-N (2s)-2-(3-phenoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-NSHDSACASA-N 0.000 claims description 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 2
- SBDNJUWAMKYJOX-UHFFFAOYSA-N Meclofenamic Acid Chemical compound CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C(O)=O)=C1Cl SBDNJUWAMKYJOX-UHFFFAOYSA-N 0.000 claims description 2
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims description 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims description 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 2
- 239000000739 antihistaminic agent Substances 0.000 claims description 2
- 229960000616 diflunisal Drugs 0.000 claims description 2
- HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical compound C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 claims description 2
- 229960005293 etodolac Drugs 0.000 claims description 2
- XFBVBWWRPKNWHW-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=N[C]3C(CC)=CC=CC3=C21 XFBVBWWRPKNWHW-UHFFFAOYSA-N 0.000 claims description 2
- 229960001419 fenoprofen Drugs 0.000 claims description 2
- 229960004369 flufenamic acid Drugs 0.000 claims description 2
- LPEPZBJOKDYZAD-UHFFFAOYSA-N flufenamic acid Chemical compound OC(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1 LPEPZBJOKDYZAD-UHFFFAOYSA-N 0.000 claims description 2
- 229960002390 flurbiprofen Drugs 0.000 claims description 2
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 claims description 2
- 229960001680 ibuprofen Drugs 0.000 claims description 2
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 2
- 229960000991 ketoprofen Drugs 0.000 claims description 2
- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 claims description 2
- 229960004752 ketorolac Drugs 0.000 claims description 2
- 229960003803 meclofenamic acid Drugs 0.000 claims description 2
- 229960003464 mefenamic acid Drugs 0.000 claims description 2
- HYYBABOKPJLUIN-UHFFFAOYSA-N mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 claims description 2
- 229960002009 naproxen Drugs 0.000 claims description 2
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims description 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims 10
- FJLGEFLZQAZZCD-MCBHFWOFSA-N (3R,5S)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-MCBHFWOFSA-N 0.000 claims 5
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 5
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 5
- 229960004205 carbidopa Drugs 0.000 claims 5
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 claims 5
- 229960004502 levodopa Drugs 0.000 claims 5
- 150000003952 β-lactams Chemical class 0.000 claims 4
- 230000000968 intestinal effect Effects 0.000 claims 3
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims 2
- 101100065700 Caenorhabditis elegans etc-1 gene Proteins 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 238000012876 topography Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 abstract description 4
- 239000004480 active ingredient Substances 0.000 description 78
- 239000000243 solution Substances 0.000 description 41
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 26
- 230000000007 visual effect Effects 0.000 description 22
- 238000003756 stirring Methods 0.000 description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 17
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 16
- 239000011521 glass Substances 0.000 description 16
- 150000001875 compounds Chemical class 0.000 description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- SBQLYHNEIUGQKH-UHFFFAOYSA-N omeprazole Chemical compound N1=C2[CH]C(OC)=CC=C2N=C1S(=O)CC1=NC=C(C)C(OC)=C1C SBQLYHNEIUGQKH-UHFFFAOYSA-N 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 12
- 238000010438 heat treatment Methods 0.000 description 11
- 229940100688 oral solution Drugs 0.000 description 11
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 11
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- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 10
- 238000010561 standard procedure Methods 0.000 description 10
- 239000008213 purified water Substances 0.000 description 8
- 239000006185 dispersion Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000003112 inhibitor Substances 0.000 description 7
- 239000007901 soft capsule Substances 0.000 description 7
- 208000019695 Migraine disease Diseases 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- 239000007902 hard capsule Substances 0.000 description 6
- 206010027599 migraine Diseases 0.000 description 6
- 239000000546 pharmaceutical excipient Substances 0.000 description 6
- 206010019233 Headaches Diseases 0.000 description 5
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 231100000869 headache Toxicity 0.000 description 5
- 239000002736 nonionic surfactant Substances 0.000 description 5
- 230000001314 paroxysmal effect Effects 0.000 description 5
- 239000008177 pharmaceutical agent Substances 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
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- 230000002496 gastric effect Effects 0.000 description 4
- 229920005862 polyol Polymers 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000003524 antilipemic agent Substances 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 150000001732 carboxylic acid derivatives Chemical group 0.000 description 3
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/354,982 US6365180B1 (en) | 1998-01-20 | 1999-07-16 | Oral liquid compositions |
| PCT/US2000/019372 WO2001013897A1 (en) | 1999-07-16 | 2000-07-14 | Oral liquid compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA80085C2 true UA80085C2 (en) | 2007-08-27 |
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ID=23395748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2002010408A UA80085C2 (en) | 1999-07-16 | 2000-07-14 | Oral liquid compositions |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6365180B1 (xx) |
| EP (1) | EP1196147A4 (xx) |
| JP (1) | JP2003507415A (xx) |
| KR (1) | KR20020050223A (xx) |
| CN (1) | CN1407887A (xx) |
| AU (1) | AU770772B2 (xx) |
| BR (1) | BR0012488A (xx) |
| CA (1) | CA2376180A1 (xx) |
| CZ (1) | CZ2002129A3 (xx) |
| HR (1) | HRP20020045A2 (xx) |
| MX (1) | MXPA02000583A (xx) |
| NO (1) | NO20020208L (xx) |
| RU (1) | RU2252019C2 (xx) |
| SI (1) | SI20849A (xx) |
| SK (1) | SK572002A3 (xx) |
| UA (1) | UA80085C2 (xx) |
| WO (1) | WO2001013897A1 (xx) |
| ZA (1) | ZA200200741B (xx) |
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1999
- 1999-07-16 US US09/354,982 patent/US6365180B1/en not_active Expired - Lifetime
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2000
- 2000-07-14 MX MXPA02000583A patent/MXPA02000583A/es active IP Right Grant
- 2000-07-14 JP JP2001518035A patent/JP2003507415A/ja active Pending
- 2000-07-14 SI SI200020031A patent/SI20849A/sl unknown
- 2000-07-14 EP EP00948703A patent/EP1196147A4/en not_active Withdrawn
- 2000-07-14 SK SK57-2002A patent/SK572002A3/sk not_active Application Discontinuation
- 2000-07-14 UA UA2002010408A patent/UA80085C2/uk unknown
- 2000-07-14 WO PCT/US2000/019372 patent/WO2001013897A1/en not_active Application Discontinuation
- 2000-07-14 AU AU62168/00A patent/AU770772B2/en not_active Ceased
- 2000-07-14 BR BR0012488-5A patent/BR0012488A/pt not_active Application Discontinuation
- 2000-07-14 RU RU2002103873/15A patent/RU2252019C2/ru not_active IP Right Cessation
- 2000-07-14 KR KR1020027000568A patent/KR20020050223A/ko not_active Application Discontinuation
- 2000-07-14 CA CA002376180A patent/CA2376180A1/en not_active Abandoned
- 2000-07-14 CN CN00812537A patent/CN1407887A/zh active Pending
- 2000-07-14 CZ CZ2002129A patent/CZ2002129A3/cs unknown
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- 2002-01-17 HR HR20020045A patent/HRP20020045A2/xx not_active Application Discontinuation
- 2002-01-28 ZA ZA200200741A patent/ZA200200741B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2252019C2 (ru) | 2005-05-20 |
| US6365180B1 (en) | 2002-04-02 |
| WO2001013897A1 (en) | 2001-03-01 |
| NO20020208L (no) | 2002-03-18 |
| MXPA02000583A (es) | 2003-10-14 |
| AU770772B2 (en) | 2004-03-04 |
| SK572002A3 (en) | 2002-08-06 |
| CA2376180A1 (en) | 2001-03-01 |
| EP1196147A1 (en) | 2002-04-17 |
| CN1407887A (zh) | 2003-04-02 |
| CZ2002129A3 (cs) | 2002-08-14 |
| KR20020050223A (ko) | 2002-06-26 |
| ZA200200741B (en) | 2003-06-25 |
| BR0012488A (pt) | 2002-04-02 |
| AU6216800A (en) | 2001-03-19 |
| SI20849A (sl) | 2002-10-31 |
| NO20020208D0 (no) | 2002-01-15 |
| EP1196147A4 (en) | 2005-04-20 |
| HRP20020045A2 (en) | 2006-06-30 |
| JP2003507415A (ja) | 2003-02-25 |
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