UA76124C2 - A crystal form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]-phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride, pharmaceutical composition and a method for producing - Google Patents
A crystal form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]-phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride, pharmaceutical composition and a method for producing Download PDFInfo
- Publication number
- UA76124C2 UA76124C2 UA2003043576A UA2003043576A UA76124C2 UA 76124 C2 UA76124 C2 UA 76124C2 UA 2003043576 A UA2003043576 A UA 2003043576A UA 2003043576 A UA2003043576 A UA 2003043576A UA 76124 C2 UA76124 C2 UA 76124C2
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- Ukraine
- Prior art keywords
- estrogen
- animals
- methanol
- piperidin
- methoxyphenyl
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- 210000000689 upper leg Anatomy 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 208000010579 uterine corpus leiomyoma Diseases 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 238000010333 wet classification Methods 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24225200P | 2000-10-20 | 2000-10-20 | |
| PCT/US2001/027773 WO2002034741A2 (en) | 2000-10-20 | 2001-10-18 | A NOVEL CRYSTALLINE FORM OF 6-HYDROXY-3-(4-[2-(PIPERIDIN-1-YL)ETHOXY]PHENOXY)-2-(4-METHOXYPHENYL)BENZO[b]THIOPHENE HYDROCHLORIDE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA76124C2 true UA76124C2 (en) | 2006-07-17 |
Family
ID=22914051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2003043576A UA76124C2 (en) | 2000-10-20 | 2001-10-18 | A crystal form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]-phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride, pharmaceutical composition and a method for producing |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20040014672A1 (cs) |
| EP (1) | EP1328521A2 (cs) |
| JP (1) | JP2004512333A (cs) |
| KR (1) | KR20030037690A (cs) |
| CN (1) | CN1268624C (cs) |
| AR (1) | AR035355A1 (cs) |
| AU (1) | AU2002214534A1 (cs) |
| BR (1) | BR0114792A (cs) |
| CA (1) | CA2426007A1 (cs) |
| CZ (1) | CZ20031098A3 (cs) |
| EA (1) | EA005116B1 (cs) |
| EC (1) | ECSP034560A (cs) |
| HR (1) | HRP20030296A2 (cs) |
| HU (1) | HUP0301403A3 (cs) |
| IL (1) | IL155487A0 (cs) |
| MX (1) | MXPA03003432A (cs) |
| MY (1) | MY125009A (cs) |
| NO (1) | NO20031753L (cs) |
| NZ (1) | NZ525364A (cs) |
| PE (1) | PE20020588A1 (cs) |
| PL (1) | PL360946A1 (cs) |
| SK (1) | SK4902003A3 (cs) |
| UA (1) | UA76124C2 (cs) |
| WO (1) | WO2002034741A2 (cs) |
| ZA (1) | ZA200303061B (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004283832B2 (en) * | 2003-10-10 | 2011-04-07 | Synthon B.V. | Solid-state montelukast |
| EP1773811B1 (en) * | 2004-07-22 | 2010-09-08 | Eli Lilly And Company | A crystalline variable hydrate of (s)-6-(4-(2-((3-(9h-carbazol-4-yloxy)-2-hydroxypropyl)amino)-2-methylpropyl)phenoxy)-3-pyridinecarbox amide hemisuccinate salt |
| BRPI0820811A2 (pt) * | 2007-12-19 | 2018-03-27 | Spectrum Pharmaceuticals Inc | formulação de sal estável de elsamitrucina |
| ATE536870T1 (de) | 2009-09-25 | 2011-12-15 | Iasomai Aktiebolag | N-acetyl-l-cystein zur behandlung von endometriose |
| PL236889B1 (pl) * | 2017-10-03 | 2021-02-22 | Univ Warszawski Medyczny | Nowa forma krystaliczna bezwodnego 17-β-estradiolu, sposób jej otrzymywania oraz kompozycja farmaceutyczna zawierająca nową formę krystaliczną bezwodnego 17-β-estradiolu i jej zastosowanie |
| MX2023011664A (es) * | 2021-04-01 | 2023-10-11 | Array Biopharma Inc | Forma cristalina de un inhibidor de shp2. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR003930A1 (es) * | 1995-02-28 | 1998-09-30 | Lilly Co Eli | Procedimiento para preparar compuestos de 2-fenil-3-fenoxi o feniltio-benzotiofeno y sales farmaceuticamente aceptables, compuestos intermediarios de aplicación exclusiva en dicho procedimiento y metodo para preparar los compuestos intermediarios mencionados |
| ZA982877B (en) * | 1997-04-09 | 1999-10-04 | Lilly Co Eli | Treatment of central nervous system disorders with selective estrogen receptor modulators. |
| AU6335600A (en) * | 1999-07-29 | 2001-02-19 | Eli Lilly And Company | A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-metho yphenyl)benzo[b]thiophene hydrochloride |
| ES2208384T3 (es) * | 1999-07-29 | 2004-06-16 | Eli Lilly And Company | Forma cristalina de clorhidrato de 6 hidroxi-3-(4-(2-(piperidin-1-il)-etoxi)-fenoxi)2--(4-metoxifenil)-benzo(b)tiofeno. |
-
2001
- 2001-10-18 CZ CZ20031098A patent/CZ20031098A3/cs unknown
- 2001-10-18 NZ NZ525364A patent/NZ525364A/en unknown
- 2001-10-18 WO PCT/US2001/027773 patent/WO2002034741A2/en not_active Ceased
- 2001-10-18 JP JP2002537732A patent/JP2004512333A/ja active Pending
- 2001-10-18 CA CA002426007A patent/CA2426007A1/en not_active Abandoned
- 2001-10-18 MY MYPI20014862A patent/MY125009A/en unknown
- 2001-10-18 EP EP01983079A patent/EP1328521A2/en not_active Withdrawn
- 2001-10-18 SK SK490-2003A patent/SK4902003A3/sk not_active Application Discontinuation
- 2001-10-18 EA EA200300491A patent/EA005116B1/ru not_active IP Right Cessation
- 2001-10-18 UA UA2003043576A patent/UA76124C2/uk unknown
- 2001-10-18 AU AU2002214534A patent/AU2002214534A1/en not_active Abandoned
- 2001-10-18 IL IL15548701A patent/IL155487A0/xx unknown
- 2001-10-18 HR HR20030296A patent/HRP20030296A2/hr not_active Application Discontinuation
- 2001-10-18 AR ARP010104895A patent/AR035355A1/es unknown
- 2001-10-18 CN CNB018175813A patent/CN1268624C/zh not_active Expired - Fee Related
- 2001-10-18 US US10/399,523 patent/US20040014672A1/en not_active Abandoned
- 2001-10-18 BR BR0114792-7A patent/BR0114792A/pt not_active IP Right Cessation
- 2001-10-18 PE PE2001001040A patent/PE20020588A1/es not_active Application Discontinuation
- 2001-10-18 KR KR10-2003-7005501A patent/KR20030037690A/ko not_active Withdrawn
- 2001-10-18 PL PL01360946A patent/PL360946A1/xx unknown
- 2001-10-18 HU HU0301403A patent/HUP0301403A3/hu unknown
- 2001-10-18 MX MXPA03003432A patent/MXPA03003432A/es not_active Application Discontinuation
-
2003
- 2003-04-15 NO NO20031753A patent/NO20031753L/no not_active Application Discontinuation
- 2003-04-16 EC EC2003004560A patent/ECSP034560A/es unknown
- 2003-04-17 ZA ZA200303061A patent/ZA200303061B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004512333A (ja) | 2004-04-22 |
| NO20031753D0 (no) | 2003-04-15 |
| KR20030037690A (ko) | 2003-05-14 |
| EP1328521A2 (en) | 2003-07-23 |
| SK4902003A3 (en) | 2003-10-07 |
| AR035355A1 (es) | 2004-05-12 |
| EA200300491A1 (ru) | 2003-08-28 |
| PE20020588A1 (es) | 2002-07-06 |
| CN1268624C (zh) | 2006-08-09 |
| BR0114792A (pt) | 2003-08-12 |
| WO2002034741A3 (en) | 2003-01-03 |
| EA005116B1 (ru) | 2004-10-28 |
| HUP0301403A3 (en) | 2009-05-28 |
| HUP0301403A2 (hu) | 2003-10-28 |
| ECSP034560A (es) | 2003-06-25 |
| AU2002214534A1 (en) | 2002-05-06 |
| IL155487A0 (en) | 2003-11-23 |
| MY125009A (en) | 2006-07-31 |
| HK1061857A1 (en) | 2004-10-08 |
| CZ20031098A3 (cs) | 2003-08-13 |
| WO2002034741A2 (en) | 2002-05-02 |
| PL360946A1 (en) | 2004-09-20 |
| CA2426007A1 (en) | 2002-05-02 |
| MXPA03003432A (es) | 2003-08-07 |
| CN1469872A (zh) | 2004-01-21 |
| US20040014672A1 (en) | 2004-01-22 |
| NO20031753L (no) | 2003-04-15 |
| ZA200303061B (en) | 2004-07-19 |
| NZ525364A (en) | 2005-09-30 |
| HRP20030296A2 (en) | 2003-06-30 |
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