UA75316C2 - Гомологи з фактором росту фібробласта - Google Patents

Гомологи з фактором росту фібробласта Download PDF

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Publication number
UA75316C2
UA75316C2 UA99042170A UA99042170A UA75316C2 UA 75316 C2 UA75316 C2 UA 75316C2 UA 99042170 A UA99042170 A UA 99042170A UA 99042170 A UA99042170 A UA 99042170A UA 75316 C2 UA75316 C2 UA 75316C2
Authority
UA
Ukraine
Prior art keywords
sequence
polypeptide
amino acid
cells
acid residue
Prior art date
Application number
UA99042170A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Тереза А. ДЕЙШЕР
Деррел К. Конклін
Фенелла К. Реймонд
Томас Р. Буковскі
Сьюзен Д. Голдерман
Бріджіт Гансен
Пол О. ШЕППАРД
Original Assignee
Займодженетікс, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Займодженетікс, Інк. filed Critical Займодженетікс, Інк.
Publication of UA75316C2 publication Critical patent/UA75316C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
UA99042170A 1996-10-16 1997-10-16 Гомологи з фактором росту фібробласта UA75316C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2864696P 1996-10-16 1996-10-16
PCT/US1997/018635 WO1998016644A1 (en) 1996-10-16 1997-10-16 Fibroblast growth factor homologs

Publications (1)

Publication Number Publication Date
UA75316C2 true UA75316C2 (uk) 2006-04-17

Family

ID=21844629

Family Applications (1)

Application Number Title Priority Date Filing Date
UA99042170A UA75316C2 (uk) 1996-10-16 1997-10-16 Гомологи з фактором росту фібробласта

Country Status (20)

Country Link
US (3) US5989866A (zh)
EP (4) EP1632574B1 (zh)
JP (1) JP4091122B2 (zh)
KR (1) KR100611063B1 (zh)
CN (1) CN1127568C (zh)
AT (2) ATE491029T1 (zh)
AU (1) AU725551B2 (zh)
BR (2) BRPI9712348C8 (zh)
CA (1) CA2269083C (zh)
CZ (1) CZ299288B6 (zh)
DE (2) DE69735352T2 (zh)
DK (2) DK1632574T3 (zh)
ES (3) ES2258788T3 (zh)
HK (2) HK1089206A1 (zh)
IL (1) IL129379A (zh)
NO (1) NO326459B1 (zh)
PL (1) PL192537B1 (zh)
PT (2) PT931148E (zh)
UA (1) UA75316C2 (zh)
WO (1) WO1998016644A1 (zh)

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US6518236B1 (en) * 1996-10-16 2003-02-11 Zymogenetics, Inc. FGF homologs
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Publication number Publication date
DK0931148T3 (da) 2006-06-19
BR9712348A (pt) 1999-08-31
CZ299288B6 (cs) 2008-06-04
US7247608B2 (en) 2007-07-24
ATE318906T1 (de) 2006-03-15
EP1632574A1 (en) 2006-03-08
BRPI9712348C8 (pt) 2020-04-22
EP0931148B1 (en) 2006-03-01
EP1632574B1 (en) 2010-12-08
DE69735352T2 (de) 2006-10-12
ES2258788T3 (es) 2006-09-01
IL129379A (en) 2008-12-29
PL192537B1 (pl) 2006-11-30
WO1998016644A1 (en) 1998-04-23
JP2001502178A (ja) 2001-02-20
BR9712348B1 (pt) 2013-06-18
US20040096936A1 (en) 2004-05-20
DE69735352D1 (de) 2006-04-27
HK1089206A1 (en) 2006-11-24
EP0931148A1 (en) 1999-07-28
EP2264175A1 (en) 2010-12-22
PT1632574E (pt) 2011-03-17
EP2339002A1 (en) 2011-06-29
US5989866A (en) 1999-11-23
DK1632574T3 (da) 2011-02-28
CN1247568A (zh) 2000-03-15
CZ131599A3 (cs) 1999-11-17
HK1148030A1 (en) 2011-08-26
EP2264175B1 (en) 2012-11-21
IL129379A0 (en) 2000-02-17
KR20000049207A (ko) 2000-07-25
NO991796D0 (no) 1999-04-15
AU4758397A (en) 1998-05-11
PL332851A1 (en) 1999-10-25
ATE491029T1 (de) 2010-12-15
US6352971B1 (en) 2002-03-05
CA2269083C (en) 2009-06-09
ES2403880T3 (es) 2013-05-22
PT931148E (pt) 2006-06-30
KR100611063B1 (ko) 2006-08-09
CA2269083A1 (en) 1998-04-23
ES2357215T3 (es) 2011-04-20
NO991796L (no) 1999-06-16
DE69740074D1 (de) 2011-01-20
AU725551B2 (en) 2000-10-12
JP4091122B2 (ja) 2008-05-28
CN1127568C (zh) 2003-11-12
NO326459B1 (no) 2008-12-08

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