PT931148E - Homologos do factor de crescimento fibroblastico - Google Patents
Homologos do factor de crescimento fibroblasticoInfo
- Publication number
- PT931148E PT931148E PT97910128T PT97910128T PT931148E PT 931148 E PT931148 E PT 931148E PT 97910128 T PT97910128 T PT 97910128T PT 97910128 T PT97910128 T PT 97910128T PT 931148 E PT931148 E PT 931148E
- Authority
- PT
- Portugal
- Prior art keywords
- nucleotide
- growth factor
- polynucleotide molecule
- homologes
- seq
- Prior art date
Links
- 230000003328 fibroblastic effect Effects 0.000 title 1
- 239000003102 growth factor Substances 0.000 title 1
- 239000002773 nucleotide Substances 0.000 abstract 6
- 125000003729 nucleotide group Chemical group 0.000 abstract 6
- 239000002157 polynucleotide Substances 0.000 abstract 4
- 102000040430 polynucleotide Human genes 0.000 abstract 4
- 108091033319 polynucleotide Proteins 0.000 abstract 4
- 102000018233 Fibroblast Growth Factor Human genes 0.000 abstract 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 229940126864 fibroblast growth factor Drugs 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2864696P | 1996-10-16 | 1996-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT931148E true PT931148E (pt) | 2006-06-30 |
Family
ID=21844629
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05021714T PT1632574E (pt) | 1996-10-16 | 1997-10-16 | Homólogos do factor de crescimento fibroblástico |
| PT97910128T PT931148E (pt) | 1996-10-16 | 1997-10-16 | Homologos do factor de crescimento fibroblastico |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05021714T PT1632574E (pt) | 1996-10-16 | 1997-10-16 | Homólogos do factor de crescimento fibroblástico |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US5989866A (pt) |
| EP (4) | EP2264175B1 (pt) |
| JP (1) | JP4091122B2 (pt) |
| KR (1) | KR100611063B1 (pt) |
| CN (1) | CN1127568C (pt) |
| AT (2) | ATE318906T1 (pt) |
| AU (1) | AU725551B2 (pt) |
| BR (2) | BR9712348B1 (pt) |
| CA (1) | CA2269083C (pt) |
| CZ (1) | CZ299288B6 (pt) |
| DE (2) | DE69735352T2 (pt) |
| DK (2) | DK0931148T3 (pt) |
| ES (3) | ES2403880T3 (pt) |
| IL (1) | IL129379A (pt) |
| NO (1) | NO326459B1 (pt) |
| PL (1) | PL192537B1 (pt) |
| PT (2) | PT1632574E (pt) |
| UA (1) | UA75316C2 (pt) |
| WO (1) | WO1998016644A1 (pt) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728546A (en) | 1995-06-05 | 1998-03-17 | Human Genome Sciences, Inc. | Fibroblast growth factor 13 |
| US6518236B1 (en) * | 1996-10-16 | 2003-02-11 | Zymogenetics, Inc. | FGF homologs |
| US20050043234A1 (en) * | 1996-10-16 | 2005-02-24 | Deisher Theresa A. | Novel FGF homologs |
| AU5433798A (en) * | 1996-11-27 | 1998-06-22 | Human Genome Sciences, Inc. | Fibroblast growth factor-13 |
| US6207442B1 (en) * | 1997-10-16 | 2001-03-27 | Zymogenetics, Inc. | Plasmid construction by homologous recombination |
| JP2002514386A (ja) * | 1998-03-09 | 2002-05-21 | カイロン コーポレイション | ヒトｆｇｆ遺伝子および遺伝子発現産物 |
| US6331523B1 (en) | 1998-03-12 | 2001-12-18 | Genentech, Inc. | Method of enhancing the survival of retinal neurons and treating ocular diseases using FGF-5 |
| EP1061943B1 (en) * | 1998-03-12 | 2002-10-23 | Genentech, Inc. | Use of fgf-5 polypeptides for preventing the death of retinal neurons and treating ocular diseases |
| CA2335326A1 (en) * | 1998-07-20 | 2000-02-03 | Curagen Corporation | Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis |
| US6537554B1 (en) | 1998-09-10 | 2003-03-25 | Curagen Corporation | Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis |
| US6458092B1 (en) | 1998-09-30 | 2002-10-01 | C. R. Bard, Inc. | Vascular inducing implants |
| US6251079B1 (en) | 1998-09-30 | 2001-06-26 | C. R. Bard, Inc. | Transthoracic drug delivery device |
| US6635249B1 (en) * | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
| US6986784B1 (en) | 1999-05-14 | 2006-01-17 | C. R. Bard, Inc. | Implant anchor systems |
| US6855160B1 (en) | 1999-08-04 | 2005-02-15 | C. R. Bard, Inc. | Implant and agent delivery device |
| WO2001022989A2 (en) * | 1999-09-30 | 2001-04-05 | Kaken Pharmaceutical Co., Ltd. | Method to enhance healing of sternum after sternotomy |
| AU1804201A (en) * | 1999-12-02 | 2001-06-12 | Zymogenetics Inc. | Methods for targeting cells that express fibroblast growth receptor-3 or-2 |
| US7470665B2 (en) | 1999-12-02 | 2008-12-30 | Zymogenetics, Inc. | Methods for targeting cells that express fibroblast growth receptor-3 or -2 |
| US7291597B2 (en) * | 2000-04-06 | 2007-11-06 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
| US7288521B2 (en) * | 2000-04-06 | 2007-10-30 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
| US7232421B1 (en) | 2000-05-12 | 2007-06-19 | C. R. Bard, Inc. | Agent delivery systems |
| US7204847B1 (en) | 2000-07-28 | 2007-04-17 | C. R. Bard, Inc. | Implant anchor systems |
| IL139380A0 (en) * | 2000-10-31 | 2001-11-25 | Prochon Biotech Ltd | Active variants of fibroblast growth factor |
| WO2003012053A2 (en) * | 2001-08-01 | 2003-02-13 | New York University | Identification of receptor and heparin binding sites in fgf4 by structure-based mutagenesis |
| WO2003057251A1 (fr) * | 2001-12-28 | 2003-07-17 | Kyowa Hakko Kogyo Co., Ltd. | Remedes contre l'arthrite |
| IL149562A0 (en) | 2002-05-09 | 2002-11-10 | Prochon Ltd | Fgf variants and methods for use thereof |
| JP2005531616A (ja) * | 2002-06-29 | 2005-10-20 | アクヴァノヴァ・ジャーマン・ソリュービリセイト・テクノロジーズ・（アーゲーテー）・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | イソフラボン濃縮物およびその製造法 |
| US8227411B2 (en) | 2002-08-20 | 2012-07-24 | BioSurface Engineering Technologies, Incle | FGF growth factor analogs |
| US7598224B2 (en) | 2002-08-20 | 2009-10-06 | Biosurface Engineering Technologies, Inc. | Dual chain synthetic heparin-binding growth factor analogs |
| US7166574B2 (en) * | 2002-08-20 | 2007-01-23 | Biosurface Engineering Technologies, Inc. | Synthetic heparin-binding growth factor analogs |
| CA2500742C (en) * | 2002-10-07 | 2014-02-18 | Zymogenetics, Inc. | Compositions of fgf-18 and hyaluronic acid for stimulating cartilage production and treating osteoarthritis |
| EP1613267A2 (en) * | 2003-03-27 | 2006-01-11 | Children's Hospital Medical Center | Use of fgf- 18 protein, target proteins and their respective encoding nucleotide sequences to induce cartilage formation |
| US7067123B2 (en) * | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| US7414028B1 (en) | 2004-02-04 | 2008-08-19 | Biosurface Engineering Technologies, Inc. | Growth factor analogs |
| US20080227696A1 (en) | 2005-02-22 | 2008-09-18 | Biosurface Engineering Technologies, Inc. | Single branch heparin-binding growth factor analogs |
| US20060024347A1 (en) * | 2004-02-10 | 2006-02-02 | Biosurface Engineering Technologies, Inc. | Bioactive peptide coatings |
| US7671012B2 (en) | 2004-02-10 | 2010-03-02 | Biosurface Engineering Technologies, Inc. | Formulations and methods for delivery of growth factor analogs |
| US7528105B1 (en) | 2004-02-10 | 2009-05-05 | Biosurface Engineering Technologies | Heterodimeric chain synthetic heparin-binding growth factor analogs |
| DE602005023714D1 (de) | 2004-02-20 | 2010-11-04 | Biosurface Eng Tech Inc | Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2) |
| WO2006014444A1 (en) | 2004-07-06 | 2006-02-09 | Zymogenetics, Inc. | Pharmaceutical composition comprising fgf18 and il-1 antagonist and method of use |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| AU2005314438B2 (en) * | 2004-12-10 | 2012-03-29 | Zymogenetics, Inc. | FGF18 production in prokaryotic hosts |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| WO2007035778A2 (en) | 2005-09-19 | 2007-03-29 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
| WO2007099953A1 (ja) * | 2006-02-28 | 2007-09-07 | National University Corporation Tokyo Medical And Dental University | 歯根形成促進剤及び歯根形成促進方法 |
| WO2007119240A2 (en) * | 2006-04-17 | 2007-10-25 | Hepacore Ltd. | Methods for bone regeneration using endothelial progenitor cell preparations |
| US7820172B1 (en) | 2006-06-01 | 2010-10-26 | Biosurface Engineering Technologies, Inc. | Laminin-derived multi-domain peptides |
| EP2046350A4 (en) | 2006-06-22 | 2011-09-14 | Biosurface Eng Tech Inc | COMPOSITION AND METHOD FOR DELIVERING AMPLIFIER / CO-ACTIVATOR OF BMP-2 TO ENHANCE OSTEOGENESIS |
| CA2664921A1 (en) | 2006-09-28 | 2008-04-03 | Hepacore Ltd. | N-terminal fgf variants having increased receptor selectivity and uses thereof |
| US7696171B1 (en) * | 2006-11-09 | 2010-04-13 | The Florida State University Research Foundation, Inc. | Mutant polypeptides of fibroblast growth factor 1 |
| JP5360593B2 (ja) * | 2007-02-19 | 2013-12-04 | 独立行政法人産業技術総合研究所 | 発毛促進剤 |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| US7659379B1 (en) * | 2007-05-24 | 2010-02-09 | Florida State University Research Foundation, Inc. | Mutants of human fibroblast growth factor having increased stability and/or mitogenic potency |
| US8685107B2 (en) | 2007-07-03 | 2014-04-01 | Histogenics Corporation | Double-structured tissue implant and a method for preparation and use thereof |
| US20090054984A1 (en) | 2007-08-20 | 2009-02-26 | Histogenics Corporation | Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects |
| CA2717725A1 (en) | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| TWI527590B (zh) | 2011-06-17 | 2016-04-01 | 艾瑞斯貿易公司 | Ｆｇｆ－１８之凍乾調配物 |
| JP6262731B2 (ja) | 2012-08-06 | 2018-01-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｆｇｆ−１８化合物に対する応答性を予測するための遺伝子マーカー |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| KR102261934B1 (ko) * | 2015-01-23 | 2021-06-08 | (주) 에스바이오메딕스 | Mbp-fgf2를 이용한 3차원 섬유아세포집합체를 제조하는 방법 |
| EP3250925B1 (en) | 2015-01-29 | 2019-04-10 | Ares Trading S.A. | Immunoassays for highly positively charged proteins |
| CN107849151B (zh) * | 2015-07-15 | 2022-05-24 | 德益阳光生物技术（北京）有限责任公司 | 融合多肽及使用方法 |
| US11572395B2 (en) | 2017-09-21 | 2023-02-07 | Merck Patent Gmbh | Fusion protein comprising an FGF-18 moiety |
| CN111163791A (zh) | 2017-09-29 | 2020-05-15 | 默克专利有限公司 | 预测对fgf-18化合物反应性的代谢生物标志物 |
| LT3688468T (lt) | 2017-09-29 | 2022-06-27 | Merck Patent Gmbh | Uždegiminiai biožymenys, skirti atsako į fgf-18 junginį numatymui |
| CN108324928B (zh) * | 2018-03-05 | 2020-09-08 | 哈尔滨医科大学 | 重组人成纤维细胞生长因子-5在促骨折愈合中的应用 |
| KR20210057764A (ko) | 2018-09-10 | 2021-05-21 | 메르크 파텐트 게엠베하 | 골관절염의 치료를 위한 강화 전략에 유용한 마커 |
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1997
- 1997-10-16 EP EP10176653A patent/EP2264175B1/en not_active Expired - Lifetime
- 1997-10-16 BR BRPI9712348-0B1A patent/BR9712348B1/pt not_active IP Right Cessation
- 1997-10-16 JP JP51857798A patent/JP4091122B2/ja not_active Expired - Lifetime
- 1997-10-16 ES ES10176653T patent/ES2403880T3/es not_active Expired - Lifetime
- 1997-10-16 IL IL129379A patent/IL129379A/en not_active IP Right Cessation
- 1997-10-16 UA UA99042170A patent/UA75316C2/uk unknown
- 1997-10-16 EP EP97910128A patent/EP0931148B1/en not_active Expired - Lifetime
- 1997-10-16 CN CN97199827A patent/CN1127568C/zh not_active Expired - Lifetime
- 1997-10-16 US US08/951,822 patent/US5989866A/en not_active Expired - Lifetime
- 1997-10-16 DE DE69735352T patent/DE69735352T2/de not_active Expired - Lifetime
- 1997-10-16 AT AT97910128T patent/ATE318906T1/de active
- 1997-10-16 ES ES97910128T patent/ES2258788T3/es not_active Expired - Lifetime
- 1997-10-16 ES ES05021714T patent/ES2357215T3/es not_active Expired - Lifetime
- 1997-10-16 EP EP05021714A patent/EP1632574B1/en not_active Expired - Lifetime
- 1997-10-16 WO PCT/US1997/018635 patent/WO1998016644A1/en not_active Ceased
- 1997-10-16 EP EP10185113A patent/EP2339002A1/en not_active Withdrawn
- 1997-10-16 PL PL332851A patent/PL192537B1/pl unknown
- 1997-10-16 BR BRPI9712348A patent/BRPI9712348C8/pt not_active IP Right Cessation
- 1997-10-16 CA CA002269083A patent/CA2269083C/en not_active Expired - Lifetime
- 1997-10-16 DE DE69740074T patent/DE69740074D1/de not_active Expired - Lifetime
- 1997-10-16 DK DK97910128T patent/DK0931148T3/da active
- 1997-10-16 AU AU47583/97A patent/AU725551B2/en not_active Expired
- 1997-10-16 CZ CZ0131599A patent/CZ299288B6/cs not_active IP Right Cessation
- 1997-10-16 PT PT05021714T patent/PT1632574E/pt unknown
- 1997-10-16 DK DK05021714.0T patent/DK1632574T3/da active
- 1997-10-16 KR KR1019997003306A patent/KR100611063B1/ko not_active Expired - Lifetime
- 1997-10-16 PT PT97910128T patent/PT931148E/pt unknown
- 1997-10-16 AT AT05021714T patent/ATE491029T1/de active
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1999
- 1999-04-15 NO NO19991796A patent/NO326459B1/no not_active IP Right Cessation
- 1999-08-05 US US09/368,951 patent/US6352971B1/en not_active Expired - Lifetime
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2001
- 2001-10-19 US US10/037,922 patent/US7247608B2/en not_active Expired - Fee Related
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