ATE182900T1 - Mutierte form von dem beta-amyloidprecursor proteine gen - Google Patents
Mutierte form von dem beta-amyloidprecursor proteine genInfo
- Publication number
- ATE182900T1 ATE182900T1 AT92400771T AT92400771T ATE182900T1 AT E182900 T1 ATE182900 T1 AT E182900T1 AT 92400771 T AT92400771 T AT 92400771T AT 92400771 T AT92400771 T AT 92400771T AT E182900 T1 ATE182900 T1 AT E182900T1
- Authority
- AT
- Austria
- Prior art keywords
- gene
- proteine
- beta
- amyloid precursor
- mutated form
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000013455 Amyloid beta-Peptides Human genes 0.000 title 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- 235000001014 amino acid Nutrition 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000002299 complementary DNA Substances 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108020004705 Codon Proteins 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92400771A EP0561087B1 (de) | 1992-03-20 | 1992-03-20 | Mutierte Form von dem Beta-Amyloidprecursor Proteine Gen |
PCT/EP1993/000701 WO1994021683A1 (en) | 1992-03-20 | 1993-03-23 | MUTATED FORM OF THE β-AMYLOID PRECURSOR PROTEIN GENE |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE182900T1 true ATE182900T1 (de) | 1999-08-15 |
Family
ID=26070020
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92400771T ATE182900T1 (de) | 1992-03-20 | 1992-03-20 | Mutierte form von dem beta-amyloidprecursor proteine gen |
Country Status (4)
Country | Link |
---|---|
US (1) | US5525714A (de) |
AT (1) | ATE182900T1 (de) |
DE (1) | DE69229718D1 (de) |
WO (1) | WO1994021683A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6248555B1 (en) * | 1995-08-31 | 2001-06-19 | The General Hospital Corporation | Genetic alterations related to familial alzheimer's disease |
AU2541497A (en) * | 1996-04-04 | 1997-10-29 | Institute Of Genomic Research, The | Variant presenilin-2 genes |
US5898094A (en) * | 1996-10-21 | 1999-04-27 | University Of South Florida | Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes |
US7078512B2 (en) * | 1998-05-01 | 2006-07-18 | Schering-Plough Animal Health Corporation | Nucleic acid encoding feline CD86 |
US20030131364A1 (en) * | 1999-04-27 | 2003-07-10 | Karen Duff | Method for producing transgenic animal models with modulated phenotype and animals produced therefrom |
US20050132423A1 (en) * | 2003-10-20 | 2005-06-16 | Envivo Pharmaceuticals, Inc. | Transgenic flies expressing Abeta42-Flemish |
US20050108779A1 (en) * | 2003-10-21 | 2005-05-19 | Envivo Pharmaceuticals, Inc. | Transgenic flies expressing Abeta42-Italian |
AU2004284937A1 (en) * | 2003-10-20 | 2005-05-12 | Envivo Pharmaceuticals, Inc. | Transgenic flies expressing mutant Abeta42 |
US20040250302A1 (en) * | 2003-10-21 | 2004-12-09 | Envivo Pharmaceuticals, Inc. | Transgenic flies expressing Abeta42-dutch |
US20050132424A1 (en) * | 2003-10-21 | 2005-06-16 | Envivo Pharmaceuticals, Inc. | Transgenic flies expressing Abeta42-Dutch |
US20050132422A1 (en) * | 2003-10-21 | 2005-06-16 | Envivo Pharmaceuticals, Inc. | Transgenic flies expressing Abeta42-Iowa |
JP5871279B2 (ja) * | 2010-07-29 | 2016-03-01 | 国立研究開発法人理化学研究所 | アミロイドβペプチド蓄積を伴う疾患の診断の為の可溶型アミロイドβ前駆体タンパク質770β切断産物の検出方法 |
RU2692634C2 (ru) * | 2013-10-07 | 2019-06-25 | Академиш Зикенхойс Лейден Х.О.Д.Н. Люмк | Направляемое антисмысловым олигонуклеотидом удаление сайтов протеолитического расщепления, мутации hchwa-d и увеличенного числа тринуклеотидных повторов |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5223482A (en) * | 1986-11-17 | 1993-06-29 | Scios Nova Inc. | Recombinant Alzheimer's protease inhibitory amyloid protein and method of use |
WO1989006689A1 (en) * | 1988-01-13 | 1989-07-27 | The Mclean Hospital Corporation | Genetic constructs containing the alzheimer brain amyloid gene |
WO1989007657A1 (en) * | 1988-02-10 | 1989-08-24 | The Children's Medical Center Corporation | Amyloid protein precursors, genetic probes, antibodies, and methods of use |
-
1992
- 1992-03-20 AT AT92400771T patent/ATE182900T1/de not_active IP Right Cessation
- 1992-03-20 DE DE69229718T patent/DE69229718D1/de not_active Expired - Lifetime
-
1993
- 1993-03-23 WO PCT/EP1993/000701 patent/WO1994021683A1/en active Application Filing
- 1993-10-08 US US08/133,248 patent/US5525714A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69229718D1 (de) | 1999-09-09 |
US5525714A (en) | 1996-06-11 |
WO1994021683A1 (en) | 1994-09-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |