UA75316C2 - Гомологи з фактором росту фібробласта - Google Patents
Гомологи з фактором росту фібробласта Download PDFInfo
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- UA75316C2 UA75316C2 UA99042170A UA99042170A UA75316C2 UA 75316 C2 UA75316 C2 UA 75316C2 UA 99042170 A UA99042170 A UA 99042170A UA 99042170 A UA99042170 A UA 99042170A UA 75316 C2 UA75316 C2 UA 75316C2
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
Landscapes
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- Cardiology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
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- Microbiology (AREA)
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Applications Claiming Priority (2)
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| US2864696P | 1996-10-16 | 1996-10-16 | |
| PCT/US1997/018635 WO1998016644A1 (en) | 1996-10-16 | 1997-10-16 | Fibroblast growth factor homologs |
Publications (1)
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| UA75316C2 true UA75316C2 (uk) | 2006-04-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| UA99042170A UA75316C2 (uk) | 1996-10-16 | 1997-10-16 | Гомологи з фактором росту фібробласта |
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| US (3) | US5989866A (de) |
| EP (4) | EP2339002A1 (de) |
| JP (1) | JP4091122B2 (de) |
| KR (1) | KR100611063B1 (de) |
| CN (1) | CN1127568C (de) |
| AT (2) | ATE491029T1 (de) |
| AU (1) | AU725551B2 (de) |
| BR (2) | BRPI9712348C8 (de) |
| CA (1) | CA2269083C (de) |
| CZ (1) | CZ299288B6 (de) |
| DE (2) | DE69735352T2 (de) |
| DK (2) | DK1632574T3 (de) |
| ES (3) | ES2258788T3 (de) |
| HK (2) | HK1089206A1 (de) |
| IL (1) | IL129379A (de) |
| NO (1) | NO326459B1 (de) |
| PL (1) | PL192537B1 (de) |
| PT (2) | PT1632574E (de) |
| UA (1) | UA75316C2 (de) |
| WO (1) | WO1998016644A1 (de) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5728546A (en) | 1995-06-05 | 1998-03-17 | Human Genome Sciences, Inc. | Fibroblast growth factor 13 |
| US6518236B1 (en) * | 1996-10-16 | 2003-02-11 | Zymogenetics, Inc. | FGF homologs |
| US20050043234A1 (en) | 1996-10-16 | 2005-02-24 | Deisher Theresa A. | Novel FGF homologs |
| AU5433798A (en) * | 1996-11-27 | 1998-06-22 | Human Genome Sciences, Inc. | Fibroblast growth factor-13 |
| US6207442B1 (en) * | 1997-10-16 | 2001-03-27 | Zymogenetics, Inc. | Plasmid construction by homologous recombination |
| EP1062339A2 (de) * | 1998-03-09 | 2000-12-27 | Chiron Corporation | Menschliches fgf-gen und seine expressionsprodukte |
| ATE226444T1 (de) * | 1998-03-12 | 2002-11-15 | Genentech Inc | Verwendung von fgf-5 polypetiden zur vorbeugung des absterbens retinaler neuronen und behandlung okularer krankheiten |
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| AU5081899A (en) * | 1998-07-20 | 2000-02-14 | Curagen Corporation | Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis |
| US6537554B1 (en) | 1998-09-10 | 2003-03-25 | Curagen Corporation | Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis |
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| US6635249B1 (en) | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
| CA2385498C (en) * | 1999-09-30 | 2013-01-08 | Kaken Pharmaceutical Co., Ltd. | Method to enhance healing of sternum after sternotomy |
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| EP1234033B1 (de) * | 1999-12-02 | 2011-12-28 | ZymoGenetics, Inc. | Methoden welche auf Zellen zielen, die die Fibroblasten Wachtumsfaktor-Rezeptoren-3 oder -2 exprimieren |
| US7288521B2 (en) * | 2000-04-06 | 2007-10-30 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
| US7291597B2 (en) * | 2000-04-06 | 2007-11-06 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
| IL139380A0 (en) * | 2000-10-31 | 2001-11-25 | Prochon Biotech Ltd | Active variants of fibroblast growth factor |
| AU2002355844A1 (en) * | 2001-08-01 | 2003-02-17 | New York University | Identification of receptor and heparin binding sites in fgf4 by structure-based mutagenesis |
| CA2471938A1 (en) * | 2001-12-28 | 2003-07-17 | Kyowa Hakko Kogyo Co., Ltd. | Agent for treating arthritis |
| IL149562A0 (en) | 2002-05-09 | 2002-11-10 | Prochon Ltd | Fgf variants and methods for use thereof |
| WO2004002469A1 (de) * | 2002-06-29 | 2004-01-08 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Isoflavonkonzentrate sowie verfahren zu ihrer herstellung |
| US7166574B2 (en) | 2002-08-20 | 2007-01-23 | Biosurface Engineering Technologies, Inc. | Synthetic heparin-binding growth factor analogs |
| US8227411B2 (en) | 2002-08-20 | 2012-07-24 | BioSurface Engineering Technologies, Incle | FGF growth factor analogs |
| US7981862B2 (en) | 2003-08-19 | 2011-07-19 | Biosurface Engineering Technologies, Inc. | Composition comprising BMP-2 amplifier/co-activator for enhancement of osteogenesis |
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| US20040136970A1 (en) * | 2002-10-07 | 2004-07-15 | Ellsworth Jeff L. | Methods for administering FGF18 |
| AU2004226421A1 (en) * | 2003-03-27 | 2004-10-14 | Children's Hospital Medical Center | Use of FGF- 18 protein, target proteins and their respective encoding nucleotide sequences to induce cartilage formation |
| US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| US7414028B1 (en) | 2004-02-04 | 2008-08-19 | Biosurface Engineering Technologies, Inc. | Growth factor analogs |
| US20060024347A1 (en) * | 2004-02-10 | 2006-02-02 | Biosurface Engineering Technologies, Inc. | Bioactive peptide coatings |
| US7671012B2 (en) | 2004-02-10 | 2010-03-02 | Biosurface Engineering Technologies, Inc. | Formulations and methods for delivery of growth factor analogs |
| US7528105B1 (en) | 2004-02-10 | 2009-05-05 | Biosurface Engineering Technologies | Heterodimeric chain synthetic heparin-binding growth factor analogs |
| US20080227696A1 (en) | 2005-02-22 | 2008-09-18 | Biosurface Engineering Technologies, Inc. | Single branch heparin-binding growth factor analogs |
| WO2005082005A2 (en) | 2004-02-20 | 2005-09-09 | Biosurface Engineering Technologies, Inc., Et Al. | Positive modulator of bone morphogenic protein-2 |
| EP1896053B1 (de) | 2004-07-06 | 2018-10-31 | ZymoGenetics, Inc. | Pharmazeutische zusammensetzung enthaltend fgf-18 und einen il-1 antagonisten sowie verfahren zur verwendung derselben |
| US20090319045A1 (en) | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US7858341B2 (en) * | 2004-12-10 | 2010-12-28 | Zymogenetics, Inc. | FGF18 production in prokaryotic hosts |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
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| JPWO2007099953A1 (ja) * | 2006-02-28 | 2009-07-16 | 国立大学法人 東京医科歯科大学 | 歯根形成促進剤及び歯根形成促進方法 |
| US8298528B2 (en) * | 2006-04-17 | 2012-10-30 | Hepacore Ltd. | Methods for bone regeneration using endothelial progenitor cell preparations |
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| US8962556B2 (en) * | 2006-09-28 | 2015-02-24 | Prochon Biotech Ltd. | FGF-2 variants having N-terminal deletions and increased receptor selectivity and uses thereof |
| US7696171B1 (en) * | 2006-11-09 | 2010-04-13 | The Florida State University Research Foundation, Inc. | Mutant polypeptides of fibroblast growth factor 1 |
| EP2127674B1 (de) * | 2007-02-19 | 2013-04-24 | National Institute of Advanced Industrial Science and Technology | Verwendung von FGF-18-Hemmers als Mittel zur Förderung des Nachwachsens von Haaren |
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| TWI527590B (zh) | 2011-06-17 | 2016-04-01 | 艾瑞斯貿易公司 | Ｆｇｆ－１８之凍乾調配物 |
| EP2880179B1 (de) | 2012-08-06 | 2017-12-13 | Merck Patent GmbH | Genetische marker zur vorhersage der reaktionsbereitschaft auf eine fgf-18-verbindung |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| KR102261934B1 (ko) * | 2015-01-23 | 2021-06-08 | (주) 에스바이오메딕스 | Mbp-fgf2를 이용한 3차원 섬유아세포집합체를 제조하는 방법 |
| US20180024142A1 (en) | 2015-01-29 | 2018-01-25 | Ares Trading S.A. | Immunoassays for high positively charged proteins |
| CN107849151B (zh) * | 2015-07-15 | 2022-05-24 | 德益阳光生物技术（北京）有限责任公司 | 融合多肽及使用方法 |
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1997
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- 1997-10-16 CZ CZ0131599A patent/CZ299288B6/cs not_active IP Right Cessation
- 1997-10-16 EP EP97910128A patent/EP0931148B1/de not_active Expired - Lifetime
- 1997-10-16 UA UA99042170A patent/UA75316C2/uk unknown
- 1997-10-16 ES ES97910128T patent/ES2258788T3/es not_active Expired - Lifetime
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- 1997-10-16 PT PT97910128T patent/PT931148E/pt unknown
- 1997-10-16 AT AT97910128T patent/ATE318906T1/de active
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1999
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