UA74772C2 - Compound for simulating activity of multiple lineage protein kinase and a method for identifying the compound; method for simulating activity of multiple lineage protein kinase (variants) - Google Patents

Compound for simulating activity of multiple lineage protein kinase and a method for identifying the compound; method for simulating activity of multiple lineage protein kinase (variants) Download PDF

Info

Publication number
UA74772C2
UA74772C2 UA2001031963A UA2001031963A UA74772C2 UA 74772 C2 UA74772 C2 UA 74772C2 UA 2001031963 A UA2001031963 A UA 2001031963A UA 2001031963 A UA2001031963 A UA 2001031963A UA 74772 C2 UA74772 C2 UA 74772C2
Authority
UA
Ukraine
Prior art keywords
carbon atoms
group
сно
compound
protein
Prior art date
Application number
UA2001031963A
Other languages
English (en)
Ukrainian (uk)
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc filed Critical Cephalon Inc
Publication of UA74772C2 publication Critical patent/UA74772C2/uk

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205Phosphotransferases in general
    • G01N2333/9121Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
UA2001031963A 1998-08-26 1999-08-18 Compound for simulating activity of multiple lineage protein kinase and a method for identifying the compound; method for simulating activity of multiple lineage protein kinase (variants) UA74772C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9798098P 1998-08-26 1998-08-26
PCT/US1999/018864 WO2000013015A1 (en) 1998-08-26 1999-08-18 Modulating multiple lineage kinase proteins

Publications (1)

Publication Number Publication Date
UA74772C2 true UA74772C2 (en) 2006-02-15

Family

ID=22266038

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2001031963A UA74772C2 (en) 1998-08-26 1999-08-18 Compound for simulating activity of multiple lineage protein kinase and a method for identifying the compound; method for simulating activity of multiple lineage protein kinase (variants)

Country Status (25)

Country Link
EP (1) EP1105728B1 (ru)
JP (1) JP2002523780A (ru)
KR (1) KR100700028B1 (ru)
CN (3) CN1206535C (ru)
AT (1) ATE293254T1 (ru)
AU (1) AU765637B2 (ru)
BG (1) BG105360A (ru)
BR (1) BR9913190A (ru)
CA (1) CA2339539A1 (ru)
CZ (1) CZ2001701A3 (ru)
DE (1) DE69924738T2 (ru)
DK (1) DK1105728T3 (ru)
EA (2) EA200500934A1 (ru)
ES (1) ES2241316T3 (ru)
HK (1) HK1037722A1 (ru)
HU (1) HUP0103079A3 (ru)
NO (1) NO20010389L (ru)
NZ (1) NZ509612A (ru)
PL (1) PL346246A1 (ru)
PT (1) PT1105728E (ru)
SK (1) SK2542001A3 (ru)
TR (2) TR200400635T2 (ru)
UA (1) UA74772C2 (ru)
WO (1) WO2000013015A1 (ru)
ZA (1) ZA200100835B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6811992B1 (en) 1998-05-14 2004-11-02 Ya Fang Liu Method for identifying MLK inhibitors for the treatment of neurological conditions
US6841567B1 (en) 1999-02-12 2005-01-11 Cephalon, Inc. Cyclic substituted fused pyrrolocarbazoles and isoindolones
US7122679B2 (en) * 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
CZ2003680A3 (cs) * 2000-08-11 2003-11-12 Cephalon, Inc. Způsob modulace kinasových proteinů s vícenásobnou vazbou a vyhledávání sloučenin modulujících kinasové proteiny s vícenásobnou vazbou
US7018999B2 (en) 2001-05-16 2006-03-28 Cephalon, Inc. Methods for the treatment and prevention of pain
FR2826653B1 (fr) * 2001-06-29 2005-10-14 Servier Lab Nouveaux derives de pyrido-pyrido-pyrrolo[3,2-g]pyrrolo [3,4-e]-indole et pyrido-pyrrolo[2,3-a]pyrrolo[3,4-c] carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2003052395A (ja) * 2001-08-09 2003-02-25 Japan Tissue Engineering:Kk 移植適正判定方法
AR069501A1 (es) 2007-11-30 2010-01-27 Genentech Inc Anticuerpos anti- vegf (factor de crecimiento endotelial vascular)
JP2011517339A (ja) * 2008-02-04 2011-06-02 ガラパゴス・ナムローゼ・フェンノートシャップ 神経変性疾患の治療に有用な分子標的及び化合物並びにこれらの同定方法
US20100056609A1 (en) * 2008-08-26 2010-03-04 Washington University Methods and compositions for inhibition of axonal degeneration by modulation of the dlk/jnk pathway
AU2015202365B2 (en) * 2008-10-22 2016-11-24 Genentech, Inc. Modulation of axon degeneration
US9101645B2 (en) 2008-10-22 2015-08-11 Genentech, Inc. Modulation of axon degeneration
MX2012004638A (es) * 2009-10-22 2012-07-04 Genentech Inc Modulacion de degeneracion de axones.
ES2385157B1 (es) * 2010-02-25 2013-07-08 Universidad Del País Vasco Compuestos para el tratamiento de alzheimer.
EP2852388A4 (en) 2012-05-23 2016-01-13 Univ Johns Hopkins COMPOUNDS AND METHOD FOR USE THEREOF FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES
CN109060472A (zh) * 2018-07-20 2018-12-21 上海市农业科学院 一种适于荧光染色的草菇菌褶组织切片的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756494A (en) * 1992-07-24 1998-05-26 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US6811992B1 (en) * 1998-05-14 2004-11-02 Ya Fang Liu Method for identifying MLK inhibitors for the treatment of neurological conditions

Also Published As

Publication number Publication date
AU765637B2 (en) 2003-09-25
DK1105728T3 (da) 2005-08-08
KR100700028B1 (ko) 2007-03-27
CZ2001701A3 (cs) 2002-04-17
AU5679399A (en) 2000-03-21
PT1105728E (pt) 2005-07-29
BR9913190A (pt) 2001-12-11
EA200100278A1 (ru) 2002-06-27
WO2000013015A1 (en) 2000-03-09
CA2339539A1 (en) 2000-03-09
DE69924738D1 (de) 2005-05-19
HUP0103079A3 (en) 2004-03-01
EA200500934A1 (ru) 2006-04-28
JP2002523780A (ja) 2002-07-30
DE69924738T2 (de) 2006-03-02
EP1105728B1 (en) 2005-04-13
HUP0103079A2 (hu) 2001-12-28
TR200400635T2 (tr) 2005-10-21
PL346246A1 (en) 2002-01-28
WO2000013015A8 (en) 2000-05-11
NO20010389D0 (no) 2001-01-23
ES2241316T3 (es) 2005-10-16
ATE293254T1 (de) 2005-04-15
NO20010389L (no) 2001-04-02
NZ509612A (en) 2003-10-31
CN1314999A (zh) 2001-09-26
HK1037722A1 (en) 2002-02-15
KR20010103573A (ko) 2001-11-23
SK2542001A3 (en) 2002-06-04
CN1206535C (zh) 2005-06-15
ZA200100835B (en) 2002-06-26
EP1105728A1 (en) 2001-06-13
CN1589788A (zh) 2005-03-09
EA006648B1 (ru) 2006-02-24
TR200100589T2 (tr) 2001-07-23
BG105360A (bg) 2001-10-31
CN1879617A (zh) 2006-12-20

Similar Documents

Publication Publication Date Title
UA74772C2 (en) Compound for simulating activity of multiple lineage protein kinase and a method for identifying the compound; method for simulating activity of multiple lineage protein kinase (variants)
CA2574150C (en) Flt3 inhibitors for immune suppression
JP6478908B2 (ja) 熱ショックタンパク質(HSP)90−βを調節することによる代謝症候群の治療方法
Boneva et al. Major pathogenic effects of anti-MuSK antibodies in myasthenia gravis
WO2011019737A1 (en) Pyrimido-pyrrolo-quinoxalinedione inhibitors of cystic fibrosis transmembrane conductance regulator protein and uses therefor
AU2001283179B2 (en) Modulating multiple lineage kinase proteins
CN103520703A (zh) eIF6用于检测、预防或治疗运动性疲劳或记忆力减退的用途
JP7185226B2 (ja) 1,5-アンヒドロフルクトース誘導体を含むampk活性化剤
AU2001283179A1 (en) Modulating multiple lineage kinase proteins
Wu et al. Up-regulation of CCT8 related to neuronal apoptosis after traumatic brain injury in adult rats
CN111253492B (zh) 一种透脑性多肽及其在制备防治老年痴呆药物中应用
JP2002532554A (ja) T細胞活性を調節するためのサイクリックアデノシンニリン酸リボース類似体
KR20170017519A (ko) miR 218-2를 유효성분으로 함유하는 염증성 뼈 질환 예방 또는 치료용 약학조성물
MXPA01002020A (en) Modulating multiple lineage kinase proteins
CN117653632A (zh) 粉防己碱作为线粒体sirt5靶向抑制剂在制备抗肿瘤药物的应用
Qi et al. Discovery of Briarane-Type Diterpenoids as the Inhibitors of Osteoclast Formation by Interrupting Keap1-Nrf2 Interaction and Activating Nrf2 Pathway
O'Malley The role of sodium channel α and β subunits in myelinating glia and demyelinating disorders