MX2012004638A - Modulacion de degeneracion de axones. - Google Patents
Modulacion de degeneracion de axones.Info
- Publication number
- MX2012004638A MX2012004638A MX2012004638A MX2012004638A MX2012004638A MX 2012004638 A MX2012004638 A MX 2012004638A MX 2012004638 A MX2012004638 A MX 2012004638A MX 2012004638 A MX2012004638 A MX 2012004638A MX 2012004638 A MX2012004638 A MX 2012004638A
- Authority
- MX
- Mexico
- Prior art keywords
- modulation
- axon degeneration
- degeneration
- axons
- neurons
- Prior art date
Links
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- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
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Abstract
La invención se refiere de manera general a tratamiento para transtornos neurológicos y lesiones del sistema nervioso. La invención específicamente proporciona métodos para usar moduladores de proteinas objetivo particulares para modular degeneración de neuronas o porciones de las mismas, tales como axones.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25419009P | 2009-10-22 | 2009-10-22 | |
PCT/US2010/053596 WO2011050192A1 (en) | 2009-10-22 | 2010-10-21 | Modulation of axon degeneration |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012004638A true MX2012004638A (es) | 2012-07-04 |
Family
ID=43900692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012004638A MX2012004638A (es) | 2009-10-22 | 2010-10-21 | Modulacion de degeneracion de axones. |
Country Status (14)
Country | Link |
---|---|
US (3) | US20120328609A1 (es) |
EP (2) | EP3011970A3 (es) |
JP (2) | JP2013508401A (es) |
KR (1) | KR20120102642A (es) |
CN (2) | CN104043126A (es) |
AU (1) | AU2010310589A1 (es) |
BR (1) | BR112012009257A2 (es) |
CA (1) | CA2778483A1 (es) |
HK (1) | HK1203350A1 (es) |
IL (1) | IL219232A0 (es) |
MX (1) | MX2012004638A (es) |
RU (1) | RU2012120783A (es) |
SG (1) | SG10201406763WA (es) |
WO (1) | WO2011050192A1 (es) |
Families Citing this family (24)
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CA2807036C (en) | 2010-10-14 | 2018-01-16 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
US9382229B2 (en) | 2011-02-15 | 2016-07-05 | The Johns Hopkins University | Compounds and methods of use thereof for treating neurodegenerative disorders |
WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
US11180760B2 (en) * | 2012-03-09 | 2021-11-23 | The Johns Hopkins University | Identification of molecular pathways and methods of use thereof for treating retinal neurodegeneration and other neurodegenerative disorders |
JP6267193B2 (ja) * | 2012-05-22 | 2018-01-24 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 置換ジピリジルアミン類及びそれらの使用 |
US9539259B2 (en) | 2012-05-23 | 2017-01-10 | The Johns Hopkins University | Compounds and methods of use thereof for treating neurodegenerative disorders |
CN104387391A (zh) * | 2013-01-18 | 2015-03-04 | 韩冰 | 一种蛋白酶抑制剂及其制备方法和用途 |
JP6199991B2 (ja) | 2013-01-18 | 2017-09-20 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 3置換ピラゾール及びdlk阻害剤としての使用 |
CN104370925A (zh) * | 2013-01-24 | 2015-02-25 | 韩冰 | 一类蛋白酶抑制剂及其制备方法和用途 |
CN104370926A (zh) * | 2013-01-24 | 2015-02-25 | 韩冰 | 一类具有神经保护作用的化合物及其制备方法和用途 |
CN104370880A (zh) * | 2013-01-24 | 2015-02-25 | 韩冰 | 一类蛋白酶抑制剂及其制备方法和用途 |
EP2961428A4 (en) * | 2013-02-28 | 2016-10-12 | Hoffmann La Roche | METHOD FOR MODULATING A DLK STABILITY |
TWI622587B (zh) | 2013-05-01 | 2018-05-01 | 赫孚孟拉羅股份公司 | 二雜芳基化合物及其用途 |
WO2014177524A1 (en) | 2013-05-01 | 2014-11-06 | F. Hoffmann-La Roche Ag | C-linked heterocycloalkyl substituted pyrimidines and their uses |
WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
EP3013353B1 (en) | 2013-06-26 | 2021-04-21 | Xigen Inflammation Ltd. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of cystitis |
WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
MX2016008110A (es) | 2013-12-20 | 2016-08-19 | Hoffmann La Roche | Derivados de pirazol como inhibidores de la cinasa de cremallera de leucina dual (dlk) y usos de los mismos. |
CN107406462B (zh) | 2015-03-09 | 2020-11-10 | 豪夫迈·罗氏有限公司 | 三环dlk抑制剂及其用途 |
GB201516905D0 (en) * | 2015-09-24 | 2015-11-11 | Stratified Medical Ltd | Treatment of Neurodegenerative diseases |
US11426389B2 (en) | 2017-07-28 | 2022-08-30 | Duke University | Compositions and methods for promoting hematopoietic stem cell regeneration |
CN114732910A (zh) | 2017-10-05 | 2022-07-12 | 弗尔康医疗公司 | P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
IL301266A (en) | 2020-10-02 | 2023-05-01 | Genentech Inc | Process for preparing biheteroaryl compounds and their crystalline forms |
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JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
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-
2010
- 2010-10-21 EP EP15189899.6A patent/EP3011970A3/en not_active Withdrawn
- 2010-10-21 AU AU2010310589A patent/AU2010310589A1/en not_active Abandoned
- 2010-10-21 EP EP10825693.4A patent/EP2490698A4/en not_active Withdrawn
- 2010-10-21 KR KR1020127013025A patent/KR20120102642A/ko not_active Application Discontinuation
- 2010-10-21 SG SG10201406763WA patent/SG10201406763WA/en unknown
- 2010-10-21 MX MX2012004638A patent/MX2012004638A/es not_active Application Discontinuation
- 2010-10-21 RU RU2012120783/15A patent/RU2012120783A/ru not_active Application Discontinuation
- 2010-10-21 CN CN201410255391.1A patent/CN104043126A/zh active Pending
- 2010-10-21 CA CA2778483A patent/CA2778483A1/en not_active Abandoned
- 2010-10-21 JP JP2012535378A patent/JP2013508401A/ja active Pending
- 2010-10-21 WO PCT/US2010/053596 patent/WO2011050192A1/en active Application Filing
- 2010-10-21 US US13/503,101 patent/US20120328609A1/en not_active Abandoned
- 2010-10-21 BR BR112012009257A patent/BR112012009257A2/pt not_active IP Right Cessation
- 2010-10-21 CN CN2010800475388A patent/CN102573855A/zh active Pending
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2012
- 2012-04-17 IL IL219232A patent/IL219232A0/en unknown
- 2012-12-05 HK HK15102710.8A patent/HK1203350A1/xx unknown
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2013
- 2013-12-20 US US14/136,379 patent/US20140328940A1/en not_active Abandoned
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2015
- 2015-03-11 US US14/644,873 patent/US20160199457A1/en not_active Abandoned
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Also Published As
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JP2013508401A (ja) | 2013-03-07 |
US20160199457A1 (en) | 2016-07-14 |
EP3011970A2 (en) | 2016-04-27 |
SG10201406763WA (en) | 2014-11-27 |
WO2011050192A1 (en) | 2011-04-28 |
EP3011970A3 (en) | 2016-06-08 |
CA2778483A1 (en) | 2011-04-28 |
BR112012009257A2 (pt) | 2016-11-22 |
EP2490698A4 (en) | 2013-09-25 |
KR20120102642A (ko) | 2012-09-18 |
HK1203350A1 (en) | 2015-10-30 |
CN102573855A (zh) | 2012-07-11 |
CN104043126A (zh) | 2014-09-17 |
EP2490698A1 (en) | 2012-08-29 |
JP2015172054A (ja) | 2015-10-01 |
US20120328609A1 (en) | 2012-12-27 |
US20140328940A1 (en) | 2014-11-06 |
IL219232A0 (en) | 2012-06-28 |
RU2012120783A (ru) | 2013-11-27 |
AU2010310589A1 (en) | 2012-05-10 |
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