AU2010310589A1 - Modulation of axon degeneration - Google Patents
Modulation of axon degeneration Download PDFInfo
- Publication number
- AU2010310589A1 AU2010310589A1 AU2010310589A AU2010310589A AU2010310589A1 AU 2010310589 A1 AU2010310589 A1 AU 2010310589A1 AU 2010310589 A AU2010310589 A AU 2010310589A AU 2010310589 A AU2010310589 A AU 2010310589A AU 2010310589 A1 AU2010310589 A1 AU 2010310589A1
- Authority
- AU
- Australia
- Prior art keywords
- antibody
- dlk
- degeneration
- neuron
- antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- C12Y—ENZYMES
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25419009P | 2009-10-22 | 2009-10-22 | |
US61/254,190 | 2009-10-22 | ||
PCT/US2010/053596 WO2011050192A1 (en) | 2009-10-22 | 2010-10-21 | Modulation of axon degeneration |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2010310589A1 true AU2010310589A1 (en) | 2012-05-10 |
Family
ID=43900692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2010310589A Abandoned AU2010310589A1 (en) | 2009-10-22 | 2010-10-21 | Modulation of axon degeneration |
Country Status (14)
Country | Link |
---|---|
US (3) | US20120328609A1 (es) |
EP (2) | EP2490698A4 (es) |
JP (2) | JP2013508401A (es) |
KR (1) | KR20120102642A (es) |
CN (2) | CN104043126A (es) |
AU (1) | AU2010310589A1 (es) |
BR (1) | BR112012009257A2 (es) |
CA (1) | CA2778483A1 (es) |
HK (1) | HK1203350A1 (es) |
IL (1) | IL219232A0 (es) |
MX (1) | MX2012004638A (es) |
RU (1) | RU2012120783A (es) |
SG (1) | SG10201406763WA (es) |
WO (1) | WO2011050192A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2807036C (en) | 2010-10-14 | 2018-01-16 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
US9382229B2 (en) | 2011-02-15 | 2016-07-05 | The Johns Hopkins University | Compounds and methods of use thereof for treating neurodegenerative disorders |
WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
US11180760B2 (en) | 2012-03-09 | 2021-11-23 | The Johns Hopkins University | Identification of molecular pathways and methods of use thereof for treating retinal neurodegeneration and other neurodegenerative disorders |
MX2014013407A (es) | 2012-05-22 | 2014-11-26 | Hoffmann La Roche | Dipiridilaminas sustituidas y uso de las mismas. |
US9539259B2 (en) | 2012-05-23 | 2017-01-10 | The Johns Hopkins University | Compounds and methods of use thereof for treating neurodegenerative disorders |
CN104387391A (zh) * | 2013-01-18 | 2015-03-04 | 韩冰 | 一种蛋白酶抑制剂及其制备方法和用途 |
MX2015009270A (es) | 2013-01-18 | 2015-10-30 | Hoffmann La Roche | Pirazoles sustituidos en posicion 3 y uso de los mismos como inhibidores de la cinasa cremallera de leucinas dual (dlk). |
CN104370880A (zh) * | 2013-01-24 | 2015-02-25 | 韩冰 | 一类蛋白酶抑制剂及其制备方法和用途 |
CN104370926A (zh) * | 2013-01-24 | 2015-02-25 | 韩冰 | 一类具有神经保护作用的化合物及其制备方法和用途 |
CN104370925A (zh) * | 2013-01-24 | 2015-02-25 | 韩冰 | 一类蛋白酶抑制剂及其制备方法和用途 |
CN105050620A (zh) * | 2013-02-28 | 2015-11-11 | 霍夫曼-拉罗奇有限公司 | 调节dlk稳定性的方法 |
CA2907912A1 (en) | 2013-05-01 | 2014-11-06 | F. Hoffmann-La Roche Ag | C-linked heterocycloalkyl substituted pyrimidines and their uses |
TWI622587B (zh) | 2013-05-01 | 2018-05-01 | 赫孚孟拉羅股份公司 | 二雜芳基化合物及其用途 |
PL3013353T3 (pl) | 2013-06-26 | 2021-09-20 | Xigen Inflammation Ltd. | Przenikające do komórki inhibitory peptydowe szlaku przekazywania sygnału jnk do leczenia zapalenia pęcherza |
WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
MX2016008110A (es) * | 2013-12-20 | 2016-08-19 | Hoffmann La Roche | Derivados de pirazol como inhibidores de la cinasa de cremallera de leucina dual (dlk) y usos de los mismos. |
EP3268373B1 (en) | 2015-03-09 | 2022-04-27 | F. Hoffmann-La Roche AG | Tricyclic dlk inhibitors and uses thereof |
GB201516905D0 (en) * | 2015-09-24 | 2015-11-11 | Stratified Medical Ltd | Treatment of Neurodegenerative diseases |
US11426389B2 (en) | 2017-07-28 | 2022-08-30 | Duke University | Compositions and methods for promoting hematopoietic stem cell regeneration |
PL3691620T3 (pl) | 2017-10-05 | 2022-11-21 | Fulcrum Therapeutics, Inc. | Inhibitory kinazy p38 zmniejszają poziom ekspresji genu dux4 i dalszych genów do leczenia fshd |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
PE20230781A1 (es) | 2020-10-02 | 2023-05-09 | Genentech Inc | Proceso para la preparacion de compuestos de biheteroarilo y formas cristalinas de estos |
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US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
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2010
- 2010-10-21 US US13/503,101 patent/US20120328609A1/en not_active Abandoned
- 2010-10-21 BR BR112012009257A patent/BR112012009257A2/pt not_active IP Right Cessation
- 2010-10-21 KR KR1020127013025A patent/KR20120102642A/ko not_active Application Discontinuation
- 2010-10-21 MX MX2012004638A patent/MX2012004638A/es not_active Application Discontinuation
- 2010-10-21 EP EP10825693.4A patent/EP2490698A4/en not_active Withdrawn
- 2010-10-21 SG SG10201406763WA patent/SG10201406763WA/en unknown
- 2010-10-21 RU RU2012120783/15A patent/RU2012120783A/ru not_active Application Discontinuation
- 2010-10-21 CA CA2778483A patent/CA2778483A1/en not_active Abandoned
- 2010-10-21 EP EP15189899.6A patent/EP3011970A3/en not_active Withdrawn
- 2010-10-21 JP JP2012535378A patent/JP2013508401A/ja active Pending
- 2010-10-21 WO PCT/US2010/053596 patent/WO2011050192A1/en active Application Filing
- 2010-10-21 CN CN201410255391.1A patent/CN104043126A/zh active Pending
- 2010-10-21 CN CN2010800475388A patent/CN102573855A/zh active Pending
- 2010-10-21 AU AU2010310589A patent/AU2010310589A1/en not_active Abandoned
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2012
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- 2012-12-05 HK HK15102710.8A patent/HK1203350A1/xx unknown
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2013
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2015
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MX2012004638A (es) | 2012-07-04 |
US20120328609A1 (en) | 2012-12-27 |
US20160199457A1 (en) | 2016-07-14 |
CA2778483A1 (en) | 2011-04-28 |
BR112012009257A2 (pt) | 2016-11-22 |
JP2015172054A (ja) | 2015-10-01 |
EP3011970A3 (en) | 2016-06-08 |
HK1203350A1 (en) | 2015-10-30 |
EP3011970A2 (en) | 2016-04-27 |
KR20120102642A (ko) | 2012-09-18 |
US20140328940A1 (en) | 2014-11-06 |
RU2012120783A (ru) | 2013-11-27 |
CN104043126A (zh) | 2014-09-17 |
EP2490698A4 (en) | 2013-09-25 |
WO2011050192A1 (en) | 2011-04-28 |
CN102573855A (zh) | 2012-07-11 |
IL219232A0 (en) | 2012-06-28 |
JP2013508401A (ja) | 2013-03-07 |
EP2490698A1 (en) | 2012-08-29 |
SG10201406763WA (en) | 2014-11-27 |
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