UA74571C2 - Compounds of pyridazinylphenyl hydrazone being used in congestive heart failure - Google Patents
Compounds of pyridazinylphenyl hydrazone being used in congestive heart failure Download PDFInfo
- Publication number
- UA74571C2 UA74571C2 UA2002108100A UA2002108100A UA74571C2 UA 74571 C2 UA74571 C2 UA 74571C2 UA 2002108100 A UA2002108100 A UA 2002108100A UA 2002108100 A UA2002108100 A UA 2002108100A UA 74571 C2 UA74571 C2 UA 74571C2
- Authority
- UA
- Ukraine
- Prior art keywords
- methyl
- hydrogen
- alkyl
- hydroxy
- pyridazin
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 79
- -1 pyridazinylphenyl hydrazone Chemical class 0.000 title claims abstract description 27
- 206010007559 Cardiac failure congestive Diseases 0.000 title claims abstract description 6
- 206010019280 Heart failures Diseases 0.000 title claims abstract description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 30
- 239000001257 hydrogen Substances 0.000 claims abstract description 30
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 16
- 125000003118 aryl group Chemical group 0.000 claims abstract description 13
- 150000003839 salts Chemical class 0.000 claims abstract description 13
- 150000002148 esters Chemical class 0.000 claims abstract description 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 8
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 7
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 5
- 150000002367 halogens Chemical class 0.000 claims abstract description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 5
- 125000002252 acyl group Chemical group 0.000 claims abstract description 4
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 4
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims abstract description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract description 3
- 125000003282 alkyl amino group Chemical group 0.000 claims abstract description 3
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 13
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- 238000000034 method Methods 0.000 claims description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20000577A FI20000577A0 (fi) | 2000-03-13 | 2000-03-13 | Pyridatsinyylifenyylihydratsoneja |
| PCT/FI2001/000241 WO2001068611A1 (en) | 2000-03-13 | 2001-03-12 | Pyridazinyl phenyl hydrazones useful against congestive heart failure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA74571C2 true UA74571C2 (en) | 2006-01-16 |
Family
ID=8557913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2002108100A UA74571C2 (en) | 2000-03-13 | 2001-12-03 | Compounds of pyridazinylphenyl hydrazone being used in congestive heart failure |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6699868B2 (sk) |
| EP (1) | EP1265871B1 (sk) |
| JP (1) | JP2003527375A (sk) |
| KR (1) | KR20030001379A (sk) |
| CN (1) | CN1191241C (sk) |
| AR (1) | AR027644A1 (sk) |
| AT (1) | ATE317388T1 (sk) |
| AU (2) | AU4657701A (sk) |
| BG (1) | BG65859B1 (sk) |
| BR (1) | BR0109136A (sk) |
| CA (1) | CA2403188A1 (sk) |
| CZ (1) | CZ20022997A3 (sk) |
| DE (1) | DE60117131T2 (sk) |
| DK (1) | DK1265871T3 (sk) |
| EA (1) | EA005574B1 (sk) |
| EE (1) | EE200200520A (sk) |
| ES (1) | ES2256222T3 (sk) |
| FI (1) | FI20000577A0 (sk) |
| HK (1) | HK1052008A1 (sk) |
| HR (1) | HRP20020816A2 (sk) |
| HU (1) | HUP0300177A3 (sk) |
| IL (2) | IL151492A0 (sk) |
| MX (1) | MXPA02008997A (sk) |
| NO (1) | NO324172B1 (sk) |
| NZ (1) | NZ521162A (sk) |
| PL (1) | PL357107A1 (sk) |
| RS (1) | RS50439B (sk) |
| SI (1) | SI1265871T1 (sk) |
| SK (1) | SK287163B6 (sk) |
| UA (1) | UA74571C2 (sk) |
| WO (1) | WO2001068611A1 (sk) |
| ZA (1) | ZA200206917B (sk) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0015228D0 (en) * | 2000-06-21 | 2000-08-16 | Portela & Ca Sa | Substituted nitrated catechols, their use in the treatment of some central and peripheral nervous system disorders |
| JP4561698B2 (ja) * | 2002-02-19 | 2010-10-13 | 小野薬品工業株式会社 | 縮合ピリダジン誘導体化合物およびその化合物を有効成分として含有する薬剤 |
| EP1612204A4 (en) * | 2003-03-31 | 2007-04-11 | Daiichi Seiyaku Co | HYDRAZONE DERIVATIVE |
| GB0503962D0 (en) | 2005-02-25 | 2005-04-06 | Kudos Pharm Ltd | Compounds |
| SI2069312T1 (sl) | 2006-07-25 | 2013-03-29 | Cephalon, Inc. | Derivati piridizinona |
| AU2008206903B2 (en) * | 2007-01-17 | 2012-07-05 | Orion Corporation | Levosimendan for use in treating chronic valvular disease |
| CN103842334B (zh) * | 2011-09-27 | 2016-06-29 | 日本瑞翁株式会社 | 聚合性化合物的制备中间体及其制备方法 |
| WO2014113620A2 (en) * | 2013-01-18 | 2014-07-24 | Bristol-Myers Squibb Company | Phthalazinones and isoquinolinones as rock inhibitors |
| US20210253518A1 (en) * | 2018-06-08 | 2021-08-19 | Nissan Chemical Corporation | Kinase inhibitor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3531658A1 (de) * | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel |
| GB8903130D0 (en) * | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
| US5185332A (en) * | 1989-02-11 | 1993-02-09 | Orion-Yhtyma Oy | Thiadiazines and pharmaceutical compositions thereof as well as method of use |
| FI973804A (fi) * | 1997-09-26 | 1999-03-27 | Orion Yhtymae Oy | Levosimendaanin oraalisia koostumuksia |
-
2000
- 2000-03-13 FI FI20000577A patent/FI20000577A0/fi unknown
-
2001
- 2001-03-12 SI SI200130518T patent/SI1265871T1/sl unknown
- 2001-03-12 SK SK1288-2002A patent/SK287163B6/sk not_active IP Right Cessation
- 2001-03-12 AT AT01919489T patent/ATE317388T1/de not_active IP Right Cessation
- 2001-03-12 AR ARP010101149A patent/AR027644A1/es unknown
- 2001-03-12 CZ CZ20022997A patent/CZ20022997A3/cs unknown
- 2001-03-12 ES ES01919489T patent/ES2256222T3/es not_active Expired - Lifetime
- 2001-03-12 EP EP01919489A patent/EP1265871B1/en not_active Expired - Lifetime
- 2001-03-12 IL IL15149201A patent/IL151492A0/xx active IP Right Grant
- 2001-03-12 EE EEP200200520A patent/EE200200520A/xx unknown
- 2001-03-12 US US10/221,348 patent/US6699868B2/en not_active Expired - Fee Related
- 2001-03-12 WO PCT/FI2001/000241 patent/WO2001068611A1/en active IP Right Grant
- 2001-03-12 MX MXPA02008997A patent/MXPA02008997A/es active IP Right Grant
- 2001-03-12 CN CNB018065309A patent/CN1191241C/zh not_active Expired - Fee Related
- 2001-03-12 HU HU0300177A patent/HUP0300177A3/hu unknown
- 2001-03-12 PL PL01357107A patent/PL357107A1/xx not_active Application Discontinuation
- 2001-03-12 NZ NZ521162A patent/NZ521162A/en unknown
- 2001-03-12 AU AU4657701A patent/AU4657701A/xx active Pending
- 2001-03-12 EA EA200200973A patent/EA005574B1/ru not_active IP Right Cessation
- 2001-03-12 KR KR1020027012066A patent/KR20030001379A/ko not_active Application Discontinuation
- 2001-03-12 BR BR0109136-0A patent/BR0109136A/pt not_active IP Right Cessation
- 2001-03-12 CA CA002403188A patent/CA2403188A1/en not_active Abandoned
- 2001-03-12 DE DE60117131T patent/DE60117131T2/de not_active Expired - Fee Related
- 2001-03-12 RS YUP-685/02A patent/RS50439B/sr unknown
- 2001-03-12 DK DK01919489T patent/DK1265871T3/da active
- 2001-03-12 JP JP2001567705A patent/JP2003527375A/ja not_active Withdrawn
- 2001-03-12 AU AU2001246577A patent/AU2001246577B2/en not_active Ceased
- 2001-12-03 UA UA2002108100A patent/UA74571C2/uk unknown
-
2002
- 2002-08-26 IL IL151492A patent/IL151492A/en not_active IP Right Cessation
- 2002-08-28 ZA ZA200206917A patent/ZA200206917B/en unknown
- 2002-09-05 NO NO20024247A patent/NO324172B1/no not_active IP Right Cessation
- 2002-10-08 BG BG107175A patent/BG65859B1/bg unknown
- 2002-10-11 HR HRP20020816 patent/HRP20020816A2/hr not_active Application Discontinuation
-
2003
- 2003-06-16 HK HK03104272A patent/HK1052008A1/xx not_active IP Right Cessation
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