UA73572C2 - 1,2-annelated quinoline enantiomer inhibiting farnesyl transferase - Google Patents
1,2-annelated quinoline enantiomer inhibiting farnesyl transferase Download PDFInfo
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- UA73572C2 UA73572C2 UA20021210152A UA20021210152A UA73572C2 UA 73572 C2 UA73572 C2 UA 73572C2 UA 20021210152 A UA20021210152 A UA 20021210152A UA 20021210152 A UA20021210152 A UA 20021210152A UA 73572 C2 UA73572 C2 UA 73572C2
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- compound
- mixture
- chlorophenyl
- cancer
- farnesyl transferase
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Classifications
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- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Medicinal Chemistry (AREA)
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- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00202181 | 2000-06-22 | ||
| PCT/EP2001/006747 WO2001098302A1 (fr) | 2000-06-22 | 2001-06-13 | Farnesyl transferase inhibant un enantiomere de quinoline 1,2 cyclise |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA73572C2 true UA73572C2 (en) | 2005-08-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20021210152A UA73572C2 (en) | 2000-06-22 | 2001-06-13 | 1,2-annelated quinoline enantiomer inhibiting farnesyl transferase |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US20030114471A1 (fr) |
| EP (1) | EP1296984B1 (fr) |
| JP (1) | JP4919575B2 (fr) |
| KR (2) | KR100831940B1 (fr) |
| CN (1) | CN1207296C (fr) |
| AR (1) | AR030704A1 (fr) |
| AT (1) | ATE294804T1 (fr) |
| AU (3) | AU6396201A (fr) |
| BG (1) | BG65894B1 (fr) |
| BR (1) | BRPI0111743B8 (fr) |
| CA (1) | CA2410232C (fr) |
| CZ (1) | CZ295278B6 (fr) |
| DE (1) | DE60110592T2 (fr) |
| EA (1) | EA005065B1 (fr) |
| EE (1) | EE04966B1 (fr) |
| EG (1) | EG24180A (fr) |
| ES (1) | ES2241830T3 (fr) |
| HK (1) | HK1058363A1 (fr) |
| HR (1) | HRP20020989B1 (fr) |
| HU (1) | HU229095B1 (fr) |
| IL (2) | IL153560A0 (fr) |
| IS (1) | IS2596B (fr) |
| JO (1) | JO2361B1 (fr) |
| MX (1) | MXPA02012845A (fr) |
| MY (1) | MY127734A (fr) |
| NO (1) | NO324494B1 (fr) |
| NZ (1) | NZ522481A (fr) |
| PA (1) | PA8519501A1 (fr) |
| PL (1) | PL209521B1 (fr) |
| SA (1) | SA01220349B1 (fr) |
| SK (1) | SK285699B6 (fr) |
| UA (1) | UA73572C2 (fr) |
| WO (1) | WO2001098302A1 (fr) |
| ZA (1) | ZA200210305B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003018135A1 (fr) | 2001-08-24 | 2003-03-06 | Wyeth Holdings Corporation | Procede d'utilisation de 5-(arylsulfonyle)-,5-(arylsulfinyle), et 5-(arylsulfanyle)-thiazolidine-2,4-diones pour l'inhibition de la farnesyle-proteine transferase |
| DE60307616T2 (de) | 2002-04-15 | 2007-10-04 | Janssen Pharmaceutica N.V. | Farnesyl transferase hemmende tricyclische quinazolinederivate substitutiert mit kohlenstoff-gebundenen imidazolen oder triazolen |
| US20050003422A1 (en) | 2003-07-01 | 2005-01-06 | Mitch Reponi | Methods for assessing and treating cancer |
| US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| WO2016090107A2 (fr) * | 2014-12-04 | 2016-06-09 | Eiger Biopharmaceuticals, Inc. | Traitement d'une infection au virus de l'hépatite delta |
| DK3285768T3 (da) | 2015-04-21 | 2021-01-25 | Eiger Biopharmaceuticals Inc | Farmaceutiske sammensætninger omfattende lonafarnib og ritonavir |
| DK3640345T3 (da) | 2015-08-17 | 2022-01-03 | Kura Oncology Inc | Fremgangsmåder til at behandle kræftpatienter med farnesyltransferaseinhibitorer |
| PL3534885T3 (pl) | 2016-11-03 | 2021-11-15 | Kura Oncology, Inc. | Inhibitory farnezylotransferazy do zastosowania w leczeniu nowotworu |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB1519765A (en) * | 1974-09-05 | 1978-08-02 | Ici Ltd | Pesticidal dihydrotetrazolo(1,5a) quinazolines compositions and processes |
| US4141979A (en) * | 1976-12-23 | 1979-02-27 | Pfizer Inc. | Tetrazolo[a]quinazol-5-ones antiallergy and antiulcer agents |
| GB9513577D0 (en) * | 1995-07-04 | 1995-09-06 | Brotherwood Rodney J | Improvements in passenger carrying vehicles |
| TW349948B (en) * | 1995-10-31 | 1999-01-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 2-quinolone derivatives |
| AU711142B2 (en) * | 1995-12-08 | 1999-10-07 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibiting (imidazol-5-YL)methyl-2-quinolinone derivatives |
| EP0891334A1 (fr) | 1996-04-03 | 1999-01-20 | Merck & Co., Inc. | Inhibiteurs de la farnesyl-proteine transferase |
| TW591030B (en) * | 1997-03-10 | 2004-06-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles |
| PL190944B1 (pl) * | 1997-04-25 | 2006-02-28 | Janssen Pharmaceutica Nv | Pochodna chinazolinonu i sposób jej wytwarzania oraz kompozycja farmaceutyczna i sposób jej wytwarzania |
| TR199902923T2 (xx) | 1997-06-02 | 2000-11-21 | Janssen Pharmaceutica N.V. | Yumu�ak kas h�cresi �o�almas� inhibit�rleri olarak (imidazol-5-il)metil-2-kuinolinon t�revleri. |
| PL193464B1 (pl) * | 1998-07-06 | 2007-02-28 | Janssen Pharmaceutica Nv | Zastosowanie inhibitora białkowej transferazy farnezylowej |
| SK285231B6 (sk) | 1998-07-06 | 2006-09-07 | Janssen Pharmaceutica N. V. | Použitie 6-[(imidazol-5-yl)metyl]chinolínovej zlúčeniny na prípravu farmaceutickej kompozície na liečbu artropatie |
| SK2442001A3 (en) * | 1998-08-27 | 2002-10-08 | Pfizer Prod Inc | Alkynyl-substituted quinolin-2-ones, pharmaceutical compositions, their use in the treatment and method for producing thereof |
| CA2341739C (fr) * | 1998-08-27 | 2005-07-12 | Pfizer Products Inc. | Derives de quinolin-2-one utiles en tant qu'agents anticancereux |
| EA004542B1 (ru) * | 1998-12-23 | 2004-06-24 | Янссен Фармацевтика Н.В. | 1, 2-аннелированные производные хинолина |
| US6462201B1 (en) * | 1998-12-29 | 2002-10-08 | Isp Investments Inc. | Process for the production of N-vinyl-2-pyrrolidone by vinylation |
| KR20010102073A (ko) * | 1999-02-11 | 2001-11-15 | 실버스타인 아써 에이. | 항암제로 유용한 헤테로아릴-치환된 퀴놀린-2-온 유도체 |
| HN2000000266A (es) | 2000-01-21 | 2001-05-21 | Pfizer Prod Inc | Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto. |
| JP2003523381A (ja) * | 2000-02-24 | 2003-08-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 投与レジメン |
| AU2002220559A1 (en) | 2000-09-25 | 2002-04-02 | Janssen Pharmaceutica N.V. | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives |
| AU2001293835A1 (en) | 2000-09-25 | 2002-04-02 | Janssen Pharmaceutica N.V. | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives |
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2001
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