UA70401C2 - Пристрій для доставки антипрогестинів, який містить силоксан з прищепленими полі(алкіленоксид)ними групами - Google Patents
Пристрій для доставки антипрогестинів, який містить силоксан з прищепленими полі(алкіленоксид)ними групами Download PDFInfo
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- UA70401C2 UA70401C2 UA2002076109A UA2002076109A UA70401C2 UA 70401 C2 UA70401 C2 UA 70401C2 UA 2002076109 A UA2002076109 A UA 2002076109A UA 2002076109 A UA2002076109 A UA 2002076109A UA 70401 C2 UA70401 C2 UA 70401C2
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- elastomer
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US6887948B2 (en) * | 1998-06-30 | 2005-05-03 | Schering Oy | Method for preparing a siloxane-based elastomer composition |
US6794464B2 (en) | 1998-06-30 | 2004-09-21 | Schering Oy | Membrane or matrix for controlling the permeation rate of drugs |
AU2002210580A1 (en) * | 2000-10-20 | 2002-04-29 | Leiras Oy | Drug delivery system |
WO2003017971A1 (en) * | 2001-08-31 | 2003-03-06 | Schering Oy | Drug delivery system |
EP1438942A1 (en) * | 2003-01-17 | 2004-07-21 | Schering Oy | An otorhinological drug delivery device |
PL1696822T3 (pl) * | 2003-11-13 | 2010-08-31 | Psivida Inc | Wstrzykiwane implanty o opóźnionym wydzielaniu mające matrycę rdzenia i powłokę podatne na erozję biologiczną |
US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
JP5137841B2 (ja) | 2005-10-13 | 2013-02-06 | シンセス ゲーエムベーハー | 薬物含浸容器 |
US20070149916A1 (en) * | 2005-12-22 | 2007-06-28 | Alza Corporation | Dry matrices as drug reservoirs in electrotransport applications |
EP1862468A1 (de) * | 2006-06-02 | 2007-12-05 | Bayer Schering Pharma Aktiengesellschaft | Kristallines 11beta-(4-Acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-on |
US20080261929A1 (en) * | 2007-04-23 | 2008-10-23 | Jens Hoffmann | Combination of progesterone-receptor antagonist together with an aromatase inhibitor for use in brca mediated diseases |
DE102007032468A1 (de) * | 2007-07-10 | 2009-01-15 | Brätter, Christian, Dr. | Transdermale Therapeutische Systeme, welche den Wirkstoff Anastrozol enthalten |
TW200930343A (en) * | 2007-09-21 | 2009-07-16 | Organon Nv | Drug delivery system |
EP2057972A1 (en) * | 2007-11-07 | 2009-05-13 | N.V. Organon | Intrauterine deposit |
TW200927141A (en) * | 2007-11-22 | 2009-07-01 | Bayer Schering Pharma Oy | Vaginal delivery system |
US11992431B2 (en) | 2008-09-17 | 2024-05-28 | Bayer Oy | Inserter |
FI20080523A0 (fi) | 2008-09-17 | 2008-09-17 | Bayer Schering Pharma Oy | Insertteri |
WO2010031902A1 (en) | 2008-09-17 | 2010-03-25 | Bayer Schering Pharma Oy | An inserter |
CN102202711B (zh) * | 2008-11-06 | 2014-06-25 | 诺沃—诺迪斯克有限公司 | 电子辅助的药物输送装置 |
US8822610B2 (en) | 2008-12-22 | 2014-09-02 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
US8815971B2 (en) | 2008-12-22 | 2014-08-26 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
WO2010123574A1 (en) | 2009-04-23 | 2010-10-28 | Atrp Solutions Inc | Star macromolecules for personal and home care |
US9783628B2 (en) | 2009-04-23 | 2017-10-10 | ATRP Solutions, Inc. | Dual-mechanism thickening agents for hydraulic fracturing fluids |
US8173750B2 (en) | 2009-04-23 | 2012-05-08 | ATRP Solutions, Inc. | Star macromolecules for personal and home care |
US8568374B2 (en) * | 2009-05-04 | 2013-10-29 | Merck Sharp & Dohme B.V. | Intrauterine system |
DE102009034362A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034368A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034367A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
DE102009034366A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034525A1 (de) | 2009-07-21 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034526A1 (de) | 2009-07-21 | 2011-02-10 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
DE102010007722A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
DE102010007719A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
EP2550288A1 (en) * | 2010-03-22 | 2013-01-30 | Repros Therapeutics Inc. | Compositions and methods for non-toxic delivery of antiprogestins |
US9587064B2 (en) | 2010-12-08 | 2017-03-07 | ATRP Solutions, Inc. | Salt-tolerant star macromolecules |
DE102011004899A1 (de) | 2011-03-01 | 2012-09-06 | Bayer Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
US9381193B2 (en) * | 2011-04-01 | 2016-07-05 | Washington University | Contraceptive methods and compositions |
BR112014001450A2 (pt) * | 2011-07-20 | 2017-07-18 | F Kiser Patrick | dispositivos intravaginais para distribuição de droga |
TWI590843B (zh) | 2011-12-28 | 2017-07-11 | 信迪思有限公司 | 膜及其製造方法 |
CA2882832C (en) | 2012-08-30 | 2021-08-24 | ATRP Solutions, Inc. | Dual mechanism thickening agents for hydraulic fracturing fluids |
CN105263978B (zh) | 2013-02-04 | 2018-04-17 | Atrp解决方案公司 | 耐盐星形大分子 |
EP2953558B1 (en) | 2013-02-06 | 2019-08-28 | Sillender, Mark | Embryo transfer catheter |
AU2014214537B2 (en) | 2013-02-06 | 2019-01-03 | Mark SILLENDER | Therapeutic substance transfer catheter and method |
US9352049B2 (en) | 2013-03-14 | 2016-05-31 | Albany Molecular Research, Inc. | Ligand-therapeutic agent conjugates, silicon-based linkers, and methods for making and using them |
HUE042368T2 (hu) | 2013-04-11 | 2019-06-28 | Bayer Pharma AG | Progeszteronreceptor-antagonista dózisformája |
US20160144067A1 (en) | 2013-06-21 | 2016-05-26 | DePuy Synthes Products, Inc. | Films and methods of manufacture |
US10106818B2 (en) | 2013-08-16 | 2018-10-23 | The J. David Gladstone Institutes | Dual-color HIV reporter system for the detection of latently-infected cells |
WO2015198104A1 (es) * | 2014-06-28 | 2015-12-30 | Laboratorios Andromaco S.A. | Pesario de cerclaje que contiene progesterona de liberación prolongada, sostenida y continua, útil para la prevención de parto prematuro |
JP6689210B2 (ja) | 2014-07-03 | 2020-04-28 | パイロット ポリマー テクノロジーズ, インク. | 界面活性剤相溶性星形高分子 |
WO2016061131A1 (en) | 2014-10-14 | 2016-04-21 | The J. David Gladstone Institutes | Compositions and methods for reactivating latent immunodeficiency virus |
WO2016138660A1 (en) * | 2015-03-05 | 2016-09-09 | Dow Corning Toray Co., Ltd. | Curable organopolysiloxane composition, a use thereof, and a laminate prepared from the composition |
EP3294300A1 (en) * | 2015-05-13 | 2018-03-21 | Bayer Oy | A long acting drug delivery device and its use in contraception |
CN106546706B (zh) * | 2015-09-21 | 2020-03-17 | 上海复旦张江生物医药股份有限公司 | pH梯度主动载药法制备的脂质体药物的体外释放测试方法 |
CN106546705B (zh) * | 2015-09-21 | 2020-03-17 | 上海复旦张江生物医药股份有限公司 | 一种脂质体药物体外释放的测试方法 |
EP3542786A1 (en) * | 2018-03-21 | 2019-09-25 | ITF Research Pharma, S.L.U. | Progesterone intravaginal devices |
EP4316477A1 (en) | 2018-08-22 | 2024-02-07 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Methods for treating cardiac valve disease |
US20220364119A1 (en) | 2019-06-14 | 2022-11-17 | The J. David Gladstone Institutes, a testamentary trust established under the Will of J.David Gladst | Compositions and methods for treating an immunodeficiency virus infection with a therapeutic interfering particle |
US10918649B2 (en) * | 2019-06-21 | 2021-02-16 | The Population Council, Inc. | System for providing birth control |
TWI803052B (zh) * | 2021-11-12 | 2023-05-21 | 佛教慈濟醫療財團法人 | 經皮遞送裝置及其使用及製造方法 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3279996A (en) * | 1962-08-28 | 1966-10-18 | Jr David M Long | Polysiloxane carrier for controlled release of drugs and other agents |
US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
US3832252A (en) * | 1970-09-29 | 1974-08-27 | T Higuchi | Method of making a drug-delivery device |
JPS519003B1 (es) * | 1970-11-07 | 1976-03-23 | ||
US3836560A (en) | 1971-03-08 | 1974-09-17 | Union Carbide Corp | Organosilicone polymers |
US4155991A (en) * | 1974-10-18 | 1979-05-22 | Schering Aktiengesellschaft | Vaginal ring |
US4323488A (en) * | 1979-03-26 | 1982-04-06 | Shin-Etsu Chemical Company Limited | Method for the preparation of silicone-modified polyoxyalkylene polyethers and room temperature-curable compositions therewith |
JPS60148560A (ja) * | 1984-01-17 | 1985-08-05 | 富士システムズ株式会社 | 皮膚用封止材 |
US4600751A (en) * | 1984-12-18 | 1986-07-15 | Dow Corning Corporation | Hydrophilic silicone-organic copolymer elastomers |
CA1257727A (en) * | 1984-12-18 | 1989-07-18 | Chi-Long Lee | Hydrophilic silicone-organic copolymer elastomers |
GB8704755D0 (en) * | 1987-02-28 | 1987-04-01 | Dow Corning Ltd | Pharmaceutical delivery device |
US4951657A (en) * | 1988-04-22 | 1990-08-28 | Dow Corning Corporation | Heat sealable membrane for transdermal drug release |
EP0545002A1 (en) | 1991-11-21 | 1993-06-09 | Kose Corporation | Silicone polymer, paste-like composition and water-in-oil type cosmetic composition comprising the same |
FI95768C (fi) * | 1993-06-17 | 1996-03-25 | Leiras Oy | Emättimensisäinen antosysteemi |
US5660848A (en) * | 1994-11-02 | 1997-08-26 | The Population Council, Center For Biomedical Research | Subdermally implantable device |
US5521166A (en) * | 1994-12-19 | 1996-05-28 | Ortho Pharmaceitical Corporation | Antiprogestin cyclophasic hormonal regimen |
JP3201940B2 (ja) * | 1995-09-12 | 2001-08-27 | 信越化学工業株式会社 | 硬化性シリコーンエラストマー組成物及びその製造方法 |
US5811487A (en) * | 1996-12-16 | 1998-09-22 | Dow Corning Corporation | Thickening silicones with elastomeric silicone polyethers |
US5889108A (en) | 1997-06-02 | 1999-03-30 | Dow Corning Corporation | Thickening solvents with elastomeric silicone polyethers |
US6013711A (en) | 1997-06-18 | 2000-01-11 | Ck Witco Corporation | Hydrophilic polysiloxane compositions |
FI103051B (fi) | 1997-08-22 | 1999-04-15 | Schering Oy | Uusia blokkikopolymeerejä ja niiden valmistus |
FI107339B (fi) | 1998-06-30 | 2001-07-13 | Leiras Oy | Lääkeaineiden läpäisynopeutta säätävä kalvo tai matriisi |
US6063395A (en) * | 1998-11-12 | 2000-05-16 | Leiras Oy | Drug delivery device especially for the delivery of progestins and estrogens |
-
1999
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