UA66344C2 - Derivatives of anthracyclinon and anthracyclin as diagnostic agent and pharmaceutical composition - Google Patents
Derivatives of anthracyclinon and anthracyclin as diagnostic agent and pharmaceutical composition Download PDFInfo
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- UA66344C2 UA66344C2 UA99010341A UA99010341A UA66344C2 UA 66344 C2 UA66344 C2 UA 66344C2 UA 99010341 A UA99010341 A UA 99010341A UA 99010341 A UA99010341 A UA 99010341A UA 66344 C2 UA66344 C2 UA 66344C2
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- UA
- Ukraine
- Prior art keywords
- denotes
- substituted
- hydroxy
- hydrogen
- amino
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 4
- 229940039227 diagnostic agent Drugs 0.000 title claims 2
- 239000000032 diagnostic agent Substances 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 49
- 206010002022 amyloidosis Diseases 0.000 claims abstract description 14
- 238000003745 diagnosis Methods 0.000 claims abstract description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 57
- 239000001257 hydrogen Substances 0.000 claims description 57
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 34
- -1 hydroxy, amino Chemical group 0.000 claims description 34
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 31
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 25
- 150000002431 hydrogen Chemical class 0.000 claims description 24
- 125000001153 fluoro group Chemical group F* 0.000 claims description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 22
- 125000003118 aryl group Chemical group 0.000 claims description 19
- 229940045799 anthracyclines and related substance Drugs 0.000 claims description 18
- 150000001720 carbohydrates Chemical class 0.000 claims description 17
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- 239000000203 mixture Substances 0.000 claims description 16
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- 229910052731 fluorine Inorganic materials 0.000 claims description 13
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 12
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 12
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- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000006038 hexenyl group Chemical group 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- VESAIDYCLWTAAV-UHFFFAOYSA-N n-benzyl-2,2,2-trifluoroethanamine Chemical compound FC(F)(F)CNCC1=CC=CC=C1 VESAIDYCLWTAAV-UHFFFAOYSA-N 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004365 octenyl group Chemical group C(=CCCCCCC)* 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- JADVWWSKYZXRGX-UHFFFAOYSA-M thioflavine T Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C1=[N+](C)C2=CC=C(C)C=C2S1 JADVWWSKYZXRGX-UHFFFAOYSA-M 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9613433.3A GB9613433D0 (en) | 1996-06-26 | 1996-06-26 | Fluoro labelled anthracyclinone and anthracycline derivatives |
| PCT/EP1997/003234 WO1997049433A1 (en) | 1996-06-26 | 1997-06-18 | Fluoro labelled anthracyclinone and anthracycline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA66344C2 true UA66344C2 (en) | 2004-05-17 |
Family
ID=10795944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA99010341A UA66344C2 (en) | 1996-06-26 | 1997-06-18 | Derivatives of anthracyclinon and anthracyclin as diagnostic agent and pharmaceutical composition |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6103700A (no) |
| EP (1) | EP0910415B1 (no) |
| JP (1) | JP2000514784A (no) |
| KR (1) | KR100451685B1 (no) |
| CN (1) | CN1263514C (no) |
| AR (1) | AR008616A1 (no) |
| AT (1) | ATE266427T1 (no) |
| AU (1) | AU726935B2 (no) |
| BR (1) | BR9710857A (no) |
| CA (1) | CA2258630A1 (no) |
| DE (1) | DE69729092D1 (no) |
| EA (1) | EA002203B1 (no) |
| GB (1) | GB9613433D0 (no) |
| HU (1) | HUP9903651A3 (no) |
| IL (1) | IL127465A (no) |
| NO (1) | NO318194B1 (no) |
| NZ (1) | NZ333660A (no) |
| PL (1) | PL190149B1 (no) |
| TW (1) | TW494099B (no) |
| UA (1) | UA66344C2 (no) |
| WO (1) | WO1997049433A1 (no) |
| ZA (1) | ZA975629B (no) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2803586C2 (ru) * | 2017-02-16 | 2023-09-18 | Монопар Терапьютикс Инк. | 3'-дезамино-3'-(2"-пирролин-1"-ил)-5-имино-13-дезоксиантрациклины и способы получения |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9805082D0 (en) * | 1998-03-10 | 1998-05-06 | Pharmacia & Upjohn Spa | Heterocyclyl anthracyclinone derivatives |
| GB9805080D0 (en) * | 1998-03-10 | 1998-05-06 | Pharmacia & Upjohn Spa | Amino anthracyclinone derivatives |
| US6589504B1 (en) | 2000-09-22 | 2003-07-08 | Pharmacia & Upjohn Company | Compounds and methods for diagnosing and treating amyloid-related conditions |
| US6828347B2 (en) | 2002-11-06 | 2004-12-07 | Illinois Institute Of Technology | Anti-viral multi-quinone compounds and regiospecific synthesis thereof |
| EP2584369A1 (en) * | 2011-10-17 | 2013-04-24 | Koninklijke Philips Electronics N.V. | Magnetic field probe for MRI with a fluoroelastomer or a solution of a fluorine-containing compound |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1573036A (en) * | 1977-05-05 | 1980-08-13 | Farmaceutici Italia | Anthracyclines |
| GB1573037A (en) * | 1977-05-05 | 1980-08-13 | Farmaceutici Italia | Anthracyclines |
| US4345070A (en) * | 1980-09-29 | 1982-08-17 | Farmitalia Carlo Erba S.P.A. | Process for the preparation of 4'-deoxy-daunorubicin and 4'-deoxy-doxorubicin |
| GB9114549D0 (en) * | 1991-07-05 | 1991-08-21 | Erba Carlo Spa | Mono and bis alkylamino-anthracyclines |
| GB9416007D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Anthracyclinone derivatives |
| GB9418260D0 (en) * | 1994-09-09 | 1994-10-26 | Erba Carlo Spa | Anthracycline derivatives |
| WO1997016191A1 (en) * | 1995-11-02 | 1997-05-09 | Warner-Lambert Company | Inhibition of amyloidosis by 9-acridinones |
-
1996
- 1996-06-26 GB GBGB9613433.3A patent/GB9613433D0/en active Pending
-
1997
- 1997-06-18 KR KR10-1998-0710656A patent/KR100451685B1/ko not_active IP Right Cessation
- 1997-06-18 HU HU9903651A patent/HUP9903651A3/hu unknown
- 1997-06-18 NZ NZ333660A patent/NZ333660A/xx unknown
- 1997-06-18 CA CA002258630A patent/CA2258630A1/en not_active Abandoned
- 1997-06-18 JP JP10502309A patent/JP2000514784A/ja not_active Withdrawn
- 1997-06-18 UA UA99010341A patent/UA66344C2/uk unknown
- 1997-06-18 EA EA199900054A patent/EA002203B1/ru not_active IP Right Cessation
- 1997-06-18 EP EP97928258A patent/EP0910415B1/en not_active Expired - Lifetime
- 1997-06-18 BR BR9710857A patent/BR9710857A/pt not_active Application Discontinuation
- 1997-06-18 PL PL97330907A patent/PL190149B1/pl not_active IP Right Cessation
- 1997-06-18 AT AT97928258T patent/ATE266427T1/de not_active IP Right Cessation
- 1997-06-18 IL IL12746597A patent/IL127465A/xx not_active IP Right Cessation
- 1997-06-18 DE DE69729092T patent/DE69729092D1/de not_active Expired - Lifetime
- 1997-06-18 CN CNB971958947A patent/CN1263514C/zh not_active Expired - Fee Related
- 1997-06-18 WO PCT/EP1997/003234 patent/WO1997049433A1/en active IP Right Grant
- 1997-06-18 AU AU32622/97A patent/AU726935B2/en not_active Ceased
- 1997-06-18 US US09/202,954 patent/US6103700A/en not_active Expired - Fee Related
- 1997-06-23 TW TW086108749A patent/TW494099B/zh not_active IP Right Cessation
- 1997-06-25 AR ARP970102787A patent/AR008616A1/es unknown
- 1997-06-25 ZA ZA9705629A patent/ZA975629B/xx unknown
-
1998
- 1998-12-17 NO NO19985928A patent/NO318194B1/no unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2803586C2 (ru) * | 2017-02-16 | 2023-09-18 | Монопар Терапьютикс Инк. | 3'-дезамино-3'-(2"-пирролин-1"-ил)-5-имино-13-дезоксиантрациклины и способы получения |
Also Published As
| Publication number | Publication date |
|---|---|
| IL127465A0 (en) | 1999-10-28 |
| AU3262297A (en) | 1998-01-14 |
| AU726935B2 (en) | 2000-11-23 |
| ATE266427T1 (de) | 2004-05-15 |
| AR008616A1 (es) | 2000-02-09 |
| ZA975629B (en) | 1998-01-30 |
| CN1223592A (zh) | 1999-07-21 |
| HUP9903651A2 (hu) | 2000-03-28 |
| US6103700A (en) | 2000-08-15 |
| PL330907A1 (en) | 1999-06-07 |
| PL190149B1 (pl) | 2005-11-30 |
| EP0910415B1 (en) | 2004-05-12 |
| BR9710857A (pt) | 1999-08-17 |
| NO985928L (no) | 1998-12-17 |
| IL127465A (en) | 2005-11-20 |
| CN1263514C (zh) | 2006-07-12 |
| KR100451685B1 (ko) | 2004-12-30 |
| TW494099B (en) | 2002-07-11 |
| EA002203B1 (ru) | 2002-02-28 |
| GB9613433D0 (en) | 1996-08-28 |
| NO318194B1 (no) | 2005-02-14 |
| HUP9903651A3 (en) | 2000-05-29 |
| KR20000022236A (ko) | 2000-04-25 |
| WO1997049433A1 (en) | 1997-12-31 |
| EA199900054A1 (ru) | 1999-06-24 |
| JP2000514784A (ja) | 2000-11-07 |
| DE69729092D1 (de) | 2004-06-17 |
| NO985928D0 (no) | 1998-12-17 |
| EP0910415A1 (en) | 1999-04-28 |
| NZ333660A (en) | 2000-07-28 |
| CA2258630A1 (en) | 1997-12-31 |
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