HUP9903651A2 - Fluorral megjelölt antraciklinon- és antraciklinszármazékok - Google Patents
Fluorral megjelölt antraciklinon- és antraciklinszármazékokInfo
- Publication number
- HUP9903651A2 HUP9903651A2 HU9903651A HUP9903651A HUP9903651A2 HU P9903651 A2 HUP9903651 A2 HU P9903651A2 HU 9903651 A HU9903651 A HU 9903651A HU P9903651 A HUP9903651 A HU P9903651A HU P9903651 A2 HUP9903651 A2 HU P9903651A2
- Authority
- HU
- Hungary
- Prior art keywords
- substituted
- atom
- hydrogen atom
- trifluoromethyl
- group
- Prior art date
Links
- 125000001153 fluoro group Chemical group F* 0.000 title abstract 6
- 229940045799 anthracyclines and related substance Drugs 0.000 title abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 9
- -1 (trifluoromethyl)-sulfonyl Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 239000000843 powder Substances 0.000 abstract 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 5
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 229910052731 fluorine Inorganic materials 0.000 abstract 3
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- XSXHWVKGUXMUQE-UHFFFAOYSA-N osmium dioxide Inorganic materials O=[Os]=O XSXHWVKGUXMUQE-UHFFFAOYSA-N 0.000 abstract 2
- 125000005942 tetrahydropyridyl group Chemical group 0.000 abstract 2
- BPGKDVZGPAKPIA-UHFFFAOYSA-N 2-(3,4-dihydro-2h-pyridin-1-yl)pyridine Chemical group C1CCC=CN1C1=CC=CC=N1 BPGKDVZGPAKPIA-UHFFFAOYSA-N 0.000 abstract 1
- NLPOZSHCOAICQC-UHFFFAOYSA-N 2-(trifluoromethylsulfonyl)pyridine Chemical group FC(F)(F)S(=O)(=O)C1=CC=CC=N1 NLPOZSHCOAICQC-UHFFFAOYSA-N 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 229920001343 polytetrafluoroethylene Chemical group 0.000 abstract 1
- 239000004810 polytetrafluoroethylene Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 210000005239 tubule Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Radiology & Medical Imaging (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A találmány egy (A) általánős képletű antraciklin- vagyantraciklinőnszármazéknak -, amelynek képletében R1 hidrőgénatőm, hidrőxicsőpőrt, halőgénatőm, alkőxicsőpőrt, adőttesetben szűbsztitűált aminőcsőpőrt vagy -OSO2(R4) általánős képletűcsőpőrt, ahől R4 alkil- vagy arilcsőpőrt, amelyek mindegyike adőtt esetben egy vagytöbb flűőratőmmal szűbsztitűált; R2 hidrőgénatőm vagy hidrőxicsőőrt; R3 hidrőgénatőm, hidrőxicsőpőrt, aminőcsőpőrt, amely egyszeresen vagykétszeresen alkil-, aril-, aralkil-, alkenil-, ciklőalkil-,ciklőalkenilcsőpőrttal szűbsztitűált, amely szűbsztitűens adőttesetben egy vagy több flűőratőmmal vagy triflűőr-metil-csőpőrttalszűbsztitűált, mőrfőlinőcsőpőrt, amely adőtt esetben alkil-, aril-,aralkil-, alkenil-, ciklőalkil-, ciklőalkenilcsőpőrttal szűbsztitűált,amely szűbsztitűens adőtt esetben egy vagy több flűőratőmmal vagytriflűőr-metilcsőpőrttal szűbsztitűált, piperazinőcsőpőrt, amely adőttesetben triflűőr-acil-, (triflűőr-metil)-szűlfőnil- vagy (triflűőr-metil)-arilcsőpőrttal szűbsztitűált, tetrahidrőpiridilcsőpőrt, (B)vagy (C) általánős képletű csőpőrt, R5 hidrőgénatőm vagy alkilcsőpőrt, R6 triflűőr-acetil- vagy (triflűőr-metil)-szűlfőnil-csőpőrt, m és n értéke 1, 2, 3 vagy 4, vagy (D) általánős képletű glikőzil-őxi-csőpőrt, amelyben R7 hidrőgénatőm, hidrőxicsőpőrt, aminőcsőpőrt, amely adőtt esetbenacil-, triflűőr-acetil-, (triflűőr-metil)-szűlfőnil-csőpőrttal,természetes előfőrdűlású aminősavból vagy szintetikűs aminősavbólszármazó csőpőrttal, vagy di- vagy tripeptidből származó csőpőrttalszűbsztitűált; R8 és R9 hidrőgénatőm, vagy R8 és R9 egyikének jelentése hidrőgénatőm,hidrőxi-, alkőxi-, tetrahidrőpiranilcsőpőrt, halőgénatőm vagy -OSO2(R4) általánős képletű csőpőrt, és R8 és R9 közül a másiknak ajelentése hidrőgénatőm vagy adőtt esetben acil-, triflűőr-acetil- vagy(triflűőr-metil)-szűlfőnil-csőpőrttal szűbsztitűált aminőcsőpőrt; Y hidrőgénatőm, hidrőxi-, alkőxi-, aminőcsőpőrt, amely adőtt esetbenacil, triflűőr-acetil-, alkil-, aril- vagy aralkilcsőpőrttalszűbsztitűált, ahől a szűbsztitűens adőtt esetben egy vagy többflűőratőmmal, mőrfőlinő-, piperazinőcsőpőrttal szűbsztitűált, amelyszűbsztitűens adőtt esetben triflűőr-acil- vagy (triflűőr-metil)-szűlfőnil-csőpőrttal szűbsztitűált, tetrahidrőpiridilcsőpőrt, (B), (C)vagy (D) általánős képletű csőpőrt; Z karbőnil-, hidrőxi-metilén- vagy metiléncsőpőrt; ahől legalább egyflűőratőm az antraciklinőn- vagy antraciklinvázhőz kapcsőlódik, vagy amőlekűla különböző helyzeteihez kapcsőlódó csőpőrtők legalább egyflűőratőmőt hőrdőznak - vagy gyógyászatilag elfőgadható sójának azamylőidősis diagnősztizálására vagy egy ilyen diganősztizálásraszőlgáló készítmény előállítására történő alkalmazására vőnatkőzik. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9613433.3A GB9613433D0 (en) | 1996-06-26 | 1996-06-26 | Fluoro labelled anthracyclinone and anthracycline derivatives |
| PCT/EP1997/003234 WO1997049433A1 (en) | 1996-06-26 | 1997-06-18 | Fluoro labelled anthracyclinone and anthracycline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9903651A2 true HUP9903651A2 (hu) | 2000-03-28 |
| HUP9903651A3 HUP9903651A3 (en) | 2000-05-29 |
Family
ID=10795944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9903651A HUP9903651A3 (en) | 1996-06-26 | 1997-06-18 | Fluoro labelled anthracyclinone and anthracycline derivatives |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6103700A (hu) |
| EP (1) | EP0910415B1 (hu) |
| JP (1) | JP2000514784A (hu) |
| KR (1) | KR100451685B1 (hu) |
| CN (1) | CN1263514C (hu) |
| AR (1) | AR008616A1 (hu) |
| AT (1) | ATE266427T1 (hu) |
| AU (1) | AU726935B2 (hu) |
| BR (1) | BR9710857A (hu) |
| CA (1) | CA2258630A1 (hu) |
| DE (1) | DE69729092D1 (hu) |
| EA (1) | EA002203B1 (hu) |
| GB (1) | GB9613433D0 (hu) |
| HU (1) | HUP9903651A3 (hu) |
| IL (1) | IL127465A (hu) |
| NO (1) | NO318194B1 (hu) |
| NZ (1) | NZ333660A (hu) |
| PL (1) | PL190149B1 (hu) |
| TW (1) | TW494099B (hu) |
| UA (1) | UA66344C2 (hu) |
| WO (1) | WO1997049433A1 (hu) |
| ZA (1) | ZA975629B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9805082D0 (en) * | 1998-03-10 | 1998-05-06 | Pharmacia & Upjohn Spa | Heterocyclyl anthracyclinone derivatives |
| GB9805080D0 (en) * | 1998-03-10 | 1998-05-06 | Pharmacia & Upjohn Spa | Amino anthracyclinone derivatives |
| US6589504B1 (en) | 2000-09-22 | 2003-07-08 | Pharmacia & Upjohn Company | Compounds and methods for diagnosing and treating amyloid-related conditions |
| US6828347B2 (en) | 2002-11-06 | 2004-12-07 | Illinois Institute Of Technology | Anti-viral multi-quinone compounds and regiospecific synthesis thereof |
| EP2584369A1 (en) * | 2011-10-17 | 2013-04-24 | Koninklijke Philips Electronics N.V. | Magnetic field probe for MRI with a fluoroelastomer or a solution of a fluorine-containing compound |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1573037A (en) * | 1977-05-05 | 1980-08-13 | Farmaceutici Italia | Anthracyclines |
| GB1573036A (en) * | 1977-05-05 | 1980-08-13 | Farmaceutici Italia | Anthracyclines |
| US4345070A (en) * | 1980-09-29 | 1982-08-17 | Farmitalia Carlo Erba S.P.A. | Process for the preparation of 4'-deoxy-daunorubicin and 4'-deoxy-doxorubicin |
| GB9114549D0 (en) * | 1991-07-05 | 1991-08-21 | Erba Carlo Spa | Mono and bis alkylamino-anthracyclines |
| GB9416007D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Anthracyclinone derivatives |
| GB9418260D0 (en) * | 1994-09-09 | 1994-10-26 | Erba Carlo Spa | Anthracycline derivatives |
| WO1997016191A1 (en) * | 1995-11-02 | 1997-05-09 | Warner-Lambert Company | Inhibition of amyloidosis by 9-acridinones |
-
1996
- 1996-06-26 GB GBGB9613433.3A patent/GB9613433D0/en active Pending
-
1997
- 1997-06-18 EP EP97928258A patent/EP0910415B1/en not_active Expired - Lifetime
- 1997-06-18 IL IL12746597A patent/IL127465A/xx not_active IP Right Cessation
- 1997-06-18 CN CNB971958947A patent/CN1263514C/zh not_active Expired - Fee Related
- 1997-06-18 DE DE69729092T patent/DE69729092D1/de not_active Expired - Lifetime
- 1997-06-18 CA CA002258630A patent/CA2258630A1/en not_active Abandoned
- 1997-06-18 US US09/202,954 patent/US6103700A/en not_active Expired - Fee Related
- 1997-06-18 EA EA199900054A patent/EA002203B1/ru not_active IP Right Cessation
- 1997-06-18 HU HU9903651A patent/HUP9903651A3/hu unknown
- 1997-06-18 JP JP10502309A patent/JP2000514784A/ja not_active Withdrawn
- 1997-06-18 AT AT97928258T patent/ATE266427T1/de not_active IP Right Cessation
- 1997-06-18 NZ NZ333660A patent/NZ333660A/xx unknown
- 1997-06-18 BR BR9710857A patent/BR9710857A/pt not_active Application Discontinuation
- 1997-06-18 KR KR10-1998-0710656A patent/KR100451685B1/ko not_active IP Right Cessation
- 1997-06-18 UA UA99010341A patent/UA66344C2/uk unknown
- 1997-06-18 AU AU32622/97A patent/AU726935B2/en not_active Ceased
- 1997-06-18 PL PL97330907A patent/PL190149B1/pl not_active IP Right Cessation
- 1997-06-18 WO PCT/EP1997/003234 patent/WO1997049433A1/en active IP Right Grant
- 1997-06-23 TW TW086108749A patent/TW494099B/zh not_active IP Right Cessation
- 1997-06-25 AR ARP970102787A patent/AR008616A1/es unknown
- 1997-06-25 ZA ZA9705629A patent/ZA975629B/xx unknown
-
1998
- 1998-12-17 NO NO19985928A patent/NO318194B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL330907A1 (en) | 1999-06-07 |
| US6103700A (en) | 2000-08-15 |
| KR100451685B1 (ko) | 2004-12-30 |
| EP0910415A1 (en) | 1999-04-28 |
| ZA975629B (en) | 1998-01-30 |
| PL190149B1 (pl) | 2005-11-30 |
| CN1223592A (zh) | 1999-07-21 |
| AR008616A1 (es) | 2000-02-09 |
| IL127465A0 (en) | 1999-10-28 |
| UA66344C2 (en) | 2004-05-17 |
| KR20000022236A (ko) | 2000-04-25 |
| NZ333660A (en) | 2000-07-28 |
| EP0910415B1 (en) | 2004-05-12 |
| NO985928D0 (no) | 1998-12-17 |
| IL127465A (en) | 2005-11-20 |
| AU3262297A (en) | 1998-01-14 |
| EA002203B1 (ru) | 2002-02-28 |
| WO1997049433A1 (en) | 1997-12-31 |
| HUP9903651A3 (en) | 2000-05-29 |
| BR9710857A (pt) | 1999-08-17 |
| NO318194B1 (no) | 2005-02-14 |
| AU726935B2 (en) | 2000-11-23 |
| DE69729092D1 (de) | 2004-06-17 |
| CN1263514C (zh) | 2006-07-12 |
| NO985928L (no) | 1998-12-17 |
| GB9613433D0 (en) | 1996-08-28 |
| ATE266427T1 (de) | 2004-05-15 |
| EA199900054A1 (ru) | 1999-06-24 |
| JP2000514784A (ja) | 2000-11-07 |
| TW494099B (en) | 2002-07-11 |
| CA2258630A1 (en) | 1997-12-31 |
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