EA199900054A1 - Меченные 19 фтором производные антрациклинона и антрациклина - Google Patents

Меченные 19 фтором производные антрациклинона и антрациклина

Info

Publication number
EA199900054A1
EA199900054A1 EA199900054A EA199900054A EA199900054A1 EA 199900054 A1 EA199900054 A1 EA 199900054A1 EA 199900054 A EA199900054 A EA 199900054A EA 199900054 A EA199900054 A EA 199900054A EA 199900054 A1 EA199900054 A1 EA 199900054A1
Authority
EA
Eurasian Patent Office
Prior art keywords
anthracyclinon
fluorinated
anthracycline derivatives
compounds
formula
Prior art date
Application number
EA199900054A
Other languages
English (en)
Other versions
EA002203B1 (ru
Inventor
Тициано Бандьера
Даниеле Фанчелли
Микеле Карузо
Жаклин Лансан
Антонино Суарато
Original Assignee
Фармация Энд Апджон С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон С.П.А. filed Critical Фармация Энд Апджон С.П.А.
Publication of EA199900054A1 publication Critical patent/EA199900054A1/ru
Publication of EA002203B1 publication Critical patent/EA002203B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Соединения формулы (А), где R, R, R, Y и Z являются органическими заместителями, могут использоваться для диагностики амилоидоза, причем некоторые соединения формулы (А) являются новыми. Описаны также способы их получения и содержащие их фармацевтические композиции.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900054A 1996-06-26 1997-06-18 Меченные 19фтором производные антрациклинона и антрациклина, фармацевтическая композиция на их основе и их применение для лечения или диагностики амилоидоза EA002203B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9613433.3A GB9613433D0 (en) 1996-06-26 1996-06-26 Fluoro labelled anthracyclinone and anthracycline derivatives
PCT/EP1997/003234 WO1997049433A1 (en) 1996-06-26 1997-06-18 Fluoro labelled anthracyclinone and anthracycline derivatives

Publications (2)

Publication Number Publication Date
EA199900054A1 true EA199900054A1 (ru) 1999-06-24
EA002203B1 EA002203B1 (ru) 2002-02-28

Family

ID=10795944

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900054A EA002203B1 (ru) 1996-06-26 1997-06-18 Меченные 19фтором производные антрациклинона и антрациклина, фармацевтическая композиция на их основе и их применение для лечения или диагностики амилоидоза

Country Status (22)

Country Link
US (1) US6103700A (ru)
EP (1) EP0910415B1 (ru)
JP (1) JP2000514784A (ru)
KR (1) KR100451685B1 (ru)
CN (1) CN1263514C (ru)
AR (1) AR008616A1 (ru)
AT (1) ATE266427T1 (ru)
AU (1) AU726935B2 (ru)
BR (1) BR9710857A (ru)
CA (1) CA2258630A1 (ru)
DE (1) DE69729092D1 (ru)
EA (1) EA002203B1 (ru)
GB (1) GB9613433D0 (ru)
HU (1) HUP9903651A3 (ru)
IL (1) IL127465A (ru)
NO (1) NO318194B1 (ru)
NZ (1) NZ333660A (ru)
PL (1) PL190149B1 (ru)
TW (1) TW494099B (ru)
UA (1) UA66344C2 (ru)
WO (1) WO1997049433A1 (ru)
ZA (1) ZA975629B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9805082D0 (en) * 1998-03-10 1998-05-06 Pharmacia & Upjohn Spa Heterocyclyl anthracyclinone derivatives
GB9805080D0 (en) * 1998-03-10 1998-05-06 Pharmacia & Upjohn Spa Amino anthracyclinone derivatives
US6589504B1 (en) 2000-09-22 2003-07-08 Pharmacia & Upjohn Company Compounds and methods for diagnosing and treating amyloid-related conditions
US6828347B2 (en) 2002-11-06 2004-12-07 Illinois Institute Of Technology Anti-viral multi-quinone compounds and regiospecific synthesis thereof
EP2584369A1 (en) * 2011-10-17 2013-04-24 Koninklijke Philips Electronics N.V. Magnetic field probe for MRI with a fluoroelastomer or a solution of a fluorine-containing compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1573036A (en) * 1977-05-05 1980-08-13 Farmaceutici Italia Anthracyclines
GB1573037A (en) * 1977-05-05 1980-08-13 Farmaceutici Italia Anthracyclines
US4345070A (en) * 1980-09-29 1982-08-17 Farmitalia Carlo Erba S.P.A. Process for the preparation of 4'-deoxy-daunorubicin and 4'-deoxy-doxorubicin
GB9114549D0 (en) * 1991-07-05 1991-08-21 Erba Carlo Spa Mono and bis alkylamino-anthracyclines
GB9416007D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Anthracyclinone derivatives
GB9418260D0 (en) * 1994-09-09 1994-10-26 Erba Carlo Spa Anthracycline derivatives
US5972956A (en) * 1995-11-02 1999-10-26 Warner-Lambert Company Inhibition of amyloidosis by 9-acridinones

Also Published As

Publication number Publication date
CA2258630A1 (en) 1997-12-31
IL127465A0 (en) 1999-10-28
JP2000514784A (ja) 2000-11-07
EA002203B1 (ru) 2002-02-28
HUP9903651A2 (hu) 2000-03-28
NO985928D0 (no) 1998-12-17
AR008616A1 (es) 2000-02-09
WO1997049433A1 (en) 1997-12-31
NO318194B1 (no) 2005-02-14
AU726935B2 (en) 2000-11-23
BR9710857A (pt) 1999-08-17
NO985928L (no) 1998-12-17
AU3262297A (en) 1998-01-14
GB9613433D0 (en) 1996-08-28
HUP9903651A3 (en) 2000-05-29
US6103700A (en) 2000-08-15
KR100451685B1 (ko) 2004-12-30
CN1223592A (zh) 1999-07-21
PL190149B1 (pl) 2005-11-30
CN1263514C (zh) 2006-07-12
NZ333660A (en) 2000-07-28
ATE266427T1 (de) 2004-05-15
ZA975629B (en) 1998-01-30
EP0910415B1 (en) 2004-05-12
DE69729092D1 (de) 2004-06-17
TW494099B (en) 2002-07-11
KR20000022236A (ko) 2000-04-25
UA66344C2 (en) 2004-05-17
EP0910415A1 (en) 1999-04-28
PL330907A1 (en) 1999-06-07
IL127465A (en) 2005-11-20

Similar Documents

Publication Publication Date Title
ES2141183T3 (es) Utilizacion de disolventes de hidrocarburos halogenados.
BR8600428A (pt) Compostos heterociclicos,processo para sua preparacao,composicoes inseticidas,processo para combate a insetos daninhos,utilizacao e processo para a preparacao de composicoes
EA200000920A1 (ru) Производные бициклических гидроксамовых кислот
EA199900166A1 (ru) Замещенные 6,6-гетеробициклические производные
EA200000391A1 (ru) Производные тиенопиримидина и тиенопиридина, полезные в качестве противораковых агентов
RU95116357A (ru) Производные пирролидина и тиазолидина, способы их получения, способ разделения энантиомеров и фармацевтическая композиция на основе производных пирролидина и тиазолидина
FI833918A (fi) -karboliner, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska preparat
MX9202996A (es) Diazabiciclo-(3-3-1)nonanos.
ES2174298T3 (es) Derivados de aminotiazol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ATE157089T1 (de) Derivate von alkanolaminen als kardiovaskuläre mittel
EA199700160A1 (ru) Производные индола в качестве антагонистов eaa
SE8505247L (sv) Organiska foreningar
ATE144498T1 (de) Herstellung von substituierten piperidinen
EA200101234A1 (ru) Новые производные аминотиазола, их получение и содержащие их фармацевтические композиции
LV10949A (lv) Aizvietoti 4-fenil-4piperidinkarboksamidi to iegusanas panemiens farmaceitiska kompozicija
EA199900054A1 (ru) Меченные 19 фтором производные антрациклинона и антрациклина
EA199800354A1 (ru) Способ получения производных камптотецина
FR2434167A1 (fr) Derives de l'hexahydro-1,2,3,3a,8,8a pyrrolo indole (2,3,-b)
EA200100984A1 (ru) Новые кристаллические формы макролидного антибиотика
GR1000887B (el) Νεα παραγωγα σπιροφουρανης.
EA199900684A1 (ru) Производные иминоазаантрациклинона для лечения амилоидоза
FI872719A0 (fi) Nya tetrahydro-benzotiazoler, deras framstaellning och anvaendning.
BR7902860A (pt) Novos derivados de 1,5-dimetil biciclo(3,2,1)octano,preparacao destes compostos,e seu uso com compostos de perfume
EA199900688A1 (ru) Хиноксалиндионы
SE8100122L (sv) Nya 2-aminometyl-6-halo-fenoler, framstellning derav och farmaceutiska kompositioner innehallande dessa

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM