HUP0104662A2 - Kombinált 5HT1A, 5HT1B és 5HT1D receptor antagonista aktivitással rendelkező kinolinszármazékok, eljárás az előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Kombinált 5HT1A, 5HT1B és 5HT1D receptor antagonista aktivitással rendelkező kinolinszármazékok, eljárás az előállításukra és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0104662A2 HUP0104662A2 HU0104662A HUP0104662A HUP0104662A2 HU P0104662 A2 HUP0104662 A2 HU P0104662A2 HU 0104662 A HU0104662 A HU 0104662A HU P0104662 A HUP0104662 A HU P0104662A HU P0104662 A2 HUP0104662 A2 HU P0104662A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- atom
- alkyl
- formula
- oxygen
- Prior art date
Links
- 101710138068 5-hydroxytryptamine receptor 1D Proteins 0.000 title 1
- 101150050738 HTR1B gene Proteins 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 hydroxy- Chemical class 0.000 abstract 3
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 101100007418 Caenorhabditis elegans cox-5A gene Proteins 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
A tal lm ny (I) ltal nos képletű vegyületekre - amelyek képletében Ra(i) ltal nos képletű csoport; amelyben P1 fenil-, biciklusos aril-vagy heterociklusos csoport; R1 halogénatom, alkil-, cikloalkil-,alkoxi-, hidroxi-, hidroxi-alkil-, hidroxi-alkoxi-, alkoxi-alkoxi-,a1kanoil-, nitro-, trifluor-metil-, ciano- -SR9, -SOR9 , -SO2R9, -SO2NR10R11, -CO2R10, -CONR10R11, -CO2NR10R11, CONR10(CH2)CCO2R11, -(CH2)NR10R11, -(CH2)cCONR10R11, -(CH2)cNR10COR11, -(CH2)cCO2(alkil), -CO(CH)OR10 -NR10R11-NRCO2R10, -NR CONR10 R11 , -CR10=NOR11 vagy -CNR10=NOR11 csoport: R9, R10 és R11 hidrogénatom vagy alkilcsoport; c1, 2, 3 vagy 4; és a 0, 1, 2 vagy 3: Ra (ii) ltal nos képletű csoport,amelyben P2 és P3 fenil-, biciklusos arilcsoport vagy heterociklusoscsoport; A kémiai k"tés, oxigénatom vagy S(O)n, karbonil-, metilén-vagy NR4 csoport; n 0, 1 vagy 2; R4 hidrogénatom vagy alkilcsoport: R1és R2 az (i) ltal nos képletnél R1 jelentésében meghat rozott;valamint a és b 0, 1, 2 vagy 3; L -Y-C(=O)-DG-, -C(=O)-DG- vagy -DG-C(=O)-csoport, ahol Y imino- vagy NR5 csoport, amelyben R5alkilcsoport, vagy Y oxigénatom, metilén-, -CH=CH- vagy -OCH2-csoport;D nitrogén-, szénatom vagy metincsoport: G hidrogénatom vagyalkilcsoport, vagy G és Rbl együtt egy W csoportot képez, ahol W -(CR16R17)t- csoport, amelyben t 2, 3 vagy 4, valamint R16 és R17hidrogénatom vagy alkilcsoport, vagy W -(CR16R17)u-J- csoport,amelyben u 0, 1, 2 vagy 3, és J oxigén-, kénatom, -CR16=CR17-, -CR16=N-, =CR16O-, =CR16S- vagy =CR16-NR17 csoport, azzal amegk"téssel, hogy a értéke 0-tól eltérő, ha J jelentése oxigén- vagykénatom; Rbl hidrogénatom, vagy Rbl és G együtt egy fentiekben meghatrozott W csoportot képez; X nitrogén-, szénatom vagy metincsoport;egyes k"tés, ha X jelentése nitrogénatom vagy metincsoport, vagykettős k"tés, ha X jelentése szénatom; és m 1, 2 vagy 3 és sóikravonatkozik. A tal lm ny kiterjed a vegyületek elő llít si elj r s ra,gyógy szati alkalmaz s ra, valamint a vegyületeket hatóanyagkénttartalmazó gyógyszerkészítményekre is. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9827882.3A GB9827882D0 (en) | 1998-12-17 | 1998-12-17 | Novel compounds |
| PCT/EP1999/009564 WO2000035919A2 (en) | 1998-12-17 | 1999-12-03 | Quinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0104662A2 true HUP0104662A2 (hu) | 2002-04-29 |
Family
ID=10844468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104662A HUP0104662A2 (hu) | 1998-12-17 | 1999-12-03 | Kombinált 5HT1A, 5HT1B és 5HT1D receptor antagonista aktivitással rendelkező kinolinszármazékok, eljárás az előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1140946A2 (hu) |
| JP (1) | JP2002532501A (hu) |
| KR (1) | KR20010108028A (hu) |
| CN (1) | CN1335850A (hu) |
| AU (1) | AU3036000A (hu) |
| BR (1) | BR9916307A (hu) |
| CA (1) | CA2355234A1 (hu) |
| CO (1) | CO5150146A1 (hu) |
| CZ (1) | CZ20012151A3 (hu) |
| GB (1) | GB9827882D0 (hu) |
| HK (1) | HK1041480A1 (hu) |
| HU (1) | HUP0104662A2 (hu) |
| IL (1) | IL143782A0 (hu) |
| NO (1) | NO20013003L (hu) |
| PL (1) | PL353156A1 (hu) |
| TR (1) | TR200101764T2 (hu) |
| WO (1) | WO2000035919A2 (hu) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9926303D0 (en) * | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
| WO2003000253A1 (en) * | 2001-06-20 | 2003-01-03 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| EP1844771A3 (en) * | 2001-06-20 | 2007-11-07 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| AU2002352878B2 (en) | 2001-11-27 | 2007-11-22 | Merck Sharp & Dohme Corp. | 2-Aminoquinoline compounds |
| UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| MXPA05006287A (es) | 2002-12-10 | 2005-09-08 | Wyeth Corp | Derivados de acido indoloxo-acetilaminoacetico sustituidos como inhibidores del inhibidor del activador de plasminogeno 1 (pai-1). |
| CA2509191A1 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| WO2004052853A2 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| CN1726190A (zh) | 2002-12-10 | 2006-01-25 | 惠氏公司 | 作为纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的取代3－羰基－1h－吲哚－1－基乙酸衍生物 |
| US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| CN1890234A (zh) | 2003-12-23 | 2007-01-03 | 辉瑞大药厂 | 新颖的喹啉衍生物 |
| UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
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| WO2018125817A1 (en) | 2016-12-29 | 2018-07-05 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| CN108570450A (zh) * | 2017-03-11 | 2018-09-25 | 华中科技大学鄂州工业技术研究院 | 一种细胞模型及其构建和筛选五羟色胺受体靶点活性物质之应用 |
| CN106883192B (zh) * | 2017-03-30 | 2019-05-14 | 苏州汉德创宏生化科技有限公司 | 含氮类杂环抗肿瘤药物活性物恶唑基修饰的苯甲酸类化合物的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995006644A1 (en) * | 1993-09-03 | 1995-03-09 | Smithkline Beecham Plc | Amide derivatives as 5ht1d receptor antagonists |
| WO1998047868A1 (en) * | 1997-04-18 | 1998-10-29 | Smithkline Beecham Plc | Heterocycle-containing urea derivatives as 5ht1a, 5ht1b and 5ht1d receptor antagonists |
| BR9809092A (pt) * | 1997-04-18 | 2002-01-22 | Smithkline Beecham Plc | Derivados de indol tendo atividade combinada de antagonista de receptor de 5ht1a, 5ht1b e 5ht1d |
| JP2002508366A (ja) * | 1997-12-12 | 2002-03-19 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | キノリンピペラジンおよびキノリンピペリジン誘導体、それらの製造方法、ならびに複合的５−ｈｔ１ａ、５−ｈｔ１ｂおよび５−ｈｔ１ｄ受容体アンタゴニストとしてのそれらの用途 |
-
1998
- 1998-12-17 GB GBGB9827882.3A patent/GB9827882D0/en not_active Ceased
-
1999
- 1999-12-03 EP EP99964526A patent/EP1140946A2/en not_active Withdrawn
- 1999-12-03 WO PCT/EP1999/009564 patent/WO2000035919A2/en not_active Application Discontinuation
- 1999-12-03 CA CA002355234A patent/CA2355234A1/en not_active Abandoned
- 1999-12-03 JP JP2000588178A patent/JP2002532501A/ja active Pending
- 1999-12-03 BR BR9916307-1A patent/BR9916307A/pt not_active Application Discontinuation
- 1999-12-03 KR KR1020017007626A patent/KR20010108028A/ko not_active Application Discontinuation
- 1999-12-03 CN CN99816080A patent/CN1335850A/zh active Pending
- 1999-12-03 HU HU0104662A patent/HUP0104662A2/hu unknown
- 1999-12-03 AU AU30360/00A patent/AU3036000A/en not_active Abandoned
- 1999-12-03 PL PL99353156A patent/PL353156A1/xx not_active Application Discontinuation
- 1999-12-03 TR TR2001/01764T patent/TR200101764T2/xx unknown
- 1999-12-03 IL IL14378299A patent/IL143782A0/xx unknown
- 1999-12-03 CZ CZ20012151A patent/CZ20012151A3/cs unknown
- 1999-12-17 CO CO99078949A patent/CO5150146A1/es unknown
-
2001
- 2001-06-15 NO NO20013003A patent/NO20013003L/no not_active Application Discontinuation
-
2002
- 2002-02-19 HK HK02101212.8A patent/HK1041480A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1041480A1 (zh) | 2002-07-12 |
| KR20010108028A (ko) | 2001-12-07 |
| AU3036000A (en) | 2000-07-03 |
| BR9916307A (pt) | 2002-01-15 |
| IL143782A0 (en) | 2002-04-21 |
| NO20013003L (no) | 2001-07-25 |
| WO2000035919A2 (en) | 2000-06-22 |
| WO2000035919A3 (en) | 2000-10-26 |
| EP1140946A2 (en) | 2001-10-10 |
| CZ20012151A3 (cs) | 2001-12-12 |
| CA2355234A1 (en) | 2000-06-22 |
| CO5150146A1 (es) | 2002-04-29 |
| JP2002532501A (ja) | 2002-10-02 |
| NO20013003D0 (no) | 2001-06-15 |
| CN1335850A (zh) | 2002-02-13 |
| GB9827882D0 (en) | 1999-02-10 |
| TR200101764T2 (tr) | 2001-10-22 |
| PL353156A1 (en) | 2003-10-20 |
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