CO5150146A1 - Nuevos compuestos y su proceso de preparacion - Google Patents

Nuevos compuestos y su proceso de preparacion

Info

Publication number
CO5150146A1
CO5150146A1 CO99078949A CO99078949A CO5150146A1 CO 5150146 A1 CO5150146 A1 CO 5150146A1 CO 99078949 A CO99078949 A CO 99078949A CO 99078949 A CO99078949 A CO 99078949A CO 5150146 A1 CO5150146 A1 CO 5150146A1
Authority
CO
Colombia
Prior art keywords
alkoxy
alkyl
nitrogen
hydroxy
nor11
Prior art date
Application number
CO99078949A
Other languages
English (en)
Inventor
Tom Daniel Heightman
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of CO5150146A1 publication Critical patent/CO5150146A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Un compuesto de la fórmula (I) o una sal de dicho compuesto:<EMI FILE="99078949_1" ID="1" IMF=JPEG >en la cual Ra se selecciona a partir de un grupo de fórmula (i)<EMI FILE="99078949_2" ID="2" IMF=JPEG >en la que p1 es fenilo, arilo bicíclico, cicloalquilo C3-C6, un anillo heterocíclico de 5 a 7 miembros que contiene 1 a 3 heteroátomos seleccionados a partir de oxígeno, nitrógeno y azufre, o un anillo heterocíclico bicíclico que contiene 1 a 3 heteroátomos seleccionados a partir de oxígeno, nitrógeno y azufre; R1 es halógeno alquilo C1-C6, cicloalquilo C3-C6, alcoxi C1-C6, hidroxi, hidroxi-alquilo C1-C6, hlidroxi-alcoxi C1-C6, alcoxi C1-C6-alcoxi C1-C6, alcanoílo C1-C6, NO2, CF3, CN, SR9, SOR9, SO2R9, SO2NR10R11, CO2R10, CONR10R11, CONR10(CH2)CCO2R11, (CH2)CNR10R11, (CH2)CCONR10R11, (CH2)CNR10COR11, (CH2)CCO2-alquilo C1-C6, CO2(CH2)COR10, NR10R11, NR10CO2R11, NR10CONR10R11, CR10=NOR11, CNR10=NOR11, en la que R9, R10 y R11 son independientemente hidrógeno o alquilo C1-C6 y c es 1 a 4; ya es 0, 1, 2 ó 3;X es nitrógeno, carbono o un CH,---- es un enlace sencillo si X es nitrógeno o CH y enlace doble si X es carbono;m es 1, 2 ó 3.
CO99078949A 1998-12-17 1999-12-17 Nuevos compuestos y su proceso de preparacion CO5150146A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9827882.3A GB9827882D0 (en) 1998-12-17 1998-12-17 Novel compounds

Publications (1)

Publication Number Publication Date
CO5150146A1 true CO5150146A1 (es) 2002-04-29

Family

ID=10844468

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99078949A CO5150146A1 (es) 1998-12-17 1999-12-17 Nuevos compuestos y su proceso de preparacion

Country Status (17)

Country Link
EP (1) EP1140946A2 (es)
JP (1) JP2002532501A (es)
KR (1) KR20010108028A (es)
CN (1) CN1335850A (es)
AU (1) AU3036000A (es)
BR (1) BR9916307A (es)
CA (1) CA2355234A1 (es)
CO (1) CO5150146A1 (es)
CZ (1) CZ20012151A3 (es)
GB (1) GB9827882D0 (es)
HK (1) HK1041480A1 (es)
HU (1) HUP0104662A2 (es)
IL (1) IL143782A0 (es)
NO (1) NO20013003L (es)
PL (1) PL353156A1 (es)
TR (1) TR200101764T2 (es)
WO (1) WO2000035919A2 (es)

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US7332521B2 (en) 2003-09-25 2008-02-19 Wyeth Substituted indoles
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US10092574B2 (en) 2012-09-26 2018-10-09 Valorisation-Recherche, Limited Partnership Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
KR20160074540A (ko) 2013-10-17 2016-06-28 다우 아그로사이언시즈 엘엘씨 살충성 화합물의 제조 방법
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Also Published As

Publication number Publication date
JP2002532501A (ja) 2002-10-02
HK1041480A1 (zh) 2002-07-12
HUP0104662A2 (hu) 2002-04-29
AU3036000A (en) 2000-07-03
WO2000035919A2 (en) 2000-06-22
GB9827882D0 (en) 1999-02-10
NO20013003D0 (no) 2001-06-15
NO20013003L (no) 2001-07-25
BR9916307A (pt) 2002-01-15
CN1335850A (zh) 2002-02-13
TR200101764T2 (tr) 2001-10-22
WO2000035919A3 (en) 2000-10-26
KR20010108028A (ko) 2001-12-07
IL143782A0 (en) 2002-04-21
PL353156A1 (en) 2003-10-20
CZ20012151A3 (cs) 2001-12-12
CA2355234A1 (en) 2000-06-22
EP1140946A2 (en) 2001-10-10

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