UA5576A1 - Спосіб отримання похідних 3,5-діаміно-1,2,4-триазіну або їх кислотно-адітивних солей - Google Patents

Спосіб отримання похідних 3,5-діаміно-1,2,4-триазіну або їх кислотно-адітивних солей

Info

Publication number
UA5576A1
UA5576A1 UA2932704A UA2932704A UA5576A1 UA 5576 A1 UA5576 A1 UA 5576A1 UA 2932704 A UA2932704 A UA 2932704A UA 2932704 A UA2932704 A UA 2932704A UA 5576 A1 UA5576 A1 UA 5576A1
Authority
UA
Ukraine
Prior art keywords
acid
diamino
triazine
derivatives
preparation
Prior art date
Application number
UA2932704A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Елан Сойер Девід
Джордж Бакстер Мартін
Реджинальд-Елфік Альберт
Айнслі Міллер Алістер
Original Assignee
Дзе Велкам Фаундейшн, Лимітед
Дзе Велкам Фаундейшн, Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10505597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA5576(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Дзе Велкам Фаундейшн, Лимітед, Дзе Велкам Фаундейшн, Лимитед filed Critical Дзе Велкам Фаундейшн, Лимітед
Publication of UA5576A1 publication Critical patent/UA5576A1/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
UA2932704A 1979-06-01 1980-06-02 Спосіб отримання похідних 3,5-діаміно-1,2,4-триазіну або їх кислотно-адітивних солей UA5576A1 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7919257 1979-06-01

Publications (1)

Publication Number Publication Date
UA5576A1 true UA5576A1 (uk) 1994-12-28

Family

ID=10505597

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2932704A UA5576A1 (uk) 1979-06-01 1980-06-02 Спосіб отримання похідних 3,5-діаміно-1,2,4-триазіну або їх кислотно-адітивних солей

Country Status (30)

Country Link
US (2) US4486354A (esLanguage)
EP (2) EP0059987B1 (esLanguage)
JP (2) JPS5625169A (esLanguage)
AR (1) AR227521A1 (esLanguage)
AT (1) AT370097B (esLanguage)
AU (2) AU530999B2 (esLanguage)
BG (1) BG60427B2 (esLanguage)
CA (1) CA1112643A (esLanguage)
CS (1) CS234018B2 (esLanguage)
CZ (1) CZ384891A3 (esLanguage)
DD (1) DD151309A5 (esLanguage)
DK (1) DK153787C (esLanguage)
ES (1) ES491998A0 (esLanguage)
FI (1) FI67844C (esLanguage)
GE (1) GEP19960470B (esLanguage)
GR (1) GR68380B (esLanguage)
HU (1) HU182086B (esLanguage)
IE (1) IE49823B1 (esLanguage)
IL (1) IL60201A (esLanguage)
IT (1) IT1147087B (esLanguage)
MX (1) MX9202962A (esLanguage)
MY (1) MY8500062A (esLanguage)
NL (1) NL950007I2 (esLanguage)
NZ (1) NZ193890A (esLanguage)
PL (1) PL124029B1 (esLanguage)
SU (1) SU1055331A3 (esLanguage)
UA (1) UA5576A1 (esLanguage)
YU (1) YU145680A (esLanguage)
ZA (1) ZA803250B (esLanguage)
ZW (1) ZW12980A1 (esLanguage)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
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IT1145308B (it) * 1979-08-16 1986-11-05 Wellcome Found Composti aromatici sostituiti
GB8328757D0 (en) * 1983-10-27 1983-11-30 Wellcome Found Chemical compounds
DE3600891A1 (de) * 1986-01-15 1987-07-16 Bayer Ag 1,8-verbrueckte 4-chinolon-3-carbonsaeuren und diese enthaltende arzneimittel
GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
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FI895821A7 (fi) 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9012312D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9124807D0 (en) * 1991-11-22 1992-01-15 Wellcome Found Pharmaceutical formulations
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
DK0522128T3 (da) * 1991-01-30 1996-02-26 Wellcome Found Vanddispergerbare tabletter indeholdende acyclovir
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
NZ253260A (en) * 1992-06-12 1997-05-26 Wellcome Found Use of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (lamotrigine) for preparing medicaments for preventing or reducing dependence on (or tolerance to or reverse tolerance to) a dependence-inducing agent
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
US6133299A (en) * 1993-02-25 2000-10-17 Warner-Lambert Company Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds
GB9305693D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
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US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9424766D0 (en) * 1994-12-07 1995-02-08 Wellcome Found Pharmaceutical composition
GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
AU4311596A (en) * 1994-12-30 1996-07-24 Wellcome Foundation Limited, The Process for the preparation of lamotrigine
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
GB9518027D0 (en) * 1995-09-05 1995-11-08 Wellcome Found Pharmacologically active compound
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ES2209639B1 (es) 2002-10-31 2005-08-01 Vita Cientifica, S.L. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio.
US7521553B2 (en) * 2003-03-17 2009-04-21 Hetero Drugs Limited Crystalline forms of lamotrigine
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GB2395483A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Crystalline lamotrigine and its monohydrate
DK1691811T3 (da) 2003-12-11 2014-10-20 Sunovion Pharmaceuticals Inc Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression
JP2007537151A (ja) * 2004-01-29 2007-12-20 ファイザー・プロダクツ・インク γ−アミノ酪酸モジュレータと５−ＨＴ１Ｂ受容体アンタゴニストとの組合せ
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DK1937259T3 (da) * 2005-09-23 2012-02-13 Janssen Pharmaceutica Nv Hexahydro-cycloheptapyrazol-cannabinoid-modulatorer
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US20070117858A1 (en) * 2005-11-23 2007-05-24 Mingde Xia Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators
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US20070254911A1 (en) * 2006-03-27 2007-11-01 Mingde Xia Tetrahydro-Pyrazolo[3,4-c]Pyridine Cannabinoid Modulators
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WO2007122638A2 (en) * 2006-04-26 2007-11-01 Ratnamani Bio-Chemicals & Pharmaceuticals Pvt. Ltd. An improved process for preparation of lamotrigine intermediates
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GB2471729A (en) 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
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GB201111712D0 (en) 2011-07-08 2011-08-24 Gosforth Ct Holdings Pty Ltd Pharmaceutical compositions
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Family Cites Families (8)

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GB759014A (en) * 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
AT190941B (de) * 1954-09-22 1957-07-25 Chemie Linz Ag Verfahren zur Herstellung neuer Guanylhydrazone
US2952677A (en) * 1956-10-01 1960-09-13 Ici Ltd Aminoguanadine compounds
BE663481A (esLanguage) * 1964-05-05
DE1802364C3 (de) * 1967-10-12 1975-03-20 Shell Internationale Research Maatschappij B.V., Den Haag (Niederlande) Arzneimittel mit thymeretischer Wirkung
GB1223492A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
US3637688A (en) * 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
IT1145308B (it) * 1979-08-16 1986-11-05 Wellcome Found Composti aromatici sostituiti

Also Published As

Publication number Publication date
JPH0144179B2 (esLanguage) 1989-09-26
ATA289680A (de) 1982-07-15
CZ384891A3 (en) 1993-10-13
EP0021121B1 (en) 1983-05-11
JPH0144706B2 (esLanguage) 1989-09-29
BG60427B2 (bg) 1995-03-31
FI801758A7 (fi) 1980-12-02
PL224633A1 (esLanguage) 1981-02-13
MY8500062A (en) 1985-12-31
ES8104993A1 (es) 1981-05-16
DK153787C (da) 1989-01-16
EP0021121A1 (en) 1981-01-07
PL124029B1 (en) 1982-12-31
AU530999B2 (en) 1983-08-04
HU182086B (en) 1983-12-28
IE801126L (en) 1980-12-01
NL950007I2 (nl) 1997-02-03
CA1112643A (en) 1981-11-17
AT370097B (de) 1983-02-25
IL60201A (en) 1984-05-31
DD151309A5 (de) 1981-10-14
EP0059987A1 (en) 1982-09-15
AR227521A1 (es) 1982-11-15
FI67844C (fi) 1985-06-10
JPS6133163A (ja) 1986-02-17
ZA803250B (en) 1982-01-27
ES491998A0 (es) 1981-05-16
ZW12980A1 (en) 1982-01-06
AU5890680A (en) 1980-12-04
FI67844B (fi) 1985-02-28
NZ193890A (en) 1984-07-06
IL60201A0 (en) 1980-07-31
SU1055331A3 (ru) 1983-11-15
US4486354A (en) 1984-12-04
GEP19960470B (en) 1996-08-29
DK153787B (da) 1988-09-05
NL950007I1 (nl) 1995-06-16
EP0059987B1 (en) 1985-08-14
IE49823B1 (en) 1985-12-25
GR68380B (esLanguage) 1981-12-28
AU566870B2 (en) 1987-11-05
MX9202962A (es) 1992-07-01
JPS5625169A (en) 1981-03-10
DK233880A (da) 1980-12-02
IT8048848A0 (it) 1980-05-30
US4602017A (en) 1986-07-22
YU145680A (en) 1983-02-28
IT1147087B (it) 1986-11-19
CS234018B2 (en) 1985-03-14

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