UA126381C2 - Нові антитіла, які специфічно зв'язуються з епітопами вірусу зіка, та їх застосування - Google Patents

Нові антитіла, які специфічно зв'язуються з епітопами вірусу зіка, та їх застосування Download PDF

Info

Publication number
UA126381C2
UA126381C2 UAA201901101A UAA201901101A UA126381C2 UA 126381 C2 UA126381 C2 UA 126381C2 UA A201901101 A UAA201901101 A UA A201901101A UA A201901101 A UAA201901101 A UA A201901101A UA 126381 C2 UA126381 C2 UA 126381C2
Authority
UA
Ukraine
Prior art keywords
same
antibody
antigen
amino acid
sequence
Prior art date
Application number
UAA201901101A
Other languages
English (en)
Ukrainian (uk)
Inventor
Давід Корті
Давид Корти
Original Assignee
Х'Юмабс Байомед Са
Хьюмабс Байомед Са
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х'Юмабс Байомед Са, Хьюмабс Байомед Са filed Critical Х'Юмабс Байомед Са
Publication of UA126381C2 publication Critical patent/UA126381C2/uk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10RNA viruses
    • C07K16/116Togaviridae (F); Matonaviridae (F); Flaviviridae (F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/524CH2 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/18Togaviridae; Flaviviridae
    • G01N2333/183Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus) or border disease virus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/10Detection of antigens from microorganism in sample from host
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
UAA201901101A 2016-07-13 2017-07-12 Нові антитіла, які специфічно зв'язуються з епітопами вірусу зіка, та їх застосування UA126381C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2016/066684 WO2018010789A1 (en) 2016-07-13 2016-07-13 Novel antibodies specifically binding to zika virus epitopes and uses thereof
PCT/EP2017/067581 WO2018011283A1 (en) 2016-07-13 2017-07-12 Novel antibodies specifically binding to zika virus epitopes and uses thereof

Publications (1)

Publication Number Publication Date
UA126381C2 true UA126381C2 (uk) 2022-09-28

Family

ID=56413654

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201901101A UA126381C2 (uk) 2016-07-13 2017-07-12 Нові антитіла, які специфічно зв'язуються з епітопами вірусу зіка, та їх застосування

Country Status (31)

Country Link
US (3) US11117954B2 (https=)
EP (2) EP3484915B1 (https=)
JP (2) JP7252888B2 (https=)
KR (1) KR102595764B1 (https=)
CN (2) CN109563157B (https=)
AU (1) AU2017297757B2 (https=)
BR (1) BR112018074456A2 (https=)
CA (1) CA3024374A1 (https=)
CL (2) CL2019000067A1 (https=)
CO (1) CO2019001111A2 (https=)
CR (1) CR20190066A (https=)
DK (1) DK3484915T5 (https=)
DO (2) DOP2019000006A (https=)
EA (1) EA201990243A1 (https=)
EC (1) ECSP19009170A (https=)
ES (1) ES2959883T3 (https=)
FI (1) FI3484915T3 (https=)
HR (1) HRP20231196T1 (https=)
HU (1) HUE063272T2 (https=)
IL (1) IL262710B2 (https=)
LT (1) LT3484915T (https=)
MX (1) MX2019000526A (https=)
MY (1) MY190553A (https=)
PE (1) PE20190398A1 (https=)
PH (1) PH12018502348B1 (https=)
PL (1) PL3484915T3 (https=)
SG (1) SG11201809879WA (https=)
SI (1) SI3484915T1 (https=)
UA (1) UA126381C2 (https=)
WO (2) WO2018010789A1 (https=)
ZA (1) ZA201807467B (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6998935B2 (ja) 2016-07-13 2022-01-18 エボニック オペレーションズ ゲーエムベーハー 溶解された脂質含有バイオマスから脂質を分離する方法
SG10201912925SA (en) 2016-10-13 2020-02-27 Massachusetts Inst Technology Antibodies that bind zika virus envelope protein and uses thereof
WO2019042555A1 (en) 2017-08-31 2019-03-07 Humabs Biomed Sa MULTISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO ZIKA VIRUS EPITOPES AND USES THEREOF
EP3527664A1 (en) 2018-02-15 2019-08-21 Evonik Degussa GmbH Method of isolating lipids from a lipids containing biomass
JP2019152666A (ja) * 2018-03-02 2019-09-12 富士レビオ株式会社 ジカウイルスを検出する方法及びキット
WO2019209974A2 (en) 2018-04-24 2019-10-31 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Potent zika virus-specific and cross-neutralizing monoclonal antibodies to zika and dengue viruses following zikv infection or vaccination
WO2019219396A1 (en) 2018-05-15 2019-11-21 Evonik Operations Gmbh Method of isolating lipids from a lysed lipids containing biomass by emulsion inversion
EP3794097B1 (en) 2018-05-15 2024-10-23 Evonik Operations GmbH Method of isolating lipids from a lipids containing biomass with aid of hydrophobic silica
WO2020061159A1 (en) * 2018-09-20 2020-03-26 Vanderbilt University Human antibodies to zika virus
WO2020078568A1 (en) 2018-10-19 2020-04-23 Humabs Biomed Sa Antibodies and methods for treatment of lyssavirus infection
WO2020092564A1 (en) * 2018-10-31 2020-05-07 Icahn School Of Medicine At Mount Sinai Human antibodies targeting zika virus ns1, ns1 polypeptides and uses thereof
WO2020106358A1 (en) 2018-11-20 2020-05-28 Takeda Vaccines, Inc. Novel anti-zika virus antibodies and uses thereof
WO2020245663A1 (en) * 2019-06-01 2020-12-10 Institut Pasteur Nanobody-based ns1 assay for the specific diagnosis of acute zika virus infection
WO2021050989A1 (en) * 2019-09-13 2021-03-18 Duke University Zika antibodies and their use
JP7725465B2 (ja) * 2019-11-07 2025-08-19 中国科学院微生物研究所 ジカ・デングワクチン及びその使用
KR20220103761A (ko) * 2019-11-19 2022-07-22 벤더르빌트 유니버시티 지카 바이러스를 중화하는 인간 항체 및 이의 사용 방법
CN111138534B (zh) * 2019-12-31 2021-09-28 武汉班科生物技术股份有限公司 寨卡病毒囊膜蛋白的鼠源单克隆抗体
CN111100201B (zh) * 2019-12-31 2021-09-28 武汉班科生物技术股份有限公司 针对寨卡病毒囊膜蛋白的鼠源单克隆抗体
JP7471555B2 (ja) * 2020-02-20 2024-04-22 国立感染症研究所長 フラビウイルス交差中和抗体及び医薬組成物
JP2023527169A (ja) 2020-05-20 2023-06-27 タケダ ワクチン,インコーポレイテッド 抗原の効力を決定するための方法
JP2023526493A (ja) 2020-05-20 2023-06-21 タケダ ワクチン,インコーポレイテッド ジカウイルス特異的抗体の検出方法
WO2021236225A1 (en) 2020-05-20 2021-11-25 Takeda Vaccines, Inc. Method for detection of zika virus specific antibodies
CN115697392B (zh) * 2020-06-28 2026-03-13 神州细胞工程有限公司 一种降低病毒ade效应的方法
EP4313102A4 (en) * 2021-04-01 2025-02-26 A2 Biotherapeutics, Inc. POLYPEPTIDES TARGETING HLA-A*11 AND METHODS OF USE THEREOF
CN112921124B (zh) * 2021-04-08 2021-09-28 广东创晟控股集团有限公司 一种快速检测病毒的试剂盒
WO2024211789A1 (en) * 2023-04-07 2024-10-10 Fred Hutchinson Cancer Center Cross-flavivirus binding domains and uses thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3766162A (en) 1971-08-24 1973-10-16 Hoffmann La Roche Barbituric acid antigens and antibodies specific therefor
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4233402A (en) 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
JPS5896026A (ja) 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
EP0098110B1 (en) 1982-06-24 1989-10-18 NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD Long-acting composition
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4831175A (en) 1986-09-05 1989-05-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
US5595721A (en) 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
US20020102208A1 (en) 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
MY133346A (en) 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
AU2003263853A1 (en) * 2002-08-16 2004-03-03 Board Of Regents The University Of Texas System Compositions and methods related to flavivirus envelope protein domain iii antigens
WO2004076677A2 (en) 2003-02-26 2004-09-10 Institute For Research In Biomedicine Monoclonal antibody production by ebv transformation of b cells
CA2529945A1 (en) 2003-06-27 2005-01-06 Biogen Idec Ma Inc. Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
MX2009012343A (es) 2007-05-14 2010-02-10 Biogen Idec Inc Regiones fc (sc fc) de cadena sencilla, polipeptidos de enlace que comprenden las mismas, y metodos relacionados con ello.
BRPI0914092B1 (pt) 2008-10-22 2021-08-31 Institute For Research In Biomedicine Método de produção de um anticorpo a partir de células plasmáticas, método de produção de um anticorpo monoclonal a partir de células plasmáticas e método de produção de um anticorpo ou de um fragmento de anticorpo
MX367668B (es) * 2013-03-15 2019-08-30 Dana Farber Cancer Inst Inc Anticuerpos neutralizadores de flavivirus y métodos de uso de los mismos.
AU2017230112A1 (en) 2016-03-11 2018-10-04 The Johns Hopkins University Live attenuated Zika virus vaccine
WO2017181098A2 (en) * 2016-04-15 2017-10-19 Visterra, Inc. Antibody molecules to zika virus and uses thereof
TW201815821A (zh) 2016-07-18 2018-05-01 美商再生元醫藥公司 抗茲卡病毒抗體及使用方法
KR102717819B1 (ko) 2017-07-28 2024-10-14 다케다 야쿠힌 고교 가부시키가이샤 Tyk2 억제제 및 이의 용도

Also Published As

Publication number Publication date
SI3484915T1 (sl) 2024-02-29
KR102595764B1 (ko) 2023-10-30
US11912757B2 (en) 2024-02-27
MX2019000526A (es) 2019-05-02
US20210363227A1 (en) 2021-11-25
KR20190027382A (ko) 2019-03-14
CR20190066A (es) 2019-09-10
PL3484915T3 (pl) 2024-03-25
DOP2019000006A (es) 2019-03-31
PH12018502348B1 (en) 2024-02-28
CL2021002994A1 (es) 2022-09-09
EP4342911A1 (en) 2024-03-27
US20190256582A1 (en) 2019-08-22
PH12018502348A1 (en) 2019-03-25
JP2019533425A (ja) 2019-11-21
WO2018011283A1 (en) 2018-01-18
PE20190398A1 (es) 2019-03-13
LT3484915T (lt) 2023-10-10
CN109563157A (zh) 2019-04-02
FI3484915T3 (fi) 2023-11-15
EP3484915B1 (en) 2023-08-16
DK3484915T5 (da) 2024-09-02
JP7252888B2 (ja) 2023-04-05
IL262710A (en) 2018-12-31
CL2019000067A1 (es) 2019-07-26
CO2019001111A2 (es) 2019-08-20
EP3484915A1 (en) 2019-05-22
DOP2021000026A (es) 2021-07-30
EA201990243A1 (ru) 2019-07-31
ZA201807467B (en) 2024-04-24
DK3484915T3 (da) 2023-10-09
JP2023062036A (ja) 2023-05-02
US20210355198A1 (en) 2021-11-18
AU2017297757B2 (en) 2024-06-13
IL262710B1 (en) 2024-01-01
ECSP19009170A (es) 2019-02-28
WO2018010789A1 (en) 2018-01-18
US11117954B2 (en) 2021-09-14
SG11201809879WA (en) 2018-12-28
IL262710B2 (en) 2024-05-01
BR112018074456A2 (pt) 2019-03-19
CN116199775A (zh) 2023-06-02
CA3024374A1 (en) 2018-01-18
ES2959883T3 (es) 2024-02-28
AU2017297757A1 (en) 2018-11-22
MY190553A (en) 2022-04-27
CN109563157B (zh) 2023-01-17
HUE063272T2 (hu) 2024-01-28
HRP20231196T1 (hr) 2024-01-19

Similar Documents

Publication Publication Date Title
UA126381C2 (uk) Нові антитіла, які специфічно зв'язуються з епітопами вірусу зіка, та їх застосування
CN102164613B (zh) 中和抗甲型流感病毒抗体及其用途
CN102272155B (zh) 登革热病毒中和抗体及其用途
CN105050621B (zh) 防止和治疗多发性硬化症的方法
KR101514682B1 (ko) 인간 b 세포에서 생산된 인플루엔자 a 바이러스 중화 활성을 가지는 결합 분자
KR20200042499A (ko) 지카 바이러스 에피토프에 특이적으로 결합하는 다중특이적 항체 및 이의 용도
TWI854285B (zh) 抗體介導屈公(chikungunya)病毒中和
EA038301B1 (ru) Антитела, которые эффективно нейтрализуют вирус гепатита в, и их применение
EA030319B1 (ru) Антитела, нейтрализующие rsv, mpv и pvm, и их применения
WO2018022786A1 (en) Antibodies to zika virus and methods of use thereof
US12534517B2 (en) Highly specific zika neutralizing human antibodies
Acciani et al. Uncovering the features of Measles-targeting human antibodies elicited by the MMR vaccine
US20260078170A1 (en) Pan-Neutralizing SARS-CoV-2 mAb Composition and Methods of Treatment Thereof
Choudhary et al. Broad-Spectrum Heavily Mutated Monoclonal Antibody Isolated from COVID-19 Convalescent Vaccinee with Capacity to Neutralize SARS-CoV2 Variants Ranging from B. 1 to BQ. 1.1.
EA046175B1 (ru) Выделенное антитело или его антигенсвязывающий фрагмент, которые специфически связываются с эпитопом вируса зика, их получение и применения
EA043940B1 (ru) Мультиспецифические антитела, специфичные в отношении эпитопов вируса зика, и их применение
HK40002097A (en) Novel antibodies specifically binding to zika virus epitopes and uses thereof
HK40002097B (en) Novel antibodies specifically binding to zika virus epitopes and uses thereof
HK40006233B (en) Novel antibodies specifically binding to zika virus epitopes and uses thereof
BR122024006890A2 (pt) Anticorpo isolado, ou um fragmento de ligação ao antígeno do mesmo, molécula de ácido nucleico, vetor, célula, composição farmacêutica, uso dos mesmos, kit de partes, bem como ensaio de bloqueio de ligação para diagóstico in vitro de infecção por zika vírus