UA115342C2 - Фармацевтична композиція, що містить n-[5-[2-(3,5-диметоксифеніл)етил]-2h-піразол-3-іл]-4-[(3r,5s)-3,5-диметилпіперазин-1-іл]бензамід - Google Patents
Фармацевтична композиція, що містить n-[5-[2-(3,5-диметоксифеніл)етил]-2h-піразол-3-іл]-4-[(3r,5s)-3,5-диметилпіперазин-1-іл]бензамідInfo
- Publication number
- UA115342C2 UA115342C2 UAA201506048A UAA201506048A UA115342C2 UA 115342 C2 UA115342 C2 UA 115342C2 UA A201506048 A UAA201506048 A UA A201506048A UA A201506048 A UAA201506048 A UA A201506048A UA 115342 C2 UA115342 C2 UA 115342C2
- Authority
- UA
- Ukraine
- Prior art keywords
- dimethylpiperazin
- dimethoxyphenyl
- pyrazol
- benzamide
- ethyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- VRQMAABPASPXMW-HDICACEKSA-N AZD4547 Chemical compound COC1=CC(OC)=CC(CCC=2NN=C(NC(=O)C=3C=CC(=CC=3)N3C[C@@H](C)N[C@@H](C)C3)C=2)=C1 VRQMAABPASPXMW-HDICACEKSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Винаходом передбачено фармацевтичні композиції, що містять, як тут визначено, сполуку Формули (І) та певну кількість лужної шипучої речовини, достатню для забезпечення задовільного розчинення in vitro; та додатково містять один або декілька фармацевтично прийнятних інгредієнтів; та способи їх отримання.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261740520P | 2012-12-21 | 2012-12-21 | |
PCT/GB2013/053356 WO2014096828A1 (en) | 2012-12-21 | 2013-12-19 | Pharmaceutical formulation of n- [5- [2-(3,5-dimethoxyphenyl) ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl] benzamide |
Publications (1)
Publication Number | Publication Date |
---|---|
UA115342C2 true UA115342C2 (uk) | 2017-10-25 |
Family
ID=49998566
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201506048A UA115342C2 (uk) | 2012-12-21 | 2013-12-19 | Фармацевтична композиція, що містить n-[5-[2-(3,5-диметоксифеніл)етил]-2h-піразол-3-іл]-4-[(3r,5s)-3,5-диметилпіперазин-1-іл]бензамід |
Country Status (26)
Country | Link |
---|---|
US (2) | US20140179712A1 (uk) |
EP (1) | EP2934494B1 (uk) |
JP (1) | JP6328138B2 (uk) |
KR (1) | KR20150096787A (uk) |
CN (1) | CN104853750B (uk) |
AR (1) | AR094203A1 (uk) |
AU (1) | AU2013366023B2 (uk) |
BR (1) | BR112015014200A2 (uk) |
CA (1) | CA2893480C (uk) |
CL (1) | CL2015001786A1 (uk) |
CR (1) | CR20150320A (uk) |
DO (1) | DOP2015000127A (uk) |
ES (1) | ES2742400T3 (uk) |
HK (1) | HK1212229A1 (uk) |
IL (1) | IL239521A0 (uk) |
MX (1) | MX368670B (uk) |
NI (1) | NI201500087A (uk) |
PE (1) | PE20151418A1 (uk) |
PH (1) | PH12015501389A1 (uk) |
RU (1) | RU2674978C2 (uk) |
SG (1) | SG11201504769WA (uk) |
TW (1) | TWI651085B (uk) |
UA (1) | UA115342C2 (uk) |
UY (1) | UY35244A (uk) |
WO (1) | WO2014096828A1 (uk) |
ZA (1) | ZA201505197B (uk) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140179712A1 (en) | 2012-12-21 | 2014-06-26 | Astrazeneca Ab | Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide |
WO2024031226A1 (zh) * | 2022-08-08 | 2024-02-15 | 无锡和誉生物医药科技有限公司 | Fgfr抑制剂的药物组合物、多晶型物及其在药学上的应用 |
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-
2013
- 2013-12-17 US US14/108,595 patent/US20140179712A1/en not_active Abandoned
- 2013-12-19 EP EP13821906.8A patent/EP2934494B1/en active Active
- 2013-12-19 MX MX2015008067A patent/MX368670B/es active IP Right Grant
- 2013-12-19 AU AU2013366023A patent/AU2013366023B2/en active Active
- 2013-12-19 ES ES13821906T patent/ES2742400T3/es active Active
- 2013-12-19 KR KR1020157019620A patent/KR20150096787A/ko not_active Application Discontinuation
- 2013-12-19 JP JP2015548757A patent/JP6328138B2/ja active Active
- 2013-12-19 SG SG11201504769WA patent/SG11201504769WA/en unknown
- 2013-12-19 BR BR112015014200A patent/BR112015014200A2/pt not_active IP Right Cessation
- 2013-12-19 CA CA2893480A patent/CA2893480C/en active Active
- 2013-12-19 AR ARP130104937A patent/AR094203A1/es unknown
- 2013-12-19 UA UAA201506048A patent/UA115342C2/uk unknown
- 2013-12-19 WO PCT/GB2013/053356 patent/WO2014096828A1/en active Application Filing
- 2013-12-19 PE PE2015001038A patent/PE20151418A1/es not_active Application Discontinuation
- 2013-12-19 CN CN201380065855.6A patent/CN104853750B/zh active Active
- 2013-12-19 RU RU2015126345A patent/RU2674978C2/ru active
- 2013-12-20 TW TW102147616A patent/TWI651085B/zh active
- 2013-12-23 UY UY0001035244A patent/UY35244A/es not_active Application Discontinuation
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2015
- 2015-05-27 DO DO2015000127A patent/DOP2015000127A/es unknown
- 2015-06-17 CR CR20150320A patent/CR20150320A/es unknown
- 2015-06-17 PH PH12015501389A patent/PH12015501389A1/en unknown
- 2015-06-18 IL IL239521A patent/IL239521A0/en unknown
- 2015-06-18 NI NI201500087A patent/NI201500087A/es unknown
- 2015-06-19 CL CL2015001786A patent/CL2015001786A1/es unknown
- 2015-07-20 ZA ZA2015/05197A patent/ZA201505197B/en unknown
-
2016
- 2016-01-12 HK HK16100256.1A patent/HK1212229A1/xx unknown
- 2016-06-15 US US15/183,088 patent/US10420764B2/en active Active
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