MX368670B - Formulación farmacéutica de n-[5-[2-(3,5-dimetoxifenil)etil]-2h-pi razol-3-il]-4-[ (3r,5s)-3,5-dimetilpiperazin-1-il] benzamida. - Google Patents

Formulación farmacéutica de n-[5-[2-(3,5-dimetoxifenil)etil]-2h-pi razol-3-il]-4-[ (3r,5s)-3,5-dimetilpiperazin-1-il] benzamida.

Info

Publication number
MX368670B
MX368670B MX2015008067A MX2015008067A MX368670B MX 368670 B MX368670 B MX 368670B MX 2015008067 A MX2015008067 A MX 2015008067A MX 2015008067 A MX2015008067 A MX 2015008067A MX 368670 B MX368670 B MX 368670B
Authority
MX
Mexico
Prior art keywords
dimethylpiperazin
dimethoxyphenyl
pyrazol
benzamide
ethyl
Prior art date
Application number
MX2015008067A
Other languages
English (en)
Other versions
MX2015008067A (es
Inventor
Alan Weldon Baker Noel
Mistry Alpesh
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49998566&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX368670(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2015008067A publication Critical patent/MX2015008067A/es
Publication of MX368670B publication Critical patent/MX368670B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporcionan composiciones farmacéuticas que comprenden un compuesto de Fórmula (I), según se define en la presente, y una cantidad de un agente efervescente alcalino que sea suficiente para proporcionar una disolución satisfactoria in vitro; y que comprenden además uno o más ingredientes farmacéuticamente aceptables; y procesos para obtenerlas.
MX2015008067A 2012-12-21 2013-12-19 Formulación farmacéutica de n-[5-[2-(3,5-dimetoxifenil)etil]-2h-pi razol-3-il]-4-[ (3r,5s)-3,5-dimetilpiperazin-1-il] benzamida. MX368670B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261740520P 2012-12-21 2012-12-21
PCT/GB2013/053356 WO2014096828A1 (en) 2012-12-21 2013-12-19 Pharmaceutical formulation of n- [5- [2-(3,5-dimethoxyphenyl) ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl] benzamide

Publications (2)

Publication Number Publication Date
MX2015008067A MX2015008067A (es) 2016-04-25
MX368670B true MX368670B (es) 2019-10-10

Family

ID=49998566

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015008067A MX368670B (es) 2012-12-21 2013-12-19 Formulación farmacéutica de n-[5-[2-(3,5-dimetoxifenil)etil]-2h-pi razol-3-il]-4-[ (3r,5s)-3,5-dimetilpiperazin-1-il] benzamida.

Country Status (26)

Country Link
US (2) US20140179712A1 (es)
EP (1) EP2934494B1 (es)
JP (1) JP6328138B2 (es)
KR (1) KR20150096787A (es)
CN (1) CN104853750B (es)
AR (1) AR094203A1 (es)
AU (1) AU2013366023B2 (es)
BR (1) BR112015014200A2 (es)
CA (1) CA2893480C (es)
CL (1) CL2015001786A1 (es)
CR (1) CR20150320A (es)
DO (1) DOP2015000127A (es)
ES (1) ES2742400T3 (es)
HK (1) HK1212229A1 (es)
IL (1) IL239521A0 (es)
MX (1) MX368670B (es)
NI (1) NI201500087A (es)
PE (1) PE20151418A1 (es)
PH (1) PH12015501389A1 (es)
RU (1) RU2674978C2 (es)
SG (1) SG11201504769WA (es)
TW (1) TWI651085B (es)
UA (1) UA115342C2 (es)
UY (1) UY35244A (es)
WO (1) WO2014096828A1 (es)
ZA (1) ZA201505197B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140179712A1 (en) 2012-12-21 2014-06-26 Astrazeneca Ab Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide
WO2024031226A1 (zh) * 2022-08-08 2024-02-15 无锡和誉生物医药科技有限公司 Fgfr抑制剂的药物组合物、多晶型物及其在药学上的应用

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Also Published As

Publication number Publication date
CA2893480C (en) 2021-01-12
RU2674978C2 (ru) 2018-12-14
US20170119759A1 (en) 2017-05-04
AU2013366023B2 (en) 2016-10-27
CR20150320A (es) 2015-09-11
EP2934494B1 (en) 2019-06-12
CN104853750A (zh) 2015-08-19
WO2014096828A1 (en) 2014-06-26
HK1212229A1 (en) 2016-06-10
TWI651085B (zh) 2019-02-21
UA115342C2 (uk) 2017-10-25
EP2934494A1 (en) 2015-10-28
CN104853750B (zh) 2018-06-26
BR112015014200A2 (pt) 2017-07-11
NI201500087A (es) 2016-02-16
CA2893480A1 (en) 2014-06-26
ES2742400T3 (es) 2020-02-14
DOP2015000127A (es) 2015-07-31
RU2015126345A (ru) 2017-01-30
SG11201504769WA (en) 2015-07-30
IL239521A0 (en) 2015-08-31
KR20150096787A (ko) 2015-08-25
CL2015001786A1 (es) 2015-08-14
PH12015501389A1 (en) 2015-09-02
UY35244A (es) 2014-01-31
TW201431553A (zh) 2014-08-16
JP2016503782A (ja) 2016-02-08
AU2013366023A1 (en) 2015-06-18
AR094203A1 (es) 2015-07-15
ZA201505197B (en) 2017-07-26
PE20151418A1 (es) 2015-10-21
US20140179712A1 (en) 2014-06-26
US10420764B2 (en) 2019-09-24
JP6328138B2 (ja) 2018-05-23
MX2015008067A (es) 2016-04-25

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