CL2015001786A1 - Composicion farmaceutica que comprende n-[5-[2-(3,5-dimetoxifenil)etil]-2h-pirazol-3-il]-4-[(3r,5s)-3,5-dimetilpiperazin-1-il]benzamida, un agente efervescente alcalino y un lubricante alternativo; formulacion de granulacion por via humeda; formulacion de compactacion con rodillo; y formulacion por compactacion directa. - Google Patents
Composicion farmaceutica que comprende n-[5-[2-(3,5-dimetoxifenil)etil]-2h-pirazol-3-il]-4-[(3r,5s)-3,5-dimetilpiperazin-1-il]benzamida, un agente efervescente alcalino y un lubricante alternativo; formulacion de granulacion por via humeda; formulacion de compactacion con rodillo; y formulacion por compactacion directa.Info
- Publication number
- CL2015001786A1 CL2015001786A1 CL2015001786A CL2015001786A CL2015001786A1 CL 2015001786 A1 CL2015001786 A1 CL 2015001786A1 CL 2015001786 A CL2015001786 A CL 2015001786A CL 2015001786 A CL2015001786 A CL 2015001786A CL 2015001786 A1 CL2015001786 A1 CL 2015001786A1
- Authority
- CL
- Chile
- Prior art keywords
- formulation
- compaction
- dimethylpiperazin
- dimethoxyphenyl
- pyrazol
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title 3
- 239000000203 mixture Substances 0.000 title 3
- VRQMAABPASPXMW-HDICACEKSA-N AZD4547 Chemical compound COC1=CC(OC)=CC(CCC=2NN=C(NC(=O)C=3C=CC(=CC=3)N3C[C@@H](C)N[C@@H](C)C3)C=2)=C1 VRQMAABPASPXMW-HDICACEKSA-N 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 238000005056 compaction Methods 0.000 title 1
- 239000000314 lubricant Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000009490 roller compaction Methods 0.000 title 1
- 238000005550 wet granulation Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261740520P | 2012-12-21 | 2012-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2015001786A1 true CL2015001786A1 (es) | 2015-08-14 |
Family
ID=49998566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2015001786A CL2015001786A1 (es) | 2012-12-21 | 2015-06-19 | Composicion farmaceutica que comprende n-[5-[2-(3,5-dimetoxifenil)etil]-2h-pirazol-3-il]-4-[(3r,5s)-3,5-dimetilpiperazin-1-il]benzamida, un agente efervescente alcalino y un lubricante alternativo; formulacion de granulacion por via humeda; formulacion de compactacion con rodillo; y formulacion por compactacion directa. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US20140179712A1 (es) |
| EP (1) | EP2934494B1 (es) |
| JP (1) | JP6328138B2 (es) |
| KR (1) | KR20150096787A (es) |
| CN (1) | CN104853750B (es) |
| AR (1) | AR094203A1 (es) |
| AU (1) | AU2013366023B2 (es) |
| BR (1) | BR112015014200A2 (es) |
| CA (1) | CA2893480C (es) |
| CL (1) | CL2015001786A1 (es) |
| CR (1) | CR20150320A (es) |
| DO (1) | DOP2015000127A (es) |
| ES (1) | ES2742400T3 (es) |
| HK (1) | HK1212229A1 (es) |
| IL (1) | IL239521A0 (es) |
| MX (1) | MX368670B (es) |
| NI (1) | NI201500087A (es) |
| PE (1) | PE20151418A1 (es) |
| PH (1) | PH12015501389A1 (es) |
| RU (1) | RU2674978C2 (es) |
| SG (1) | SG11201504769WA (es) |
| TW (1) | TWI651085B (es) |
| UA (1) | UA115342C2 (es) |
| UY (1) | UY35244A (es) |
| WO (1) | WO2014096828A1 (es) |
| ZA (1) | ZA201505197B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140179712A1 (en) | 2012-12-21 | 2014-06-26 | Astrazeneca Ab | Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide |
| WO2024031226A1 (zh) * | 2022-08-08 | 2024-02-15 | 无锡和誉生物医药科技有限公司 | Fgfr抑制剂的药物组合物、多晶型物及其在药学上的应用 |
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-
2013
- 2013-12-17 US US14/108,595 patent/US20140179712A1/en not_active Abandoned
- 2013-12-19 EP EP13821906.8A patent/EP2934494B1/en active Active
- 2013-12-19 MX MX2015008067A patent/MX368670B/es active IP Right Grant
- 2013-12-19 AU AU2013366023A patent/AU2013366023B2/en active Active
- 2013-12-19 ES ES13821906T patent/ES2742400T3/es active Active
- 2013-12-19 KR KR1020157019620A patent/KR20150096787A/ko not_active Application Discontinuation
- 2013-12-19 JP JP2015548757A patent/JP6328138B2/ja active Active
- 2013-12-19 SG SG11201504769WA patent/SG11201504769WA/en unknown
- 2013-12-19 BR BR112015014200A patent/BR112015014200A2/pt not_active IP Right Cessation
- 2013-12-19 CA CA2893480A patent/CA2893480C/en active Active
- 2013-12-19 AR ARP130104937A patent/AR094203A1/es unknown
- 2013-12-19 UA UAA201506048A patent/UA115342C2/uk unknown
- 2013-12-19 WO PCT/GB2013/053356 patent/WO2014096828A1/en active Application Filing
- 2013-12-19 PE PE2015001038A patent/PE20151418A1/es not_active Application Discontinuation
- 2013-12-19 CN CN201380065855.6A patent/CN104853750B/zh active Active
- 2013-12-19 RU RU2015126345A patent/RU2674978C2/ru active
- 2013-12-20 TW TW102147616A patent/TWI651085B/zh active
- 2013-12-23 UY UY0001035244A patent/UY35244A/es not_active Application Discontinuation
-
2015
- 2015-05-27 DO DO2015000127A patent/DOP2015000127A/es unknown
- 2015-06-17 CR CR20150320A patent/CR20150320A/es unknown
- 2015-06-17 PH PH12015501389A patent/PH12015501389A1/en unknown
- 2015-06-18 IL IL239521A patent/IL239521A0/en unknown
- 2015-06-18 NI NI201500087A patent/NI201500087A/es unknown
- 2015-06-19 CL CL2015001786A patent/CL2015001786A1/es unknown
- 2015-07-20 ZA ZA2015/05197A patent/ZA201505197B/en unknown
-
2016
- 2016-01-12 HK HK16100256.1A patent/HK1212229A1/xx unknown
- 2016-06-15 US US15/183,088 patent/US10420764B2/en active Active
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