UA114593C2 - Спосіб одержання метаксалону - Google Patents
Спосіб одержання метаксалонуInfo
- Publication number
- UA114593C2 UA114593C2 UAA201305952A UAA201305952A UA114593C2 UA 114593 C2 UA114593 C2 UA 114593C2 UA A201305952 A UAA201305952 A UA A201305952A UA A201305952 A UAA201305952 A UA A201305952A UA 114593 C2 UA114593 C2 UA 114593C2
- Authority
- UA
- Ukraine
- Prior art keywords
- solvent
- tgic
- metaxalone
- reaction
- dielectric constant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
Даний винахід стосується способу одержання метаксалону, що включає реакцію тригліцидилу ізоціанурату (ТГІЦ) з м-ксиленолом, де зазначену реакцію проводять у суміші розчинників, що включає апротонний полярний розчинник з діелектричною проникністю, більшою ніж або рівною 30, та щонайменше один інший розчинник, вибраний з групи, що включає аполярні розчинники та апротонні полярні розчинники з діелектричною проникністю нижче 30, де зазначена суміш розчинників включає від 5 до 40 мас. % зазначеного першого розчинника та від 95 до 60 мас. % зазначеного другого розчинника, додаючи ТГІЦ при температурі між 30 °C та 50 °C, та після додавання ТГІЦ підвищуючи температуру реакційного розчину до значення від 80 °C до 180 °C впродовж часу від 120 до 180 хвилин при швидкості зростання не більше ніж 1,25 °C на хвилину. Винахід також стосується метаксалону із зниженим вмістом домішок, отримуваних з обернених реакцій та/або бічних реакцій способу виробництва.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11152849 | 2011-02-01 | ||
| PCT/EP2012/050609 WO2012104139A1 (en) | 2011-02-01 | 2012-01-17 | Method of preparation of metaxalone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA114593C2 true UA114593C2 (uk) | 2017-07-10 |
Family
ID=44115617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201305952A UA114593C2 (uk) | 2011-02-01 | 2012-01-17 | Спосіб одержання метаксалону |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US20130261160A1 (uk) |
| EP (1) | EP2670737B1 (uk) |
| JP (1) | JP2014503564A (uk) |
| KR (1) | KR101907599B1 (uk) |
| CN (1) | CN103298797B (uk) |
| AR (1) | AR084946A1 (uk) |
| AU (1) | AU2012213666B2 (uk) |
| BR (1) | BR112013013134B1 (uk) |
| CA (1) | CA2817462C (uk) |
| CY (1) | CY1118348T1 (uk) |
| DK (1) | DK2670737T3 (uk) |
| EA (1) | EA024417B1 (uk) |
| ES (1) | ES2605425T3 (uk) |
| GE (1) | GEP20156352B (uk) |
| HK (1) | HK1191006A1 (uk) |
| HR (1) | HRP20161660T1 (uk) |
| HU (1) | HUE029476T2 (uk) |
| IL (1) | IL226329A (uk) |
| LT (1) | LT2670737T (uk) |
| MX (1) | MX339346B (uk) |
| PL (1) | PL2670737T3 (uk) |
| PT (1) | PT2670737T (uk) |
| SG (2) | SG192090A1 (uk) |
| SI (1) | SI2670737T1 (uk) |
| SM (1) | SMT201600415B (uk) |
| UA (1) | UA114593C2 (uk) |
| WO (1) | WO2012104139A1 (uk) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102181881B1 (ko) | 2014-11-21 | 2020-11-24 | 삼성디스플레이 주식회사 | 비전 검사 장치 및 이의 감마 및 얼룩 보정 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1545951A1 (de) * | 1965-07-24 | 1970-05-14 | Henkel & Cie Gmbh | Verfahren zur Herstellung von substituierten Oxazolidonen |
| FR1487641A (fr) | 1965-07-24 | 1967-07-07 | Henkel & Cie Gmbh | Procédé de préparation d'oxazolidones substituées |
| WO2003061552A2 (en) * | 2002-01-14 | 2003-07-31 | Sun Pharmaceutical Industries Limited | Novel process for the preparation of substantially pure 5-(3,5-dimethylphenoxy)methyl-2-oxazolidinone |
| US6562980B1 (en) * | 2002-08-19 | 2003-05-13 | Yung Shin Pharma Ind. Co., Ltd. | Method for producing 5-aryloxymethyl-2-oxazolidinones |
| WO2007074477A2 (en) * | 2005-12-29 | 2007-07-05 | Dabur Pharma Limited | Metaxalone polymorphs |
| WO2008006096A1 (en) | 2006-07-07 | 2008-01-10 | Boehringer Ingelheim Chemicals, Inc. | Metaxalone synthesis |
| CN101921241A (zh) * | 2009-06-12 | 2010-12-22 | 北京京卫燕康药物研究所有限公司 | 具有光学活性的美他沙酮的合成 |
-
2012
- 2012-01-17 EA EA201390787A patent/EA024417B1/ru unknown
- 2012-01-17 SG SG2013055991A patent/SG192090A1/en unknown
- 2012-01-17 PL PL12700288T patent/PL2670737T3/pl unknown
- 2012-01-17 HU HUE12700288A patent/HUE029476T2/en unknown
- 2012-01-17 ES ES12700288.9T patent/ES2605425T3/es active Active
- 2012-01-17 GE GEAP201213202A patent/GEP20156352B/en unknown
- 2012-01-17 DK DK12700288.9T patent/DK2670737T3/en active
- 2012-01-17 SG SG10201600357WA patent/SG10201600357WA/en unknown
- 2012-01-17 UA UAA201305952A patent/UA114593C2/uk unknown
- 2012-01-17 EP EP12700288.9A patent/EP2670737B1/en active Active
- 2012-01-17 AU AU2012213666A patent/AU2012213666B2/en active Active
- 2012-01-17 US US13/990,974 patent/US20130261160A1/en not_active Abandoned
- 2012-01-17 BR BR112013013134-9A patent/BR112013013134B1/pt active IP Right Grant
- 2012-01-17 WO PCT/EP2012/050609 patent/WO2012104139A1/en active Application Filing
- 2012-01-17 PT PT127002889T patent/PT2670737T/pt unknown
- 2012-01-17 SI SI201230789A patent/SI2670737T1/sl unknown
- 2012-01-17 CN CN201280004303.XA patent/CN103298797B/zh active Active
- 2012-01-17 LT LTEP12700288.9T patent/LT2670737T/lt unknown
- 2012-01-17 KR KR1020137016255A patent/KR101907599B1/ko active IP Right Grant
- 2012-01-17 CA CA2817462A patent/CA2817462C/en active Active
- 2012-01-17 MX MX2013008426A patent/MX339346B/es active IP Right Grant
- 2012-01-17 JP JP2013550823A patent/JP2014503564A/ja active Pending
- 2012-01-30 AR ARP120100285A patent/AR084946A1/es active IP Right Grant
-
2013
- 2013-05-13 IL IL226329A patent/IL226329A/en active IP Right Grant
-
2014
- 2014-04-30 HK HK14104176.2A patent/HK1191006A1/zh unknown
-
2015
- 2015-06-17 US US14/742,203 patent/US9416116B2/en active Active
-
2016
- 2016-11-15 SM SM201600415T patent/SMT201600415B/it unknown
- 2016-12-01 CY CY20161101242T patent/CY1118348T1/el unknown
- 2016-12-06 HR HRP20161660TT patent/HRP20161660T1/hr unknown
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