HRP20161660T1 - Postupak za proizvodnju metaksalona - Google Patents
Postupak za proizvodnju metaksalona Download PDFInfo
- Publication number
- HRP20161660T1 HRP20161660T1 HRP20161660TT HRP20161660T HRP20161660T1 HR P20161660 T1 HRP20161660 T1 HR P20161660T1 HR P20161660T T HRP20161660T T HR P20161660TT HR P20161660 T HRP20161660 T HR P20161660T HR P20161660 T1 HRP20161660 T1 HR P20161660T1
- Authority
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- Croatia
- Prior art keywords
- production
- solvent
- reaction solution
- metaxalone
- molar
- Prior art date
Links
- IMWZZHHPURKASS-UHFFFAOYSA-N Metaxalone Chemical compound CC1=CC(C)=CC(OCC2OC(=O)NC2)=C1 IMWZZHHPURKASS-UHFFFAOYSA-N 0.000 title claims 14
- 229960000509 metaxalone Drugs 0.000 title claims 14
- 238000000034 method Methods 0.000 title claims 14
- OUPZKGBUJRBPGC-UHFFFAOYSA-N 1,3,5-tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione Chemical compound O=C1N(CC2OC2)C(=O)N(CC2OC2)C(=O)N1CC1CO1 OUPZKGBUJRBPGC-UHFFFAOYSA-N 0.000 claims 9
- 239000002904 solvent Substances 0.000 claims 9
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 6
- 239000003513 alkali Substances 0.000 claims 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 4
- 239000011877 solvent mixture Substances 0.000 claims 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- 239000003054 catalyst Substances 0.000 claims 3
- 230000007704 transition Effects 0.000 claims 3
- KUFFULVDNCHOFZ-UHFFFAOYSA-N 2,4-xylenol Chemical compound CC1=CC=C(O)C(C)=C1 KUFFULVDNCHOFZ-UHFFFAOYSA-N 0.000 claims 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims 2
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 claims 2
- BGTOWKSIORTVQH-UHFFFAOYSA-N cyclopentanone Chemical compound O=C1CCCC1 BGTOWKSIORTVQH-UHFFFAOYSA-N 0.000 claims 2
- CATSNJVOTSVZJV-UHFFFAOYSA-N heptan-2-one Chemical compound CCCCCC(C)=O CATSNJVOTSVZJV-UHFFFAOYSA-N 0.000 claims 2
- 229940043265 methyl isobutyl ketone Drugs 0.000 claims 2
- XNLICIUVMPYHGG-UHFFFAOYSA-N pentan-2-one Chemical compound CCCC(C)=O XNLICIUVMPYHGG-UHFFFAOYSA-N 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- 239000008096 xylene Substances 0.000 claims 2
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 claims 1
- POEDHWVTLBLWDA-UHFFFAOYSA-N 1-butylindole-2,3-dione Chemical compound C1=CC=C2N(CCCC)C(=O)C(=O)C2=C1 POEDHWVTLBLWDA-UHFFFAOYSA-N 0.000 claims 1
- NVLHGZIXTRYOKT-UHFFFAOYSA-N 1-chloro-2,3-dimethylbenzene Chemical group CC1=CC=CC(Cl)=C1C NVLHGZIXTRYOKT-UHFFFAOYSA-N 0.000 claims 1
- QQZOPKMRPOGIEB-UHFFFAOYSA-N 2-Oxohexane Chemical compound CCCCC(C)=O QQZOPKMRPOGIEB-UHFFFAOYSA-N 0.000 claims 1
- JWUJQDFVADABEY-UHFFFAOYSA-N 2-methyltetrahydrofuran Chemical compound CC1CCCO1 JWUJQDFVADABEY-UHFFFAOYSA-N 0.000 claims 1
- UNDXPKDBFOOQFC-UHFFFAOYSA-N 4-[2-nitro-4-(trifluoromethyl)phenyl]morpholine Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=CC=C1N1CCOCC1 UNDXPKDBFOOQFC-UHFFFAOYSA-N 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 claims 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 150000001342 alkaline earth metals Chemical class 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- POLCUAVZOMRGSN-UHFFFAOYSA-N dipropyl ether Chemical compound CCCOCCC POLCUAVZOMRGSN-UHFFFAOYSA-N 0.000 claims 1
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 claims 1
- 150000004679 hydroxides Chemical class 0.000 claims 1
- AUHZEENZYGFFBQ-UHFFFAOYSA-N mesitylene Substances CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 claims 1
- 125000001827 mesitylenyl group Chemical group [H]C1=C(C(*)=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- -1 phosphonium halide Chemical class 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (12)
1. Postupak za proizvodnju metaksalona, naznačen time, da metaksalon ima sljedeću strukturnu formulu (I):
[image]
gdje postupak obuhvaća reakciju triglicidil-izocijanurata (TGIC) sljedeće formule (III):
[image]
s m-ksilenolom sljedeće formule (V):
[image]
naznačen time, da se navedena reakcija provodi u smjesi otapala koja sadrži prvo otapalo odabrano iz skupine koju čine: N-metilpirolidon, dimetilformamid, dimetilsulfoksid, heksametilfosforamid, dimetilacetamid i acetonitril, te drugo otapalo odabrano iz skupine koju čine: cikloheksan, heptan, benzen, toluen, ksilen, mezitilen, naftalen, klorobenzen, kloroksilen, kloroform, propileter, izopropileter, butileter, pentileter, benziletileter, tetrahidrofuran (THF), 2-metil-tetrahidrofuran, aceton, metiletilketon, metilbutilketon, metilizobutilketon,
2-pentanon, ciklopentanon i 2-heptanon, gdje navedena smjesa otapala sadrži od 5 do 40 masenih % od navedenog prvog otapala i od 95 do 60 masenih % od navedenog drugog otapala, pri čemu se TGIC dodaje na temperaturi između 30°C i 50°C, a
nakon dodavanja TGIC, temperatura reakcijske otopine se podiže na vrijednost između 80°C i 180°C, u vremenskom periodu od 120 do 180 minuta, pri brzini povećanja temperature koja nije veća od 1,25°C po minuti.
2. Postupak za proizvodnju metaksalona prema zahtjevu 1, naznačen time, da je navedeno prvo otapalo odabrano iz skupine koju čine N-metilpirolidon i dimetilformamid.
3. Postupak za proizvodnju metaksalona prema zahtjevu 1, naznačen time, da je navedeno drugo otapalo odabrano iz skupine koju čine toluen i ksilen.
4. Postupak za proizvodnju metaksalona prema zahtjevu 1, naznačen time, da navedeno drugo otapalo je metilizobutilketon.
5. Postupak za proizvodnju metaksalona prema zahtjevu 1, naznačen time, da navedena smjesa otapala sadrži od 10 do 30 masenih % od navedenog prvog otapala i od 90 do 70 masenih % od navedenog drugog otapala.
6. Postupak za proizvodnju metaksalona prema zahtjevu 1, naznačen time, da reakcijska otopina nadalje sadrži organsku ili anorgansku lužinu, poželjno jednu anorgansku lužinu odabranu iz skupine koju čine oksidi ili hidroksidi alkalijskih metala i karbonati alkalijskih ili zemnoalkalijskih metala, te katalizator faznog prijelaza, poželjno halogenid kvaternog amonijaka ili fosfonija.
7. Postupak za proizvodnju metaksalona prema zahtjevu 6, naznačen time, da reakcijska otopina sadrži navedenu organsku ili anorgansku lužinu u količini od 3 do 10 molarnih %, poželjno od 3 do 6 molarnih %, u odnosu na molarnu količinu od TGIC koji je prisutan u navedenoj reakcijskoj otopini.
8. Postupak za proizvodnju metaksalona prema zahtjevu 6, naznačen time, da reakcijska otopina sadrži navedeni katalizator faznog prijelaza u količini od 0,5 do 5 molarnih %, poželjno od 1 do 3 molarnih %, u odnosu na količinu od TGIC koji je prisutan u navedenoj reakcijskoj otopini.
9. Postupak za proizvodnju metaksalona prema zahtjevu 6, naznačen time, da se otopina koja sadrži m-ksilenol, lužinu i katalizator faznog prijelaza otopljene u smjesi otapala, zagrijava na temperaturu između 35°C i 45°C, prije nego što se dodaje TGIC.
10. Postupak za proizvodnju metaksalona prema bilo kojem od prethodnih zahtjeva, naznačen time, da nakon što se doda TGIC, reakcijska otopina se postepeno zagrijava na temperaturu između 80°C i 180°C, u vremenskom periodu od 120 do 180 minuta.
11. Postupak za proizvodnju metaksalona prema bilo kojem od prethodnih zahtjeva, naznačen time, da se reakcijska otopina postepeno zagrijava pri brzini povećanja temperature koja nije veća od 1°C po minuti, poželjno brzina nije veća od 0,75°C po minuti.
12. Postupak za proizvodnju metaksalona prema zahtjevu 11, naznačen time, da se na kraju faze postepenog povećavanja temperature, ponovno dodaje lužina u početnu reakcijsku otopinu, u količini od 3 do 10 molarnih %, poželjno od 5 do 8 molarnih %, u odnosu na molarnu količinu od TGIC koji je prisutan u početnoj reakcijskoj otopini.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11152849 | 2011-02-01 | ||
US201161439127P | 2011-02-03 | 2011-02-03 | |
EP12700288.9A EP2670737B1 (en) | 2011-02-01 | 2012-01-17 | Method of preparation of metaxalone |
PCT/EP2012/050609 WO2012104139A1 (en) | 2011-02-01 | 2012-01-17 | Method of preparation of metaxalone |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20161660T1 true HRP20161660T1 (hr) | 2017-01-13 |
Family
ID=44115617
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20161660TT HRP20161660T1 (hr) | 2011-02-01 | 2016-12-06 | Postupak za proizvodnju metaksalona |
Country Status (27)
Country | Link |
---|---|
US (2) | US20130261160A1 (hr) |
EP (1) | EP2670737B1 (hr) |
JP (1) | JP2014503564A (hr) |
KR (1) | KR101907599B1 (hr) |
CN (1) | CN103298797B (hr) |
AR (1) | AR084946A1 (hr) |
AU (1) | AU2012213666B2 (hr) |
BR (1) | BR112013013134B1 (hr) |
CA (1) | CA2817462C (hr) |
CY (1) | CY1118348T1 (hr) |
DK (1) | DK2670737T3 (hr) |
EA (1) | EA024417B1 (hr) |
ES (1) | ES2605425T3 (hr) |
GE (1) | GEP20156352B (hr) |
HK (1) | HK1191006A1 (hr) |
HR (1) | HRP20161660T1 (hr) |
HU (1) | HUE029476T2 (hr) |
IL (1) | IL226329A (hr) |
LT (1) | LT2670737T (hr) |
MX (1) | MX339346B (hr) |
PL (1) | PL2670737T3 (hr) |
PT (1) | PT2670737T (hr) |
SG (2) | SG192090A1 (hr) |
SI (1) | SI2670737T1 (hr) |
SM (1) | SMT201600415B (hr) |
UA (1) | UA114593C2 (hr) |
WO (1) | WO2012104139A1 (hr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102181881B1 (ko) | 2014-11-21 | 2020-11-24 | 삼성디스플레이 주식회사 | 비전 검사 장치 및 이의 감마 및 얼룩 보정 방법 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1487641A (fr) | 1965-07-24 | 1967-07-07 | Henkel & Cie Gmbh | Procédé de préparation d'oxazolidones substituées |
DE1545951A1 (de) * | 1965-07-24 | 1970-05-14 | Henkel & Cie Gmbh | Verfahren zur Herstellung von substituierten Oxazolidonen |
WO2003061552A2 (en) * | 2002-01-14 | 2003-07-31 | Sun Pharmaceutical Industries Limited | Novel process for the preparation of substantially pure 5-(3,5-dimethylphenoxy)methyl-2-oxazolidinone |
US6562980B1 (en) * | 2002-08-19 | 2003-05-13 | Yung Shin Pharma Ind. Co., Ltd. | Method for producing 5-aryloxymethyl-2-oxazolidinones |
WO2007074477A2 (en) * | 2005-12-29 | 2007-07-05 | Dabur Pharma Limited | Metaxalone polymorphs |
WO2008006096A1 (en) * | 2006-07-07 | 2008-01-10 | Boehringer Ingelheim Chemicals, Inc. | Metaxalone synthesis |
CN101921241A (zh) * | 2009-06-12 | 2010-12-22 | 北京京卫燕康药物研究所有限公司 | 具有光学活性的美他沙酮的合成 |
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2012
- 2012-01-17 JP JP2013550823A patent/JP2014503564A/ja active Pending
- 2012-01-17 CA CA2817462A patent/CA2817462C/en active Active
- 2012-01-17 EA EA201390787A patent/EA024417B1/ru unknown
- 2012-01-17 CN CN201280004303.XA patent/CN103298797B/zh active Active
- 2012-01-17 ES ES12700288.9T patent/ES2605425T3/es active Active
- 2012-01-17 PL PL12700288T patent/PL2670737T3/pl unknown
- 2012-01-17 EP EP12700288.9A patent/EP2670737B1/en active Active
- 2012-01-17 KR KR1020137016255A patent/KR101907599B1/ko active IP Right Grant
- 2012-01-17 PT PT127002889T patent/PT2670737T/pt unknown
- 2012-01-17 HU HUE12700288A patent/HUE029476T2/en unknown
- 2012-01-17 UA UAA201305952A patent/UA114593C2/uk unknown
- 2012-01-17 US US13/990,974 patent/US20130261160A1/en not_active Abandoned
- 2012-01-17 GE GEAP201213202A patent/GEP20156352B/en unknown
- 2012-01-17 MX MX2013008426A patent/MX339346B/es active IP Right Grant
- 2012-01-17 SG SG2013055991A patent/SG192090A1/en unknown
- 2012-01-17 WO PCT/EP2012/050609 patent/WO2012104139A1/en active Application Filing
- 2012-01-17 SI SI201230789A patent/SI2670737T1/sl unknown
- 2012-01-17 AU AU2012213666A patent/AU2012213666B2/en active Active
- 2012-01-17 DK DK12700288.9T patent/DK2670737T3/en active
- 2012-01-17 BR BR112013013134-9A patent/BR112013013134B1/pt active IP Right Grant
- 2012-01-17 LT LTEP12700288.9T patent/LT2670737T/lt unknown
- 2012-01-17 SG SG10201600357WA patent/SG10201600357WA/en unknown
- 2012-01-30 AR ARP120100285A patent/AR084946A1/es active IP Right Grant
-
2013
- 2013-05-13 IL IL226329A patent/IL226329A/en active IP Right Grant
-
2014
- 2014-04-30 HK HK14104176.2A patent/HK1191006A1/zh unknown
-
2015
- 2015-06-17 US US14/742,203 patent/US9416116B2/en active Active
-
2016
- 2016-11-15 SM SM201600415T patent/SMT201600415B/it unknown
- 2016-12-01 CY CY20161101242T patent/CY1118348T1/el unknown
- 2016-12-06 HR HRP20161660TT patent/HRP20161660T1/hr unknown
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