UA107811C2 - Method of receiving 2-[(3,5-difluoro-3'-methoxy-1,1' biphenyl-4-yl)amino]nicotinic acid - Google Patents
Method of receiving 2-[(3,5-difluoro-3'-methoxy-1,1' biphenyl-4-yl)amino]nicotinic acidInfo
- Publication number
- UA107811C2 UA107811C2 UAA201205649A UAA201205649A UA107811C2 UA 107811 C2 UA107811 C2 UA 107811C2 UA A201205649 A UAA201205649 A UA A201205649A UA A201205649 A UAA201205649 A UA A201205649A UA 107811 C2 UA107811 C2 UA 107811C2
- Authority
- UA
- Ukraine
- Prior art keywords
- difluoro
- biphenyl
- methoxy
- amino
- nicotinic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09382212A EP2314577A1 (en) | 2009-10-16 | 2009-10-16 | Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid |
| PCT/EP2010/006283 WO2011045059A1 (en) | 2009-10-16 | 2010-10-14 | Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA107811C2 true UA107811C2 (en) | 2015-02-25 |
Family
ID=41402565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201205649A UA107811C2 (en) | 2009-10-16 | 2010-10-14 | Method of receiving 2-[(3,5-difluoro-3'-methoxy-1,1' biphenyl-4-yl)amino]nicotinic acid |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US8598363B2 (ru) |
| EP (2) | EP2314577A1 (ru) |
| JP (1) | JP5809630B2 (ru) |
| KR (1) | KR101699999B1 (ru) |
| CN (2) | CN102574800B (ru) |
| AU (1) | AU2010306098B2 (ru) |
| BR (1) | BR112012008464B1 (ru) |
| CA (1) | CA2776328C (ru) |
| CL (1) | CL2012000739A1 (ru) |
| CO (1) | CO6430508A2 (ru) |
| CR (1) | CR20120185A (ru) |
| CY (1) | CY1115161T1 (ru) |
| DK (1) | DK2488497T3 (ru) |
| EA (1) | EA022805B1 (ru) |
| ES (1) | ES2467165T3 (ru) |
| HK (1) | HK1168101A1 (ru) |
| HR (1) | HRP20140523T1 (ru) |
| IL (1) | IL218446A (ru) |
| IN (1) | IN2012DN01938A (ru) |
| ME (1) | ME01812B (ru) |
| MX (1) | MX2012004033A (ru) |
| MY (1) | MY160308A (ru) |
| NZ (1) | NZ598429A (ru) |
| PE (1) | PE20121173A1 (ru) |
| PL (1) | PL2488497T3 (ru) |
| PT (1) | PT2488497E (ru) |
| RS (1) | RS53319B (ru) |
| SI (1) | SI2488497T1 (ru) |
| SM (1) | SMT201400064B (ru) |
| UA (1) | UA107811C2 (ru) |
| WO (1) | WO2011045059A1 (ru) |
| ZA (1) | ZA201201563B (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
| UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
| EP2135610A1 (en) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
| EP2239256A1 (en) | 2009-03-13 | 2010-10-13 | Almirall, S.A. | Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ294700B6 (cs) | 1995-06-21 | 2005-02-16 | Sofotec Gmbh & Co. Kg | Pouzdro na farmaceutický prášek pro práškové inhalátory |
| DE19547648A1 (de) | 1995-12-20 | 1997-06-26 | Hoechst Ag | Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate |
| DE19610955A1 (de) | 1996-03-20 | 1997-09-25 | Hoechst Ag | Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid |
| GB9804343D0 (en) | 1998-02-27 | 1998-04-22 | Univ Cardiff | Chemical compounds |
| AU775157B2 (en) | 1999-06-10 | 2004-07-22 | Warner-Lambert Company Llc | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits |
| ATE396719T1 (de) | 2001-04-05 | 2008-06-15 | Aventis Pharma Inc | Verwendung von (z)-2-cyano-3-hydroxy-but-2- ensäure-(4'-trifluoromethylphenyl)-amid zur behandlung der multiplen sklerose |
| WO2002102374A1 (en) | 2001-06-19 | 2002-12-27 | Merck & Co., Inc. | Amine salt of an integrin receptor antagonist |
| DE10129703A1 (de) | 2001-06-22 | 2003-01-02 | Sofotec Gmbh & Co Kg | Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren |
| MXPA04000224A (es) | 2001-07-10 | 2005-07-25 | 4Sc Ag | Novedosos compuestos como agentes antiinflamatorios, inmunomoduladores y antiproliferativos. |
| US7258118B2 (en) | 2002-01-24 | 2007-08-21 | Sofotec Gmbh & Co, Kg | Pharmaceutical powder cartridge, and inhaler equipped with same |
| DE10202940A1 (de) | 2002-01-24 | 2003-07-31 | Sofotec Gmbh & Co Kg | Patrone für einen Pulverinhalator |
| KR20040081201A (ko) * | 2002-02-13 | 2004-09-20 | 글락소 그룹 리미티드 | 항정신병제로서 벤젠술폰아미드 유도체 |
| WO2003089414A1 (en) * | 2002-04-13 | 2003-10-30 | Hanlim Pharmaceutical Co., Ltd. | Amlodipine nicotinate and process for the preparation thereof |
| PE20040844A1 (es) * | 2002-11-26 | 2004-12-30 | Novartis Ag | Acidos fenilaceticos y derivados como inhibidores de la cox-2 |
| US7071355B2 (en) | 2002-12-23 | 2006-07-04 | 4 Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| EP1581478A1 (en) | 2002-12-23 | 2005-10-05 | 4Sc Ag | Dhodh-inhibitors and method for their identification |
| SE0400234D0 (sv) | 2004-02-06 | 2004-02-06 | Active Biotech Ab | New compounds, methods for their preparation and use thereof |
| KR20070044399A (ko) | 2004-05-21 | 2007-04-27 | 유에이비 리서치 파운데이션 | 피리미딘 합성 저해제 관련 조성물 및 방법 |
| WO2006022442A1 (ja) | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| JP2008517059A (ja) | 2004-10-19 | 2008-05-22 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | 炎症性腸疾患を治療するための（ｚ）−２−シアノ−３−ヒドロキシ−ブタ−２−エン酸−（４’−トリフルオロメチルフェニル）−アミドの使用 |
| ES2265276B1 (es) | 2005-05-20 | 2008-02-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
| CN1696100B (zh) * | 2005-06-01 | 2010-11-24 | 黑龙江福和华星制药集团股份有限公司 | 痤疮治疗药阿达帕林的新型简捷合成方法 |
| ES2319596B1 (es) * | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
| ES2366000T3 (es) | 2007-02-06 | 2011-10-14 | Chelsea Therapeutics, Inc. | Nuevos compuestos, métodos para su preparación y uso de los mismos. |
| UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
| EP2135610A1 (en) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
| EP2210615A1 (en) | 2009-01-21 | 2010-07-28 | Almirall, S.A. | Combinations comprising methotrexate and DHODH inhibitors |
| EP2230232A1 (en) | 2009-03-13 | 2010-09-22 | Almirall, S.A. | Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors |
| EP2239256A1 (en) | 2009-03-13 | 2010-10-13 | Almirall, S.A. | Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor |
| EP2228367A1 (en) | 2009-03-13 | 2010-09-15 | Almirall, S.A. | Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as DHODH inhibitors |
-
2009
- 2009-10-16 EP EP09382212A patent/EP2314577A1/en not_active Withdrawn
-
2010
- 2010-10-14 DK DK10765586.2T patent/DK2488497T3/da active
- 2010-10-14 PL PL10765586T patent/PL2488497T3/pl unknown
- 2010-10-14 CA CA2776328A patent/CA2776328C/en active Active
- 2010-10-14 ES ES10765586.2T patent/ES2467165T3/es active Active
- 2010-10-14 MY MYPI2012001685A patent/MY160308A/en unknown
- 2010-10-14 RS RS20140253A patent/RS53319B/en unknown
- 2010-10-14 CN CN201080046816.8A patent/CN102574800B/zh active Active
- 2010-10-14 JP JP2012533527A patent/JP5809630B2/ja active Active
- 2010-10-14 NZ NZ598429A patent/NZ598429A/en unknown
- 2010-10-14 AU AU2010306098A patent/AU2010306098B2/en active Active
- 2010-10-14 SI SI201030632T patent/SI2488497T1/sl unknown
- 2010-10-14 MX MX2012004033A patent/MX2012004033A/es active IP Right Grant
- 2010-10-14 US US13/501,847 patent/US8598363B2/en active Active
- 2010-10-14 BR BR112012008464-0A patent/BR112012008464B1/pt active IP Right Grant
- 2010-10-14 EP EP10765586.2A patent/EP2488497B1/en active Active
- 2010-10-14 PE PE2012000491A patent/PE20121173A1/es active IP Right Grant
- 2010-10-14 CN CN201410085756.0A patent/CN103936668A/zh active Pending
- 2010-10-14 WO PCT/EP2010/006283 patent/WO2011045059A1/en active Application Filing
- 2010-10-14 ME MEP-2014-50A patent/ME01812B/me unknown
- 2010-10-14 UA UAA201205649A patent/UA107811C2/ru unknown
- 2010-10-14 KR KR1020127009609A patent/KR101699999B1/ko active IP Right Grant
- 2010-10-14 PT PT107655862T patent/PT2488497E/pt unknown
- 2010-10-14 EA EA201200594A patent/EA022805B1/ru unknown
-
2012
- 2012-03-01 IL IL218446A patent/IL218446A/en active IP Right Grant
- 2012-03-01 ZA ZA2012/01563A patent/ZA201201563B/en unknown
- 2012-03-05 IN IN1938DEN2012 patent/IN2012DN01938A/en unknown
- 2012-03-23 CL CL2012000739A patent/CL2012000739A1/es unknown
- 2012-04-16 CO CO12061780A patent/CO6430508A2/es active IP Right Grant
- 2012-04-16 CR CR20120185A patent/CR20120185A/es unknown
- 2012-09-12 HK HK12108881.1A patent/HK1168101A1/xx unknown
-
2014
- 2014-06-03 SM SM201400064T patent/SMT201400064B/xx unknown
- 2014-06-05 HR HRP20140523AT patent/HRP20140523T1/hr unknown
- 2014-06-06 CY CY20141100405T patent/CY1115161T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UA115531C2 (uk) | Каталізатор і спосіб його одержання | |
| DK1881957T3 (da) | Fremgangsmåde til fremstilling af biproduktfattige methylglycin-N,N-diedikkesyre-trialkalimetalsalte | |
| NZ607969A (en) | Cd33 binding agents | |
| UA107811C2 (en) | Method of receiving 2-[(3,5-difluoro-3'-methoxy-1,1' biphenyl-4-yl)amino]nicotinic acid | |
| AR088514A1 (es) | Inmunoligantes biespecificos dirigidos contra tnf | |
| WO2010096123A3 (en) | Amino acid salts of prostaglandins | |
| MX2013007527A (es) | Anticuerpo monoclonal que reconoce la proteina l2 de virus de papiloma humano y metodo para medir el titulo del anticuerpo neutralizante de vph utilizando el mismo. | |
| BR112012030901A2 (pt) | método para preparação de acroleína a partir de glicerol ou glicerina, método para fabricar aldeído 3-(metiltio)propionico mmp, 2 hidroxi-4-metiltiobutironitrila hmtbn, metionina, ácido 2-hidroxi-4-metiltiobutanoico hmtba, ésteres deste último, ou ácido 2-oxo-metiltiobutanoico kmb, a partir de acroleína e uso de um catalisador | |
| JP2010209099A5 (ru) | ||
| ITMI20072262A1 (it) | Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico | |
| EA201291209A1 (ru) | Способ получения феррохина конвергентным восстановительным аминированием | |
| PE20060400A1 (es) | Formulacion farmaceutica de una sal de enantiomero de mirtazapina que no sublima | |
| JP2008260009A5 (ru) | ||
| WO2007071649A3 (de) | Salze der styphninsäure | |
| WO2010093214A3 (en) | Monoclonal antibody recognizing scye1 and use thereof | |
| TH130490B (th) | กระบวนการในการผลิตกรด 2-[(3,5-ไดฟลูออโร-3'-เมธอกซี-1,1'-ไบเฟนิล-4-อิล)อะมิโน]นิโคตินิก | |
| ECSP12011706A (es) | Procedimiento para fabricar ácido 2-[(3,5-difluoro-3'-metoxi-1,1'-bifenil-4-il)amino]nicotínico | |
| RU2008136365A (ru) | Способ получения о-метил-n-нитроизомочевины | |
| MX2012008362A (es) | Metodos y usos relacionados con la identificacion de un compuesto implicado en el dolor, asi como metodos de diagnostico de algesia. | |
| IL223427A (en) | Methods for Preparing 13 -Cyclohexyl-3-Methoxy-6- [Methyl- (2- {2- [Methyl- (Sulfamoyl) -amino] -ethonoxy} -ethyl) -carbamoyl] -7 h- Indolo- [1,2- a ] [2] -Benzazepine-10-Carboxylic Acid and Intermediates | |
| WO2012052189A8 (en) | Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia | |
| WO2012019268A3 (pt) | Composição imunogênica para vacina e kit para teste imunodiagnóstico de leishmaniose visceral | |
| TH130490A (th) | กระบวนการในการผลิตกรด 2-[(3,5-ไดฟลูออโร-3'-เมธอกซี-1,1'-ไบเฟนิล-4-อิล)อะมิโน]นิโคตินิก | |
| WO2009117160A3 (en) | Compound and method for treatment of gastroesophageal reflux | |
| IT1395286B1 (it) | Soluzione acquosa concentrata di tensioattivo anfotero, particolarmente betaina, e procedimento per la sua preparazione |