SMT201400064B - Procedimento per la produzione di acido 2-[(3,5-difluoro-3'-metossi-1,1'-bifenil-4-il) amino] nicotinico - Google Patents
Procedimento per la produzione di acido 2-[(3,5-difluoro-3'-metossi-1,1'-bifenil-4-il) amino] nicotinicoInfo
- Publication number
- SMT201400064B SMT201400064B SM201400064T SM201400064T SMT201400064B SM T201400064 B SMT201400064 B SM T201400064B SM 201400064 T SM201400064 T SM 201400064T SM 201400064 T SM201400064 T SM 201400064T SM T201400064 B SMT201400064 B SM T201400064B
- Authority
- SM
- San Marino
- Prior art keywords
- difluoro
- biphenyl
- methoxy
- amino
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09382212A EP2314577A1 (en) | 2009-10-16 | 2009-10-16 | Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid |
| PCT/EP2010/006283 WO2011045059A1 (en) | 2009-10-16 | 2010-10-14 | Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201400064B true SMT201400064B (it) | 2014-07-07 |
Family
ID=41402565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201400064T SMT201400064B (it) | 2009-10-16 | 2014-06-03 | Procedimento per la produzione di acido 2-[(3,5-difluoro-3'-metossi-1,1'-bifenil-4-il) amino] nicotinico |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US8598363B2 (xx) |
| EP (2) | EP2314577A1 (xx) |
| JP (1) | JP5809630B2 (xx) |
| KR (1) | KR101699999B1 (xx) |
| CN (2) | CN103936668A (xx) |
| AU (1) | AU2010306098B2 (xx) |
| BR (1) | BR112012008464B1 (xx) |
| CA (1) | CA2776328C (xx) |
| CL (1) | CL2012000739A1 (xx) |
| CO (1) | CO6430508A2 (xx) |
| CR (1) | CR20120185A (xx) |
| CY (1) | CY1115161T1 (xx) |
| DK (1) | DK2488497T3 (xx) |
| EA (1) | EA022805B1 (xx) |
| ES (1) | ES2467165T3 (xx) |
| HK (1) | HK1168101A1 (xx) |
| HR (1) | HRP20140523T1 (xx) |
| IL (1) | IL218446A (xx) |
| IN (1) | IN2012DN01938A (xx) |
| ME (1) | ME01812B (xx) |
| MX (1) | MX2012004033A (xx) |
| MY (1) | MY160308A (xx) |
| NZ (1) | NZ598429A (xx) |
| PE (1) | PE20121173A1 (xx) |
| PL (1) | PL2488497T3 (xx) |
| PT (1) | PT2488497E (xx) |
| RS (1) | RS53319B (xx) |
| SI (1) | SI2488497T1 (xx) |
| SM (1) | SMT201400064B (xx) |
| UA (1) | UA107811C2 (xx) |
| WO (1) | WO2011045059A1 (xx) |
| ZA (1) | ZA201201563B (xx) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
| UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
| EP2135610A1 (en) * | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
| EP2239256A1 (en) | 2009-03-13 | 2010-10-13 | Almirall, S.A. | Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor |
| JP7343373B2 (ja) * | 2019-12-02 | 2023-09-12 | 花王株式会社 | 香料組成物 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9608997A (pt) | 1995-06-21 | 1999-06-29 | Asta Medica Ag | Cartucho para pó farmacêutico com dispositivo de medição integrado e intalador para medicamentos em pó |
| DE19547648A1 (de) | 1995-12-20 | 1997-06-26 | Hoechst Ag | Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate |
| DE19610955A1 (de) | 1996-03-20 | 1997-09-25 | Hoechst Ag | Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid |
| GB9804343D0 (en) | 1998-02-27 | 1998-04-22 | Univ Cardiff | Chemical compounds |
| JP2003504310A (ja) | 1999-06-10 | 2003-02-04 | ワーナー−ランバート・カンパニー | アミロイドタンパク質凝集阻害方法およびアミロイド沈着物の画像化方法 |
| AR033459A1 (es) | 2001-04-05 | 2003-12-17 | Aventis Pharma Inc | Uso de (41-trifluorometilfenil)-amida del acido (z)-2-ciano-3-hidroxi-but-2-enoico para el tratamiento de la esclerosis multiple |
| WO2002102374A1 (en) | 2001-06-19 | 2002-12-27 | Merck & Co., Inc. | Amine salt of an integrin receptor antagonist |
| DE10129703A1 (de) | 2001-06-22 | 2003-01-02 | Sofotec Gmbh & Co Kg | Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren |
| WO2003006424A1 (en) | 2001-07-10 | 2003-01-23 | 4Sc Ag | Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| US7258118B2 (en) | 2002-01-24 | 2007-08-21 | Sofotec Gmbh & Co, Kg | Pharmaceutical powder cartridge, and inhaler equipped with same |
| DE10202940A1 (de) | 2002-01-24 | 2003-07-31 | Sofotec Gmbh & Co Kg | Patrone für einen Pulverinhalator |
| BR0307557A (pt) * | 2002-02-13 | 2005-01-04 | Glaxo Group Ltd | Derivados benzenosulfonamida como agentes antipsicóticos |
| US20070135488A1 (en) * | 2002-04-13 | 2007-06-14 | Chung You S | Amlodipine nicotinate and process for the preparation thereof |
| PE20040844A1 (es) * | 2002-11-26 | 2004-12-30 | Novartis Ag | Acidos fenilaceticos y derivados como inhibidores de la cox-2 |
| EP1581478A1 (en) | 2002-12-23 | 2005-10-05 | 4Sc Ag | Dhodh-inhibitors and method for their identification |
| WO2004056746A1 (en) | 2002-12-23 | 2004-07-08 | 4Sc Ag | Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| SE0400234D0 (sv) | 2004-02-06 | 2004-02-06 | Active Biotech Ab | New compounds, methods for their preparation and use thereof |
| EP1763346A4 (en) | 2004-05-21 | 2009-03-04 | Uab Research Foundation | COMPOSITION AND METHODS RELATING TO INHIBITORS OF PYRIMIDINE SYNTHESIS |
| WO2006022442A1 (ja) | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| BRPI0518205A (pt) | 2004-10-19 | 2008-11-04 | Aventis Pharma Inc | uso de (4'-trifluorometilfenil)-amida de ácido (z)-2-ciano-3-hidróxi-but-2-enóico para o tratamento de doença inflamatória do intestino |
| ES2265276B1 (es) | 2005-05-20 | 2008-02-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
| CN1696100B (zh) * | 2005-06-01 | 2010-11-24 | 黑龙江福和华星制药集团股份有限公司 | 痤疮治疗药阿达帕林的新型简捷合成方法 |
| ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
| WO2008097180A1 (en) | 2007-02-06 | 2008-08-14 | Chelsea Therapeutics, Inc. | New compounds, methods for their preparation and use thereof |
| UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
| EP2135610A1 (en) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
| EP2210615A1 (en) | 2009-01-21 | 2010-07-28 | Almirall, S.A. | Combinations comprising methotrexate and DHODH inhibitors |
| EP2239256A1 (en) | 2009-03-13 | 2010-10-13 | Almirall, S.A. | Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor |
| EP2228367A1 (en) | 2009-03-13 | 2010-09-15 | Almirall, S.A. | Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as DHODH inhibitors |
| EP2230232A1 (en) | 2009-03-13 | 2010-09-22 | Almirall, S.A. | Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors |
-
2009
- 2009-10-16 EP EP09382212A patent/EP2314577A1/en not_active Withdrawn
-
2010
- 2010-10-14 US US13/501,847 patent/US8598363B2/en active Active
- 2010-10-14 PL PL10765586T patent/PL2488497T3/pl unknown
- 2010-10-14 PT PT107655862T patent/PT2488497E/pt unknown
- 2010-10-14 BR BR112012008464-0A patent/BR112012008464B1/pt active IP Right Grant
- 2010-10-14 DK DK10765586.2T patent/DK2488497T3/da active
- 2010-10-14 EA EA201200594A patent/EA022805B1/ru unknown
- 2010-10-14 MX MX2012004033A patent/MX2012004033A/es active IP Right Grant
- 2010-10-14 WO PCT/EP2010/006283 patent/WO2011045059A1/en active Application Filing
- 2010-10-14 CN CN201410085756.0A patent/CN103936668A/zh active Pending
- 2010-10-14 AU AU2010306098A patent/AU2010306098B2/en active Active
- 2010-10-14 KR KR1020127009609A patent/KR101699999B1/ko active IP Right Grant
- 2010-10-14 EP EP10765586.2A patent/EP2488497B1/en active Active
- 2010-10-14 CA CA2776328A patent/CA2776328C/en active Active
- 2010-10-14 ES ES10765586.2T patent/ES2467165T3/es active Active
- 2010-10-14 ME MEP-2014-50A patent/ME01812B/me unknown
- 2010-10-14 UA UAA201205649A patent/UA107811C2/ru unknown
- 2010-10-14 CN CN201080046816.8A patent/CN102574800B/zh active Active
- 2010-10-14 SI SI201030632T patent/SI2488497T1/sl unknown
- 2010-10-14 RS RS20140253A patent/RS53319B/en unknown
- 2010-10-14 JP JP2012533527A patent/JP5809630B2/ja active Active
- 2010-10-14 PE PE2012000491A patent/PE20121173A1/es active IP Right Grant
- 2010-10-14 NZ NZ598429A patent/NZ598429A/en unknown
- 2010-10-14 MY MYPI2012001685A patent/MY160308A/en unknown
-
2012
- 2012-03-01 IL IL218446A patent/IL218446A/en active IP Right Grant
- 2012-03-01 ZA ZA2012/01563A patent/ZA201201563B/en unknown
- 2012-03-05 IN IN1938DEN2012 patent/IN2012DN01938A/en unknown
- 2012-03-23 CL CL2012000739A patent/CL2012000739A1/es unknown
- 2012-04-16 CO CO12061780A patent/CO6430508A2/es active IP Right Grant
- 2012-04-16 CR CR20120185A patent/CR20120185A/es unknown
- 2012-09-12 HK HK12108881.1A patent/HK1168101A1/xx unknown
-
2014
- 2014-06-03 SM SM201400064T patent/SMT201400064B/xx unknown
- 2014-06-05 HR HRP20140523AT patent/HRP20140523T1/hr unknown
- 2014-06-06 CY CY20141100405T patent/CY1115161T1/el unknown
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